Clinical usefulness of response profiles to rapidly incremental cardiopulmonary exercise testing

Pulmonary Medicine

Volumn , Issue , 2013, Pages

  Ramos, Roberta P ^a   Alencar, Maria Clara N ^a   Treptow, Erika ^a   Arbex, Flávio ^a   Ferreira, Eloara M V ^a   Neder, J Alberto ^a,b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b KINGSTON GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CARBON DIOXIDE; CARBONIC ACID;

CARDIOPULMONARY EXERCISE TEST; CLINICAL ASSESSMENT; DISEASE SEVERITY; GLYCOLYSIS; HEART FAILURE; HEART MUSCLE ISCHEMIA; HEART OUTPUT; HEART RATE; HUMAN; LUNG VENTILATION; MUSCLE CONTRACTION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROGNOSIS; PULMONARY HYPERTENSION; REVIEW; TIDAL VOLUME;

EID: 84878698241     PISSN: 20901836     EISSN: 20901844     Source Type: Journal    
DOI: 10.1155/2013/359021     Document Type: Review

References (263)

1. Wasserman K., Whipp B. J., Exercise physiology in health and disease. The American Review of Respiratory Disease 1975 112 2 219 249 2-s2.0-0016593346
2. Wasserman K., Hansen J. E., Sue D. Y., Stringer W. W., Sietsema K. E., Sun X. G., Whipp B. J., Principles of Exercise Testing and Interpretation 2012 5th Philadelphia, Pa, USA Lippincott Williams & Wilkins
3. Beaver W. L., Wasserman K., Whipp B. J., On-line computer analysis and breath-by-breath graphical display of exercise function tests. Journal of Applied Physiology 1973 34 1 128 132 2-s2.0-0015547883
4. Whipp B. J., Davis J. A., Torres F., Wasserman K., A test to determine parameters of aerobic function during exercise. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1981 50 1 217 221 2-s2.0-0019349265 (Pubitemid 11168030)
5. Buchfuhrer M. J., Hansen J. E., Robinson T. E., Optimizing the exercise protocol for cardiopulmonary assessment. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1983 55 5 1558 1564 2-s2.0-0021028105 (Pubitemid 14231465)
6. Hansen J. E., Sue D. Y., Wasserman K., Predicted values for clinical exercise testing. The American Review of Respiratory Disease 1984 129 2 S49 S55 2-s2.0-0021368736 (Pubitemid 14190983)
7. Koch B., Schäper C., Ittermann T., Spielhagen T., Dörr M., Völzke H., Opitz C. F., Ewert R., Gläser S., Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study. European Respiratory Journal 2009 33 2 389 397 2-s2.0-59649117147 10.1183/09031936. 00074208
8. Hansen J. E., Casaburi R., Cooper D. M., Wasserman K., Oxygen uptake as related to work rate increment during cycle ergometer exercise. European Journal of Applied Physiology and Occupational Physiology 1988 57 2 140 145 2-s2.0-0023848220 (Pubitemid 18048470)
9. Fairbarn M. S., Blackie S. P., McElvaney N. G., Wiggs B. R., Pare P. D., Pardy R. L., Prediction of heart rate and oxygen uptake during incremental and maximal exercise in healthy adults. Chest 1994 105 5 1365 1369 2-s2.0-0028260843 (Pubitemid 24152589)
10. Neder J. A., Nery L. E., Peres C., Whipp B. J., Reference values for dynamic responses to incremental cycle ergometry in males and females aged 20 to 80. American Journal of Respiratory and Critical Care Medicine 2001 164 8 I 1481 1486 2-s2.0-0035888755 (Pubitemid 33124031)
11. Sun X. G., Hansen J. E., Garatachea N., Storer T. W., Wasserman K., Ventilatory efficiency during exercise in healthy subjects. American Journal of Respiratory and Critical Care Medicine 2002 166 11 1443 1448 2-s2.0-0036893514 10.1164/rccm.2202033 (Pubitemid 35387293)
12. Steinacker J., Ward S. A., The Physiology and Pathophysiology of Exercise Toleranceedition 1984 1st New York, NY, USA Plenum Press
13. Weisman I. M., Marciniuk D., Martinez F. J., ATS/ACCP Statement on cardiopulmonary exercise testing. American Journal of Respiratory and Critical Care Medicine 2003 167 2 211 277 10.1164/rccm.167.2.211
14. Palange P., Ward S. A., Carlsen K. H., Casaburi R., Gallagher C. G., Gosselink R., O'Donnell D. E., Puente-Maestu L., Schols A. M., Singh S., Whipp B. J., Recommendations on the use of exercise testing in clinical practice. European Respiratory Journal 2007 29 1 185 209 2-s2.0-33846211019 10.1183/09031936.00046906 (Pubitemid 46092015)
15. Whipp B. J., Wagner P. D., Agusti A., Factors determining the response to exercise in healthy subjects. European Respiratory Monograph 1997 2 6 3 31 2-s2.0-0031427267 (Pubitemid 28158941)
16. Whipp B. J., Wagner A P. D., Ward S. A., Palange P., Agusti A., Determinants of the physiological systems responses to muscular exercise in healthy subjects. Clinical Exercise Testing 2007 36 European Respiratory Monograph 1 35
17. Ward S. A., Ward S. A., Palange P., Discriminating features of responses in cardiopulmonary exercise testing. Clinical Exercise Testing 2007 36 European Respiratory Monograph 36 68
18. Grant S., McMurray J., Aitchison T., McDonagh T., Christie J., Davie A., Dargie H. J., The reproducibility of symptoms during a submaximal exercise test in chronic heart failure. British Journal of Clinical Pharmacology 1998 45 3 287 290 2-s2.0-0031917391 10.1046/j.1365-2125.1998.00682.x (Pubitemid 28081925)
19. Kettner A., Goldberg A., Hagberg J., Cardiovascular and metabolic responses to submaximal exercise in hemodialysis patients. Kidney International 1984 26 1 66 71 2-s2.0-0021141209 (Pubitemid 14060590)
20. Lipkin D. P., Bayliss J., Poole-Wilson P. A., The ability of a submaximal exercise test to predict maximal exercise capacity in patients with heart failure. European Heart Journal 1985 6 10 829 833 2-s2.0-0022355858 (Pubitemid 16218087)
21. Clark A. L., Rafferty D., Arbuthnott K., Exercise dynamics at submaximal workloads in patients with chronic heart failure. Journal of Cardiac Failure 1997 3 1 15 19 2-s2.0-0031090144 (Pubitemid 127675004)
22. Belardinelli R., Zhang Y. Y., Wasserman K., Purcaro A., Agostoni P. G., A four-minute submaximal constant work rate exercise test to assess cardiovascular functional class in chronic heart failure. The American Journal of Cardiology 1998 81 10 1210 1214 2-s2.0-0032525083 10.1016/S0002-9149(98) 00093-9 (Pubitemid 28226133)
23. Metra M., Nodari S., Raccagni D., Garbellini M., Boldi E., Bontempi L., Gaiti M., Cas L. D., Maximal and submaximal exercise testing in heart failure. Journal of Cardiovascular Pharmacology 1998 32 1 S36 S45 2-s2.0-0031688374 (Pubitemid 28415090)
24. Faggiano P., Gualeni A., Methodology of exercise test in patients with heart failure. Maximal test and submaximal test. Italian Heart Journal 2000 1 313 319
25. Bittner V., Exercise testing in heart failure: maximal, submaximal, or both? Journal of the American College of Cardiology 2003 42 1 123 125 2-s2.0-0037868056 10.1016/S0735-1097(03)00501-1 (Pubitemid 36760772)
26. Woods P. R., Bailey K. R., Wood C. M., Johnson B. D., Submaximal exercise gas exchange is an important prognostic tool to predict adverse outcomes in heart failure. European Journal of Heart Failure 2011 13 3 303 310 2-s2.0-79951821759 10.1093/eurjhf/hfq187
27. Leite J. J., Mansur A. J., De Freitas H. F. G., Chizola P. R., Bocchi E. A., Terra-Filho M., Neder J. A., Lorenzi-Filho G., Periodic breathing during incremental exercise predicts mortality in patients with chronic heart failure evaluated for cardiac transplantation. Journal of the American College of Cardiology 2003 41 12 2175 2181 2-s2.0-0038714311 10.1016/S0735-1097(03)00460-1 (Pubitemid 36724263)
28. Ramos R. P., Arakaki J. S., Barbosa P., Treptow E., Valois F. M., Ferreira E. V., Nery L. E., Neder J. A., Heart rate recovery in pulmonary arterial hypertension: relationship with exercise capacity and prognosis. American Heart Journal 2012 163 4 580 588 10.1016/j.ahj.2012.01.023
29. Wasserman K., Whipp B. J., Koyal S. N., Beaver W. L., Anaerobic threshold and respiratory gas exchange during exercise. Journal of Applied Physiology 1973 35 2 236 243 2-s2.0-0015785043
30. Green H. J., Hughson R. L., Orr G. W., Ranney D. A., Anaerobic threshold, blood lactate, and muscle metabolites in progressive exercise. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1983 54 4 1032 1038 2-s2.0-0020626211 (Pubitemid 13123920)
31. Beaver W. L., Wasserman K., Whipp B. J., Bicarbonate buffering of lactic acid generated during exercise. Journal of Applied Physiology 1985 60 2 472 478 2-s2.0-0022210997 (Pubitemid 16019931)
32. Green H. J., Hughson R. L., Anaerobic threshold: review of the concept and directions for future research. Medicine and Science in Sports and Exercise 1985 17 5 621 624 2-s2.0-0022140691
33. Hopker J. G., Jobson S. A., Pandit J. J., Controversies in the physiological basis of the 'anaerobic threshold' and their implications for clinical cardiopulmonary exercise testing. Anaesthesia 2011 66 2 111 123 10.1111/j.1365-2044.2010.06604.x
34. Wasserman K., Beaver W. L., Whipp B. J., Gas exchange theory and the lactic acidosis (anaerobic) threshold. Circulation 1990 81 supplement 1 II14 II30 (Pubitemid 20022872)
35. Wasserman K., Koike A., Is the anaerobic threshold truly anaerobic? Chest 1992 101 supplement 5 211S 218S 2-s2.0-0026765321
36. Brooks G. A., Current concepts in lactate exchange. Medicine and Science in Sports and Exercise 1991 23 8 895 906 2-s2.0-0025888968
37. Beaver W. L., Wasserman K., Whipp B. J., A new method for detecting anaerobic threshold by gas exchange. Journal of Applied Physiology 1986 60 6 2020 2027 2-s2.0-0022542458 (Pubitemid 16066969)
38. Reinhard U., Muller P. H., Schmulling R. M., Determination of anaerobic threshold by the ventilation equivalent in normal individuals. Respiration 1979 38 1 36 42 10.1159/000194056 (Pubitemid 9215208)
39. 2 stores on ventilatory dynamics during exercise. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1983 55 3 742 749 2-s2.0-0020566555 (Pubitemid 13009119)
40. 2 stores on pulmonary gas exchange dynamics during incremental exercise in humans. Experimental Physiology 1999 84 5 999 1011 2-s2.0-0032854924 (Pubitemid 29465716)
41. 2 exchange dynamics during exercise. Experimental Physiology 2007 92 2 347 355 2-s2.0-33847725932 10.1113/expphysiol.2006.034363 (Pubitemid 46376325)
42. Neder J. A., Nery L. E., Castelo A., Andreoni S., Lerario M. C., Sachs A., Silva A. C., Whipp B. J., Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry: a randomised study. European Respiratory Journal 1999 14 6 1304 1313 2-s2.0-0033381743 (Pubitemid 30019525)
43. Wasserman K., The anaerobic threshold measurement to evaluate exercise performance. The American Review of Respiratory Disease 1984 129 2 S35 S40 2-s2.0-0021362958 (Pubitemid 14190979)
44. Wasserman K., Determinants and detection of anaerobic threshold and consequences of exercise above it. Circulation 1987 76 6 I-29 I-39 2-s2.0-0023484482
45. Wasserman K., The anaerobic threshold: definition, physiological significance and identification. Advances in Cardiology 35 1 1 23
46. Wasserman K., Reduced aerobic enzyme activity in skeletal muscles of patients with heart failure. A prelimary defect or a result of limited cardiac output? Circulation 1991 84 4 1868 1870 2-s2.0-0025939934
47. Sullivan M. J., Cobb F. R., The anaerobic threshold in chronic heart failure. Relation to blood lactate, ventilatory basis, reproducibility, and response to exercise training. Circulation 1990 81 1 II47 II58 2-s2.0-0025191368 (Pubitemid 20022875)
48. Sullivan M. J., Green H. J., Cobb F. R., Altered skeletal muscle metabolic response to exercise in chronic heart failure. Relation to skeletal muscle aerobic enzyme activity. Circulation 1991 84 4 1597 1607 2-s2.0-0025951504
49. Koike A., Hiroe M., Adachi H., Yajima T., Nogami A., Ito H., Takamoto T., Taniguchi K., Marumo F., Anaerobic metabolism as an indicator of aerobic function during exercise in cardiac patients. Journal of the American College of Cardiology 1992 20 1 120 126 2-s2.0-0026659410
50. Older P., Smith R., Courtney P., Hone R., Preoperative evaluation of cardiac failure and ischemia in elderly patients by cardiopulmonary exercise testing. Chest 1993 104 3 701 704 2-s2.0-0027275088 (Pubitemid 23268935)
51. Older P., Hall A., Hader R., Cardiopulmonary exercise testing as a screening test for perioperative management of major surgery in the elderly. Chest 1999 116 2 355 362 2-s2.0-0032809781 10.1378/chest.116.2.355 (Pubitemid 29382118)
52. Gitt A. K., Wasserman K., Kilkowski C., Kleemann T., Kilkowski A., Bangert M., Schneider S., Schwarz A., Senges J., Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death. Circulation 2002 106 24 3079 3084 2-s2.0-0037058867 10.1161/01.CIR.0000041428.99427.06 (Pubitemid 35440292)
53. Sun X. G., Hansen J. E., Oudiz R. J., Wasserman K., Exercise pathophysiology in patients with primary pulmonary hypertension. Circulation 2001 104 4 429 435 2-s2.0-0035943014 (Pubitemid 32678273)
54. Patessio A., Carone M., Ioli F., Donner C. F., Ventilatory and metabolic changes as a result of exercise training in COPD patients. Chest 1992 101 5 274S 278S 2-s2.0-0026723374
55. Casaburi R., Patessio A., Ioli F., Zanaboni S., Donner C. F., Wasserman K., Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease. The American Review of Respiratory Disease 1991 143 1 9 18 2-s2.0-0025964922
56. Kavanagh T., Myers M. G., Baigrie R. S., Mertens D. J., Sawyer P., Shephard R. J., Quality of life and cardiorespiratory function in chronic heart failure: effects of 12 months' aerobic training. Heart 1996 76 1 42 49 2-s2.0-0029816872 (Pubitemid 26267137)
57. Belardinelli R., Georgiou D., Cianci G., Purcaro A., Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation 1999 99 9 1173 1182 2-s2.0-0033537699 (Pubitemid 29120089)
58. Gimenez M., Servera E., Vergara P., Bach J. R., Polu J. M., Endurance training in patients with chronic obstructive pulmonary disease: a comparison of high versus moderate intensity. Archives of Physical Medicine and Rehabilitation 2000 81 1 102 109 2-s2.0-0033989222 10.1053/apmr.2000.0810102 (Pubitemid 30036882)
59. Hambrecht R., Walther C., Möbius-Winkler S., Gielen S., Linke A., Conradi K., Erbs S., Kluge R., Kendziorra K., Sabri O., Sick P., Schuler G., Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation 2004 109 11 1371 1378 2-s2.0-12144287053 10.1161/01.CIR.0000121360.31954.1F (Pubitemid 38387823)
60. Klocek M., Kubinyi A., Bacior B., Kawecka-Jaszcz K., Effect of physical training on quality of life and oxygen consumption in patients with congestive heart failure. International Journal of Cardiology 2005 103 3 323 329 2-s2.0-23644455484 10.1016/j.ijcard.2004.10.021 (Pubitemid 41132603)
61. Zainuldin R., Mackey M. G., Alison J. A., Intensity and type of exercise for lower limb endurance training to optimise exercise capacity for people with chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2009 4 2-s2.0-77950169801 10.1002/14651858.CD008008 CD008008
62. Hambrecht R., Neibauer J., Fiehn E., Kalberer B., Offner B., Hauer K., Riede U., Schlierf G., Kubler W., Schuler G., Physical training in patients with stable chronic heart failure: effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles. Journal of the American College of Cardiology 1995 25 6 1239 1249 2-s2.0-0028916564 10.1016/0735-1097(94)00568-B
63. Desai S. A., Channick R. N., Exercise in patients with pulmonary arterial hypertension. Journal of Cardiopulmonary Rehabilitation and Prevention 2008 28 1 12 16 2-s2.0-39449115812 10.1097/01.HCR.0000311502.57022.73 (Pubitemid 351271739)
64. Mereles D., Ehlken N., Kreuscher S., Ghofrani S., Hoeper M. M., Halank M., Meyer F. J., Karger G., Buss J., Juenger J., Holzapfel N., Opitz C., Winkler J., Herth F. F. J., Wilkens H., Katus H. A., Olschewski H., Grünig E., Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation 2006 114 14 1482 1489 2-s2.0-33749525364 10.1161/CIRCULATIONAHA.106.618397 (Pubitemid 44527003)
65. Uchi M., Saji T., Harada T., Feasibility of cardiopulmonary rehabilitation in patients with idiopathic pulmonary arterial hypertension treated with intravenous prostacyclin infusion therapy. Journal of Cardiology 2005 46 5 183 193 2-s2.0-28844470383 (Pubitemid 41769698)
66. Grunig E., Ehlken N., Ghofrani A., Staehler G., Meyer F. J., Juenger J., Opitz C. F., Klose H., Wilkens H., Rosenkranz S., Olschewski H., Halank M., Effect of exercise and respiratory training on clinical progression and survival in patients with severe chronic pulmonary hypertension. Respiration 2011 81 5 394 401 10.1159/000322475
67. Arena R., Exercise testing and training in chronic lung disease and pulmonary arterial hypertension. Progress in Cardiovascular Diseases 2011 53 6 454 463 2-s2.0-79955527637 10.1016/j.pcad.2011.02.003
68. Grunig E., Lichtblau M., Ehlken N., Ghofrani H. A., Reichenberger F., Staehler G., Halank M., Fischer C., Seyfarth H. J., Klose H., Meyer A., Sorichter S., Wilkens H., Rosenkranz S., Opitz C., Leuchte H., Karger G., Speich R., Nagel C., Safety and efficacy of exercise training in various forms of pulmonary hypertension. European Respiratory Journal 2012 40 1 84 92 10.1183/09031936.00123711
69. Grunig E., Maier F., Ehlken N., Fischer C., Lichtblau M., Blank N., Fiehn C., Stockl F., Prange F., Staehler G., Reichenberger F., Tiede H., Halank M., Seyfarth H. J., Wagner S., Nagel C., Exercise training in pulmonary arterial hypertension associated with connective tissue diseases. Arthritis Research and Therapy 2012 14 3 R148 10.1186/ar3883
70. Casaburi R., Patessio A., Ioli F., Zanaboni S., Donner C. F., Wasserman K., Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease. The American Review of Respiratory Disease 1991 143 1 9 18 2-s2.0-0025964922
71. Vogiatzis I., Terzis G., Stratakos G., Cherouveim E., Athanasopoulos D., Spetsioti S., Nasis I., Manta P., Roussos C., Zakynthinos S., Effect of pulmonary rehabilitation on peripheral muscle fiber remodeling in patients with COPD in GOLD stages II to IV. Chest 2011 140 3 744 752 10.1378/chest.10-3058
72. Meyer T., Görge G., Schwaab B., Hildebrandt K., Walldorf J., Schäfer C., Kindermann I., Scharhag J., Kindermann W., An alternative approach for exercise prescription and efficacy testing in patients with chronic heart failure: a randomized controlled training study. American Heart Journal 2005 149 5 926.e1 926.e7 2-s2.0-14244253691 10.1016/j.ahj.2004.12.006 (Pubitemid 40718894)
73. Curnier D., Galinier M., Pathak A., Fourcade J., Bousquet M., Senard J. M., Fauvel J. M., Bounhoure J. P., Montastruc J. L., Rehabilitation of patients with congestive heart failure with or without β -blockade therapy. Journal of Cardiac Failure 2001 7 3 241 248 2-s2.0-0034821120 10.1054/jcaf.2001.26565 (Pubitemid 32867964)
74. Zacarias E. C., Neder J. A., Cendom S. P., Nery L. E., Jardim J. R., Heart rate at the estimated lactate threshold in patients with chronic obstructive pulmonary disease: effects on the target intensity for dynamic exercise training. Journal of Cardiopulmonary Rehabilitation 2000 20 6 369 376 2-s2.0-0033637737
75. O'Donnell D. E., McGuire M., Samis L., Webb K. A., General exercise training improves ventilatory and peripheral muscle strength and endurance in chronic airflow limitation. American Journal of Respiratory and Critical Care Medicine 1998 157 5 1489 1497 2-s2.0-0031747543
76. Inbar O., Oren A., Scheinowitz M., Rotstein A., Dlin R., Casaburi R., Normal cardiopulmonary responses during incremental exercise in 20- to 70- yr-old men. Medicine and Science in Sports and Exercise 1994 26 5 538 546 2-s2.0-0028350791 (Pubitemid 24139214)
77. Hansen J. E., Sue D. Y., Oren A., Wasserman K., Relation of oxygen uptake to work rate in normal men and men with circulatory disorders. The American Journal of Cardiology 1987 59 6 669 674 2-s2.0-0023119039 (Pubitemid 17047341)
78. Solal A. C., Chabernaud J. M., Gourgon R., Comparison of oxygen uptake during bicycle exercise in patients with chronic heart failure and in normal subjects. Journal of the American College of Cardiology 1990 16 1 80 85 2-s2.0-0025285824 (Pubitemid 20217045)
79. Koike A., Wasserman K., Effect of acute reduction in oxygen transport on parameters of aerobic function during exercise. Annals of the Academy of Medicine Singapore 1992 21 1 14 22 2-s2.0-0026486084
80. Jones S., Elliott P. M., Sharma S., McKenna W. J., Whipp B. J., Cardiopulmonary responses to exercise in patients with hypertrophic cardiomyopathy. Heart 1998 80 1 60 67 2-s2.0-0031856712 (Pubitemid 28351122)
81. Gimenes A. C., Neder J. A., dal Corso S., Nogueira C. R., Nápolis L., Mello M. T., Bulle A. S., Nery L. E., Relationship between work rate and oxygen uptake in mitochondrial myopathy during ramp-incremental exercise. Brazilian Journal of Medical and Biological Research 2011 44 4 354 360 2-s2.0-79955394370 10.1590/S0100-879X2011007500023
82. Belardinelli R., Lacalaprice F., Carle F., Minnucci A., Cianci G., Perna G. P., D'Eusanio G., Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing. European Heart Journal 2003 24 14 1304 1313 2-s2.0-0041402838 10.1016/S0195-668X(03)00210-0 (Pubitemid 36917701)
83. Schmid J. P., Detection of exercise induced ischaemia: a new role for cardiopulmonary exercise testing. European Heart Journal 2003 24 14 1285 1286 2-s2.0-0042244287 10.1016/S0195-668X(03)00280-X (Pubitemid 36917698)
84. Chaudhry S., Arena R., Wasserman K., Hansen J. E., Lewis G. D., Myers J., Chronos N., Boden W. E., Exercise-induced myocardial ischemia detected by cardiopulmonary exercise testing. The American Journal of Cardiology 2009 103 5 615 619 2-s2.0-60249100966 10.1016/j.amjcard.2008.10.034
85. Bussotti M., Apostolo A., Andreini D., Palermo P., Contini M., Agostoni P., Cardiopulmonary evidence of exercise-induced silent ischaemia. European Journal of Cardiovascular Prevention and Rehabilitation 2006 13 2 249 253 2-s2.0-33746228614 10.1097/01.hjr.0000189809.99353.76 (Pubitemid 44097731)
86. Balady G. J., Arena R., Sietsema K., Clinician's guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 2010 122 2 191 225 10.1161/CIR.0b013e3181e52e69
87. Chaudhry S., Arena R. A., Hansen J. E., Lewis G. D., Myers J. N., Sperling L. S., LaBudde B. D., Wasserman K., The utility of cardiopulmonary exercise testing to detect and track early-stage ischemic heart disease. Mayo Clinic Proceedings 2010 85 10 928 932 2-s2.0-77957955851 10.4065/mcp.2010.0183
88. Chaudhry S., Arena R., Wasserman K., Hansen J. E., Lewis G. D., Myers J., Belardinelli R., Labudde B., Menasco N., Boden W. E., The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia. International Journal of Cardiology 2011 148 1 e7 e9 2-s2.0-77957966444 10.1016/j.ijcard.2009.01.055
89. Sun X. G., Hansen J. E., Stringer W. W., Oxygen uptake efficiency plateau best predicts early death in heart failure. Chest 2012 141 5 1284 1294 10.1378/chest.11-1270
90. Davies L. C., Wensel R., Georgiadou P., Cicoira M., Coats A. J. S., Piepoli M. F., Francis D. P., Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope. European Heart Journal 2006 27 6 684 690 2-s2.0-33644889404 10.1093/eurheartj/ehi672
91. Arena R., Brubaker P., Moore B., Kitzman D., The oxygen uptake efficiency slope is reduced in older patients with heart failure and a normal ejection fraction. International Journal of Cardiology 2010 144 1 101 102 2-s2.0-77954757793 10.1016/j.ijcard.2008.12.143
92. Arena R., Myers J., Abella J., Pinkstaff S., Brubaker P., Kitzman D., Peberdy M. A., Bensimhon D., Chase P., Guazzi M., Prognostic significance of the oxygen uptake efficiency slope: percent-predicted versus actual value. American Journal of Cardiology 2010 105 5 757 758 2-s2.0-76849090845 10.1016/j.amjcard.2009.10.004
93. 2 slope in heart failure. Medicine and Science in Sports and Exercise 2012 44 3 428 434 2-s2.0-79960881457 10.1249/MSS.0b013e31822f8427
94. Arena R., Guazzi M., Myers J., Chase P., Bensimhon D., Cahalin L. P., Peberdy M. A., Ashley E., West E., Forman D. E., The relationship between minute ventilation and oxygen consumption in heart failure: comparing peak VE/VO(2) and the oxygen uptake efficiency slope. International Journal of Cardiology 2012 154 3 384 385 10.1016/j.ijcard.2011.11.038
95. Fu T. C., Wang C. H., Lin P. S., Hsu C. C., Cherng W. J., Huang S. C., Liu M. H., Chiang C. L., Wang J. S., Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. International Journal of Cardiology. In press
96. Myers J., Gademan M., Brunner K., Kottman W., Boesch C., Dubach P., Effects of high-intensity training on indices of ventilatory efficiency in chronic heart failure. Journal Cardiopulmonary Rehabilitation and Prevention 2012 32 9 16
97. Groepenhoff H., Vonk-Noordegraaf A., Boonstra A., Spreeuwenberg M. D., Postmus P. E., Bogaard H. J., Exercise testing to estimate survival in pulmonary hypertension. Medicine and Science in Sports and Exercise 2008 40 10 1725 1732 2-s2.0-58149289783 10.1249/MSS.0b013e31817c92c0
98. Deboeck G., Scoditti C., Huez S., Luc Vachiery J., Lamotte M., Sharples L., Melot C., Naeije R., Exercise to predict outcome in idiopathic vs associated pulmonary arterial hypertension. European Respiratory Journal 2012 40 6 1410 1419 10.1183/09031936.00217911
99. Arena R. A., Guazzi M., Myers J., Abella J., The prognostic value of ventilatory efficiency with beta-blocker therapy in heart failure. Medicine and Science in Sports and Exercise 2007 39 2 213 219 2-s2.0-33846849459 10.1249/01.mss.0000241655.45500.c7 (Pubitemid 46204286)
100. Wolk R., Johnson B. D., Somers V. K., Allison T. G., Squires R. W., Gau G. T., Olson L. J., Effects of β -blocker therapy on ventilatory responses to exercise in patients with heart failure. Journal of Cardiac Failure 2005 11 5 333 339 2-s2.0-20444400288 10.1016/j.cardfail.2004.11.008
101. Agostoni P., Contini M., Magini A., Apostolo A., Cattadori G., Bussotti M., Veglia F., Andreini D., Palermo P., Carvedilol reduces exercise-induced hyperventilation: a benefit in normoxia and a problem with hypoxia. European Journal of Heart Failure 2006 8 7 729 735 2-s2.0-33750417152 10.1016/j.ejheart.2006.02.001 (Pubitemid 44637272)
102. Agostoni P., Guazzi M., Bussotti M., De Vita S., Palermo P., Carvedilol reduces the inappropriate increase of ventilation during exercise in heart failure patients. Chest 2002 122 6 2062 2067 2-s2.0-0036936261 10.1378/chest.122.6.2062 (Pubitemid 36054183)
103. Jaussaud J., Aimable L., Bordachar P., Dos Santos P., Barandon L., Ritter P., Roudaut R., Douard H., Cardiac resynchronization therapy reduces metaboreflex contribution to the ventilatory response in heart failure population. Cardiology Research and Practice 2012 2012 6 914071 10.1155/2012/914071
104. Ting H., Sun X. G., Chuang M. L., Lewis D. A., Hansen J. E., Wasserman K., A noninvasive assessment of pulmonary perfusion abnormality in patients with primary pulmonary hypertension. Chest 2001 119 3 824 832 2-s2.0-0035089738 10.1378/chest.119.3.824 (Pubitemid 32197655)
105. Oudiz R. J., Roveran G., Hansen J. E., Sun X. G., Wasserman K., Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension. European Journal of Heart Failure 2007 9 9 917 921 2-s2.0-34548215143 10.1016/j.ejheart.2007.06.013 (Pubitemid 47332322)
106. Matsuda H., Ogino H., Minatoya K., Sasaki H., Nakanishi N., Kyotani S., Kobayashi J., Yagihara T., Kitamura S., Long-term recovery of exercise ability after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. The Annals of Thoracic Surgery 2006 82 4 1338 1343 2-s2.0-33748934934 10.1016/j.athoracsur.2006.03.105 (Pubitemid 44429915)
107. Myers J., Dziekan G., Goebbels U., Dubach P., Influence of high-intensity exercise training on the ventilatory response to exercise in patients with reduced ventricular function. Medicine and Science in Sports and Exercise 1999 31 7 929 937 2-s2.0-0032978175 10.1097/00005768-199907000-00003 (Pubitemid 29316187)
108. Chua T. P., Ponikowski P., Harrington D., Anker S. D., Webb-Peploe K., Clark A. L., Poole-Wilson P. A., Coats A. J. S., Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure. Journal of the American College of Cardiology 1997 29 7 1585 1590 2-s2.0-0343907194 10.1016/S0735-1097(97)00078-8 (Pubitemid 27272454)
109. Arena R., Myers J., Abella J., Peberdy M. A., Bensimhon D., Chase P., Guazzi M., Development of a ventilatory classification system in patients with heart failure. Circulation 2007 115 18 2410 2417 2-s2.0-34247159821 10.1161/CIRCULATIONAHA.107.686576 (Pubitemid 46717963)
110. Torchio R., Guglielmo M., Giardino R., Ardissone F., Ciacco C., Gulotta C., Veljkovic A., Bugiani M., Exercise ventilatory inefficiency and mortality in patients with chronic obstructive pulmonary disease undergoing surgery for non-small-cell lung cancer. European Journal of Cardio-thoracic Surgery 2010 38 1 14 19 2-s2.0-77953289003 10.1016/j.ejcts.2010.01.032
111. 2 abnormality and exercise limitation in patients with primary pulmonary hypertension. Chest 2005 127 5 1637 1646 2-s2.0-19844364523 10.1378/chest.127.5.1637 (Pubitemid 46218789)
112. Arena R., Myers J., Abella J., Pinkstaff S., Brubaker P., Moore B., Kitzman D., Peberdy M. A., Bensimhon D., Chase P., Guazzi M., The partial pressure of resting end-tidal carbon dioxide predicts major cardiac events in patients with systolic heart failure. American Heart Journal 2008 156 5 982 988 2-s2.0-54449096829 10.1016/j.ahj.2008.06.024
113. Arena R., Peberdy M. A., Myers J., Guazzi M., Tevald M., Prognostic value of resting end-tidal carbon dioxide in patients with heart failure. International Journal of Cardiology 2006 109 3 351 358 2-s2.0-33646240579 10.1016/j.ijcard.2005.06.032
114. Arena R., Guazzi M., Myers J., Chase P., Bensimhon D., Cahalin L. P., Peberdy M. A., Ashley E., West E., Forman D. E., Prognostic value of capnography during rest and exercise in patients with heart failure. Congestive Heart Failure 2012 18 6 302 307 10.1111/j.1751-7133.2012.00296.x
115. Arena R., Guazzi M., Myers J., Prognostic value of end-tidal carbon dioxide during exercise testing in heart failure. International Journal of Cardiology 2007 117 1 103 108 2-s2.0-33947135291 10.1016/j.ijcard.2006.04.058 (Pubitemid 46399975)
116. 2 pressure during exercise in patients with left ventricular dysfunction. Journal of Physiological Sciences 2009 59 1 49 55 2-s2.0-67349286464 10.1007/s12576-008- 0004-8
117. Wensel R., Opitz C. F., Anker S. D., Winkler J., Höffken G., Kleber F. X., Sharma R., Hummel M., Hetzer R., Ewert R., Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing. Circulation 2002 106 3 319 324 2-s2.0-0037118681 10.1161/01.CIR.0000022687.18568.2A (Pubitemid 34778955)
118. Sun X. G., Hansen J. E., Oudiz R. J., Wasserman K., Gas exchange detection of exercise-induced right-to-left shunt in patients with primary pulmonary hypertension. Circulation 2002 105 1 54 60 2-s2.0-0036143896 10.1161/hc0102.101509 (Pubitemid 34049142)
119. Oudiz R. J., Midde R., Hovenesyan A., Sun X. G., Roveran G., Hansen J. E., Wasserman K., Usefulness of right-to-left shunting and poor exercise gas exchange for predicting prognosis in patients with pulmonary arterial hypertension. The American Journal of Cardiology 2010 105 8 1186 1191 2-s2.0-77950363702 10.1016/j.amjcard.2009.12.024
120. 2 pressure during exercise in patients after acute myocardial infarction. Circulation Journal 2004 68 8 778 783 2-s2.0-3843059994 10.1253/circj.68.778 (Pubitemid 39044960)
121. Corrà U., Giordano A., Bosimini E., Mezzani A., Piepoli M., Coats A. J. S., Giannuzzi P., Oscillatory ventilation during exercise in patients with chronic heart failure: clinical correlates and prognostic implications. Chest 2002 121 5 1572 1580 2-s2.0-0036247731 10.1378/chest.121.5.1572 (Pubitemid 34499673)
122. Corrà U., Pistono M., Mezzani A., Braghiroli A., Giordano A., Lanfranchi P., Bosimini E., Gnemmi M., Giannuzzi P., Sleep and exertional periodic breathing in chronic heart failure: prognostic importance and interdependence. Circulation 2006 113 1 44 50 2-s2.0-33644861801 10.1161/CIRCULATIONAHA.105.543173 (Pubitemid 43958487)
123. Murphy R. M., Shah R. V., Malhotra R., Pappagianopoulos P. P., Hough S. S., Systrom D. M., Semigran M. J., Lewis G. D., Exercise oscillatory ventilation in systolic heart failure: an indicator of impaired hemodynamic response to exercise. Circulation 2011 124 1442 1451
124. Sun X. G., Hansen J. E., Beshai J. F., Wasserman K., Oscillatory breathing and exercise gas exchange abnormalities prognosticate early mortality and morbidity in heart failure. Journal of the American College of Cardiology
125. Olson L. J., Arruda-Olson A. M., Somers V. K., Scott C. G., Johnson B. D., Exercise oscillatory ventilation: instability of breathing control associated with advanced heart failure. Chest 2008 133 2 474 481 2-s2.0-39449084976 10.1378/chest.07-2146 (Pubitemid 351272408)
126. Arena R., Guazzi M., Myers J., Chase P., Bensimhon D., Cahalin L., Peberdy M. A., Ashley E., West E., Forman D. E., Exercise oscillatory ventilation reflects diminished quality of life and perceived functional capacity in patients with heart failure. International Journal of Cardiology 2011 153 2 213 214 10.1016/j.ijcard.2011.09.072
127. Nery L. E., Wasserman K., French W., Contrasting cardiovascular and respiratory responses to exercise in mitral valve and chronic obstructive pulmonary diseases. Chest 1983 83 3 446 453 2-s2.0-0020693282 (Pubitemid 13156485)
128. Munhoz E. C., Hollanda R., Vargas J. P., Silveira C. W., Lemos A. L., Hollanda R. M. K., Ribeiro J. P., Flattening of oxygen pulse during exercise may detect extensive myocardial ischemia. Medicine and Science in Sports and Exercise 2007 39 8 1221 1226 2-s2.0-34548318957 10.1249/mss.0b013e3180601136 (Pubitemid 47344002)
129. Belardinelli R., Lacalaprice F., Carle F., Minnucci A., Cianci G., Perna G. P., D'Eusanio G., Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing. European Heart Journal 2003 24 14 1304 1313 2-s2.0-0041402838 10.1016/S0195-668X(03)00210-0 (Pubitemid 36917701)
130. Grassi B., Porcelli S., Marzorati M., Lanfranconi F., Vago P., Marconi C., Morandi L., Metabolic myopathies: functional evaluation by analysis of oxygen uptake kinetics. Medicine and Science in Sports and Exercise 2009 41 12 2120 2127 2-s2.0-73449086290 10.1249/MSS.0b013e3181aae96b
131. Whipp B. J., Higgenbotham M. B., Cobb F. C., Estimating exercise stroke volume from asymptotic oxygen pulse in humans. Journal of Applied Physiology 1996 81 6 2674 2679 2-s2.0-0030479388 (Pubitemid 27043387)
132. Inbar O., Yamin C., Bar-On I., Nice S., David D., Effects of percutaneous transluminal coronary angioplasty on cardiopulmonary responses during exercise. Journal of Sports Medicine and Physical Fitness 2008 48 2 235 245 2-s2.0-46349086007
133. Chaudhry S., Arena R., Wasserman K., Hansen J. E., Lewis G. D., Myers J., Chronos N., Boden W. E., Exercise-induced myocardial ischemia detected by cardiopulmonary exercise testing. The American Journal of Cardiology 2009 103 5 615 619 2-s2.0-60249100966 10.1016/j.amjcard.2008.10.034
134. Cole C. R., Blackstone E. H., Pashkow F. J., Snader C. E., Lauer M. S., Heart-rate recovery immediately after exercise as a predictor of mortality. The New England Journal of Medicine 1999 341 18 1351 1357 2-s2.0-0032694263 10.1056/NEJM199910283411804 (Pubitemid 29503574)
135. Watanabe J., Thamilarasan M., Blackstone E. H., Thomas J. D., Lauer M. S., Heart rate recovery immediately after treadmill exercise and left ventricular systolic dysfunction as predictors of mortality: the case of stress echocardiography. Circulation 2001 104 16 1911 1916 2-s2.0-0035899934 (Pubitemid 32983233)
136. Chacko K. M., Bauer T. A., Dale R. A., Dixon J. A., Schrier R. W., Estacio R. O., Heart rate recovery predicts mortality and cardiovascular events in patients with type 2 diabetes. Medicine and Science in Sports and Exercise 2008 40 2 288 295 2-s2.0-38649090095 10.1249/mss.0b013e31815c4844 (Pubitemid 351164875)
137. Lacasse M., Maltais F., Poirier P., Lacasse Y., Marquis K., Jobin J., LeBlanc P., Post-exercise heart rate recovery and mortality in chronic obstructive pulmonary disease. Respiratory Medicine 2005 99 7 877 886 2-s2.0-20444366201 10.1016/j.rmed.2004.11.012 (Pubitemid 40796563)
138. Spies C., Otte C., Kanaya A., Pipkin S. S., Schiller N. B., Whooley M. A., Association of metabolic syndrome with exercise capacity and heart rate recovery in patients with coronary heart disease in the heart and soul study. The American Journal of Cardiology 2005 95 10 1175 1179 2-s2.0-18144411645 10.1016/j.amjcard.2005.01.045 (Pubitemid 40616419)
139. Nanas S., Sakellariou D., Kapsimalakou S., Dimopoulos S., Tassiou A., Tasoulis A., Anastasiou-Nana M., Vagiakis E., Roussos C., Heart rate recovery and oxygen kinetics after exercise in obstructive sleep apnea syndrome. Clinical Cardiology 2010 33 1 46 51 2-s2.0-74949092132 10.1002/clc.20707
140. Ardic I., Kaya M. G., Yarlioglues M., Dogdu O., Buyukoglan H., Kalay N., Kanbay A., Zencir C., Ergin A., Impaired heart rate recovery index in patients with sarcoidosis. Chest 2011 139 1 60 68 2-s2.0-78651445937 10.1378/chest.09- 3022
141. Dogdu O., Yarlioglues M., Kaya M. G., Ardic I., Oguzhan N., Akpek M., Sahin O., Akyol L., Kelesoglu S., Koc F., Ozdogru I., Oguzhan A., Deterioration of heart rate recovery index in patients with systemic lupus erythematosus. The Journal of Rheumatology 2010 37 12 2511 2515 2-s2.0-78649723335 10.3899/jrheum.100163
142. Kaya E. B., Okutucu S., Aksoy H., Karakulak U. N., Tulumen E., Ozdemir O., Inanici F., Aytemir K., Kabakci G., Tokgozoglu L., Ozkutlu H., Oto A., Evaluation of cardiac autonomic functions in patients with ankylosing spondylitis via heart rate recovery and heart rate variability. Clinical Research in Cardiology 2010 99 12 803 808 2-s2.0-78649667626 10.1007/s00392-010-0187-x
143. Tekin G., Tekin A., Kiliçarslan E. B., Haydardedeolu B., Katircibaşi T., Koçum T., Erol T., Çölkesen Y., Sezgin A. T., Müderrisolu H., Altered autonomic neural control of the cardiovascular system in patients with polycystic ovary syndrome. International Journal of Cardiology 2008 130 1 49 55 2-s2.0-53549113624 10.1016/j.ijcard.2007. 08.037
144. Orscelik O., Kocyigit I., Baran O., Kaya C., Dogdu O., Zengin H., Karadavut S., Gedikli O., Kut E., Duran M., Calapkorur B., Tokgoz B., Kaya M. G., Impairment of heart rate recovery index in autosomal-dominant polycystic kidney disease patients without hypertension. Blood Pressure 2012 21 5 300 305 10.3109/08037051.2012.680691
145. Cade W. T., Reeds D. N., Lassa-Claxton S., Davila-Roman V. G., Waggoner A. D., Powderly W. G., Yarasheski K. E., Post-exercise heart rate recovery in HIV-positive individuals on highly active antiretroviral therapy: early indicator of cardiovascular disease? HIV Medicine 2008 9 2 96 100 2-s2.0-38949107333 10.1111/j.1468-1293.2007.00524.x (Pubitemid 351228132)
146. Tiukinhoy S., Beohar N., Hsie M., Improvement in heart rate recovery after cardiac rehabilitation. Journal of Cardiopulmonary Rehabilitation 2003 23 2 84 87 2-s2.0-0037344886 10.1097/00008483-200303000-00002 (Pubitemid 36378663)
147. Georgiopoulou V. V., Dimopoulos S., Sakellariou D., Papazachou O., Gerovasili V., Tasoulis A., Agapitou V., Vogiatzis I., Roussos C., Nanas S., Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD. Respiratory Care 2012 57 2095 2103
148. Kline C. E., Crowley E. P., Ewing G. B., Burch J. B., Blair S. N., Durstine J. L., Davis J. M., Youngstedt S. D., Blunted heart rate recovery is improved following exercise training in overweight adults with obstructive sleep apnea. International Journal of Cardiology. In press
149. Miossi R., Benatti F. B., de Sa Pinto A. L., Lima F. R., Borba E. F., Lprado D. M., Perandini L. A., Gualano B., Bonfa E., Roschel H., Exercise training counterbalances chronotropic incompetence and delayed heart rate recovery in systemic lupus erythematosus: a randomized trial. Arthritis Care and Research 2012 64 8 1159 1166 10.1002/acr.21678
150. Nishime E. O., Cole C. R., Blackstone E. H., Pashkow F. J., Lauer M. S., Heart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. The Journal of the American Medical Association 2000 284 11 1392 1398 2-s2.0-0034692586
151. Vivekananthan D. P., Blackstone E. H., Pothier C. E., Lauer M. S., Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. Journal of the American College of Cardiology 2003 42 5 831 838 2-s2.0-0041375475 10.1016/S0735-1097(03)00833-7 (Pubitemid 37059740)
152. Shetler K., Marcus R., Froelicher V. F., Vora S., Kalisetti D., Prakash M., Do D., Myers J., Heart rate recovery: validation and methodologic issues. Journal of the American College of Cardiology 2001 38 7 1980 1987 2-s2.0-0035196137 10.1016/S0735-1097(01)01652-7 (Pubitemid 33116574)
153. Cole C. R., Foody J. M., Blackstone E. H., Lauer M. S., Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Annals of Internal Medicine 2000 132 7 552 555 2-s2.0-0034603691 (Pubitemid 30171895)
154. Arena R., Guazzi M., Myers J., Peberdy M. A., Prognostic value of heart rate recovery in patients with heart failure. American Heart Journal 2006 151 4 851 e7 2-s2.0-33645230201 10.1016/j.ahj.2005.09.012
155. Nanas S., Anastasiou-Nana M., Dimopoulos S., Sakellariou D., Alexopoulos G., Kapsimalakou S., Papazoglou P., Tsolakis E., Papazachou O., Roussos C., Nanas J., Early heart rate recovery after exercise predicts mortality in patients with chronic heart failure. International Journal of Cardiology 2006 110 3 393 400 2-s2.0-33744910060 10.1016/j.ijcard.2005.10.032 (Pubitemid 43841909)
156. Guazzi M., Myers J., Peberdy M. A., Bensimhon D., Chase P., Arena R., Heart rate recovery predicts sudden cardiac death in heart failure. International Journal of Cardiology 2010 144 1 121 123 2-s2.0-77952534436 10.1016/j.ijcard.2008.12.149
157. Hansen J. E., Sue D. Y., Oren A., Wasserman K., Relation of oxygen uptake to work rate in normal men and men with circulatory disorders. The American Journal of Cardiology 1987 59 6 669 674 2-s2.0-0023119039 (Pubitemid 17047341)
158. 2 extraction during ramp exercise. Journal of Applied Physiology 2007 103 6 1999 2004 2-s2.0-36849043514 10.1152/japplphysiol.01414.2006 (Pubitemid 350232382)
159. Boone J., Koppo K., Barstow T. J., Bouckaert J., Aerobic fitness, muscle efficiency, and motor unit recruitment during ramp exercise. Medicine and Science in Sports and Exercise 2010 42 2 402 408 2-s2.0-75149188902 10.1249/MSS.0b013e3181b0f2e2
160. Barstow T. J., Jones A. M., Nguyen P. H., Casaburi R., Influence of muscle fibre type and fitness on the oxygen uptake/power output slope during incremental exercise in humans. Experimental Physiology 2000 85 1 109 116 2-s2.0-0033994089 (Pubitemid 30122170)
161. Myers J., Salleh A., Buchanan N., Smith D., Neutel J., Bowes E., Froelicher V. F., Ventilatory mechanisms of exercise intolerance in chronic heart failure. American Heart Journal 1992 124 3 710 719 2-s2.0-0026667806 10.1016/0002-8703(92)90282-Z
162. Piepoli M., Clark A. L., Volterrani M., Adamopoulos S., Sleight P., Coats A. J. S., Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training. Circulation 1996 93 5 940 952 2-s2.0-0030003477 (Pubitemid 26074831)
163. Ponikowski P., Francis D. P., Piepoli M. F., Davies L. C., Chua T. P., Davos C. H., Florea V., Banasiak W., Poole-Wilson P. A., Coats A. J. S., Anker S. D., Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance: marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis. Circulation 2001 103 7 967 972 2-s2.0-0035916265 (Pubitemid 32183802)
164. Hollenberg M., Tager I. B., Oxygen uptake efficiency slope: an index of exercise performance and cardiopulmonary reserve requiring only submaximal exercise. Journal of the American College of Cardiology 2000 36 1 194 201 2-s2.0-0033926548 10.1016/S0735-1097(00)00691-4 (Pubitemid 30466133)
165. Baba R., Nagashima M., Goto M., Nagano Y., Yokota M., Tauchi N., Nishibata K., Oxygen uptake efficiency slope: a new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise. Journal of the American College of Cardiology 1996 28 6 1567 1572 2-s2.0-0030588919 10.1016/S0735-1097(96)00412-3 (Pubitemid 26391865)
166. Baba R., Tsuyuki K., Kimura Y., Ninomiya K., Aihara M., Ebine K., Tauchi N., Nishibata K., Nagashima M., Oxygen uptake efficiency slope as a useful measure of cardiorespiratory functional reserve in adult cardiac patients. European Journal of Applied Physiology and Occupational Physiology 1999 80 5 397 401 2-s2.0-0032822049 10.1007/s004210050610 (Pubitemid 29440502)
167. Baba R., Nagashima M., Nagano Y., Ikoma M., Nishibata K., Role of the oxygen uptake efficiency slope in evaluating exercise tolerance. Archives of Disease in Childhood 1999 81 1 73 75 2-s2.0-0033022566 (Pubitemid 29307463)
168. Olson T. P., Joyner M. J., Johnson B. D., Influence of locomotor muscle metaboreceptor stimulation on the ventilatory response to exercise in heart failure. Circulation: Heart Failure 2010 3 2 212 219 2-s2.0-77951916888 10.1161/CIRCHEARTFAILURE.109.879684
169. Sun X. G., Hansen J. E., Stringer W. W., Oxygen uptake efficiency plateau: physiology and reference values. European Journal of Applied Physiology 2011 1 10 2-s2.0-79959206384 10.1007/s00421-011-2030-0
170. Whipp B. J., Ward S. A., Whipp B. J., Wasserman K., The coupling of ventilation to pulmonary gas exchange during exercise. Pulmonary Physiology and Pathophysiology of Exercise 1991 New York, NY, USA Dekker 271 307
171. Van Laethem C., Bartunek J., Goethals M., Nellens P., Andries E., Vanderheyden M., Oxygen uptake efficiency slope, a new submaximal parameter in evaluating exercise capacity in chronic heart failure patients. American Heart Journal 2005 149 1 175 180 2-s2.0-12344333507 10.1016/j.ahj.2004.07.004 (Pubitemid 40126506)
172. Van Laethem C., De Sutter J., Peersman W., Calders P., Intratest reliability and test-retest reproducibility of the oxygen uptake efficiency slope in healthy participants. European Journal of Cardiovascular Prevention and Rehabilitation 2009 16 4 493 498 2-s2.0-70349198001 10.1097/HJR. 0b013e32832c88a8
173. Williamson W., Fuld J., Westgate K., Sylvester K., Ekelund U., Brage S., Validity of reporting oxygen uptake efficiency slope from submaximal exercise using respiratory exchange ratio as secondary criterion. Pulmonary Medicine 2012 2012 8 874020 10.1155/2012/874020
174. Gruet M., Brisswalter J., Mely L., Vallier J. M., Clinical utility of the oxygen uptake efficiency slope in cystic fibrosis patients. Journal of Cystic Fibrosis 2010 9 5 307 313 2-s2.0-77956922928 10.1016/j.jcf.2010.03.003
175. Phypers B. J., Robiony-Rogers D., Pickering R. M., Garden A. L., Test-retest reliability of the oxygen uptake efficiency slope in surgical patients. Anaesthesia 2011 66 8 659 666 2-s2.0-79960351788 10.1111/j.1365-2044. 2011.06714.x
176. Baba R., Kubo N., Morotome Y., Iwagaki S., Reproducibility of the oxygen uptake efficiency slope in normal healthy subjects. Journal of Sports Medicine and Physical Fitness 1999 39 3 202 206 2-s2.0-0032708627 (Pubitemid 29507837)
177. Akkerman M., Van Brussel M., Hulzebos E., Vanhees L., Helders P. J. M., Takken T., The oxygen uptake efficiency slope: what do we know? Journal of Cardiopulmonary Rehabilitation and Prevention 2010 30 6 357 373 2-s2.0-78649318065 10.1097/HCR.0b013e3181ebf316
178. Arena R., Myers J., Hsu L., Peberdy M. A., Pinkstaff S., Bensimhon D., Chase P., Vicenzi M., Guazzi M., The minute ventilation/carbon dioxide production slope is prognostically superior to the oxygen uptake efficiency slope. Journal of Cardiac Failure 2007 13 6 462 469 2-s2.0-34547455264 10.1016/j.cardfail.2007.03.004 (Pubitemid 47176925)
179. Myers J., Arena R., Dewey F., Bensimhon D., Abella J., Hsu L., Chase P., Guazzi M., Peberdy M. A., A cardiopulmonary exercise testing score for predicting outcomes in patients with heart failure. American Heart Journal 2008 156 6 1177 1183 2-s2.0-56349097630 10.1016/j.ahj.2008.07.010
180. Bongers B. C., Hulzebos E. H., Arets B. G., Takken T., Validity of the oxygen uptake efficiency slope in children with cystic fibrosis and mild-to-moderate airflow obstruction. Pediatric Exercise Science 2012 24 129 141
181. 2 uptake kinetics during whole body NMR spectroscopy. Journal of Applied Physiology 1999 86 2 742 747 2-s2.0-0033018876 (Pubitemid 29075833)
182. 2 Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1980 48 3 540 544 2-s2.0-0018857989 (Pubitemid 10141911)
183. Gaesser G. A., Brooks G. A., Metabolic bases of excess post-exercise oxygen consumption: a review. Medicine Science in Sports Exercise 1984 16 29 43 (Pubitemid 14170598)
184. Yoshida T., Whipp B. J., Dynamic asymmetries of cardiac output transients in response to muscular exercise in man. Journal of Physiology 1994 480 2 355 359 2-s2.0-0027995501 (Pubitemid 24340939)
185. De Groote P., Millaire A., Decoulx E., Nugue O., Guimier P., Ducloux G., Kinetics of oxygen consumption during and after exercise in patients with dilated cardiomyopathy: new markers of exercise intolerance with clinical implications. Journal of the American College of Cardiology 1996 28 1 168 175 2-s2.0-0030198590 10.1016/0735-1097(96)00126-X (Pubitemid 26266637)
186. Koike A., Yajima T., Adachi H., Shimizu N., Kano H., Sugimoto K., Niwa A., Marumo F., Hiroe M., Evaluation of exercise capacity using submaximal exercise at a constant work rate in patients with cardiovascular disease. Circulation 1995 91 6 1719 1724 2-s2.0-0028912133
187. Kemps H. M., Schep G., Zonderland M. L., Thijssen E. J., De Vries W. R., Wessels B., Doevendans P. A., Wijn P. F., Are oxygen uptake kinetics in chronic heart failure limited by oxygen delivery or oxygen utilization? International Journal of Cardiology 2010 142 2 138 144 2-s2.0-77953239246 10.1016/j.ijcard. 2008.12.088
188. Nanas S., Nanas J., Kassiotis C., Nikolaou C., Tsagalou E., Sakellariou D., Terovitis I., Papazachou O., Drakos S., Papamichalopoulos A., Roussos C., Early recovery of oxygen kinetics after submaximal exercise test predicts functional capacity in patients with chronic heart failure. European Journal of Heart Failure 2001 3 6 685 692 2-s2.0-0035195933 10.1016/S1388-9842(01)00187-8 (Pubitemid 33121345)
189. Nanas S., Nanas J., Kassiotis C., Alexopoulos G., Samakovli A., Kanakakis J., Tsolakis E., Roussos C., Respiratory muscles performance is related to oxygen kinetics during maximal exercise and early recovery in patients with congestive heart failure. Circulation 1999 100 5 503 508 2-s2.0-0033520016 (Pubitemid 29360159)
190. Cohen-Solal A., Laperche T., Morvan D., Geneves M., Caviezel B., Gourgon R., Prolonged kinetics of recovery of oxygen consumption after maximal graded exercise in patients with chronic heart failure: analysis with gas exchange measurements and NMR spectroscopy. Circulation 1995 91 12 2924 2932 2-s2.0-0029057293
191. Daida H., Allison T. G., Johnson B. D., Squires R. W., Gau G. T., Further increase in oxygen uptake during early active recovery following maximal exercise in chronic heart failure. Chest 1996 109 1 47 51 2-s2.0-0030029298 (Pubitemid 26017591)
192. Cohen-Solal A., Czitrom D., Geneves M., Gourgon R., Delayed attainment of peak oxygen consumption after the end of exercise in patients with chronic heart failure. International Journal of Cardiology 1997 60 1 23 29 2-s2.0-0030806995 10.1016/S0167-5273(97)00059-4 (Pubitemid 27288253)
193. 2 "Hump" phenomenon as an indicator for inducible myocardial ischemia in patients with acute anterior myocardial infarction. International Journal of Cardiology 2006 111 1 67 74 2-s2.0-33746279727 10.1016/j.ijcard.2005.07.012 (Pubitemid 44107541)
194. Kriatselis C. D., Nedios S., Kelle S., Helbig S., Gottwik M., von Bary C., Oxygen kinetics and heart rate response during early recovery from exercise in patients with heart failure. Cardiology Research and Practice 2012 2012 7 512857 10.1155/2012/512857
195. Tajima A., Itoh H., Osada N., Omiya K., Maeda T., Ohkoshi N., Kawara T., Aizawa T., Wasserman K., Oxygen uptake kinetics during and after exercise are useful markers of coronary artery disease in patients with exercise electrocardiography suggesting myocardial ischemia. Circulation Journal 2009 73 10 1864 1870 2-s2.0-70349881673 10.1253/circj.CJ-09-0222
196. Chick T. W., Cagle T. G., Vegas F. A., Poliner J. K., Murata G. H., Recovery of gas exchange variables and heart rate after maximal exercise in COPD. Chest 1990 97 2 276 279 2-s2.0-0025137173 (Pubitemid 20050658)
197. Pouliou E., Nanas S., Papamichalopoulos A., Kyprianou T., Perpati G., Mavrou I., Roussos C., Prolonged oxygen kinetics during early recovery from maximal exercise in adult patients with cystic fibrosis. Chest 2001 119 4 1073 1078 2-s2.0-0034924295 10.1378/chest.119.4.1073 (Pubitemid 32679433)
198. 2) kinetics during early recovery from peak exercise in patients with Type 2 diabetes. Diabetic Medicine 2011 28 5 612 617 2-s2.0-79954477291 10.1111/j.1464-5491.2011.03229.x
199. 2 kinetics on constant-load exercise following bed-rest-induced deconditioning. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1984 57 5 1545 1550 2-s2.0-0021530855 (Pubitemid 15216453)
200. Tanabe Y., Takahashi M., Hosaka Y., Ito M., Ito E., Suzuki K., Prolonged recovery of cardiac output after maximal exercise in patients with chronic heart failure. Journal of the American College of Cardiology 2000 35 5 1228 1236 2-s2.0-0034076079 10.1016/S0735-1097(00)00517-9 (Pubitemid 30206898)
201. Giardini A., Donti A., Specchia S., Coutsoumbas G., Formigari R., Prandstraller D., Bronzetti G., Bonvicini M., Picchio F. M., Recovery kinetics of oxygen uptake is prolonged in adults with an atrial septal defect and improves after transcatheter closure. American Heart Journal 2004 147 5 910 914 2-s2.0-3042817485 10.1016/j.ahj.2003.11.013 (Pubitemid 38881007)
202. Johnson R. L., Gas exchange efficiency in congestive heart failure. Circulation 2000 101 24 2774 2776 2-s2.0-0034691242
203. 2 set point on ventilatory response to exercise. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1981 51 1 185 189 2-s2.0-0019402177 (Pubitemid 11083332)
204. Wasserman K., Zhang Y. Y., Gilt A., Belardinelli R., Koike A., Lubarsky L., Agostoni P. G., Lung function and exercise gas exchange in chronic heart failure. Circulation 1997 96 7 2221 2227 2-s2.0-0030823248 (Pubitemid 27425826)
205. Sue D. Y., Excess ventilation during exercise and prognosis in chronic heart failure. American Journal of Respiratory and Critical Care Medicine 2011 183 10 1302 1310 2-s2.0-79956203802 10.1164/rccm.201006-0965CI
206. 2 partial pressure. European Heart Journal 2005 26 5 472 480 2-s2.0-14644437029 10.1093/eurheartj/ ehi060 (Pubitemid 40314763)
207. Arena R., Myers J., Aslam S. S., Varughese E. B., Peberdy M. A., Technical considerations related to the minute ventilation/carbon dioxide output slope in patients with heart failure. Chest 2003 124 2 720 727 2-s2.0-0042231096 10.1378/chest.124.2.720 (Pubitemid 37000154)
208. Davis J. A., Whipp B. J., Wasserman K., The relation of ventilation to metabolic rate during moderate exercise in man. European Journal of Applied Physiology and Occupational Physiology 1980 44 2 97 108 2-s2.0-0018859150 (Pubitemid 10093005)
209. Kleber F. X., Vietzke G., Wernecke K. D., Bauer U., Opitz C., Wensel R., Sperfeld A., Gläser S., Impairment of ventilatory efficiency in heart failure: prognostic impact. Circulation 2000 101 24 2803 2809 2-s2.0-0034691301 (Pubitemid 30396010)
210. Robbins M., Francis G., Pashkow F. J., Snader C. E., Hoercher K., Young J. B., Lauer M. S., Ventilatory and heart rate responses to exercise better predictors of heart failure mortality than peak oxygen consumption. Circulation 1999 100 24 2411 2417 2-s2.0-0032763176
211. Myers J., Arena R., Dewey F., Bensimhon D., Abella J., Hsu L., Chase P., Guazzi M., Peberdy M. A., A cardiopulmonary exercise testing score for predicting outcomes in patients with heart failure. American Heart Journal 2008 156 6 1177 1183 2-s2.0-56349097630 10.1016/j.ahj.2008.07.010
212. 2 ratio during exercise as a predictor of outcomes in patients with heart failure. Journal of Cardiac Failure 2009 15 9 756 762 2-s2.0-70350566016 10.1016/j.cardfail.2009.05.012
213. Schwaiblmair M., Faul C., von Scheidt W., Berghaus T., Ventilatory efficiency testing as prognostic value in patients with pulmonary hypertension. BMC Pulmonary Medicine 2012 12 23 10.1186/1471-2466-12-23
214. Guazzi M., Myers J., Vicenzi M., Bensimhon D., Chase P., Pinkstaff S., Arena R., Cardiopulmonary exercise testing characteristics in heart failure patients with and without concomitant chronic obstructive pulmonary disease. American Heart Journal 2010 160 5 900 905 2-s2.0-78649380350 10.1016/j.ahj.2010.07.014
215. Deboeck G., Niset G., Lamotte M., Vachiéry J. L., Naeije R., Exercise testing in pulmonary arterial hypertension and in chronic heart failure. European Respiratory Journal 2004 23 5 747 751 2-s2.0-2442554199 10.1183/09031936.04.00111904 (Pubitemid 38618147)
216. Zhai Z., Murphy K., Tighe H., Wang C., Wilkins M. R., Gibbs J. S., Howard L. S., Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Chest 2011 140 5 1284 1291 10.1378/chest.10-3357
217. Roman M. A., Casaburi J. D., Porszasz J., Casaburi R., Noninvasive assessment of normality of V, (D)/V (T) in clinical cardiopulmonary exercise testing utilizing incremental cycle ergometry. European Journal of Applied Physiology 2012 113 1 33 40 10.1007/s00421-012-2407-8
218. Zimmerman M. I., Miller A., Brown L. K., Bhuptani A., Sloane M. F., Teirstein A. S., Estimated vs actual values for dead space/tidal volume ratios during incremental exercise in patients evaluated for dyspnea. Chest 1994 106 1 131 136 2-s2.0-0028284054 (Pubitemid 24214741)
219. 2 pressure decreases during exercise in cardiac patients. Journal of the American College of Cardiology 2000 36 1 242 249 2-s2.0-0034222901 10.1016/S0735-1097(00)00702-6 (Pubitemid 30466140)
220. 2 pressure and cardiac performance during exercise in heart failure. Medicine and science in sports and exercise 2009 41 1 19 25 2-s2.0-65849275868
221. Jones P. W., French W., Weissman M. L., Wasserman K., Ventilatory responses to cardiac output changes in patients with pacemakers. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 1981 51 5 1103 1107 2-s2.0-0019788173 (Pubitemid 12235874)
222. Arena R., Myers J., Abella J., Peberdy M. A., Pinkstaff S., Bensimhon D., Chase P., Guazzi M., Prognostic value of timing and duration characteristics of exercise oscillatory ventilation in patients with heart failure. The Journal of Heart and Lung Transplantation 2008 27 3 341 347 2-s2.0-40649119236 10.1016/j.healun.2007.11.574 (Pubitemid 351375105)
223. Olson L. J., Arruda-Olson A. M., Somers V. K., Scott C. G., Johnson B. D., Exercise oscillatory ventilation: instability of breathing control associated with advanced heart failure. Chest 2008 133 2 474 481 2-s2.0-39449084976 10.1378/chest.07-2146 (Pubitemid 351272408)
224. Koike A., Shimizu N., Tajima A., Aizawa T., Fu L. T., Watanabe H., Itoh H., Relation between oscillatory ventilation at rest before cardiopulmonary exercise testing and prognosis in patients with left ventricular dysfunction. Chest 2003 123 2 372 379 2-s2.0-0037331169 10.1378/chest.123.2.372 (Pubitemid 36269418)
225. Ben-Dov I., Sietsema K. E., Casaburi R., Wasserman K., Evidence that circulatory oscillations accompany ventilatory oscillations during exercise in patients with heart failure. The American Review of Respiratory Disease 1992 145 4 I 776 781 2-s2.0-0026600693
226. Ponikowski P., Anker S. D., Chua T. P., Francis D., Banasiak W., Poole-Wilson P. A., Coats A. J. S., Piepoli M., Oscillatory breathing patterns during wakefulness in patients with chronic heart failure: clinical implications and role of augmented peripheral chemosensitivity. Circulation 1999 100 24 2418 2424 2-s2.0-0032785887
227. Francis D. P., Willson K., Davies L. C., Coats A. J. S., Piepoli M., Quantitative general theory for periodic breathing in chronic heart failure and its clinical implications. Circulation 2000 102 18 2214 2221 2-s2.0-0034739480
228. 2 Chest 1993 104 4 1079 1084 2-s2.0-0027515509 (Pubitemid 23306056)
229. Javaheri S., A mechanism of central sleep apnea in patients with heart failure. The New England Journal of Medicine 1999 341 13 949 954 2-s2.0-0033598326 10.1056/NEJM199909233411304 (Pubitemid 29441549)
230. Ponikowski P., Chua T. P., Anker S. D., Francis D. P., Doehner W., Banasiak W., Poole-Wilson P. A., Piepoli M. F., Coats A. J. S., Peripheral chemoreceptor hypersensitivity an ominous sign in patients with chronic heart failure. Circulation 2001 104 5 544 549 2-s2.0-0035979393 (Pubitemid 32738123)
231. Sanders M. H., Article reviewed: a mechanism of central sleep apnea in patients with heart failure. Sleep Medicine 2000 1 1 63 64 10.1016/S1389- 9457(00)00003-4
232. Ribeiro J. P., Periodic breathing in heart failure: bridging the gap between the sleep laboratory and the exercise laboratory. Circulation 2006 113 1 9 10 2-s2.0-33644862633 10.1161/CIRCULATIONAHA.105.590265 (Pubitemid 43958482)
233. Andreas S., Central sleep apnea and chronic heart failure. Sleep 2000 23 4 S220 S223 2-s2.0-0034659318 (Pubitemid 30462690)
234. Piepoli M. F., Kaczmarek A., Francis D. P., Davies L. C., Rauchhaus M., Jankowska E. A., Anker S. D., Capucci A., Banasiak W., Ponikowski P., Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure. Circulation 2006 114 2 126 134 2-s2.0-33747065311 10.1161/ CIRCULATIONAHA.105.605980 (Pubitemid 44420744)
235. Francis D. P., Davies L. C., Piepoli M., Rauchhaus M., Ponikowski P., Coats A. J. S., Origin of oscillatory kinetics of respiratory gas exchange in chronic heart failure. Circulation 1999 100 10 1065 1070 2-s2.0-0033533559 (Pubitemid 29416232)
236. Guazzi M., Raimondo R., Vicenzi M., Arena R., Proserpio C., Sarzi Braga S., Pedretti R., Exercise oscillatory ventilation may predict sudden cardiac death in heart failure patients. Journal of the American College of Cardiology 2007 50 4 299 308 2-s2.0-34447311088 10.1016/j.jacc.2007.03.042 (Pubitemid 47058880)
237. Ribeiro J. P., Knutzen A., Rocco M. B., Hartley L. H., Colucci W. S., Periodic breathing during exercise in severe heart failure: reversal with milrinone or cardiac transplantation. Chest 1987 92 3 555 556 2-s2.0-0023513571 (Pubitemid 18006626)
238. Ingle L., Isted A., Witte K. K., Cleland J. G. F., Clark A. L., Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure. European Journal of Cardiovascular Prevention and Rehabilitation 2009 16 4 451 456 2-s2.0-70349208986 10.1097/HJR.0b013e32832a4f54
239. Guazzi M., Arena R., Ascione A., Piepoli M., Guazzi M. D., Exercise oscillatory breathing and increased ventilation to carbon dioxide production slope in heart failure: an unfavorable combination with high prognostic value. American Heart Journal 2007 153 5 859 867 2-s2.0-34247095100 10.1016/j.ahj.2007.02.034 (Pubitemid 46602158)
240. Guazzi M., Myers J., Peberdy M. A., Bensimhon D., Chase P., Arena R., Exercise oscillatory breathing in diastolic heart failure: prevalence and prognostic insights. European Heart Journal 2008 29 22 2751 2759 2-s2.0-56449126506 10.1093/eurheartj/ehn437
241. Kremser C. B., O'Toole M. F., Leff A. R., Oscillatory hyperventilation in severe congestive heart failure secondary to idiopathic dilated cardiomyopathy or to ischemic cardiomyopathy. The American Journal of Cardiology 1987 59 8 900 905 2-s2.0-0023260127 (Pubitemid 17061311)
242. Miyagi K., Asanoi H., Ishizaka S., Kameyama T., Sasayama S., Limited value of anaerobic threshold for assessing functional capacity in patients with heart failure. Clinical Cardiology 1993 16 2 133 137 2-s2.0-0027399091 (Pubitemid 23044974)
243. Dall'Ago P., Chiappa G. R. S., Guths H., Stein R., Ribeiro J. P., Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. Journal of the American College of Cardiology 2006 47 4 757 763 2-s2.0-32644443471 10.1016/j.jacc.2005.09.052 (Pubitemid 43243097)
244. Zurek M., Corra U., Piepoli M. F., Binder R. K., Saner H., Schmid J. P., Exercise training reverses exertional oscillatory ventilation in heart failure patients. European Respiratory Journal 2012 40 5 1238 1244 10.1183/09031936. 00167011
245. Winkelmann E. R., Chiappa G. R., Lima C. O. C., Viecili P. R. N., Stein R., Ribeiro J. P., Addition of inspiratory muscle training to aerobic training improves cardiorespiratory responses to exercise in patients with heart failure and inspiratory muscle weakness. American Heart Journal 2009 158 5 768 e1 2-s2.0-70350043288 10.1016/j.ahj.2009.09.005
246. Laughlin M. H., Cardiovascular response to exercise. The American Journal of Physiology 1999 277 6 S244 S259 2-s2.0-18544409054
247. Bodner M. E., Rhodes E. C., A review of the concept of the heart rate deflection point. Sports Medicine 2000 30 1 31 46 2-s2.0-0033923058 (Pubitemid 30449784)
248. Bevilacqua M., Savonitto S., Bosisio E., Chebat E., Bertora P. L., Sardina M., Norbiato G., Role of the frank-starling mechanism in maintaining cardiac output during increasing levels of treadmill exercise in β -blocked normal men. The American Journal of Cardiology 1989 63 12 853 857 2-s2.0-0024547896 (Pubitemid 19094229)
249. Miller T. D., Gibbons R. J., Squires R. W., Allison T. G., Gau G. T., Sinus node deceleration during exercise as a marker of significant narrowing of the right coronary artery. The American Journal of Cardiology 1993 71 4 371 373 2-s2.0-0027471897 10.1016/0002-9149(93)90815-T (Pubitemid 23053458)
250. Jorde U. P., Vittorio T. J., Kasper M. E., Arezzi E., Colombo P. C., Goldsmith R. L., Ahuja K., Tseng C. H., Haas F., Hirsh D. S., Chronotropic incompetence, β -blockers, and functional capacity in advanced congestive heart failure: time to pace? European Journal of Heart Failure 2008 10 1 96 101 2-s2.0-37549035386 10.1016/j.ejheart.2007.11.006
251. Pierpont G. L., Voth E. J., Assessing autonomic function by analysis of heart rate recovery from exercise in healthy subjects. The American Journal of Cardiology 2004 94 1 64 68 2-s2.0-3042654884 10.1016/j.amjcard.2004.03.032 (Pubitemid 38813456)
252. Imai K., Sato H., Hori M., Kusuoka H., Ozaki H., Yokoyama H., Takeda H., Inoue M., Kamada T., Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. Journal of the American College of Cardiology 1994 24 6 1529 1535 2-s2.0-0028114888 (Pubitemid 24344250)
253. Seshadri N., Gildea T. R., McCarthy K., Pothier C., Kavuru M. S., Lauer M. S., Association of an abnormal exercise heart rate recovery with pulmonary function abnormalities. Chest 2004 125 4 1286 1291 2-s2.0-16544394424 10.1378/chest.125.4.1286 (Pubitemid 38501340)
254. Dimopoulos S., Anastasiou-Nana M., Katsaros F., Papazachou O., Tzanis G., Gerovasili V., Pozios H., Roussos C., Nanas J., Nanas S., Impairment of autonomic nervous system activity in patients with pulmonary arterial hypertension: a case control study. Journal of Cardiac Failure 2009 15 10 882 889 10.1016/j.cardfail.2009.06.001
255. Savonen K. P., Kiviniemi V., Laaksonen D. E., Lakka T. A., Laukkanen J. A., Tuomainen T. P., Rauramaa R., Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality in middle-aged men. Journal of Internal Medicine 2011 270 6 589 596 10.1111/j.1365-2796.2011.02434.x
256. Cahalin L. P., Arena R., Guazzi M., Comparison of heart rate recovery after the six-minute walk test to cardiopulmonary exercise testing in patients with heart failure and reduced and preserved ejection fraction. The American Journal of Cardiology 2012 110 3 467 468
257. Minai O. A., Gudavalli R., Mummadi S., Liu X., McCarthy K., Dweik R. A., Heart rate recovery predicts clinical worsening in patients with pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine 2012 185 4 400 408 10.1164/rccm.201105-0848OC
258. Aijaz B., Squires R. W., Thomas R. J., Johnson B. D., Allison T. G., Predictive value of heart rate recovery and peak oxygen consumption for long-term mortality in patients with coronary heart disease. The American Journal of Cardiology 2009 103 12 1641 1646 2-s2.0-67649398878 10.1016/j.amjcard.2009.02.013
259. Ritt L. E., Oliveira R. B., Myers J., Arena R., Peberdy M. A., Bensimhon D., Chase P., Forman D., Guazzi M., Patients with heart failure in the, "intermediate range" of peak oxygen uptake: additive value of heart rate recovery and the minute ventilation/carbon dioxide output slope in predicting mortality. Journal of Cardiopulmonary Rehabilitation and Prevention 2012 32 141 146
260. Liu J. L., Irvine S., Reid I. A., Patel K. P., Zucker I. H., Chronic exercise reduces sympathetic nerve activity in rabbits with pacing-induced heart failure: a role for angiotensin II. Circulation 2000 102 15 1854 1862 2-s2.0-0034633804
261. Lucini D., Milani R. V., Costantino G., Lavie C. J., Porta A., Pagani M., Effects of cardiac rehabilitation and exercise training on autonomic regulation in patients with coronary artery disease. American Heart Journal 2002 143 6 977 983 2-s2.0-0036089085 10.1067/mhj.2002.123117 (Pubitemid 34666887)
262. Hai J. J., Siu C. W., Ho H. H., Li S. W., Lee S., Tse H. F., Relationship between changes in heart rate recovery after cardiac rehabilitation on cardiovascular mortality in patients with myocardial infarction. Heart Rhythm 2010 7 7 929 936 2-s2.0-77954042346 10.1016/j.hrthm.2010.03.023
263. Maeder M. T., Ammann P., Rickli H., Brunner-La Rocca H. P., Impact of the exercise mode on heart rate recovery after maximal exercise. European Journal of Applied Physiology 2009 105 2 247 255 2-s2.0-58549095225 10.1007/s00421-008- 0896-2