Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving β-blocker therapy: Data from the HF-ACTION trial

European Heart Journal

Volumn 34, Issue 29, 2013, Pages 2271-2280

  Dobre, Daniela ^a   Zannad, Faiez ^a   Keteyian, Steven J ^b   Stevens, Susanna R ^c   Rossignol, Patrick ^a,d   Kitzman, Dalane W ^e   Landzberg, Joel ^f   Howlett, Jonathan ^g   Kraus, William E ^c   Ellis, Stephen J ^c  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b HENRY FORD HOSPITAL   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITÉ DE LORRAINE   (France)

^e WAKE FOREST SCHOOL OF MEDICINE   (United States)

^f HACKENSACK UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF CALGARY   (Canada)

Author keywords

Chronic heart failure; Chronotropic incompetence; Chronotropic index; Heart rate; Heart rate reserve

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; AGED; ARTICLE; CARDIAC PATIENT; CARDIOVASCULAR MORTALITY; CHRONOTROPISM; EXERCISE TEST; FEMALE; FOLLOW UP; HEART EJECTION FRACTION; HEART FAILURE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RESTING HEART RATE; SENSITIVITY ANALYSIS; SINUS RHYTHM;

CHRONIC HEART FAILURE; CHRONOTROPIC INCOMPETENCE; CHRONOTROPIC INDEX; HEART RATE; HEART RATE RESERVE;

ADRENERGIC BETA-ANTAGONISTS; AGED; CAUSE OF DEATH; EXERCISE; FEMALE; HEART FAILURE; HEART RATE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84878652237     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehs433     Document Type: Article

References (26)

1. Pocock SJ, Wang D, Pfeffer MA, Yusuf S, McMurray JJ, Swedberg KB, Ostergren J, Michelson EL, Pieper KS, Granger CB. Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J 2006;27:65-75. (Pubitemid 41785934)
2. Lechat P, Hulot JS, Escolano S, Mallet A, Leizorovicz A, Werhlen-Grandjean M, Pochmalicki G, Dargie H. Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial. Circulation 2001;103:1428-1433. (Pubitemid 32220636)
3. Swedberg K, Komajda M, Bohm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 2010;376:875-885.
4. Colucci WS, Ribeiro JP, Rocco MB, Quigg RJ, Creager MA, Marsh JD, Gauthier DF, Hartley LH. Impaired chronotropic response to exercise in patients with congestive heart failure. Role of postsynaptic beta-adrenergic desensitization. Circulation 1989;80:314-323.
5. Lauer MS, Okin PM, Larson MG, Evans JC, Levy D. Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation 1996;93:1520-1526.
6. Lauer MS, Pashkow FJ, Larson MG, Levy D. Association of cigarette smoking with chronotropic incompetence and prognosis in the Framingham Heart Study. Circulation 1997;96:897-903. (Pubitemid 27329625)
7. Azarbal B, Hayes SW, Lewin HC, Hachamovitch R, Cohen I, Berman DS. The incremental prognostic value of percentage of heart rate reserve achieved over myocardial perfusion single-photon emission computed tomography in the prediction of cardiac death and all-cause mortality: superiority over 85% of maximal age-predicted heart rate. J Am Coll Cardiol 2004;44:423-430. (Pubitemid 38950605)
8. Khan MN, Pothier CE, Lauer MS. Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol). Am J Cardiol 2005;96:1328-1333. (Pubitemid 41505419)
9. Witte KK, Cleland JG, Clark AL. Chronic heart failure, chronotropic incompetence, and the effects of beta blockade. Heart 2006;92:481-486.
10. Al-Najjar Y, Witte KK, Clark AL. Chronotropic incompetence and survival in chronic heart failure. Int J Cardiol 2010;157:48-52.
11. O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Pina IL. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 2009;301:1439-1450.
12. Whellan DJ, O'Connor CM, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Houston-Miller N, Fleg JL, Schulman KA, Pina IL. Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale. Am Heart J 2007;153: 201-211. (Pubitemid 46096868)
13. Di Lenarda A, Sabbadini G, Salvatore L, Sinagra G, Mestroni L, Pinamonti B, Gregori D, Ciani F, Muzzi A, Klugmann S, Camerini F. Long-term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite chronic metoprolol. The Heart-Muscle Disease Study Group. J Am Coll Cardiol 1999;33:1926-1934.
14. Maack C, Elter T, Nickenig G, LaRosee K, Crivaro M, Stablein A, Wuttke H, Bohm M. Prospective crossover comparison of carvedilol and metoprolol in patients with chronic heart failure. J Am Coll Cardiol 2001;38:939-946. (Pubitemid 32912692)
15. Astrand I. Aerobic work capacity in men and women with special reference to age. Acta Physiol Scand Suppl 1960;49:1-92.
16. Keteyian SJ, Kitzman D, Zannad F, Landzberg J, Arnold JM, Brubaker P, Brawner CA, Bensimhon D, Hellkamp AS, Ewald G. Predicting maximal heart rate in heart failure patients on beta-blockade therapy. Med Sci Sports Exerc 2012;44:371-376.
17. O'Connor CM, Whellan DJ,Wojdyla D, Leifer E, Clare RM, Ellis SJ, Fine LJ, Fleg JL, Zannad F, Keteyian SJ, Kitzman DW, Kraus WE, Rendall D, Pina IL, Cooper LS, Fiuzat M, Lee KL. Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model. Circ Heart Fail 2012;5:63-71.
18. Gauri AJ, Raxwal VK, Roux L, Fearon WF, Froelicher VF. Effects of chronotropic incompetence and beta-blocker use on the exercise treadmill test in men. Am Heart J 2001;142:136-141. (Pubitemid 32595385)
19. Elhendy A, Mahoney DW, Khandheria BK, Burger K, Pellikka PA. Prognostic significance of impairment of heart rate response to exercise: impact of left ventricular function and myocardial ischemia. J Am Coll Cardiol 2003;42: 823-830. (Pubitemid 37059739)
20. Lauer MS, Francis GS, Okin PM, Pashkow FJ, Snader CE, Marwick TH. Impaired chronotropic response to exercise stress testing as a predictor of mortality. JAMA 1999;281:524-529. (Pubitemid 29081305)
21. Carvalho VO, Guimaraes GV, Ciolac EG, Bocchi EA. Heart rate dynamics during a treadmill cardiopulmonary exercise test in optimized beta-blocked heart failure patients. Clinics (Sao Paulo) 2008;63:479-482.
22. Brubaker PH, Kitzman DW. Prevalence and management of chronotropic incompetence in heart failure. Curr Cardiol Rep 2007;9:229-235. (Pubitemid 46784418)
23. Samejima H, Omiya K, Uno M, Inoue K, Tamura M, Itoh K, Suzuki K, Akashi Y, Seki A, Suzuki N, Osada N, Tanabe K, Miyake F, Itoh H. Relationship between impaired chronotropic response, cardiac output during exercise, and exercise tolerance in patients with chronic heart failure. Jpn Heart J 2003;44:515-525. (Pubitemid 41518989)
24. Sanders P, Kistler PM, Morton JB, Spence SJ, Kalman JM. Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve. Circulation 2004;110:897-903. (Pubitemid 39128614)
25. Gademan MG, Swenne CA, Verwey HF, van der Laarse A, Maan AC, van de Vooren H, van Pelt J, van Exel HJ, Lucas CM, Cleuren GV, Somer S, Schalij MJ, van der Wall EE. Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure. J Card Fail 2007;13:294-303. (Pubitemid 46766637)
26. Tse HF, Siu CW, Lee KL, Fan K, Chan HW, Tang MO, Tsang V, Lee SW, Lau CP. The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy. J Am Coll Cardiol 2005;46:2292-2297. (Pubitemid 41785500)