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Volumn 15, Issue 6, 2013, Pages 1810-1820

Microcystin production revisited: Conjugate formation makes a major contribution

Author keywords

[No Author keywords available]

Indexed keywords

METHANOL; MICROCYSTIN;

EID: 84878630312     PISSN: 14622912     EISSN: 14622920     Source Type: Journal    
DOI: 10.1111/1462-2920.12072     Document Type: Article
Times cited : (85)

References (44)
  • 1
    • 25144488823 scopus 로고    scopus 로고
    • Molecular biology of cyanobacterial toxins. Genetic basis of microcystin production
    • Huisman, J., Matthijs, H.C.P., and Visser, P. (eds). Dordrecht, the Netherlands: Springer -.
    • Börner, T., and Dittmann, E. (2005) Molecular biology of cyanobacterial toxins. Genetic basis of microcystin production. In Aquatic Ecology Series, Vol. 3. Huisman, J., Matthijs, H.C.P., and Visser, P. (eds). Dordrecht, the Netherlands: Springer, pp. 25-40.
    • (2005) Aquatic Ecology Series , vol.3 , pp. 25-40
    • Börner, T.1    Dittmann, E.2
  • 2
    • 37049095866 scopus 로고
    • The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis-aeruginosa
    • Botes, D.P., Tuinman, A.A., Wessels, P.L., Viljoen, C.C., Kruger, H., Williams, D.H., etal. (1984) The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis-aeruginosa. J Chem Soc [Perkin 1] 1: 2311-2318.
    • (1984) J Chem Soc [Perkin 1] , vol.1 , pp. 2311-2318
    • Botes, D.P.1    Tuinman, A.A.2    Wessels, P.L.3    Viljoen, C.C.4    Kruger, H.5    Williams, D.H.6
  • 3
    • 85109198269 scopus 로고    scopus 로고
    • Chorus, I., and Bartram, J. (eds) () . London, UK: The World Health Organization, E. and F.N. Spon.
    • Chorus, I., and Bartram, J. (eds) (2001) Toxic Cyanobacteria in Water. London, UK: The World Health Organization, E. and F.N. Spon.
    • (2001) Toxic Cyanobacteria in Water
  • 4
    • 31544477132 scopus 로고    scopus 로고
    • Cyanobacterial toxins - occurrence, biosynthesis and impact on human affairs
    • Dittmann, E., and Wiegand, C. (2006) Cyanobacterial toxins - occurrence, biosynthesis and impact on human affairs. Mol Nutr Food Res 50: 7-17.
    • (2006) Mol Nutr Food Res , vol.50 , pp. 7-17
    • Dittmann, E.1    Wiegand, C.2
  • 5
    • 0030723581 scopus 로고    scopus 로고
    • Insertional mutagenesis of a peptide synthetase gene that is responsible for hepatotoxin production in the cyanobacterium Microcystis aeruginosa PCC 7806
    • Dittmann, E., Neilan, B.A., Erhard, M., von Döhren, H., and Börner, T. (1997) Insertional mutagenesis of a peptide synthetase gene that is responsible for hepatotoxin production in the cyanobacterium Microcystis aeruginosa PCC 7806. Mol Microbiol 26: 779-787.
    • (1997) Mol Microbiol , vol.26 , pp. 779-787
    • Dittmann, E.1    Neilan, B.A.2    von Erhard, M.3    Döhren, H.4    Börner, T.5
  • 6
    • 84870854383 scopus 로고    scopus 로고
    • Cyanobacterial toxins: biosynthetic routes and evolutionary roots
    • Dittmann, E., Fewer, D.P., and Neilan, B.A. (2013) Cyanobacterial toxins: biosynthetic routes and evolutionary roots. FEMS Microbiol Rev 37: 23-43.
    • (2013) FEMS Microbiol Rev , vol.37 , pp. 23-43
    • Dittmann, E.1    Fewer, D.P.2    Neilan, B.A.3
  • 7
    • 0001637247 scopus 로고
    • pH changes in the cytoplasm of the blue-green alga Anacystis nidulans caused by light dependent proton flux into the thylakoid space
    • Falkner, F., Horner, F., Werdan, K., and Heldt, H.W. (1976) pH changes in the cytoplasm of the blue-green alga Anacystis nidulans caused by light dependent proton flux into the thylakoid space. Plant Physiol 58: 717-718.
    • (1976) Plant Physiol , vol.58 , pp. 717-718
    • Falkner, F.1    Horner, F.2    Werdan, K.3    Heldt, H.W.4
  • 8
    • 31344443358 scopus 로고    scopus 로고
    • An advanced technique for immuno-labelling of microcystins in cryosectioned cells of Microcystis aeruginosa PCC 7806 (cyanobacteria): implementations of an experiment with varying light scenarios and culture densities
    • Gerbersdorf, S.U. (2006) An advanced technique for immuno-labelling of microcystins in cryosectioned cells of Microcystis aeruginosa PCC 7806 (cyanobacteria): implementations of an experiment with varying light scenarios and culture densities. Toxicon 47: 218-228.
    • (2006) Toxicon , vol.47 , pp. 218-228
    • Gerbersdorf, S.U.1
  • 9
    • 0242476702 scopus 로고    scopus 로고
    • Effects of light and nutrient supply on growth and microcystin content of different strains of Microcystis aeruginosa
    • Chorus, I. (ed.). Berlin, Germany: Springer Verlag -.
    • Hesse, K., and Kohl, J.G. (2001) Effects of light and nutrient supply on growth and microcystin content of different strains of Microcystis aeruginosa. In Cyanotoxins: Occurrence, Causes, Consequences. Chorus, I. (ed.). Berlin, Germany: Springer Verlag, pp. 104-115.
    • (2001) Cyanotoxins: Occurrence, Causes, Consequences , pp. 104-115
    • Hesse, K.1    Kohl, J.G.2
  • 10
    • 0035998334 scopus 로고    scopus 로고
    • Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds
    • Ito, E., Takai, A., Kondo, F., Masui, H., Imanishi, S., and Harada, K. (2002) Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds. Toxicon 40: 1017-1025.
    • (2002) Toxicon , vol.40 , pp. 1017-1025
    • Ito, E.1    Takai, A.2    Kondo, F.3    Masui, H.4    Imanishi, S.5    Harada, K.6
  • 11
    • 35948934722 scopus 로고    scopus 로고
    • Impact of inorganic carbon availability on microcystin production by Microcystis aeruginosa PCC 7806
    • Jähnichen, S., Ihle, T., Petzoldt, T., and Benndorf, J. (2007) Impact of inorganic carbon availability on microcystin production by Microcystis aeruginosa PCC 7806. Appl Environ Microbiol 73: 6994-7002.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 6994-7002
    • Jähnichen, S.1    Ihle, T.2    Petzoldt, T.3    Benndorf, J.4
  • 12
    • 81455158760 scopus 로고    scopus 로고
    • Microcystin production by Microcystis aeruginosa: direct regulation by multiple environmental factors
    • Jähnichen, S., Long, B.M., and Petzoldt, T. (2011) Microcystin production by Microcystis aeruginosa: direct regulation by multiple environmental factors. Harmful Algae 12: 95-104.
    • (2011) Harmful Algae , vol.12 , pp. 95-104
    • Jähnichen, S.1    Long, B.M.2    Petzoldt, T.3
  • 13
    • 18144451569 scopus 로고    scopus 로고
    • Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil
    • Jochimsen, E.M., Carmichael, W.W., An, J.S., Cardo, D.M., Cookson, S.T., Holmes, C.E., etal. (1998) Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. N Engl J Med 338: 873-878.
    • (1998) N Engl J Med , vol.338 , pp. 873-878
    • Jochimsen, E.M.1    Carmichael, W.W.2    An, J.S.3    Cardo, D.M.4    Cookson, S.T.5    Holmes, C.E.6
  • 14
    • 0033856746 scopus 로고    scopus 로고
    • Light and the transcriptional response of the microcystin biosynthesis gene cluster
    • Kaebernick, M., Neilan, B.A., Börner, T., and Dittmann, E. (2000) Light and the transcriptional response of the microcystin biosynthesis gene cluster. Appl Environ Microbiol 66: 3387-3392.
    • (2000) Appl Environ Microbiol , vol.66 , pp. 3387-3392
    • Kaebernick, M.1    Neilan, B.A.2    Börner, T.3    Dittmann, E.4
  • 15
    • 0026739225 scopus 로고
    • Formation, characterization, and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins
    • Kondo, F., Ikai, Y., Oka, H., Okumura, M., Ishikawa, N., Harada, K., etal. (1992) Formation, characterization, and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins. Chem Res Toxicol 5: 591-596.
    • (1992) Chem Res Toxicol , vol.5 , pp. 591-596
    • Kondo, F.1    Ikai, Y.2    Oka, H.3    Okumura, M.4    Ishikawa, N.5    Harada, K.6
  • 16
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 18
    • 37049080007 scopus 로고
    • Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters
    • Lawton, L.A., Edwards, C., and Codd, G.A. (1994) Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters. Analyst 119: 1525-1530.
    • (1994) Analyst , vol.119 , pp. 1525-1530
    • Lawton, L.A.1    Edwards, C.2    Codd, G.A.3
  • 19
    • 0035158449 scopus 로고    scopus 로고
    • Cellular microcystin content in N-limited Microcystis aeruginosa can be predicted from growth rate
    • Long, B.M., Jones, G.J., and Orr, P.T. (2001) Cellular microcystin content in N-limited Microcystis aeruginosa can be predicted from growth rate. Appl Environ Microbiol 67: 278-283.
    • (2001) Appl Environ Microbiol , vol.67 , pp. 278-283
    • Long, B.M.1    Jones, G.J.2    Orr, P.T.3
  • 20
    • 0027405256 scopus 로고
    • Influence of trace-metals on growth and toxin production of Microcystis aeruginosa
    • Lukac, M., and Aegerter, R. (1993) Influence of trace-metals on growth and toxin production of Microcystis aeruginosa. Toxicon 31: 293-305.
    • (1993) Toxicon , vol.31 , pp. 293-305
    • Lukac, M.1    Aegerter, R.2
  • 21
    • 74149091840 scopus 로고    scopus 로고
    • Detection of free and covalently bound microcystins in animal tissues by liquid chromatography-tandem mass spectrometry
    • Neffling, M.R., Lance, E., and Meriluoto, J. (2010) Detection of free and covalently bound microcystins in animal tissues by liquid chromatography-tandem mass spectrometry. Environ Pollut 158: 948-952.
    • (2010) Environ Pollut , vol.158 , pp. 948-952
    • Neffling, M.R.1    Lance, E.2    Meriluoto, J.3
  • 22
    • 84876492505 scopus 로고    scopus 로고
    • Environmental conditions that influence toxin biosynthesis in cyanobacteria
    • doi: 10.1111/j.1462-2920.2012.02729.
    • Neilan, B.A., Pearson, L.A., Muenchhoff, J., Moffitt, M.C., and Dittmann, E. (2012) Environmental conditions that influence toxin biosynthesis in cyanobacteria. Environ Microbiol. doi: 10.1111/j.1462-2920.2012.02729.
    • (2012) Environ Microbiol
    • Neilan, B.A.1    Pearson, L.A.2    Muenchhoff, J.3    Moffitt, M.C.4    Dittmann, E.5
  • 23
    • 0032873121 scopus 로고    scopus 로고
    • Genetic analysis of the peptide synthetase genes for a cyclic heptapeptide microcystin in Microcystis spp
    • Nishizawa, T., Asayama, M., Fujii, K., Harada, K., and Shirai, M. (1999) Genetic analysis of the peptide synthetase genes for a cyclic heptapeptide microcystin in Microcystis spp. J Biochem (Tokyo) 126: 520-529.
    • (1999) J Biochem (Tokyo) , vol.126 , pp. 520-529
    • Nishizawa, T.1    Asayama, M.2    Fujii, K.3    Harada, K.4    Shirai, M.5
  • 24
    • 0031771802 scopus 로고    scopus 로고
    • Relationship between microcystin production and cell division rates in nitrogen-limited Microcystis aeruginosa cultures
    • Orr, P.T., and Jones, G.J. (1998) Relationship between microcystin production and cell division rates in nitrogen-limited Microcystis aeruginosa cultures. Limnol Oceanogr 43: 1604-1614.
    • (1998) Limnol Oceanogr , vol.43 , pp. 1604-1614
    • Orr, P.T.1    Jones, G.J.2
  • 26
    • 0030994088 scopus 로고    scopus 로고
    • Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena spp. as a function of growth stimuli
    • Rapala, J., Sivonen, K., Lyra, C., and Niemela, S.I. (1997) Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena spp. as a function of growth stimuli. Appl Environ Microbiol 63: 2206-2212.
    • (1997) Appl Environ Microbiol , vol.63 , pp. 2206-2212
    • Rapala, J.1    Sivonen, K.2    Lyra, C.3    Niemela, S.I.4
  • 27
    • 20544476984 scopus 로고    scopus 로고
    • Water analysis: emerging contaminants and current issues
    • Richardson, S.D., and Ternes, T.A. (2005) Water analysis: emerging contaminants and current issues. Anal Chem 77: 3807-3838.
    • (2005) Anal Chem , vol.77 , pp. 3807-3838
    • Richardson, S.D.1    Ternes, T.A.2
  • 29
    • 0024202813 scopus 로고
    • Isolation and purification of cyanobacteria
    • Rippka, R. (1988) Isolation and purification of cyanobacteria. Methods Enzymol 167: 3-27.
    • (1988) Methods Enzymol , vol.167 , pp. 3-27
    • Rippka, R.1
  • 30
    • 0028863478 scopus 로고
    • In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A
    • Runnegar, M., Berndt, N., Kong, S.M., Lee, E.Y., and Zhang, L. (1995) In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A. Biochem Biophys Res Commun 216: 162-169.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 162-169
    • Runnegar, M.1    Berndt, N.2    Kong, S.M.3    Lee, E.Y.4    Zhang, L.5
  • 31
    • 77954756369 scopus 로고    scopus 로고
    • Spatiotemporal variations in microcystin concentrations and in the proportions of microcystin-producing cells in several Microcystis aeruginosa populations
    • Sabart, M., Pobel, D., Briand, E., Combourieu, B., Salencon, M.J., Humbert, J.F., and Latour, D. (2010) Spatiotemporal variations in microcystin concentrations and in the proportions of microcystin-producing cells in several Microcystis aeruginosa populations. Appl Environ Microbiol 76: 4750-4759.
    • (2010) Appl Environ Microbiol , vol.76 , pp. 4750-4759
    • Sabart, M.1    Pobel, D.2    Briand, E.3    Combourieu, B.4    Salencon, M.J.5    Humbert, J.F.6    Latour, D.7
  • 32
    • 51649111883 scopus 로고    scopus 로고
    • Iron availability affects mcyD expression and microcystin-LR synthesis in Microcystis aeruginosa PCC7806
    • Sevilla, E., Martin-Luna, B., Vela, L., Bes, M.T., Fillat, M.F., and Peleato, M.L. (2008) Iron availability affects mcyD expression and microcystin-LR synthesis in Microcystis aeruginosa PCC7806. Environ Microbiol 10: 2476-2483.
    • (2008) Environ Microbiol , vol.10 , pp. 2476-2483
    • Sevilla, E.1    Martin-Luna, B.2    Vela, L.3    Bes, M.T.4    Fillat, M.F.5    Peleato, M.L.6
  • 33
    • 0001781394 scopus 로고    scopus 로고
    • Cyanobacterial toxins
    • Chorus, I., and Bartram, J. (eds). London, UK: The World Health Organization, E. and F.N. Spon -.
    • Sivonen, K., and Jones, G. (1999) Cyanobacterial toxins. In Toxic Cyanobacteria in Water. Chorus, I., and Bartram, J. (eds). London, UK: The World Health Organization, E. and F.N. Spon, pp. 41-111.
    • (1999) Toxic Cyanobacteria in Water , pp. 41-111
    • Sivonen, K.1    Jones, G.2
  • 34
    • 1642349412 scopus 로고    scopus 로고
    • Screening for cyanobacterial hepatotoxins, microcystins and nodularin in environmental water samples by reversed-phase liquid chromatography-electrospray ionisation mass spectrometry
    • 12020
    • Spoof, L., Vesterkvist, P., Lindholm, T., and Meriluoto, J. (2003) Screening for cyanobacterial hepatotoxins, microcystins and nodularin in environmental water samples by reversed-phase liquid chromatography-electrospray ionisation mass spectrometry. J Chromatogr A 12020: 105-119.
    • (2003) J Chromatogr A , pp. 105-119
    • Spoof, L.1    Vesterkvist, P.2    Lindholm, T.3    Meriluoto, J.4
  • 35
    • 0024039897 scopus 로고
    • Removal of dodecyl sulfate from protein solution
    • Suzuki, H., and Terada, T. (1988) Removal of dodecyl sulfate from protein solution. Anal Biochem 172: 259-263.
    • (1988) Anal Biochem , vol.172 , pp. 259-263
    • Suzuki, H.1    Terada, T.2
  • 36
    • 0033780306 scopus 로고    scopus 로고
    • Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system
    • Tillett, D., Dittmann, E., Erhard, M., von Döhren, H., Börner, T., and Neilan, B.A. (2000) Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system. Chem Biol 7: 753-764.
    • (2000) Chem Biol , vol.7 , pp. 753-764
    • Tillett, D.1    Dittmann, E.2    von Erhard, M.3    Döhren, H.4    Börner, T.5    Neilan, B.A.6
  • 37
    • 25144454346 scopus 로고    scopus 로고
    • The microcystin composition of the cyanobacterium Planktothrix agardhii changes toward a more toxic variant with increasing light intensity
    • Tonk, L., Visser, P.M., Christiansen, G., Dittmann, E., Snelder, E.O., Wiedner, C., etal. (2005) The microcystin composition of the cyanobacterium Planktothrix agardhii changes toward a more toxic variant with increasing light intensity. Appl Environ Microbiol 71: 5177-5181.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 5177-5181
    • Tonk, L.1    Visser, P.M.2    Christiansen, G.3    Dittmann, E.4    Snelder, E.O.5    Wiedner, C.6
  • 38
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
    • Towbin, H., Staehelin, T., and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 39
    • 80052071222 scopus 로고    scopus 로고
    • Reversal in competitive dominance of a toxic versus non-toxic cyanobacterium in response to rising CO(2)
    • Van de Waal, D.B., Verspagen, J.M., Finke, J.F., Vournazou, V., Immers, A.K., Kardinaal, W.E., etal. (2011) Reversal in competitive dominance of a toxic versus non-toxic cyanobacterium in response to rising CO(2). ISME J 5: 1438-1450.
    • (2011) ISME J , vol.5 , pp. 1438-1450
    • Van de Waal, D.B.1    Verspagen, J.M.2    Finke, J.F.3    Vournazou, V.4    Immers, A.K.5    Kardinaal, W.E.6
  • 40
    • 0003156394 scopus 로고
    • Effect of temperature and light on the toxicity and growth of the blue-green-alga Microcystis-aeruginosa (Uv-006)
    • Vanderwesthuizen, A.J., and Eloff, J.N. (1985) Effect of temperature and light on the toxicity and growth of the blue-green-alga Microcystis-aeruginosa (Uv-006). Planta 163: 55-59.
    • (1985) Planta , vol.163 , pp. 55-59
    • Vanderwesthuizen, A.J.1    Eloff, J.N.2
  • 41
    • 0036561208 scopus 로고    scopus 로고
    • Effect of nitrogen and phosphorus on growth of toxic and nontoxic Microcystis strains and on intracellular microcystin concentrations
    • Vezie, C., Rapala, J., Vaitomaa, J., Seitsonen, J., and Sivonen, K. (2002) Effect of nitrogen and phosphorus on growth of toxic and nontoxic Microcystis strains and on intracellular microcystin concentrations. Microb Ecol 43: 443-454.
    • (2002) Microb Ecol , vol.43 , pp. 443-454
    • Vezie, C.1    Rapala, J.2    Vaitomaa, J.3    Seitsonen, J.4    Sivonen, K.5
  • 42
    • 4644305667 scopus 로고    scopus 로고
    • Distribution of microcystin-producing and non-microcystin-producing Microcystis sp. in European freshwater bodies: detection of microcystins and microcystin genes in individual colonies
    • Via-Ordorika, L., Fastner, J., Kurmayer, R., Hisbergues, M., Dittmann, E., Komarek, J., etal. (2004) Distribution of microcystin-producing and non-microcystin-producing Microcystis sp. in European freshwater bodies: detection of microcystins and microcystin genes in individual colonies. Syst Appl Microbiol 27: 592-602.
    • (2004) Syst Appl Microbiol , vol.27 , pp. 592-602
    • Via-Ordorika, L.1    Fastner, J.2    Kurmayer, R.3    Hisbergues, M.4    Dittmann, E.5    Komarek, J.6
  • 44
    • 79952802915 scopus 로고    scopus 로고
    • The cyanobacterial hepatotoxin microcystin binds to proteins and increases the fitness of Microcystis under oxidative stress conditions
    • Zilliges, Y., Kehr, J.C., Meissner, S., Ishida, K., Mikkat, S., Hagemann, M., etal. (2011) The cyanobacterial hepatotoxin microcystin binds to proteins and increases the fitness of Microcystis under oxidative stress conditions. PloS ONE 6: e17615.
    • (2011) PloS ONE , vol.6
    • Zilliges, Y.1    Kehr, J.C.2    Meissner, S.3    Ishida, K.4    Mikkat, S.5    Hagemann, M.6


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