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Volumn 49, Issue 5, 2013, Pages 303-315

Tivozanib: Practical implications for renal cell carcinoma and other solid tumors

Author keywords

TIVo; Tivozanib; VEgFr 1 (FLT 1) inhibitors; VEgFr 2 (FLK 1 KDr) inhibitors; VEgFr 3 (FLT 4) inhibitors

Indexed keywords

AXITINIB; BEVACIZUMAB; BRIVANIB ALANINATE; CAPECITABINE; CEDIRANIB; EVEROLIMUS; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FLT3 LIGAND; FLUOROPYRIMIDINE; FLUOROURACIL; IRINOTECAN; LINIFANIB; OXALIPLATIN; PACLITAXEL; PAZOPANIB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; REGORAFENIB; SORAFENIB; TIVOZANIB; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 84878710646     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2013.49.5.1960218     Document Type: Article
Times cited : (9)

References (86)
  • 1
  • 2
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel, R., Ward, E., Brawley, O., Jemal, A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. Ca Cancer J Clin 2011, 61(4): 212-36.
    • (2011) Ca Cancer J Clin , vol.61 , Issue.4 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 3
    • 0344442746 scopus 로고    scopus 로고
    • Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease
    • DOI 10.1016/S0094-0143(03)00056-9
    • Janzen, N.K., Kim, H.L., Figlin, R.A., Belldegrun, A.S. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin north am 2003, 30(4): 843-52. (Pubitemid 37485197)
    • (2003) Urologic Clinics of North America , vol.30 , Issue.4 , pp. 843-852
    • Janzen, N.K.1    Kim, H.L.2    Figlin, R.A.3    Belldegrun, A.S.4
  • 4
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer, R.J., hutson, T.E., Tomczak, P. et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin oncol 2009, 27(22): 3584-90.
    • (2009) J Clin Oncol , vol.27 , Issue.22 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 5
    • 48249117436 scopus 로고    scopus 로고
    • High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : A retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006
    • Klapper, J.A., Downey, S.G., Smith, F.O. et al. High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006. Cancer 2008, 113(2): 293-301.
    • (2008) Cancer , vol.113 , Issue.2 , pp. 293-301
    • Klapper, J.A.1    Downey, S.G.2    Smith, F.O.3
  • 7
    • 65949112237 scopus 로고    scopus 로고
    • Treatment of kidney cancer: Insights provided by the VHL tumor-suppressor protein
    • Kaelin, W.G., Jr. Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein. Cancer 2009, 115(10, Suppl.): 2262-72.
    • (2009) Cancer , vol.115 , Issue.10 SUPPL. , pp. 2262-2272
    • Kaelin Jr., W.G.1
  • 8
    • 51049084870 scopus 로고    scopus 로고
    • Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
    • nickerson, M.L., Jaeger, E., Shi, Y. et al. Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer res 2008, 14(15): 4726-34.
    • (2008) Clin Cancer Res , vol.14 , Issue.15 , pp. 4726-4734
    • Nickerson, M.L.1    Jaeger, E.2    Shi, Y.3
  • 9
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • DOI 10.1200/JCO.2004.05.061
    • Kim, W.Y., Kaelin, W.G. Role of VHL gene mutation in human cancer. J Clin oncol 2004, 22(24): 4991-5004. (Pubitemid 46646218)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.24 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 10
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G.L. Targeting HIF-1 for cancer therapy. nat rev Cancer 2003, 3(10): 721-32. (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 12
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg, C.N., Davis, I.D., Mardiak, J. et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin oncol 2010, 28(6): 1061-8.
    • (2010) J Clin Oncol , vol.28 , Issue.6 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 13
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
    • rini, B.I., Escudier, B., Tomczak, P. et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011, 378(9807): 1931-9.
    • (2011) Lancet , vol.378 , Issue.9807 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3
  • 14
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P., Jain, R.K. Angiogenesis in cancer and other diseases. nature 2000, 407(6801): 249-57.
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 15
    • 84865506371 scopus 로고    scopus 로고
    • Patient preference between pazopanib (Paz) and sunitinib (Sun): Results of a randomized double-blind, placebo-controlled, cross-over study in patients with metastatic renal cell carcinoma (mRCC)-PISCES study, NCT 01064310
    • 48th annu Meet am Soc Clin oncol (aSCo) (June 1-5, Chicago) 2012], abst Cra4502
    • Escudier, B.J., porta, C., Bono, P. et al. Patient preference between pazopanib (Paz) and sunitinib (Sun): Results of a randomized double-blind, placebo-controlled, cross-over study in patients with metastatic renal cell carcinoma (mRCC)-PISCES study, NCT 01064310. J Clin oncol [48th annu Meet am Soc Clin oncol (aSCo) (June 1-5, Chicago) 2012] 2012, 30(18, Suppl.): abst Cra4502.
    • (2012) J Clin Oncol , vol.30 , Issue.18 SUPPL.
    • Escudier, B.J.1    Porta, C.2    Bono, P.3
  • 16
    • 79959944026 scopus 로고    scopus 로고
    • Antiangiogenic therapy, hypoxia, and metastasis: Risky liaisons, or not?
    • De Bock, K., Mazzone, M., Carmeliet, P. Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? Nat rev Clin oncol 2011, 8(7): 393-404.
    • Nat Rev Clin Oncol 2011 , vol.8 , Issue.7 , pp. 393-404
    • De Bock, K.1    Mazzone, M.2    Carmeliet, P.3
  • 17
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet, J.M., ricci, S., Mazzaferro, V. et al. Sorafenib in advanced hepatocellular carcinoma. n Engl J Med 2008, 359(4): 378-90.
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 19
    • 84861098484 scopus 로고    scopus 로고
    • Pazopanib for metastatic soft-tissue sarcoma (PALETTE): A randomised, double-blind, placebo-controlled phase 3 trial
    • van der graaf, W.T., Blay, J.Y., Chawla, S.P. et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012, 379(9829): 1879-86.
    • (2012) Lancet , vol.379 , Issue.9829 , pp. 1879-1886
    • Van Der Graaf, W.T.1    Blay, J.Y.2    Chawla, S.P.3
  • 21
    • 38949178751 scopus 로고    scopus 로고
    • Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model
    • DOI 10.1111/j.1349-7006.2007.00724.x
    • Taguchi, E., nakamura, K., Miura, T., Shibuya, M., Isoe, T. Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci 2008, 99(3): 623-30. (Pubitemid 351228583)
    • (2008) Cancer Science , vol.29 , Issue.3 , pp. 623-630
    • Taguchi, E.1    Nakamura, K.2    Miura, T.3    Shibuya, M.4    Isoe, T.5
  • 25
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib: From rational design to clinical efficacy
    • DOI 10.1200/JCO.2006.06.3602
    • Chow, L.Q., Eckhardt, S.G. Sunitinib: from rational design to clinical efficacy. J Clin oncol 2007, 25(7): 884-96. (Pubitemid 350002890)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.7 , pp. 884-896
    • Chow, L.Q.M.1    Eckhardt, S.G.2
  • 26
    • 84892116875 scopus 로고    scopus 로고
    • Absorption, metabolism, and excretion of [14C]-tivozanib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in healthy male participants: A phase I, open-label, mass-balance study
    • Cotreau, M.M., hale, C.L., Jacobson, L. et al. Absorption, metabolism, and excretion of [14C]-tivozanib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in healthy male participants: A phase I, open-label, mass-balance study. Clin pharmacol Drug Dev 2012, 1(3): 102-9.
    • (2012) Clin Pharmacol Drug Dev , vol.1 , Issue.3 , pp. 102-109
    • Cotreau, M.M.1    Hale, C.L.2    Jacobson, L.3
  • 27
    • 81255128983 scopus 로고    scopus 로고
    • Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1,-2, and-3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors
    • Eskens, F.A., de Jonge, M.J., Bhargava, P. et al. Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1,-2, and-3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors. Clin Cancer res 2011, 17(22): 7156-63.
    • (2011) Clin Cancer Res , vol.17 , Issue.22 , pp. 7156-7163
    • Eskens, F.A.1    De Jonge, M.J.2    Bhargava, P.3
  • 28
    • 84878676519 scopus 로고    scopus 로고
    • A single center, open-label, randomized, two-period crossover food effect study of single doses of tivozanib (AV-951) in healthy subjects (NCT01316848)
    • accessed april 29
    • A single center, open-label, randomized, two-period crossover food effect study of single doses of tivozanib (AV-951) in healthy subjects (NCT01316848). Clinical Trials.gov Web site, accessed april 29, 2013.
    • (2013) Clinical Trials.gov Web Site
  • 29
    • 84878716686 scopus 로고    scopus 로고
    • A phase 1 study to evaluate the effect of ketoconazole on the pharmacokinetics of tivozanib in healthy subjects (NCT01363778)
    • accessed april 29
    • A phase 1 study to evaluate the effect of ketoconazole on the pharmacokinetics of tivozanib in healthy subjects (NCT01363778). Clinical Trials.gov Web site, accessed april 29, 2013.
    • (2013) Clinical Trials.gov Web Site
  • 30
    • 84878733678 scopus 로고    scopus 로고
    • A phase 1 study to evaluate the effect of rifampin on the pharmacokinetics of tivozanib in healthy subjects (NCT01363804)
    • accessed april 29
    • A phase 1 study to evaluate the effect of rifampin on the pharmacokinetics of tivozanib in healthy subjects (NCT01363804). Clinical Trials.gov Web site, accessed april 29, 2013.
    • (2013) Clinical Trials.gov Web Site
  • 31
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer, E.A., Therasse, P., Bogaerts, J. et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009, 45(2): 228-47.
    • (2009) Eur J Cancer , vol.45 , Issue.2 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 32
    • 79960363399 scopus 로고    scopus 로고
    • A phase i trial of combined tivozanib (AV-951) and temsirolimus therapy in patients (pts) with renal cell carcinoma (RCC)
    • genitourin Cancers Symp (Feb 17-19, orlando) 2011], abst 330
    • Kabbinavar, F.F., Srinivas, S., hauke, R.J. et al. A phase I trial of combined tivozanib (AV-951) and temsirolimus therapy in patients (pts) with renal cell carcinoma (RCC). J Clin oncol [genitourin Cancers Symp (Feb 17-19, orlando) 2011] 2011, 29(7, Suppl.): abst 330.
    • (2011) J Clin Oncol , vol.29 , Issue.7 SUPPL.
    • Kabbinavar, F.F.1    Srinivas, S.2    Hauke, R.J.3
  • 33
    • 84863755452 scopus 로고    scopus 로고
    • Antitumor activity and safety of tivozanib (AV-951) in a phase II randomized discontinuation trial in patients with renal cell carcinoma
    • nosov, D.A., Esteves, B., Lipatov, O.N. et al. Antitumor activity and safety of tivozanib (AV-951) in a phase II randomized discontinuation trial in patients with renal cell carcinoma. J Clin oncol 2012, 30(14): 1678-85.
    • (2012) J Clin Oncol , vol.30 , Issue.14 , pp. 1678-1685
    • Nosov, D.A.1    Esteves, B.2    Lipatov, O.N.3
  • 34
    • 80052735494 scopus 로고    scopus 로고
    • Activity of tivozanib (AV-951) in patients (Pts) with different histologic subtypes of renal cell carcinoma (RCC)
    • Genitourin Cancers Symp (Feb 17-19, orlando) 2011], abst 327
    • Bhargava, P., Esteves, B., al-adhami, M. et al. Activity of tivozanib (AV-951) in patients (Pts) with different histologic subtypes of renal cell carcinoma (RCC). J Clin oncol [genitourin Cancers Symp (Feb 17-19, orlando) 2011] 2011, 29(7, Suppl.): abst 327.
    • (2011) J Clin Oncol , vol.29 , Issue.7 SUPPL.
    • Bhargava, P.1    Esteves, B.2    Al-Adhami, M.3
  • 35
    • 84867755853 scopus 로고    scopus 로고
    • Tivozanib versus sorafenib as initial targeted therapy for patients with advanced renal cell carcinoma: Results from a phase III randomized, open-label, multicenter trial
    • 48th annu Meet am Soc Clin oncol (aSCo) (June 1-5, Chicago) 2012], abst 4501
    • Motzer, R.J., nosov, D., Eisen, T. et al. Tivozanib versus sorafenib as initial targeted therapy for patients with advanced renal cell carcinoma: Results from a phase III randomized, open-label, multicenter trial. J Clin oncol [48th annu Meet am Soc Clin oncol (aSCo) (June 1-5, Chicago) 2012] 2012, 30(15, Suppl.): abst 4501.
    • (2012) J Clin Oncol , vol.30 , Issue.15 SUPPL.
    • Motzer, R.J.1    Nosov, D.2    Eisen, T.3
  • 36
    • 79955767772 scopus 로고    scopus 로고
    • Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
    • rini, B.I., Cohen, D.P., Lu, D.R. et al. Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J natl Cancer Inst 2011, 103(9): 763-73.
    • (2011) J Natl Cancer Inst , vol.103 , Issue.9 , pp. 763-773
    • Rini, B.I.1    Cohen, D.P.2    Lu, D.R.3
  • 37
    • 84879057754 scopus 로고    scopus 로고
    • Treatment benefit of tivozanib hydrochloride versus sorafenib on health-related quality of life (HRQoL) among patients (pts) with advanced/metastatic renal cell carcinoma (mRCC): TIVO-1 study results
    • genitourin Cancers Symp (Feb 14-16, orlando) 2013], abst 355
    • Cella, D., Ivanescu, C., Skaltsa, K. et al. Treatment benefit of tivozanib hydrochloride versus sorafenib on health-related quality of life (HRQoL) among patients (pts) with advanced/metastatic renal cell carcinoma (mRCC): TIVO-1 study results. J Clin oncol [genitourin Cancers Symp (Feb 14-16, orlando) 2013] 2013, 31(6, Suppl.): abst 355.
    • (2013) J Clin Oncol , vol.31 , Issue.6 SUPPL.
    • Cella, D.1    Ivanescu, C.2    Skaltsa, K.3
  • 38
    • 84878711441 scopus 로고    scopus 로고
    • Overall survival results from a phase III study of tivozanib hydrochloride versus sorafenib in patients with renal cell carcinoma
    • genitourin Cancers Symp (Feb 14-16, orlando) 2013], abst 350
    • Motzer, R.J., Eisen, T., hutson, T.E. et al. Overall survival results from a phase III study of tivozanib hydrochloride versus sorafenib in patients with renal cell carcinoma. J Clin oncol [genitourin Cancers Symp (Feb 14-16, orlando) 2013] 2013, 31(6, Suppl.): abst 350.
    • (2013) J Clin Oncol , vol.31 , Issue.6 SUPPL.
    • Motzer, R.J.1    Eisen, T.2    Hutson, T.E.3
  • 39
    • 81855163888 scopus 로고    scopus 로고
    • A phase Ib, open-label, dose-escalation study of tivozanib and FOLFOX6 in patients (pts) with advanced gastrointestinal (GI) tumors
    • gastrointest Cancers Symp (Feb 17-19, orlando) 2011], abst 549
    • Eskens, F., oldenhuis, C.N., Bhargava, P. et al. A phase Ib, open-label, dose-escalation study of tivozanib and FOLFOX6 in patients (pts) with advanced gastrointestinal (GI) tumors. J Clin oncol [gastrointest Cancers Symp (Feb 17-19, orlando) 2011] 2011, 29(4, Suppl.): abst 549.
    • (2011) J Clin Oncol , vol.29 , Issue.4 SUPPL.
    • Eskens, F.1    Oldenhuis, C.N.2    Bhargava, P.3
  • 40
    • 84877008488 scopus 로고    scopus 로고
    • Final results of a phase Ib study of tivozanib and FOLFOX6 in patients (pts) with advanced gastrointestinal (GI) tumors
    • 48th annu Meet am Soc Clin oncol (aSCo) (June 1-5, Chicago) 2012], abst 4132
    • Eskens, F., oldenhuis, C.N., Loos, W.J. et al. Final results of a phase Ib study of tivozanib and FOLFOX6 in patients (pts) with advanced gastrointestinal (GI) tumors. J Clin oncol [48th annu Meet am Soc Clin oncol (aSCo) (June 1-5, Chicago) 2012] 2012, 30(15, Suppl.): abst 4132.
    • (2012) J Clin Oncol , vol.30 , Issue.15 SUPPL.
    • Eskens, F.1    Oldenhuis, C.N.2    Loos, W.J.3
  • 41
    • 84878718819 scopus 로고    scopus 로고
    • A study combining mFOLFOX6 with tivozanib or bevacizumab in patients with metastatic colorectal cancer as first line therapy (NCT01478594)
    • accessed april 29
    • A study combining mFOLFOX6 with tivozanib or bevacizumab in patients with metastatic colorectal cancer as first line therapy (NCT01478594). Clinical Trials.gov Web site, accessed april 29, 2013.
    • (2013) Clinical Trials.gov Web Site
  • 42
    • 84878687669 scopus 로고    scopus 로고
    • A trial of tivozanib (AV-951) in combination with capecitabine (Xeloda®) in subjects with advanced solid tumors (NCT01306630)
    • accessed april 29
    • A trial of tivozanib (AV-951) in combination with capecitabine (Xeloda®) in subjects with advanced solid tumors (NCT01306630). Clinical Trials.gov Web site, accessed april 29, 2013.
    • (2013) Clinical Trials.gov Web Site
  • 43
    • 84871430564 scopus 로고    scopus 로고
    • Multicenter phase Ib/II study of everolimus (RAD001) and tivozanib (AV-951) in patients with refractory, metastatic colorectal cancer
    • gastrointest Cancers Symp (Jan 19-21, San Francisco) 2012], abst 560
    • Wolpin, B.M., ng, K., Zhu, A.X. et al. Multicenter phase Ib/II study of everolimus (RAD001) and tivozanib (AV-951) in patients with refractory, metastatic colorectal cancer. J Clin oncol [gastrointest Cancers Symp (Jan 19-21, San Francisco) 2012] 2012, 30(4, Suppl.): abst 560.
    • (2012) J Clin Oncol , vol.30 , Issue.4 SUPPL.
    • Wolpin, B.M.1    Ng, K.2    Zhu, A.X.3
  • 44
    • 81855163889 scopus 로고    scopus 로고
    • Combination of tivozanib (AV-951) with weekly paclitaxel for metastatic breast cancer: Results of a phase i study
    • 47th annu Meet am Soc Clin oncol (aSCo) (June 3-7, Chicago) 2011], abst 1092
    • Mayer, E.L., Scheulen, M.E., Beckman, J. et al. Combination of tivozanib (AV-951) with weekly paclitaxel for metastatic breast cancer: Results of a phase I study. J Clin oncol [47th annu Meet am Soc Clin oncol (aSCo) (June 3-7, Chicago) 2011] 2011, 29(15, Suppl.): abst 1092.
    • (2011) J Clin Oncol , vol.29 , Issue.15 SUPPL.
    • Mayer, E.L.1    Scheulen, M.E.2    Beckman, J.3
  • 45
    • 84878686018 scopus 로고    scopus 로고
    • AVEO and Astellas announce initiation of patient enrollment in phase 2 trial of tivozanib in combination with paclitaxel in patients with advanced triple negative breast cancer
    • [news release]. December 3, accessed January 12, 2013
    • AVEO and Astellas announce initiation of patient enrollment in phase 2 trial of tivozanib in combination with paclitaxel in patients with advanced triple negative breast cancer [news release]. aVEo pharmaceuticals, December 3, 2012. http://investor.aveooncology.com/phoenix.zhtml?c=21965 1&p=irol-newsarticle&ID=1763550&highlight=. accessed January 12, 2013.
    • (2012) AVEo Pharmaceuticals
  • 46
    • 84878718405 scopus 로고    scopus 로고
    • AVEO and Astellas announce FDA acceptance of NDA filing for tivozanib for the treatment of advanced renal cell carcinoma
    • [news release]. november 28, accessed January 12, 2013
    • AVEO and Astellas announce FDA acceptance of NDA filing for tivozanib for the treatment of advanced renal cell carcinoma [news release]. aVEo oncology, november 28, 2012. accessed January 12, 2013.
    • (2012) AVEo Oncology
  • 47
    • 84878688498 scopus 로고    scopus 로고
    • AVEO reports second quarter 2012 financial results
    • [news release]. august 2, 2012. accessed January 12
    • AVEO reports second quarter 2012 financial results [news release]. aVEo pharmaceuticals, august 2, 2012. http://investor.aveooncology.com/phoenix.zhtml? c=21965 1&p=irol-newsarticle&ID=1721417&highlight=. accessed January 12, 2013.
    • (2013) AVEo Pharmaceuticals
  • 48
    • 79961227138 scopus 로고    scopus 로고
    • Use of progression-free survival (PFS) to predict overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC)
    • (June 4-8, Chicago), abst 4525
    • halabi, S., rini, B.I., Stadler, W.M., Small, E.J. Use of progression-free survival (PFS) to predict overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC). 46th annu Meet am Soc Clin oncol (aSCo) (June 4-8, Chicago) 2010, 28(15, Suppl.): abst 4525.
    • (2010) 46th Annu Meet Am Soc Clin Oncol (ASCo) , vol.28 , Issue.15 SUPPL.
    • Halabi, S.1    Rini, B.I.2    Stadler, W.M.3    Small, E.J.4
  • 49
    • 84878727900 scopus 로고    scopus 로고
    • Patient preference for tivozanib hydrochloride or suntinib in the treatment of metastatic renal cell carcinoma (mRCC): TAURUS study
    • (Sept 28-oct 2, Vienna), abst 892Tip
    • Escudier, B., Steelman, L., Cesic, D., Berkenblit, A. Patient preference for tivozanib hydrochloride or suntinib in the treatment of metastatic renal cell carcinoma (mRCC): TAURUS study. Eur Soc Med oncol (ESMo) Sci Edu Conf (Sept 28-oct 2, Vienna) 2012, abst 892Tip.
    • (2012) Eur Soc Med Oncol (ESMo) Sci Edu Conf
    • Escudier, B.1    Steelman, L.2    Cesic, D.3    Berkenblit, A.4
  • 50
    • 24944453855 scopus 로고    scopus 로고
    • Phase i trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • rugo, H.S., herbst, R.S., Liu, G. et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin oncol 2005, 23(24): 5474-83.
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3
  • 51
    • 58149337448 scopus 로고    scopus 로고
    • Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
    • hu-Lowe, D.D., Zou, H.Y., grazzini, M.L. et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer res 2008, 14(22): 7272-83.
    • (2008) Clin Cancer Res , vol.14 , Issue.22 , pp. 7272-7283
    • Hu-Lowe, D.D.1    Zou, H.Y.2    Grazzini, M.L.3
  • 53
    • 84861988031 scopus 로고    scopus 로고
    • Cardiovascular comorbidities for prediction of progressionfree survival in patients with metastatic renal cell carcinoma treated with sorafenib
    • Szmit, S., Zaborowska, M., Wasko-grabowska, A. et al. Cardiovascular comorbidities for prediction of progressionfree survival in patients with metastatic renal cell carcinoma treated with sorafenib. Kidney Blood press res 2012, 35(6): 468-76.
    • (2012) Kidney Blood Press Res , vol.35 , Issue.6 , pp. 468-476
    • Szmit, S.1    Zaborowska, M.2    Wasko-Grabowska, A.3
  • 54
    • 79957909038 scopus 로고    scopus 로고
    • Diastolic blood pressure as a biomarker of axitinib efficacy in solid tumors
    • rini, B.I., Schiller, J.H., Fruehauf, J.P. et al. Diastolic blood pressure as a biomarker of axitinib efficacy in solid tumors. Clin Cancer res 2011, 17(11): 3841-9.
    • (2011) Clin Cancer Res , vol.17 , Issue.11 , pp. 3841-3849
    • Rini, B.I.1    Schiller, J.H.2    Fruehauf, J.P.3
  • 55
    • 80755140681 scopus 로고    scopus 로고
    • Key predictive factors of axitinib (AG-013736)-induced proteinuria and efficacy: A phase II study in Japanese patients with cytokine-refractory metastatic renal cell Carcinoma
    • Tomita, Y., Uemura, H., Fujimoto, H. et al. Key predictive factors of axitinib (AG-013736)-induced proteinuria and efficacy: a phase II study in Japanese patients with cytokine-refractory metastatic renal cell Carcinoma. Eur J Cancer 2011, 47(17): 2592-602.
    • (2011) Eur J Cancer , vol.47 , Issue.17 , pp. 2592-2602
    • Tomita, Y.1    Uemura, H.2    Fujimoto, H.3
  • 57
    • 34547779489 scopus 로고    scopus 로고
    • Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: Modulation of VEGF and VEGF-related proteins
    • Deprimo, S.E., Bello, C.L., Smeraglia, J. et al. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med 2007, 5: 32.
    • (2007) J Transl Med , vol.5 , pp. 32
    • Deprimo, S.E.1    Bello, C.L.2    Smeraglia, J.3
  • 58
    • 84864333467 scopus 로고    scopus 로고
    • Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: A retrospective analysis of phase 2 and phase 3 trials
    • Tran, H.T., Liu, Y., Zurita, A.J. et al. Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials. Lancet oncol 2012, 13(8): 827-37.
    • (2012) Lancet Oncol , vol.13 , Issue.8 , pp. 827-837
    • Tran, H.T.1    Liu, Y.2    Zurita, A.J.3
  • 59
    • 79959316184 scopus 로고    scopus 로고
    • Pazopanib efficacy in renal cell carcinoma: Evidence for predictive genetic markers in angiogenesis-related and exposure-related genes
    • Xu, C.F., Bing, N.X., Ball, H.A. et al. Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes. J Clin oncol 2011, 29(18): 2557-64.
    • (2011) J Clin Oncol , vol.29 , Issue.18 , pp. 2557-2564
    • Xu, C.F.1    Bing, N.X.2    Ball, H.A.3
  • 60
    • 70649112122 scopus 로고    scopus 로고
    • Identification of TNF-alpha and MMP-9 as potential baseline predictive serum markers of sunitinib activity in patients with renal cell carcinoma using a human cytokine array
    • perez-gracia, J.L., prior, C., guillen-grima, F. et al. Identification of TNF-alpha and MMP-9 as potential baseline predictive serum markers of sunitinib activity in patients with renal cell carcinoma using a human cytokine array. Br J Cancer 2009, 101(11): 1876-83.
    • (2009) Br J Cancer , vol.101 , Issue.11 , pp. 1876-1883
    • Perez-Gracia, J.L.1    Prior, C.2    Guillen-Grima, F.3
  • 61
    • 63849092341 scopus 로고    scopus 로고
    • Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: Clinical outcomes and plasma angiogenesis markers
    • Kontovinis, L.F., papazisis, K.T., Touplikioti, P., andreadis, C., Mouratidou, D., Kortsaris, A.H. Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: clinical outcomes and plasma angiogenesis markers. BMC Cancer 2009, 9: 82.
    • (2009) BMC Cancer , vol.9 , pp. 82
    • Kontovinis, L.F.1    Papazisis, K.T.2    Touplikioti, P.3    Andreadis, C.4    Mouratidou, D.5    Kortsaris, A.H.6
  • 62
    • 84877008341 scopus 로고    scopus 로고
    • A phase II biomarker assessment of tivozanib in oncology (BATON) trial in patients (pts) with advanced renal cell carcinoma (RCC)
    • (June 1-5, Chicago) 2012], abst TpS4686
    • hutson, T.E., rathmell, K., hudes, G.R. et al. A phase II biomarker assessment of tivozanib in oncology (BATON) trial in patients (pts) with advanced renal cell carcinoma (RCC). J Clin oncol [48th annu Meet am Soc Clin oncol (aSCo) (June 1-5, Chicago) 2012] 2012, 30(15, Suppl.): abst TpS4686.
    • (2012) J Clin Oncol [48th Annu Meet Am Soc Clin Oncol (ASCo) , vol.30 , Issue.15 SUPPL.
    • Hutson, T.E.1    Rathmell, K.2    Hudes, G.R.3
  • 63
    • 84877009436 scopus 로고    scopus 로고
    • Correlation of a tivozanib response biomarker identified in a preclinical model with clinical activity in a phase II study in renal cell carcinoma (RCC)
    • 46th annu Meet am Soc Clin oncol (aSCo) (June 4-8, Chicago) 2010], abst e13564
    • robinson, M.O., Lin, J., Feng, B. et al. Correlation of a tivozanib response biomarker identified in a preclinical model with clinical activity in a phase II study in renal cell carcinoma (RCC). J Clin oncol [46th annu Meet am Soc Clin oncol (aSCo) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): abst e13564.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Robinson, M.O.1    Lin, J.2    Feng, B.3
  • 64
    • 84879041143 scopus 로고    scopus 로고
    • Relationship of hypoxia signature with variant subgroup of clear cell renal cell carcinoma (ccRCC) and its association with clinical activity on tivozanib hydrochloride
    • genitourin Cancers Symp (Feb 14-16, orlando) 2013], abst 361
    • robinson, M.O., Feng, B., nicoletti, R. et al. Relationship of hypoxia signature with variant subgroup of clear cell renal cell carcinoma (ccRCC) and its association with clinical activity on tivozanib hydrochloride. J Clin oncol [genitourin Cancers Symp (Feb 14-16, orlando) 2013] 2013, 31(6, Suppl.): abst 361.
    • (2013) J Clin Oncol , vol.31 , Issue.6 SUPPL.
    • Robinson, M.O.1    Feng, B.2    Nicoletti, R.3
  • 65
    • 80051713290 scopus 로고    scopus 로고
    • Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: A phase III, randomized, open-label trial
    • robert, N.J., Saleh, M.N., paul, D. et al. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial. Clin Breast Cancer 2011, 11(2): 82-92.
    • (2011) Clin Breast Cancer , vol.11 , Issue.2 , pp. 82-92
    • Robert, N.J.1    Saleh, M.N.2    Paul, D.3
  • 66
    • 82955232920 scopus 로고    scopus 로고
    • Phase i study of sunitinib and irinotecan for patients with recurrent malignant glioma
    • reardon, D.A., Vredenburgh, J.J., Coan, A. et al. Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma. J neurooncol 2011, 105(3): 621-7.
    • (2011) J Neurooncol , vol.105 , Issue.3 , pp. 621-627
    • Reardon, D.A.1    Vredenburgh, J.J.2    Coan, A.3
  • 67
    • 84874112681 scopus 로고    scopus 로고
    • Sunitinib combined with pemetrexed and cisplatin: Results of a phase i dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma
    • Camidge, D.R., Blais, N., Jonker, D.J. et al. Sunitinib combined with pemetrexed and cisplatin: results of a phase I dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma. Cancer Chemother pharmacol 2012, 71(2): 307-19.
    • (2012) Cancer Chemother Pharmacol , vol.71 , Issue.2 , pp. 307-319
    • Camidge, D.R.1    Blais, N.2    Jonker, D.J.3
  • 68
    • 49249113484 scopus 로고    scopus 로고
    • Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
    • azad, N.S., posadas, E.M., Kwitkowski, V.E. et al. Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin oncol 2008, 26(22): 3709-14.
    • (2008) J Clin Oncol , vol.26 , Issue.22 , pp. 3709-3714
    • Azad, N.S.1    Posadas, E.M.2    Kwitkowski, V.E.3
  • 69
    • 77649322923 scopus 로고    scopus 로고
    • Safety and efficacy of combining sunitinib with bevacizumab + paclitaxel/carboplatin in non-small cell lung cancer
    • Socinski, M.A., Scappaticci, F.A., Samant, M., Kolb, M.M., Kozloff, M.F. Safety and efficacy of combining sunitinib with bevacizumab + paclitaxel/carboplatin in non-small cell lung cancer. J Thorac oncol 2010, 5(3): 354-60.
    • (2010) J Thorac Oncol , vol.5 , Issue.3 , pp. 354-360
    • Socinski, M.A.1    Scappaticci, F.A.2    Samant, M.3    Kolb, M.M.4    Kozloff, M.F.5
  • 70
    • 70349673595 scopus 로고    scopus 로고
    • A phase i study of sunitinib plus bevacizumab in advanced solid tumors
    • rini, B.I., garcia, J.A., Cooney, M.M. et al. A phase I study of sunitinib plus bevacizumab in advanced solid tumors. Clin Cancer res 2009, 15(19): 6277-83.
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6277-6283
    • Rini, B.I.1    Garcia, J.A.2    Cooney, M.M.3
  • 71
    • 84869188311 scopus 로고    scopus 로고
    • Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02
    • Lee, E.Q., Kuhn, J., Lamborn, K.R. et al. Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02. neuro oncol 2012, 14(12): 1511-8.
    • (2012) Neuro Oncol , vol.14 , Issue.12 , pp. 1511-1518
    • Lee, E.Q.1    Kuhn, J.2    Lamborn, K.R.3
  • 72
    • 84865721505 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer
    • paz-ares, L.G., Biesma, B., heigener, D. et al. Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer. J Clin oncol 2012, 30(25): 3084-92.
    • (2012) J Clin Oncol , vol.30 , Issue.25 , pp. 3084-3092
    • Paz-Ares, L.G.1    Biesma, B.2    Heigener, D.3
  • 73
    • 78650992277 scopus 로고    scopus 로고
    • Phase i study of pazopanib in combination with weekly paclitaxel in patients with advanced solid tumors
    • Tan, A.R., Dowlati, A., Jones, S.F. et al. Phase I study of pazopanib in combination with weekly paclitaxel in patients with advanced solid tumors. oncologist 2010, 15(12): 1253-61.
    • (2010) Oncologist , vol.15 , Issue.12 , pp. 1253-1261
    • Tan, A.R.1    Dowlati, A.2    Jones, S.F.3
  • 74
    • 84872287977 scopus 로고    scopus 로고
    • A Phase i study of pazopanib in combination with gemcitabine in patients with advanced solid tumors
    • plummer, R., Madi, A., Jeffels, M. et al. A Phase I study of pazopanib in combination with gemcitabine in patients with advanced solid tumors. Cancer Chemother pharmacol 2013, 71(1): 93-101.
    • (2013) Cancer Chemother Pharmacol , vol.71 , Issue.1 , pp. 93-101
    • Plummer, R.1    Madi, A.2    Jeffels, M.3
  • 75
    • 84867400512 scopus 로고    scopus 로고
    • Phase i study of axitinib combined with paclitaxel, docetaxel or capecitabine in patients with advanced solid tumours
    • Martin, L.P., Kozloff, M.F., herbst, R.S. et al. Phase I study of axitinib combined with paclitaxel, docetaxel or capecitabine in patients with advanced solid tumours. Br J Cancer 2012, 107(8): 1268-76.
    • (2012) Br J Cancer , vol.107 , Issue.8 , pp. 1268-1276
    • Martin, L.P.1    Kozloff, M.F.2    Herbst, R.S.3
  • 76
    • 84867398104 scopus 로고    scopus 로고
    • Phase i trial of axitinib combined with platinum doublets in patients with advanced non-small cell lung cancer and other solid tumours
    • Kozloff, M.F., Martin, L.P., Krzakowski, M. et al. Phase I trial of axitinib combined with platinum doublets in patients with advanced non-small cell lung cancer and other solid tumours. Br J Cancer 2012, 107(8): 1277-85.
    • (2012) Br J Cancer , vol.107 , Issue.8 , pp. 1277-1285
    • Kozloff, M.F.1    Martin, L.P.2    Krzakowski, M.3
  • 77
    • 77951907727 scopus 로고    scopus 로고
    • A phase i study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors
    • Sharma, S., abhyankar, V., Burgess, R.E. et al. A phase I study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors. ann oncol 2010, 21(2): 297-304.
    • (2010) Ann Oncol , vol.21 , Issue.2 , pp. 297-304
    • Sharma, S.1    Abhyankar, V.2    Burgess, R.E.3
  • 78
    • 84878687120 scopus 로고    scopus 로고
    • U.S. Food and Drug administration. accessed January 16
    • U.S. Food and Drug administration. Approved drugs: Axitinib. http://www.fda.gov/Drugs/InformationonDrugs/approvedDrugs/ucm289439.htm. accessed January 16, 2013.
    • (2013) Approved Drugs: Axitinib
  • 79
    • 79952967812 scopus 로고    scopus 로고
    • A phase i study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors
    • Jonker, D.J., rosen, L.S., Sawyer, M.B. et al. A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors. ann oncol 2011, 22(6): 1413-9.
    • (2011) Ann Oncol , vol.22 , Issue.6 , pp. 1413-1419
    • Jonker, D.J.1    Rosen, L.S.2    Sawyer, M.B.3
  • 80
    • 84856199835 scopus 로고    scopus 로고
    • A phase II study of dovitinib (TKI258), an FGFR-and VEGFR-inhibitor, in patients with advanced or metastatic renal cell cancer (mRCC)
    • 47th annu Meet am Soc Clin oncol (aSCo) (June 3-7, Chicago) 2011], abst 4551
    • Angevin, E., Grunwald, V., Ravaud, A. et al. A phase II study of dovitinib (TKI258), an FGFR-and VEGFR-inhibitor, in patients with advanced or metastatic renal cell cancer (mRCC). J Clin oncol [47th annu Meet am Soc Clin oncol (aSCo) (June 3-7, Chicago) 2011] 2011, 29(15, Suppl.): abst 4551.
    • (2011) J Clin Oncol , vol.29 , Issue.15 SUPPL.
    • Angevin, E.1    Grunwald, V.2    Ravaud, A.3
  • 81
    • 84860531989 scopus 로고    scopus 로고
    • A phase i dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors
    • Mross, K., Frost, A., Steinbild, S. et al. A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors. Clin Cancer res 2012, 18(9): 2658-67.
    • (2012) Clin Cancer Res , vol.18 , Issue.9 , pp. 2658-2667
    • Mross, K.1    Frost, A.2    Steinbild, S.3
  • 82
    • 70350464165 scopus 로고    scopus 로고
    • Phase i and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies
    • Wong, C.I., Koh, T.S., Soo, R. et al. Phase I and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies. J Clin oncol 2009, 27(28): 4718-26.
    • (2009) J Clin Oncol , vol.27 , Issue.28 , pp. 4718-4726
    • Wong, C.I.1    Koh, T.S.2    Soo, R.3
  • 84
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer, R.J., Escudier, B., oudard, S. et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008, 372(9637): 449-56.
    • (2008) Lancet , vol.372 , Issue.9637 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 85
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer, J.R., Tykodi, S.S., Chow, L.Q. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. n Engl J Med 2012, 366(26): 2455-65.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 86
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S.L., hodi, F.S., Brahmer, J.R. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. n Engl J Med 2012, 366(26): 2443-54.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3


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