Relationship between impaired chronotropic response cardiac output during exercise, and exercise tolerance in patients with chronic heart failure

Japanese Heart Journal

Volumn 44, Issue 4, 2003, Pages 515-525

  Samejima, Hisanori ^a   Omiya, Kazuto ^a   Uno, Masato ^a   Inoue, Kohji ^a   Tamura, Masachika ^a   Itoh, Kae ^a   Suzuki, Kengo ^a   Akashi, Yoshihiro ^a   Seki, Atsushi ^a   Suzuki, Noriyuki ^a   Osada, Naohiko ^a   Tanabe, Kazuhiko ^a   Miyake, Fumihiko ^a   Itoh, Haruki ^b  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b THE CARDIOVASCULAR INSTITUTE   (Japan)

Author keywords

Cardiac output; Chronic heart failure; Exercise tolerance; Impaired chronotropic response; Norepinephrine

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CARBON DIOXIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; NITRATE; NORADRENALIN;

ADULT; AGED; ANAEROBIC THRESHOLD; ARTICLE; BREATHING; CALCULATION; CHRONOTROPISM; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEART INDEX; HEART OUTPUT; HEART RATE; HUMAN; IMPEDANCE; MALE; NORADRENALIN BLOOD LEVEL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REST; SYMPATHETIC NERVE; TIME; CONGESTIVE HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; MIDDLE AGED; PATHOPHYSIOLOGY;

ADULT; AGED; CARDIAC OUTPUT; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART FAILURE, CONGESTIVE; HEART RATE; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; VENTRICULAR DYSFUNCTION, LEFT;

EID: 18844480814     PISSN: 00214868     EISSN: 1348673X     Source Type: Journal    
DOI: 10.1536/jhj.44.515     Document Type: Article

References (22)

1. Mcneer JF, Margolis JR, Lee KL, et al. The role of the exercise test in the evaluation of patients for ischemic heart disease. Circulation 1978; 57: 64-70.
2. Morris SN, McHenry PL. Role of exercise stress testing in healthy subjects and patients with coronary heart disease. Am J Cardiol 1978; 42: 659-66.
3. Chin CF, Messenger JC, Greenberg PS, Ellestad MH. Chronotropic incompetence in exercise testing. Clin Cardiol 1979; 2: 12-8.
4. Wiens RD, Lafia P, Marder CM, Evans RG, Kennedy HL. Chronotropic incompetence in clinical exercise testing. Am J Cardiol 1984; 54: 74-8.
5. Hinkle LE, Carver ST, Plakun A. Slow heart rates and increased risk of cardiac death in middle-aged men. Arch Intern Med 1972; 129: 732-48.
6. Sullivan MJ, Higginbotham MB, Cobb FR. Exercise training in patients with severe left ventricular dysfunction. Hemodynamic and metabolic effects. Circulation 1988; 78: 506-15.
7. Colucci WS, Ribeiro JP, Rocco MB, et al. Impaired chronotropic response to exercise in patients with congestive heart failure: Role of postsynaptic β-adrenergic desensitization. Circulation 1989; 80: 314-23.
8. Clark AL, Coats AJ. Chronotropic incompetence in chronic heart failure. Int J Cardiol 1995; 49: 225-31.
9. Keteyian SJ, Brawner CA, Schairer JR, et al. Effects of exercise training on chronotropic incompetence in patients with heart failure. Am Heart J 1999; 138: 233-40.
10. Bristow MR, Ginsburg R, Minobe W, et al. Decreased catecholamine sensitivity and β - adrenergic-receptor density in failing human hearts. N Engl J Med 1982; 307: 205-11.
11. Matsuyama T, Sato H, Kitabatake A, et al. Blunted cardiac responses to exercise-induced sympathetic stimulation in non-failing aortic regurgitation: Insight into role of cardiac dilatation in hyporesponse of failing hearts. Jpn Circ J 1992; 56: 117-27.
12. Balady GJ, Berra KA, Golding LA, et al. Clinical exercise testing. In: Franklin BA, Whaley MH, Howley ET editors. ACSM's Guidelines for Exercise Testing and Prescription. Sixth edition. Philadelphia: Lea & Febiger, 2000; 91-114.
13. Wasserman K, Hansen JE, Sue DY, Casaburi R, Whipp BJ. Physiology of exercise. In: Weinberg R, editor. Principles of Exercise Testing and Interpretation. Third edition. Philadelphia: Lea & Febiger, 1999; 10-61.
14. Belardinelli R, Ciampani N, Costantini C, Blandini A, Purcaro A. Comparison on impedance cardiography with thermodilution and direct Fick methods for noninvasive measurement of stroke volume and cardiac output during incremental exercise in patients with ischemic cardiomyopathy. Am J Cardiol 1996; 77: 1293-301.
15. Tanabe K, Yamamoto A, Suzuki N, et al. Exercise-induced changes in plasma atrial natriuretic peptides and brain natriuretic peptide concentration in healthy subjects with chronic sleep deprivation. Jpn Circ J 1999; 63: 447-52.
16. Kanaya S, Fujino T, Komiya S, et al. The responses of plasma catecholamines, serum potassium, lipids and blood glucose levels during graded exercise and recovery. Kenkokagaku 1985; 7: 51-9 (in Japanese with English abstract).
17. Fei L, Keeling PJ, Sadoul N, et al. Decreased heart rate variability in patients with congestive heart failure and chronotropic incompetence. PACE 1996; 19: 477-83.
18. Oikawa K, Fukuma N, Kimura Y, Mabuchi K, Munakata K, Takano T. Attenuated heart rate response to exercise correlates with severity of heart failure. Jpn J Appl Physiol 2001; 31: 315-22.
19. Robbins M, Francis G, Pashkow FJ, et al. Ventilatory and heart rate responses to exercise. Better predictors of heart failure mortality than peak oxygen consumption. Circulation 1999; 100: 2411-7.
20. Sato H, Hori M, Kitakaze M, et al. Endogenous adenosine blunts β - adrenoreceptor-mediated inotropic response in hypoperfused canine myocardium. Circulation 1992; 85: 1594-603.
21. Koike A, Itoh H, Taniguchi K, Hiroe M. Detecting abnormalities in left ventricular function during exercise by respiratory measurement. Circulation 1989; 80: 1737-46.
22. Tanabe K, Yamamoto A, Suzuki N, et al. Physiological role of endothelin-1 in nonworking muscles during exercise in healthy subjects. Jpn Circ J 2000; 64: 27-31.