ITRAQ reveals candidate pancreatic cancer serum biomarkers: Influence of obstructive jaundice on their performance

British Journal of Cancer

Volumn 108, Issue 9, 2013, Pages 1846-1853

  Tonack, S ^a   Jenkinson, C ^a   Cox, T ^a   Elliott, V ^a   Jenkins, R E ^a   Kitteringham, N R ^a   Greenhalf, W ^a   Shaw, V ^a   Michalski, C W ^b   Friess, H ^b   Neoptolemos, J P ^a   Costello, E ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Biliary obstruction; Biomarker; Complement 5a; ITIH3; Pancreatic cancer; PIGR

Indexed keywords

ALPHA1 GLYCOPROTEIN; BILIRUBIN; BIOLOGICAL MARKER; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5A; INTER ALPHA TRYPSIN INHIBITOR; SECRETORY COMPONENT;

ADULT; AGED; ARTICLE; CHOLESTASIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEAVY CHAIN; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; OBSTRUCTIVE JAUNDICE; PANCREAS ADENOCARCINOMA; PANCREAS JUICE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY;

AGED; ALPHA-GLOBULINS; ANTIGENS, NEOPLASM; CA-19-9 ANTIGEN; COMPLEMENT C5; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULINS; JAUNDICE, OBSTRUCTIVE; LECTINS, C-TYPE; MALE; MIDDLE AGED; PANCREATIC JUICE; PANCREATIC NEOPLASMS; RECEPTORS, POLYMERIC IMMUNOGLOBULIN; TUMOR MARKERS, BIOLOGICAL;

EID: 84878618547     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.150     Document Type: Article

References (30)

1. Bauer AS, Keller A, Costello E, Greenhalf W, Bier M, Borries A, Beier M, Neoptolemos J, Buchler M, Werner J, Giese N, Hoheisel JD (2012) Diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis by measurement of microRNA abundance in blood and tissue. PLoS One 7(4): e34151.
2. Brand RE, Nolen BM, Zeh HJ, Allen PJ, Eloubeidi MA, Goldberg M, Elton E, Arnoletti JP, Christein JD, Vickers SM, Langmead CJ, Landsittel DP, Whitcomb DC, Grizzle WE, Lokshin AE (2011) Serum biomarker panels for the detection of pancreatic cancer. Clin Cancer Res 17(4): 805-816.
3. Chong PK, Lee H, Zhou J, Liu SC, Loh MC, Wang TT, Chan SP, Smoot DT, Ashktorab H, So JB, Lim KH, Yeoh KG, Lim YP (2010) ITIH3 is a potential biomarker for early detection of gastric cancer. J Proteome Res 9(7): 3671-3679.
4. Costello E, Greenhalf W, Neoptolemos JP (2012) New biomarkers and targets in pancreatic cancer and their application to treatment. Nat Rev Gastroenterol Hepatol 9(8): 435-444.
5. Costello E, Neoptolemos JP (2011) Pancreatic cancer in 2010: new insights for early intervention and detection. Nat Rev Gastroenterol Hepatol 8(2): 71-73.
6. Duraker N, Hot S, Polat Y, Hobek A, Gencler N, Urhan N (2007) CEA, CA 19-9, and CA 125 in the differential diagnosis of benign and malignant pancreatic diseases with or without jaundice. J Surg Oncol 95(2): 142-147.
7. Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, Depinho RA, Bardeesy N, Hanash SM (2008) A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med 5(6): e123.
8. Hidalgo M (2010) Pancreatic cancer. N Engl J Med 362(17): 1605-1617.
9. Li C, Simeone DM, Brenner DE, Anderson MA, Shedden KA, Ruffin MT, Lubman DM (2009) Pancreatic cancer serum detection using a lectin/ glyco-antibody array method. J Proteome Res 8(2): 483-492.
10. Locker GY, Hamilton S, Harris J, Jessup JM, Kemeny N, Macdonald JS, Somerfield MR, Hayes DF, Bast Jr RC (2006) ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol 24(33): 5313-5327.
11. Makawita S, Smith C, Batruch I, Zheng Y, Ruckert F, Grutzmann R, Pilarsky C, Gallinger S, Diamandis EP (2011) Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers. Mol Cell Proteomics 10(10): M111 008599.
12. Marrelli D, Caruso S, Pedrazzani C, Neri A, Fernandes E, Marini M, Pinto E, Roviello F (2009) CA19-9 serum levels in obstructive jaundice: clinical value in benign and malignant conditions. Am J Surg 198(3): 333-339.
13. Okamoto H (1999) The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells. J Hepatobiliary Pancreat Surg 6(3): 254-262.
14. Pan S, Chen R, Crispin DA, May D, Stevens T, McIntosh MW, Bronner MP, Ziogas A, Anton-Culver H, Brentnall TA (2011) Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling. J Proteome Res 10(5): 2359-2376.
15. Ross PL, Huang YN, Marchese JN, Williamson B, Parker K, Hattan S, Khainovski N, Pillai S, Dey S, Daniels S, Purkayastha S, Juhasz P, Martin S, Bartlet-Jones M, He F, Jacobson A, Pappin DJ (2004) Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics 3(12): 1154-1169.
16. Rosty C, Christa L, Kuzdzal S, Baldwin WM, Zahurak ML, Carnot F, Chan DW, Canto M, Lillemoe KD, Cameron JL, Yeo CJ, Hruban RH, Goggins M (2002) Identification of hepatocarcinoma-intestine-pancreas/ pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res 62(6): 1868-1875.
17. Sener SF, Fremgen A, Menck HR, Winchester DP (1999) Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database. J Am Coll Surg 189(1): 1-7.
18. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62(1): 10-29.
19. Singh S, Tang SJ, Sreenarasimhaiah J, Lara LF, Siddiqui A (2011) The clinical utility and limitations of serum carbohydrate antigen (CA19-9) as a diagnostic tool for pancreatic cancer and cholangiocarcinoma. Dig Dis Sci 56(8): 2491-2496.
20. Smith RA, Bosonnet L, Ghaneh P, Raraty M, Sutton R, Campbell F, Neoptolemos JP (2008) Preoperative CA19-9 levels and lymph node ratio are independent predictors of survival in patients with resected pancreatic ductal adenocarcinoma. Dig Surg 25(3): 226-232.
21. Stathis A, Moore MJ (2010) Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol 7(3): 163-172.
22. Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y, Han JX (2008) Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer 8: 241.
23. Tonack S, Aspinall-O'Dea M, Jenkins RE, Elliot V, Murray S, Lane CS, Kitteringham NR, Neoptolemos JP, Costello E (2009) A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ. J Proteomics 73: 352-356.
24. Tonack S, Neoptolemos JP, Costello E (2010) Analysis of serum proteins by LC-MS/MS. Methods Mol Biol 658: 281-291.
25. Tuveson DA, Neoptolemos JP (2012) Understanding metastasis in pancreatic cancer: a call for new clinical approaches. Cell 148(1-2): 21-23.
26. Van Laethem JL, Verslype C, Iovanna JL, Michl P, Conroy T, Louvet C, Hammel P, Mitry E, Ducreux M, Maraculla T, Uhl W, Van Tienhoven G, Bachet JB, Marechal R, Hendlisz A, Bali M, Demetter P, Ulrich F, Aust D, Luttges J, Peeters M, Mauer M, Roth A, Neoptolemos JP, Lutz M (2012) New strategies and designs in pancreatic cancer research: consensus guidelines report from a European expert panel. Ann Oncol 23(3): 570-576.
27. Wong D, Ko AH, Hwang J, Venook AP, Bergsland EK, Tempero MA (2008) Serum CA19-9 decline compared to radiographic response as a surrogate for clinical outcomes in patients with metastatic pancreatic cancer receiving chemotherapy. Pancreas 37(3): 269-274.
28. Yue T, Maupin KA, Fallon B, Li L, Partyka K, Anderson MA, Brenner DE, Kaul K, Zeh H, Moser AJ, Simeone DM, Feng Z, Brand RE, Haab BB (2011) Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers. PLoS One 6(12): e29180.
29. Zhao J, Patwa TH, Qiu W, Shedden K, Hinderer R, Misek DE, Anderson MA, Simeone DM, Lubman DM (2007) Glycoprotein microarrays with multilectin detection: unique lectin binding patterns as a tool for classifying normal, chronic pancreatitis and pancreatic cancer sera. J Proteome Res 6(5): 1864-1874.
30. Zhuo L, Hascall VC, Kimata K (2004) Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex. J Biol Chem 279(37): 38079-38082.