Suppression of Lefty expression in induced pluripotent cancer cells

FASEB Journal

Volumn 27, Issue 6, 2013, Pages 2165-2174

  Saito, Akiko ^a   Ochiai, Hiromi ^a   Okada, Shoko ^a   Miyata, Naoteru ^b   Azuma, Toshifumi ^a  

^a TOKYO DENTAL COLLEGE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

DNA methylation; Ras MAPK signalling; Tgf

Indexed keywords

LEFT RIGHT DETERMINATION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CANCER CELL; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA STRAND; ECTODERM; EMBRYONIC STEM CELL; ENDODERM; HUMAN; HUMAN CELL; LIVER CANCER; MESODERM; PANCREAS CANCER; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

DNA METHYLATION; RAS-MAPK SIGNALING; TGF-Β;

CELL LINE, TUMOR; CELL TRANSDIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LEFT-RIGHT DETERMINATION FACTORS; PROMOTER REGIONS, GENETIC; SUPPRESSION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

IPS;

EID: 84878747831     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-221432     Document Type: Article

References (48)

1. Topczewska, J. M., Postovit, L.-M., Margaryan, N. V., Sam, A., Hess, A. R., Wheaton, W. W., Nickoloff, B. J., Topczewski, J., and Hendrix, M. J. C. (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat. Med. 12, 925-9322
2. Hendrix, M. J. C., Seftor, E. A., Seftor, R. E. B., Kasemeier- Kulesa, J., Kulesa, P. M., and Postovit, L.-M. (2007) Reprogramming metastatic tumour cells with embryonic microenvironments. Nat. Rev. Cancer 7, 246-2555
3. Tabibzadeh, S., and Hemmati-Brivanlou, A. (2006) Lefty at the crossroads of 'stemness' and differentiative events. Stem Cells 24, 1998-20066
4. Postovit, L.-M., Margaryan, N. V., Seftor, E. A., Kirschmann, D. A., Lipavsky, A., Wheaton, W. W., Abbott, D. E., Seftor, R. E. B., and Hendrix, M. J. C. (2008) Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc. Natl. Acad. Sci. U. S. A. 105, 4329-43344
5. Costa, F. F., Seftor, E. A., Bischof, J. M., Kirschmann, D. A., Strizzi, L., Arndt, K., de Fatima Bonaldo, M., Soares, M. B., and Hendrix, M. J. C. (2009) Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment. Epigenomics 1, 387-3988
6. Malchenko, S., Galat, V., Seftor, E. A., Vanin, E. F., Costa, F. F., Seftor, R. E. B., Soares, M. B., and Hendrix, M. J. C. (2010) Cancer hallmarks in induced pluripotent cells: new insights. J. Cell. Physiol. 225, 390-3933
7. Joan, M. (2008) TGFβ in cancer. Cell 134, 215-2300
8. Derynck, R., and Zhang, Y. E. (2003) Smad-dependent and Smadindependent pathways in TGFβ family signalling. Nature 425, 577-5844
9. Ikushima, H., and Miyazono, K. (2010) TGFβ signalling: a complex web in cancer progression. Nat. Rev. Cancer 10, 415-4244
10. Bierie, B., and Moses, H. L. (2006) Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer. Nat. Rev. Cancer 6, 506-5200
11. Heldin, C.-H., Landström, M., and Moustakas, A. (2009) Mechanism of TGFβ signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr. Opin. Cell Biol. 21, 166-1766
12. Miyata, N., Azuma, T., Hozawa, S., Higuchi, H., Yokoyama, A., Kabashima, A., Igarashi, T., Saeki, K., and Hibi, T. (2012) Transforming growth factor and Ras/MEK/ERK signaling regulate the expression level of a novel tumor suppressor lefty. Pancreas 41, 745-7522
13. Kim, K., Doi, A., Wen, B., Ng, K., Zhao, R., Cahan, P., Kim, J., Aryee, M. J., Ji, H., Ehrlich, L. I. R., Yabuuchi, A., Takeuchi, A., Cunniff, K. C., Hongguang, H., Mckinney-Freeman, S., Naveiras, O., Yoon, T. J., Irizarry, R. A., Jung, N., Seita, J., Hanna, J., Murakami, P., Jaenisch, R., Weissleder, R., Orkin, S. H., Weissman, I. L., Feinberg, A. P., and Daley, G. Q. (2010) Epigenetic memory in induced pluripotent stem cells. Nature 467, 285-2900
14. Bilic, J., and Belmonte, J. C. I. (2012) Concise review: induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart? Stem Cells 30, 33-411
15. Miyoshi, N., Ishii, H., Nagai, K., Hoshino, H., Mimori, K., Tanaka, F., Nagano, H., Sekimoto, M., Doki, Y., and Mori, M. (2010) Defined factors induce reprogramming of gastrointestinal cancer cells. Proc. Natl. Acad. Sci. U. S. A. 107, 40-455
16. Thillainadesan, G., Chitilian, J. M., Isovic, M., Ablack, J. N. G., Mymryk, J. S., Tini, M., and Torchia, J. (2012) TGFβ-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex. Mol. Cell 46, 636-6499
17. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-8722
18. Yajima, T., Ochiai, H., Uchiyama, T., Takano, N., Shibahara, T., and Azuma, T. (2009) Resistance to cytotoxic chemotherapy-induced apoptosis in side population cells of human oral squamous cell carcinoma cell line Ho-1-N-1. Inter. J. Oncol. 35, 273-2800
19. Besser, D. (2004) Expression of Nodal, Lefty-A, and Lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3. J. Biol. Chem. 279, 45076-450844
20. Gouas, D. A., Shi, H., Hautefeuille, A. H., Ortiz-Cuaran, S. L., Legros, P. C., Szymanska, K. J., Galy, O., Egevad, L. A., Abedi- Ardekani, B., Wiman, K. G., Hantz, O., Caron de Fromentel, C., Chemin, I. A., and Hainaut, P. L. (2010) Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein. Carcinogenesis 31, 1475-14822
21. Bellini, M. F., Cadamuro, A. C. T., Succi, M., Proença, M. A., and Silva, A. E. (2012) Alterations of the TP53 gene in gastric and esophageal carcinogenesis. J. Biomed. Biotechnol. 2012, 891961
22. Suzuki, K., and Matsubara, H. (2011) Recent advances in p53 research and cancer treatment. J. Biomed. Biotechnol. 2011, 978312
23. Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., and Belmonte, J. C. I. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460, 1140-11444
24. Utikal, J., Polo, J. M., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J. G., and Hochedlinger, K. (2009) Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460, 1145-11488
25. Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., and Yamanaka, S. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132-11355
26. Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Canamero, M., Blasco, M. A., and Serrano, M. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460, 1136-11399
27. Daemer, R. J., Feinstone, S. M., Alexander, J. J., Tully, J. G., London, W. T., Wong, D. C., and Purcell, R. H. (1980) PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity. Infect. Immun. 30, 607-6111
28. Marion, P. L., Salazar, F. H., Alexander, J. J., and Robinson, W. S. (1979) Polypeptides of hepatitis B virus surface antigen produced by a hepatoma cell line. J. Virol. 32, 796-8022
29. Motoo, Y., Mahmoudi, M., Osther, K., and Bollon, A. P. (1986) Oncogene expression in human hepatoma cells PLC/PRF/5. Biochem. Biophys. Res. Commun. 135, 262-2688
30. Sumi, S., Beauchamp, R. D., Townsend, C. M., Jr., Pour, P. M., Ishizuka, J., and Thompson, J. C. (1994) Lovastatin inhibits pancreatic cancer growth regardless of RAS mutation. Pancreas 9, 657-6611
31. Furukawa, T. (2009) Molecular pathology of pancreatic cancer: implications for molecular targeting therapy. Clin. Gastroenterol. Hepatol. 7, S35-S399
32. Maitra, A., and Hruban, R. H. (2008) Pancreatic cancer. Annu. Rev. Pathol. 3, 157-1888
33. Baines, A. T., Xu, D., and Der, C. J. (2011) Inhibition of Ras for cancer treatment: the search continues. Fut. Med. Chem. 3, 1787-18088
34. Schmelzer, E., Zhang, L., Bruce, A., Wauthier, E., Ludlow, J., Yao, H., Moss, N., Melhem, A., McClelland, R., Turner, W., Kulik, M., Sherwood, S., Tallheden, T., Cheng, N., Furth, M. E., and Reid, L. M. (2007) Human hepatic stem cells from fetal and postnatal donors. J. Exp. Med. 204, 1973-19877
35. Schmelzer, E., Wauthier, E., and Reid, L. M. (2006) The phenotypes of pluripotent human hepatic progenitors. Stem Cells 24, 1852-18588
36. Brait, M., and Sidransky, D. (2011) Cancer epigenetics: above and beyond. Toxicol. Mech. Methods 21, 275-2888
37. Tsai, H.-C., and Baylin, S. B. (2011) Cancer epigenetics: linking basic biology to clinical medicine. Cell Res. 21, 502-5177
38. Jones, P. A., and Baylin, S. B. (2007) The epigenomics of cancer. Cell 128, 683-6922
39. Sharma, S., Kelly, T. K., and Jones, P. A. (2010) Epigenetics in cancer. Carcinogenesis 31, 27-366
40. Esteller, M. (2008) Epigenetics in cancer. N. Engl. J. Med. 358, 1148-11599
41. Herman, J. G., and Baylin, S. B. (2003) Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349, 2042-20544
42. Reya, T., Morrison, S. J., Clarke, M. F., and Weissman, I. L. (2001) Stem cells, cancer, and cancer stem cells. Nature 414, 105-1111
43. Wicha, M. S., Liu, S., and Dontu, G. (2006) Cancer stem cells: an old idea - a paradigm shift. Cancer Res. 66, 1883-18900
44. Falzacappa, M. V. V., Ronchini, C., Reavie, L. B., and Pelicci, P. G. (2012) Regulation of self-renewal in normal and cancer stem cells. FEBS J. 10.1111/j.1742-4658.2012.08727.x..
45. Tysnes, B. B. (2010) Tumor-initiating and -propagating cells: cells that we would like to identify and control. Neoplasia 12, 506-5155
46. Barroso-delJesus, A., Lucena-Aguilar, G., Sanchez, L., Ligero, G., Gutierrez-Aranda, I., and Menendez, P. (2011) The nodal inhibitor lefty is negatively modulated by the microRNA miR- 302 in human embryonic stem cells. FASEB J. 25, 1497-15088
47. Greer Card, D. A., Hebbar, P. B., Li, L., Trotter, K. W., Komatsu, Y., Mishina, Y., and Archer, T. K. (2008) Oct4/Sox2-Regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol. Cell. Biol. 28, 6426-64388
48. Dvash, T., Sharon, N., Yanuka, O., and Benvenisty, N. (2007) Molecular analysis of LEFTY-expressing cells in early human embryoid bodies. Stem Cells 25, 465-4722