메뉴 건너뛰기




Volumn 133, Issue 6, 2013, Pages 1572-1581

Constitutive rac activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAC PROTEIN; RAC1 PROTEIN; RAF PROTEIN; RAS PROTEIN;

EID: 84878583077     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.23     Document Type: Article
Times cited : (23)

References (28)
  • 1
    • 23244452354 scopus 로고    scopus 로고
    • Stem cell depletion through epidermal deletion of Rac1
    • Benitah SA, Frye M, Glogauer M et al. (2005) Stem cell depletion through epidermal deletion of Rac1. Science 309:933-5
    • (2005) Science , vol.309 , pp. 933-935
    • Benitah, S.A.1    Frye, M.2    Glogauer, M.3
  • 2
    • 84861427327 scopus 로고    scopus 로고
    • Melanoma genome sequencing reveals frequent PREX2 mutations
    • Berger MF, Hodis E, Heffernan TP et al. (2012) Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 485:502-6
    • (2012) Nature , vol.485 , pp. 502-506
    • Berger, M.F.1    Hodis, E.2    Heffernan, T.P.3
  • 3
    • 20744460575 scopus 로고    scopus 로고
    • Generation and characterization of Rac3 knockout mice
    • Corbetta S, Gualdoni S, Albertinazzi C et al. (2005) Generation and characterization of Rac3 knockout mice. Mol Cell Biol 25:5763-76
    • (2005) Mol Cell Biol , vol.25 , pp. 5763-5776
    • Corbetta, S.1    Gualdoni, S.2    Albertinazzi, C.3
  • 4
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis E, Watson IR, Kryukov GV et al. (2012) A landscape of driver mutations in melanoma. Cell 150:251-63
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1    Watson, I.R.2    Kryukov, G.V.3
  • 5
    • 0033581944 scopus 로고    scopus 로고
    • Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors
    • Jordan P, Brazao R, Boavida MG et al. (1999) Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. Oncogene 18:6835-9
    • (1999) Oncogene , vol.18 , pp. 6835-6839
    • Jordan, P.1    Brazao, R.2    Boavida, M.G.3
  • 6
    • 3242699514 scopus 로고    scopus 로고
    • Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer
    • Kamai T, Yamanishi T, Shirataki H et al. (2004) Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res 10:4799-805
    • (2004) Clin Cancer Res , vol.10 , pp. 4799-4805
    • Kamai, T.1    Yamanishi, T.2    Shirataki, H.3
  • 7
    • 0028800305 scopus 로고
    • Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
    • Khosravi-Far R, Solski PA, Clark GJ et al. (1995) Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol 15:6443-53
    • (1995) Mol Cell Biol , vol.15 , pp. 6443-6453
    • Khosravi-Far, R.1    Solski, P.A.2    Clark, G.J.3
  • 8
    • 34548583283 scopus 로고    scopus 로고
    • Requirement for Rac1 in a K-ras induced lung cancer in the mouse
    • Kissil JL, Walmsley MJ, Hanlon L et al. (2007) Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Res 67:8089-94
    • (2007) Cancer Res , vol.67 , pp. 8089-8094
    • Kissil, J.L.1    Walmsley, M.J.2    Hanlon, L.3
  • 9
    • 84865684161 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
    • Krauthammer M, Kong Y, Ha BH et al. (2012) Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet 44:1006-14
    • (2012) Nat Genet , vol.44 , pp. 1006-1014
    • Krauthammer, M.1    Kong, Y.2    Ha, B.H.3
  • 10
    • 79952706224 scopus 로고    scopus 로고
    • Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?
    • Lazer G, Katzav S (2011) Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy? Cell Signal 23:969-79
    • (2011) Cell Signal , vol.23 , pp. 969-979
    • Lazer, G.1    Katzav, S.2
  • 11
    • 84867848046 scopus 로고    scopus 로고
    • Activated Mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism
    • Li A, Ma Y, Jin M et al. (2012) Activated Mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism. J Invest Dermatol 132:2610-21
    • (2012) J Invest Dermatol , vol.132 , pp. 2610-2621
    • Li, A.1    Ma, Y.2    Jin, M.3
  • 12
    • 80054772505 scopus 로고    scopus 로고
    • Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cellcycle progression
    • Li A, Ma Y, Yu X et al. (2011) Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cellcycle progression. Dev Cell 21:722-34
    • (2011) Dev Cell , vol.21 , pp. 722-734
    • Li, A.1    Ma, Y.2    Yu, X.3
  • 13
    • 82555196623 scopus 로고    scopus 로고
    • P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
    • Lindsay CR, Lawn S, Campbell AD et al. (2011) P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun 2:555
    • (2011) Nat Commun , vol.2 , pp. 555
    • Lindsay, C.R.1    Lawn, S.2    Campbell, A.D.3
  • 14
    • 79956009900 scopus 로고    scopus 로고
    • The diverse roles of Rac signaling in tumorigenesis
    • Mack NA, Whalley HJ, Castillo-Lluva S et al. (2010) The diverse roles of Rac signaling in tumorigenesis. Cell Cycle 10:1571-81
    • (2010) Cell Cycle , vol.10 , pp. 1571-1581
    • MacK, N.A.1    Whalley, H.J.2    Castillo-Lluva, S.3
  • 15
    • 84055199840 scopus 로고    scopus 로고
    • The Akt signaling pathway: An emerging therapeutic target in malignant melanoma
    • Madhunapantula SV, Mosca PJ, Robertson GP (2011) The Akt signaling pathway: an emerging therapeutic target in malignant melanoma. Cancer Biol Ther 12:1032-49
    • (2011) Cancer Biol Ther , vol.12 , pp. 1032-1049
    • Madhunapantula, S.V.1    Mosca, P.J.2    Robertson, G.P.3
  • 16
    • 1842832363 scopus 로고    scopus 로고
    • Determination of the activity of Rho-like GTPases in cells
    • Malliri A, ten Klooster JP, Olivio C et al. (2002a) Determination of the activity of Rho-like GTPases in cells. Methods Mol Biol 189:99-109
    • (2002) Methods Mol Biol , vol.189 , pp. 99-109
    • Malliri, A.1    Ten Klooster, J.P.2    Olivio, C.3
  • 17
    • 0037142034 scopus 로고    scopus 로고
    • Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
    • Malliri A, van der Kammen RA, Clark K et al. (2002b) Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature 417:867-71
    • (2002) Nature , vol.417 , pp. 867-871
    • Malliri, A.1    Van Der Kammen, R.A.2    Clark, K.3
  • 18
    • 70349783431 scopus 로고    scopus 로고
    • Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model
    • Michailidou C, Jones M, Walker P et al. (2009) Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Dis Model Mech 2:399-411
    • (2009) Dis Model Mech , vol.2 , pp. 399-411
    • Michailidou, C.1    Jones, M.2    Walker, P.3
  • 19
    • 0029079431 scopus 로고
    • A role for Rac in Tiam1-induced membrane ruffling and invasion
    • Michiels F, Habets GG, Stam JC et al. (1995) A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature 375:338-40
    • (1995) Nature , vol.375 , pp. 338-340
    • Michiels, F.1    Habets, G.G.2    Stam, J.C.3
  • 20
    • 1242317791 scopus 로고    scopus 로고
    • Expression of seven main Rho family members in gastric carcinoma
    • Pan Y, Bi F, Liu N et al. (2004) Expression of seven main Rho family members in gastric carcinoma. Biochem Biophys Res Commun 315:686-91
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 686-691
    • Pan, Y.1    Bi, F.2    Liu, N.3
  • 21
    • 13444258032 scopus 로고    scopus 로고
    • BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
    • Patton EE, Widlund HR, Kutok JL et al. (2005) BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 15:249-54
    • (2005) Curr Biol , vol.15 , pp. 249-254
    • Patton, E.E.1    Widlund, H.R.2    Kutok, J.L.3
  • 22
    • 0028903247 scopus 로고
    • An essential role for Rac in Ras transformation
    • Qiu RG, Chen J, Kirn D et al. (1995) An essential role for Rac in Ras transformation. Nature 374:457-9
    • (1995) Nature , vol.374 , pp. 457-459
    • Qiu, R.G.1    Chen, J.2    Kirn, D.3
  • 23
    • 44449162944 scopus 로고    scopus 로고
    • The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation
    • Rygiel TP, Mertens AE, Strumane K et al. (2008) The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation. J Cell Sci 121:1183-92
    • (2008) J Cell Sci , vol.121 , pp. 1183-1192
    • Rygiel, T.P.1    Mertens, A.E.2    Strumane, K.3
  • 24
    • 79951889870 scopus 로고    scopus 로고
    • K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity
    • Samuel MS, Lourenco FC, Olson MF (2011) K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity. PLoS One 6:e17143
    • (2011) PLoS One , vol.6
    • Samuel, M.S.1    Lourenco, F.C.2    Olson, M.F.3
  • 25
    • 0034659739 scopus 로고    scopus 로고
    • Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new isoform, Rac1b
    • Schnelzer A, Prechtel D, Knaus U et al. (2000) Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19:3013-20
    • (2000) Oncogene , vol.19 , pp. 3013-3020
    • Schnelzer, A.1    Prechtel, D.2    Knaus, U.3
  • 26
    • 77953480305 scopus 로고    scopus 로고
    • Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo
    • Wang Z, Pedersen E, Basse A et al. (2010) Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo. Oncogene 29:3362-73
    • (2010) Oncogene , vol.29 , pp. 3362-3373
    • Wang, Z.1    Pedersen, E.2    Basse, A.3
  • 27
    • 57649123250 scopus 로고    scopus 로고
    • Changes in the presentation of nodular and superficial spreading melanomas over 35 years
    • Warycha MA, Christos PJ, Mazumdar M et al. (2008) Changes in the presentation of nodular and superficial spreading melanomas over 35 years. Cancer 113:3341-8
    • (2008) Cancer , vol.113 , pp. 3341-3348
    • Warycha, M.A.1    Christos, P.J.2    Mazumdar, M.3
  • 28
    • 77950627707 scopus 로고    scopus 로고
    • Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression
    • Woodcock SA, Rushton HJ, Castaneda-Saucedo E et al. (2010) Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression. Curr Biol 20:669-75
    • (2010) Curr Biol , vol.20 , pp. 669-675
    • Woodcock, S.A.1    Rushton, H.J.2    Castaneda-Saucedo, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.