Human uraemic serum displays calcific potential in vitro that increases with advancing chronic kidney disease

Clinical Science

Volumn 125, Issue 5, 2013, Pages 237-245

  Patidar, Ashish ^a   Singh, Dhruv K ^b   Winocour, Peter ^c   Farrington, Ken ^a,b   Baydoun, Anwar R ^a  

^a UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^b LISTER HOSPITAL   (United Kingdom)

^c QUEEN ELIZABETH II HOSPITAL   (United Kingdom)

Author keywords

Aortic smooth muscle cell; Calcific potential; Chronic kidney disease; Human uraemic serum; Vascular calcification

Indexed keywords

C REACTIVE PROTEIN; CALCIUM CHLORIDE; GLYCEROL 2 PHOSPHATE; HEMOGLOBIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE; PHOSPHATE; SERUM ALBUMIN;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD VESSEL CALCIFICATION; CELL VIABILITY; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; FEMALE; GLOMERULUS FILTRATION RATE; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; UREMIA;

AGED; ANIMALS; BIOLOGICAL ASSAY; BIOLOGICAL MARKERS; CALCINOSIS; CASE-CONTROL STUDIES; CELLS, CULTURED; COMORBIDITY; ENGLAND; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; RATS; RATS, WISTAR; SMOKING; UREMIA;

EID: 84878601281     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120638     Document Type: Article

References (29)

1. Christian, R. C. and Fitzpatrick, L. A. (1999) Vascular calcification. Curr. Opin. Nephrol. Hypertens. 8, 443-448
2. Blacher, J., Safar, M. E., Guerin, A. P., Pannier, B., Marchais, S. J. and London, G. M. (2003) Aortic pulse wave velocity index and mortality in end-stage renal disease. Kidney Int. 63, 1852-1860
3. London, G. M. (2003) Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function. J. Am. Soc. Nephrol. 14, S305-S309
4. Demer, L. L. and Tintut, Y. (2003) Mineral exploration: search for the mechanism of vascular calcification and beyond. Arterioscler. Thromb. Vasc. Biol. 23, 1739-1743
5. Chen, N. X., O'Neill, K. D., Duan, D. and Moe, S. M. (2002) Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells. Kidney Int. 62, 1724-1731
6. Wileman, S. M., Mann, G. E. and Baydoun, A. R. (1995) Induction of L-arginine transport and nitric oxide synthase in vascular smooth muscle cells: synergistic actions of pro-inflammatory cytokines and bacterial lipopolysaccharide. Br. J. Pharmacol. 116, 3243-3250
7. Kanno, Y., Into, T., Lowenstein, C. J. and Matsushita, K. (2008) Nitric oxide regulates vascular calcification by interfering with TGF- signalling. Cardiovasc. Res. 77, 221-230
8. Shioi, A., Nishizawa, Y., Jono, S., Koyama, H., Hosoi, M. and Morii, H. (1995) β-Glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 15, 2003-2009
9. Thakur, S. and Baydoun, A. R. (2012) Post-transcriptional divergence in the regulation of CAT-2A, CAT-2B and iNOS expression by dexamethasone in vascular smooth muscle cells. Amino Acids 43, 667-676
10. Du, Y., Gao, C., Liu, Z., Wang, L., Liu, B., He, F., Zhang, T., Wang, Y., Wang, X., Xu, M. et al. (2012) Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7 by miR-29 repression mediates vascular smooth muscle calcification. Arterioscler. Thromb. Vasc. Biol. 32, 2580-2588
11. Kircelli, F., Peter, M. E., Sevinc, O. k., E., Celenk, F. G., Yilmaz, M., Steppan, S., Asci, G., Ok, E. and Passlick-Deetjen, J. (2012) Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner. Nephrol. Dial. Transplant. 27, 514-521
12. Jono, S., McKee, M. D., Murry, C. E., Shioi, A., Nishizawa, Y., Mori, K., Morii, H. and Giachelli, C. M. (2000) Phosphate regulation of vascular smooth muscle cell calcification. Circ. Res. 87, E10-E17
13. Roos, M., Lutz, J., Salmhofer, H., Luppa, P., Knauss, A., Braun, S., Martinof, S., Schomig, A., Heemann, U., Kastrati, A. et al. (2008) Relation between plasma fibroblast growth factor-23, serum fetuin-A levels and coronary artery calcification evaluated by multislice computed tomography in patients with normal kidney function. Clin. Endocrinol. 68, 660-665
14. Moe, S. M., Duan, D., Doehle, B. P., O'Neill, K. D. and Chen, N. X. (2003) Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. Kidney Int. 63, 1003-1011
15. Kestenbaum, B. (2007) Phosphate metabolism in the setting of chronic kidney disease: significance and recommendations for treatment. Semin. Dial. 20, 286-294
16. El-Abbadi, M. M., Pai, A. S., Leaf, E. M., Yang, H. Y., Bartley, B. A., Quan, K. K., Ingalls, C. M., Liao, H. W. and Giachelli, C. M. (2009) Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int. 75, 1297-1307
17. Goldsmith, D. J., Covic, A., Sambrook, P. A. and Ackrill, P. (1997) Vascular calcification in long-term haemodialysis patients in a single unit: a retrospective analysis. Nephron. 77, 37-43
18. London, G. M., Marty, C., Marchais, S. J., Guerin, A. P., Metivier, F. and de Vernejoul, M. C. (2004) Arterial calcifications and bone histomorphometry in end-stage renal disease. J. Am. Soc. Nephrol. 15, 1943-1951
19. Adragao, T., Pires, A., Lucas, C., Birne, R., Magalhaes, L., Goncalves, M. and Negrao, A. P. (2004) A simple vascular calcification score predicts cardiovascular risk in haemodialysis patients. Nephrol. Dial. Transplant. 19, 1480-1488
20. Palmer, S. C., Hayen, A., Macaskill, P., Pellegrini, F., Craig, J. C., Elder, G. J. and Strippoli, G. F. (2011) Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis. JAMA, J. Am. Med. Assoc. 305, 1119-1127
21. Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L. et al. (1998) osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 12, 1260-1268
22. Price, P. A., June, H. H., Buckley, J. R. and Williamson, M. K. (2001) Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler. Thromb. Vasc. Biol. 21, 1610-1616
23. Nitta, K., Akiba, T., Uchida, K., Otsubo, S., Takei, T., Yumura, W., Kabaya, T. and Nihei, H. (2004) Serum osteoprotegerin levels and the extent of vascular calcification in haemodialysis patients. Nephrol. Dial. Transplant. 19, 1886-1889
24. Morena, M., Terrier, N., Jaussent, I., Leray-Moragues, H., Chalabi, L., Rivory, J. P., Maurice, F., Delcourt, C., Cristol, J. P., Canaud, B. and Dupuy, A. M. (2006) Plasma osteoprotegerin is associated with mortality in hemodialysis patients. J. Am. Soc. Nephrol. 17, 262-270
25. Jono, S., Ikari, Y., Shioi, A., Mori, K., Miki, T., Hara, K. and Nishizawa, Y. (2002) Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease. Circulation 106, 1192-1194
26. Schoppet, M., Sattler, A. M., Schaefer, J. R., Herzum, M., Maisch, B. and Hofbauer, L. C. (2003) Increased osteoprotegerin serum levels in men with coronary artery disease. J. Clin. Endocrinol. Metab. 88, 1024-1028
27. Combes, C., Rey, C. and Freche, M. (1999) In vitro crystallization of octacalcium phosphate on type I collagen: influence of serum albumin. J. Mater. Sci. Mater. Med. 10, 153-160
28. Fakhrzadeh, H., Ghaderpanahi, M., Sharifi, F., Badamchizade, Z., Mirarefin, M. and Larijani, B. (2009) Increased risk of chronic kidney disease in elderly with metabolic syndrome and high levels of C-reactive protein: Kahrizak Elderly Study. Kidney Blood Press Res. 32, 457-463
29. Van Summeren, M. J., Hameleers, J. M., Schurgers, L. J., Hoeks, A. P., Uiterwaal, C. S., Kruger, T., Vermeer, C., Kuis, W. and Lilien, M. R. (2008) Circulating calcification inhibitors and vascular properties in children after renal transplantation. Pediatr. Nephrol. 23, 985-993