Nociceptin/orphanin FQ receptor activation decreases the airway hyperresponsiveness induced by allergen in sensitized mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 304, Issue 10, 2013, Pages

  Sullo, Nikol ^a   Roviezzo, Fiorentina ^b   Matteis, Maria ^a   Ianaro, Angela ^b   Calò, Girolamo ^c   Guerrini, Remo ^c   de Gruttola, Luana ^b   Spaziano, Giuseppe ^a   Cirino, Giuseppe ^b   Rossi, Francesco ^a   D'Agostino, Bruno ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

Airway hyperresponsiveness; Allergen sensitization; Allergic asthma; Immune response; Nociceptin orphanin FQ

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; NOCICEPTIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; LEUKOCYTE DIFFERENTIAL COUNT; LUNG INFILTRATE; LUNG LAVAGE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INDUCTION; RESPIRATORY TRACT ALLERGY;

AIRWAY HYPERRESPONSIVENESS; ALLERGEN SENSITIZATION; ALLERGIC ASTHMA; IMMUNE RESPONSE; NOCICEPTIN/ORPHANIN FQ;

ALLERGENS; ANIMALS; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CELL PROLIFERATION; FEMALE; IMMUNOGLOBULIN E; INTERLEUKIN-13; LUNG; LYMPHOCYTES; MICE; MICE, INBRED BALB C; OPIOID PEPTIDES; OVALBUMIN; RECEPTORS, OPIOID;

EID: 84878652945     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00358.2012     Document Type: Article

References (32)

1. Anton B, Leff P, Meissler JJ, Calva JC, Acevedo R, Salazar A, Matus M, Flores A, Martinez M, Adler MW, Gaughan JP, Eisenstein TK. Nociceptin/orphanin FQ suppresses adaptive immune responses in vivo and at picomolar levels in vitro. J Neuroimmune Pharmacol 5: 143-154, 2010.
2. Arjomand J, Cole S, Evans CJ. Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells. J Neuroimmunol 130: 100-108, 2002.
3. Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8: 183-192, 2008.
4. Broccardo M, Guerrini R, Morini G, Agostini S, Petrella C, Improta G. The gastric effects of UFP 112, a new agonist of the NOP receptor, in physiological and pathological conditions. Peptides 28: 1974-1981, 2007.
5. Calò G, Rizzi A, Cifani C, Micioni Di Bonaventura MV, Regoli D, Massi M, Salvadori S, Lambert DG, Guerrini R. UFP-112 a potent and long-lasting agonist selective for the nociceptin/orphanin FQ receptor. CNS Neurosci Ther 17: 178-198, 2011.
6. D'Agostino B, Marrocco G, De Nardo M, Calò G, Guerrini R, Gallelli L, Advenier C, Rossi F. Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux. Br J Pharmacol 144: 813-820, 2005.
7. D'Agostino B, Orlotti D, Calò G, Sullo N, Russo M, Guerrini R, De Nardo M, Mazzeo F, Candeletti S, Rossi F. Nociceptin modulates bronchoconstriction induced by sensory nerve activation in mouse lung. Am J Respir Cell Mol Biol 42: 1-5, 2010.
8. Easten KH, Harry RA, Purcell WM, McLeod JD. Nociceptin-induced modulation of human T cell function. Peptides 30: 926-934, 2009.
9. Economidou D, Fedeli A, Fardon RM, Weiss F, Massi M, Ciccocioppo R. Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats. Peptides 27: 3299-3306, 2006.
10. Fischer A, McGregor GP, Saria A, Philippin B, Kummer W. Induction of tachykinin gene and peptide expression in guinea pig no dose primary afferent neurons by allergic airway inflammation. J Clin Invest 98: 2284-2291, 1996.
11. Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 454: 445-454, 2008.
12. Goldfarb Y, Reinscheid RK, Kusnecov AW. Orphanin FQ/nociceptin interactions with the immune system in vivo: gene expression changes in lymphoid organs and regulation of the cytokine response to staphylococcal enterotoxin A. J Neuroimmunol 176: 76-85, 2006.
13. Halford WP, Gebhardt BM, Carr DJ. Functional role and sequence analysis of a lymphocyte orphan opioid receptor. J Neuroimmunol 59: 91-101, 1995.
14. Ianaro A, O'Donnell CA, Di Rosa M, Liew FY. A nitric oxide synthase inhibitor reduces inflammation, down-regulates inflammatory cytokines and enhances interleukin-10 production in carrageenin-induced oedema in mice. Immunology 82: 370-375, 1994.
15. Jiang H, Xie Y, Abel PW, Toews ML, Townley RG, Casale TB, Tu Y. Targeting phosphoinositide 3-kinase γ in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness. J Pharmacol Exp Ther 342: 305-311, 2012.
16. Lambert DG. The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential. Nat Rev Drug Discov 7: 694-710, 2008.
17. Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 6: 761-771, 2006.
18. Lee MG, Undem BJ, Brown C, Carr MJ. Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs. Am J Respir Crit Care Med 173: 271-275, 2006.
19. Leigh R, Ellis R, Wattie J, Donaldson DD, Inman MD. Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice? Am J Respir Crit Care Med 170: 851-856, 2004.
20. Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B, Mazarguil H, Vassart G, Parmentier M, Costentin J. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377: 532-535, 1995.
21. Miller TR, Fulford AJ. Regulation of nociceptin/orphaninFQ secretion by immune cells and functional modulation of interleukin-2. Peptides 28: 2243-2252, 2007.
22. Nakano T, Inoue H, Fukuyama S, Matsumoto K, Matsumura M, Tsuda M, Matsumoto T, Aizawa H, Nakanishi Y. Niflumic acid suppresses interleukin-13-induced asthma phenotypes. Am J Respir Crit Care Med 173: 1216-1221, 2006.
23. Patel HJ, Giembycz MA, Spicuzza L, Barnes PJ, Belvisi MG. Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin. Br J Pharmacol 120: 735-736, 1997.
24. Peluso J, Gaveriaux-Ruff C, Matthes HW, Filliol D, Kieffer BL. Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation. Brain Res Bull 54: 655-660, 2001.
25. Peluso J, LaForge KS, Matthes HW, Kreek MJ, Kieffer BL, Gaveriaux-Ruff C. Distribution of nociceptin/orphaninFQ receptor transcript in human central nervous system and immune cells. J Neuroimmunol 81: 184-192, 1998.
26. Reinscheid RK, Nothacker H, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ Jr, Civelli O. A neuropeptide that activates an opioid like G protein-coupled receptor. Science 270: 792-794, 1995.
27. Rizzi A, Spagnolo B, Wainford RD, Fischetti C, Guerrini R, Marzola G, Baldisserotto A, Salvadori S, Regoli D, Kapusta DR, Calo G. In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor. Peptides 28: 1240-1251, 2007.
28. Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G. Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. Am J Respir Cell Mol Biol 36: 757-762, 2007.
29. Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G. Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse. Am J Respir Cell Mol Biol 42: 572-577, 2010.
30. Serhan CN, Fierro IM, Chiang N, Pouliot M. Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirintriggered 15-epi-lipoxin A4. J Immunol 166: 3650-3654, 2001.
31. Taube C, Duez C, Cui ZH, Takeda K, Rha YH, Park JW, Balhorn A, Donaldson DD, Dakhama A, Gelfand EW. The role of IL-13 in established allergic airway disease. J Immunol 169: 6482-6489, 2002.
32. Waits PS, Purcell WM, Fulford AJ, McLeod JD. Nociceptin/orphanin FQ modulates human T cell function in vitro. J Neuroimmunol 149: 110-120, 2004.