Pre-treatment with bone marrow-derived mesenchymal stem cells inhibits systemic intravascular coagulation and attenuates organ dysfunction in lipopolysaccharide-induced disseminated intravascular coagulation rat model

Chinese Medical Journal

Volumn 125, Issue 10, 2012, Pages 1753-1759

  Wang, Bia ^a,b   Wu, Shu Ming ^b   Wang, Tao ^b   Liu, Kai ^b   Zhang, Gong ^b   Zhang, Xi Quan ^b   Yu, Jian Hua ^b   Liu, Chuan Zhen ^a   Fang, Chang Cun ^a  

^a BEIJING HOSPITAL   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Disseminated intravascular coagulation; Lipopolysaccharide; Mesenchymal stem cells; Proinflammatory cytokine

Indexed keywords

ALANINE AMINOTRANSFERASE; BACTERIUM LIPOPOLYSACCHARIDE; CREATINE KINASE MB; CREATININE; D DIMER; ENDOTHELIN; FIBRINOGEN; GAMMA INTERFERON; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CELL DIFFERENTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISSEMINATED INTRAVASCULAR CLOTTING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PHASE CONTRAST MICROSCOPY; PROTHROMBIN TIME; RAT; THROMBOCYTE COUNT; ANIMAL; BONE MARROW CELL; CYTOLOGY; DRUG EFFECT; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ALANINE TRANSAMINASE; ANIMALS; BLOOD COAGULATION; BONE MARROW CELLS; CREATININE; INTERFERON-GAMMA; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MESENCHYMAL STROMAL CELLS; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84871679811     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn     Document Type: Article

References (29)

1. Lee SY, Chang SK, Lee IH, Kim YM, Chung SI. Depletion of plasma factor VIII prevents disseminated intravascular coagulation-induced organ damage. Thromb Haemost 2001; 85: 464-469.
2. Sjoukie HS, Arnold S, Hugo C. Disseminated intravascular coagulation. Hematol J 2003; 4: 295-302.
3. Ozmen L, Pericin M, Hakimi J. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. J Exp Med 1994; 180: 907-915.
4. Koide N, Narita K, Kato Y. Expression of Fas and Fas ligand on mouse renal tubular epithelial cells in the generalized Shwartzman reaction and its relationship to apoptosis. Infect Immun 1999; 67: 4112-4118.
5. Koide N, Abe K, Narita K. Apoptotic cell death of vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction. FEMS Immunol Med Microbiol 1996; 16: 205-211.
6. Alan T, Vito P. Mesenchymal stem cells combat sepsis. Nat Med 2009; 15: 18-20.
7. Nemeth K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009; 15: 42-49.
8. Laurence O, Marcus P, John H, Richard AC, Maria W, Giorgio T, et al. Interleukin12, interferon j, and tumor necrosis factor a are key cytokines of generalized shwartzman reaction. J Exp Med 1994; 180: 907-915.
9. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989; 170: 827-834.
10. Stern AS, Podlaski FJ, Hulmes JD, Pan YC, Quinn PM, Wolitzky AG, et al. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 2008; 87: 6808-6815.
11. Brunda MJ. Interleukin-12. J Leukocyte Biol 1994; 55: 280-282.
12. Scott P, Wysocka M, Scharton TM, Trinchieri G IL12 production in murine cutaneous leishmaniasis. J Immunol 1993; 150: 86-90.
13. Baggiolini M, Dewald B, Walz A, Garotta G, Talmadge KW, Sinigaglia F. Biochmical changes associated with the activation of human macrophages: effects of intereferons in human disease. Clin Immunol 1991; 1: 303-311.
14. Landolfo S, Garotta G An immunomodulatory and proinflammatory lymphokine. J Immunol Res 2009; 9: 81-86.
15. Okajima K, Yang WP, Inoue M, Okabe H, Takatsuki K. Role of leukocytes in the activation of intravascular coagulation in patients with septicemia. Am J Hematol 1991; 36: 265-277.
16. Naworth PP, Stern DM. Modulation of endothelial cell hemostati properties by tumor necrosis factor. J Exp Med 1986; 163: 740-745.
17. Moore KL, Esmon CT, Esmon NL. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989; 73: 159-165.
18. Kobayashi M, Shimada K, Ozama T. Human recombinant interleukin-1p and tumor necrosis factor-a-mediated suppression of heparin-like compounds on cultured porcine aortic endothelial cells. J Cell Physiol 1990; 144: 383-390.
19. Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkel BS, Palladino MR. Activation of human polymorphonuclear neutrophil functions by interferon-y and tumor necrosis factors. J Immunol 1985; 135: 2069-2073.
20. Campbell EJ, Senior RM, Mcdonald JA, Cox DL. Proteolysis by neutrophils. J Clin Invest 1982; 70: 845-852.
21. Weiss SJ, LoBuglio AE. An oxygen-dependent mechanism of neutrophil-mediated cytotoxicity. Blood 1980; 55: 1020-1024
22. Schleef RR, Bevilacua MP, Sawdey M, Gimborne MA, Loskutoff DJ. Cytokine activation of vascular endothelium. J Biol Chem 1988; 263: 5797-5803.
23. Kenji O. Regulation of inflammatory responses by natural anticoagulants. Immunol Rev 2001; 184: 258-274.
24. Raffaghello L, Bianchi G, Bertolotto M, Montecucco F, Busca A, Dallegri F, et al. Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche. Stem Cells 2008; 26: 151-162.
25. Zhang B, Liu R, Shi D, Liu XX, Chen Y Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population. Blood 2009; 113: 46-57.
26. Kaddoura S, Curzen ZP, Evans JD, Poole-Wilson PA. Tissue expression of endothelin-1 mRNA in endotoxaemia. Biochem Biophys Res Commun 1996; 218: 641-647.
27. Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999; 341: 586-592.
28. Bick RL. Disseminated intravascular coagulation: pathophysiological mechanisms and manifestations. Semin Thromb Hemost 1998; 24: 3-18.
29. Toh CH, Dennis M. Disseminated intravascular coagulation: old disease, new hope. BMJ 2003; 327: 974-977.