Left bundle branch block predicts better survival in women than men receiving cardiac resynchronization therapy: Long-term follow-up of ∼145,000 patients

JACC: Heart Failure

Volumn 1, Issue 3, 2013, Pages 237-244

  Loring, Zak ^a,b   Caños, Daniel A ^a   Selzman, Kimberly ^a,c   Herz, Naomi D ^a   Silverman, Henry ^d   MaCurdy, Thomas E ^d   Worrall, Christopher M ^e   Kelman, Jeffrey ^e   Ritchey, Mary E ^a   Piña, Ileana L ^a,f   Strauss, David G ^a  

^a CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d Acumen LLC   (United States)

^e CENTERS FOR MEDICARE AND MEDICAID SERVICES   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiac resynchronization therapy; Left bundle branch block; Sex

Indexed keywords

ADULT; AGE; AGED; ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; CARDIAC RESYNCHRONIZATION THERAPY DEVICE; CEREBROVASCULAR ACCIDENT; COMORBIDITY; DIABETES MELLITUS; DISEASE ASSOCIATION; ELECTROCARDIOGRAPHY; FALSE POSITIVE RESULT; FEMALE; FOLLOW UP; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEART LEFT BUNDLE BRANCH BLOCK; HOSPITAL BILLING; HUMAN; HYPERTENSION; ISCHEMIC CARDIOMYOPATHY; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MEDICARE; MORTALITY; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; QRS COMPLEX; SEX DIFFERENCE; SURVIVAL;

CARDIAC RESYNCHRONIZATION THERAPY; LEFT BUNDLE BRANCH BLOCK; SEX;

ADULT; AGED; AGED, 80 AND OVER; BUNDLE-BRANCH BLOCK; CARDIAC RESYNCHRONIZATION THERAPY; DEFIBRILLATORS, IMPLANTABLE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; SEX FACTORS; TIME FACTORS;

EID: 84878664266     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2013.03.005     Document Type: Article

References (29)

1. Bristow M.R., Saxon L.A., Boehmer J., et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004, 350:2140-2150.
2. Moss A.J., Hall W.J., Cannom D.S., et al. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 2009, 361:1329-1338.
3. Cleland J.G., Daubert J.C., Erdmann E., et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 2005, 352:1539-1549.
4. McAlister F.A., Ezekowitz J.A., Wiebe N., et al. Systematic review: cardiac resynchronization in patients with symptomatic heart failure. Ann Intern Med 2004, 141:381-390.
5. Al-Majed N.S., McAlister F.A., Bakal J.A., Ezekowitz J.A. Meta-analysis: cardiac resynchronization therapy for patients with less symptomatic heart failure. Ann Intern Med 2011, 154:401-412.
6. Zareba W., Klein H., Cygankiewicz I., et al. Effectiveness of cardiac resynchronization therapy by QRS morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). Circulation 2011, 123:1061-1072.
7. Tang A.S., Wells G.A., Talajic M., et al. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med 2010, 363:2385-2395.
8. Gold M.R., Thebault C., Linde C., et al. Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: results from the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) study. Circulation 2012, 126:822-829.
9. Bilchick K.C., Kamath S., Dimarco J.P., Stukenborg G.J. Bundle-branch block morphology and other predictors of outcome after cardiac resynchronization therapy in Medicare patients. Circulation 2010, 122:2022-2030.
10. Strauss D.G., Selvester R.H., Wagner G.S. Defining left bundle branch block in the era of cardiac resynchronization therapy. Am J Cardiol 2011, 107:927-934.
11. Selzman K., Shein M. QRS morphology rather than QRS duration for predicting CRT response. Arch Intern Med 2011, 171:1859-1860.
12. Yi-Zhou X., Friedman P., Webster T., et al. Cardiac resynchronization therapy: do women benefit more than men?. J Cardiovasc Electrophysiol 2012, 23:172-178.
13. Pina I.L., Kokkinos P., Kao A., et al. Baseline differences in the HF-ACTION trial by sex. Am Heart J 2009, 158:S16-S23.
14. Sipahi I., Carrigan T.P., Rowland D.Y., Stambler B.S., Fang J.C. Impact of QRS duration on clinical event reduction with cardiac resynchronization therapy: meta-analysis of randomized controlled trials. Arch Intern Med 2011, 171:1454-1462.
15. Dupont M., Rickard J., Baranowski B., et al. Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration. Journal of the American College of Cardiology 2012, 60:592-598.
16. Macfarlane P., Oosterom A.V., Pahlm O., Kligfield P., Janse M., Camm J. Appendix 1: Normal Limits. Comprehensive Electrocardiology: Second Edition 2011, 2057-2125. Springer-Verlag London Limited, London, UK.
17. Vassallo J.A., Cassidy D.M., Marchlinski F.E., et al. Endocardial activation of left bundle branch block. Circulation 1984, 69:914-923.
18. Auricchio A., Fantoni C., Regoli F., et al. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation 2004, 109:1133-1139.
19. Charlson M.E., Pompei P., Ales K.L., MacKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987, 40:373-383.
20. Goldenberg I., Moss A.J., Hall W.J., et al. Predictors of response to cardiac resynchronization therapy in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT). Circulation 2011, 124:1527-1536.
21. Wilton S.B., Leung A.A., Ghali W.A., Faris P., Exner D.V. Outcomes of cardiac resynchronization therapy in patients with versus those without atrial fibrillation: a systematic review and meta-analysis. Heart Rhythm 2011, 8:1088-1094.
22. Boston Scientific Corporation. Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT): sponsor's executive summary, P010012/S230. Available at: Accessed May 30, 2012. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/CirculatorySystemDevicesPanel/UCM204607.pdf.
23. Mascioli G., Padeletti L., Sassone B., et al. Electrocardiographic criteria of true left bundle branch block: a simple sign to predict a better clinical and instrumental response to CRT. Pacing Clin Electrophysiol 2012, 35:927-934.
24. Strauss D.G., Selvester R.H. The QRS complex-a biomarker that " images" the heart: QRS scores to quantify myocardial scar in the presence of normal and abnormal ventricular conduction. J Electrocardiol 2009, 42:85-96.
25. Bleeker G.B., Kaandorp T.A., Lamb H.J., et al. Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy. Circulation 2006, 113:969-976.
26. Adelstein E.C., Saba S. Scar burden by myocardial perfusion imaging predicts echocardiographic response to cardiac resynchronization therapy in ischemic cardiomyopathy. Am Heart J 2007, 153:105-112.
27. Loring Z., Strauss D.G., Gerstenblith G., Tomaselli G.F., Weiss R.G., Wu K.C. Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort. Heart Rhythm 2013, 10:659-665.
28. White J.A., Yee R., Yuan X., et al. Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony. J Am Coll Cardiol 2006, 48:1953-1960.
29. Hartzema A.G., Racoosin J.A., MaCurdy T.E., Gibbs J.M., Kelman J.A. Utilizing Medicare claims data for real-time drug safety evaluations: is it feasible?. Pharmacoepidemiol Drug Saf 2011, 20:684-688.