Impaired chronotropic response to exercise stress testing as a predictor of mortality

JAMA

Volumn 281, Issue 6, 1999, Pages 524-529

  Lauer, Michael S ^a   Francis, Gary S ^a   Okin, Peter M ^b   Pashkow, Fredric J ^a   Snader, Claire E ^a   Marwick, Thomas H ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THALLIUM 201;

ADULT; AGED; ARTICLE; CHRONOTROPISM; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; EXERCISE TEST; FEMALE; FOLLOW UP; HEART PERFUSION; HEART RATE; HEART SCINTISCANNING; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; TREADMILL EXERCISE;

EID: 0033540644     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.281.6.524     Document Type: Article

References (24)

1. Lauer MS, Okin PM, Larson MG, Evans JC, Levy D. Impaired heart rate response to graded exercise: prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation. 1996;93:1520-1526.
2. Ellestad MH. Chronotropic incompetence: the implications of heart rate response to exercise (compensatory parasympathetic hyperactivity?). Circulation. 1996;93:1485-1487
3. Heller GV, Ahmed I, Tilkemeier PL, Barbour MM, Garber CE. Influence of exercise intensity on the presence, distribution, and size of thallium-201 defects. Am Heart J. 1992;123:909-916.
4. Ladenheim ML, Pollock BH, Rozanski A, et al. Extent and severity of myocardial hypoperfusion as predictors of prognosis in patients with suspected coronary artery disease. J Am Coll Cardiol. 1986;7: 464-471.
5. Snader CE, Marwick TH, Pashkow FJ, Harvey SA, Thomas JD, Lauer MS. Importance of estimated functional capacity as a predictor of all-cause mortality among patients referred for exercise thallium single-photon emission computed tomography: report of 3,400 patients from a single center. J Am Coll Cardiol. 1997;30:641-648.
6. Lauer MS, Pashkow FJ, Snader CE, Harvey SA, Thomas JD, Marwick TH. Gender and referral for coronary angiography after treadmill thallium testing. Am J Cardiol. 1996;78:278-283.
7. The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V). Arch Intern Med. 1993;153: 154-183.
8. Lauer MS, Pashkow FJ, Harvey SA, Marwick TH, Thomas JD. Angiographic and prognostic implications of an exaggerated exercise systolic blood pressure response and rest systolic blood pressure in adults undergoing evaluation for suspected coronary artery disease. J Am Coll Cardiol. 1995;26:1630-1636.
9. Marwick TH, Mehta R, Arheart K, Lauer MS. Use of exercise echocardiography for prognostic evaluation of patients with known or suspected coronary artery disease. J Am Coll Cardiol. 1997;30:83-90.
10. Fletcher GF, Balady G, Froelicher VF, Hartley LH, Haskell WL, Pollock ML. Exercise standards: a statement for healthcare professionals from the American Heart Association. Circulation. 1995;91:580-615.
11. Wilkoff BL, Miller RE. Exercise testing for chronotropic assessment. Cardiol Clin. 1992;10:705-717.
12. Okin PM, Lauer MS, Kligfield P. Chronotropic response to exercise: improved performance of ST-segment depression criteria after adjustment for heart rate reserve. Circulation. 1996;94:3226-3231.
13. Go RT, Marwick TH, MacIntyre WJ, et al. A prospective comparison of rubidium-82 PET and thallium-201 SPECT myocardial perfusion imaging utilizing a single dipyridamole stress in the diagnosis of coronary artery disease. J Nucl Med. 1990;31: 1899-1905.
14. Boyle CA, Decoufle P. National sources of vital status information: extent of coverage and possible selectivity in reporting. Am J Epidemiol. 1990;131: 160-168.
15. Cox D. Regression models and life tables. J R Stat Soc B. 1972;34:187-220.
16. Okin PM, Kligfield P. Heart rate adjustment of ST segment depression and performance of the exercise electrocardiogram: a critical evaluation. J Am Coll Cardiol. 1995;25:1726-1735.
17. Huang PJ, Chieng PU, Lee YT, et al. Exercise thallium-201 tomographic scintigraphy in the diagnosis of coronary artery disease: emphasis on the effect of exercise level. J Formos Med Assoc. 1992;91: 1096-1101.
18. Francis GS, Goldsmith SR, Ziesche S, Nakajima H, Cohn JN. Relative attenuation of sympathetic drive during exercise in patients with congestive heart failure. J Am Coll Cardiol. 1985;5:832-839.
19. Colucci WS, Ribeiro JP, Rocco MB, et al. Impaired chronotropic response to exercise in patients with congestive heart failure: role of postsynaptic beta-adrenergic desensitization. Circulation. 1989;80: 314-323.
20. Schwartz PJ, La Rovere MT, Vanoli E. Autonomic nervous system and sudden cardiac death: experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation. 1992;85:177-191.
21. Barron HV, Lesh MD. Autonomic nervous system and sudden cardiac death [published erratum appears in J Am Coll Cardiol. 1996;28:286]. J Am Coll Cardiol. 1996;27:1053-1060.
22. Fauchier L, Babuty D, Cosnay P, Autret ML, Fauchier JP. Heart rate variability in idiopathic dilated cardiomyopathy: characteristics and prognostic value. J Am Coll Cardiol. 1997;30:1009-1014.
23. Perkiomaki JS, Huikuri HV, Koistinen JM, Makikallio T, Castellanos A, Myerburg RJ. Heart rate variability and dispersion of QT interval in patients with vulnerability to ventricular tachycardia and ventricular fibrillation after previous myocardial infarction. J Am Coll Cardiol. 1997;30:1331-1338.
24. Myers J, Buchanan N, Walsh D, et al. Comparison of the ramp versus standard exercise protocols. J Am Coll Cardiol. 1991;17:1334-1342.