Intraventricular and interventricular cellular heterogeneity of inotropic responses to α1-adrenergic stimulation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 7, 2013, Pages

  Chu, Charles ^a,b   Thai, Kevin ^a,b   Park, Ki Wan ^a,b   Wang, Paul ^a,b   Makwana, Om ^a,b   Lovett, David H ^a,b   Simpson, Paul C ^a,b   Baker, Anthony J ^a,b  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

1 adrenergic; Calcium; Inotropic; Myocyte

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; CALCIUM ION;

ALPHA ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL HETEROGENEITY; CELL ISOLATION; CONTROLLED STUDY; HEART CONTRACTION; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE RELAXATION; HEART RIGHT VENTRICLE; INOTROPISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM;

ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANIMALS; CALCIUM; CALCIUM SIGNALING; HEART VENTRICLES; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; MYOFIBRILS; RECEPTORS, ADRENERGIC, ALPHA-1; SARCOPLASMIC RETICULUM;

EID: 84878587633     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00822.2012     Document Type: Article

References (28)

1. Bassani JW, Bassani RA, Bers DM. Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms. J Physiol 476: 279-293, 1994.
2. + currents in adult mouse ventricles. J Physiol 559: 103-120, 2004.
3. Cazorla O, Lacampagne A. Regional variation in myofilament lengthdependent activation. Pflügers Arch 462: 15-28, 2011.
4. Cazorla O, Pascarel C, Garnier D, Le Guennec JY. Resting tension participates in the modulation of active tension in isolated guinea pig ventricular myocytes. J Mol Cell Cardiol 29: 1629-1637, 1997.
5. Davis JS, Hassanzadeh S, Winitsky S, Lin H, Satorius C, Vemuri R, Aletras AH, Wen H, Epstein ND. The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation. Cell 107: 631-641, 2001.
6. Deng XF, Sculptoreanu A, Mulay S, Peri KG, Li JF, Zheng WH, Chemtob S, Varma DR. Crosstalk between alpha-1A and alpha-1B adrenoceptors in neonatal rat myocardium: implications in cardiac hypertrophy. J Pharmacol Exp Ther 286: 489-496, 1998.
7. Dilly KW, Rossow CF, Votaw VS, Meabon JS, Cabarrus JL, Santana LF. Mechanisms underlying variations in excitation-contraction coupling across the mouse left ventricular free wall. J Physiol 572: 227-241, 2006.
8. Fedida D, Bouchard RA. Mechanisms for the positive inotropic effect of alpha 1-adrenoceptor stimulation in rat cardiac myocytes. Circ Res 71: 673-688, 1992.
9. 2+ and pH homeostasis in rat cardiac myocytes. Am J Physiol Heart Circ Physiol 274: H1152-H1162, 1998.
10. 2+ responsiveness and altered diastolic function in intact ventricular muscle. Circ Res 76: 1036-1048, 1995.
11. Grupp IL, Lorenz JN, Walsh RA, Boivin GP, Rindt H. Overexpression of α1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy. Am J Physiol Heart Circ Physiol 275: H1338-H1350, 1998.
12. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
13. Hirano S, Kusakari Y, JOU, Morimoto S, Kawai M, Hongo K, Kurihara S. Intracellular mechanism of the negative inotropic effect induced by alpha1-adrenoceptor stimulation in mouse myocardium. J Physiol Sci 56: 297-304, 2006.
14. Kim N, Cannell MB, Hunter PJ. Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart. Prog Biophys Mol Biol 103: 28-34, 2010.
15. Kondo RP, Dederko DA, Teutsch C, Chrast J, Catalucci D, Chien KR, Giles WR. Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform. J Physiol 571: 131-146, 2006.
16. Lin F, Owens WA, Chen S, Stevens ME, Kesteven S, Arthur JF, Woodcock EA, Feneley MP, Graham RM. Targeted α1A-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy. Circ Res 89: 343-350, 2001.
17. Lopez JE, Myagmar BE, Swigart PM, Montgomery MD, Haynam S, Bigos M, Rodrigo MC, Simpson PC. β-Myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes. Circ Res 109: 629-638, 2011.
18. McCloskey DT, Rokosh DG, O'Connell TD, Keung EC, Simpson PC, Baker AJ. α1-Adrenoceptor subtypes mediate negative inotropy in myocardium from α1A/C-knockout and wild type mice. J Mol Cell Cardiol 34: 1007-1017, 2002.
19. 2+ exchange in mouse ventricle. Am J Physiol Heart Circ Physiol 280: H132-H141, 2001.
20. O'Connell TD, Rodrigo MC, Simpson PC. Isolation and culture of adult mouse cardiac myocytes. Methods Mol Biol 357: 271-296, 2007.
21. Petrashevskaya NN, Bodi I, Koch SE, Akhter SA, Schwartz A. Effects of alpha1-adrenergic stimulation on normal and hypertrophied mouse hearts. Relation to caveolin-3 expression. Cardiovasc Res 63: 561-572, 2004.
22. Ross SA, Rorabaugh BR, Chalothorn D, Yun J, Gonzalez-Cabrera PJ, McCune DF, Piascik MT, Perez DM. The α1B-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model. Cardiovasc Res 60: 598-607, 2003.
23. Steinberg SF. α1-Adrenergic receptor subtype function in cardiomyocytes: lessons from genetic models in mice. J Mol Cell Cardiol 34: 1141-1145, 2002.
24. Steinfath M, Chen YY, Lavicky J, Magnussen O, Nose M, Rosswag S, Schmitz W, Scholz H. Cardiac alpha 1-adrenoceptor densities in different mammalian species. Br J Pharmacol 107: 185-188, 1992.
25. van der Velden J, Merkus D, de Beer V, Hamdani N, Linke WA, Boontje NM, Stienen GJ, Duncker DJ. Transmural heterogeneity of myofilament function and sarcomeric protein phosphorylation in remodeled myocardium of pigs with a recent myocardial infarction. Front Physiol 2: 83, 2011.
26. Varma DR, Rindt H, Chemtob S, Mulay S. Mechanism of the negative inotropic effects of alpha 1-adrenoceptor agonists on mouse myocardium. Can J Physiol Pharmacol 81: 783-789, 2003.
27. Wang G, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ. Heart failure switches the RV α1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol 298: H913-H920, 2010.
28. Wang GY, McCloskey DT, Turcato S, Swigart PM, Simpson PC, Baker AJ. Contrasting inotropic responses to α1-adrenergic receptor stimulation in left versus right ventricular myocardium. Am J Physiol Heart Circ Physiol 291: H2013-H2017, 2006.