Platinum(II) complexes with mono-aminophosphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: Synthesis, crystal structure and antitumour activity

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 76-84

  Huang, Ke Bin ^a,b   Chen, Zhen Feng ^b   Liu, Yan Cheng ^b   Li, Zhu Quan ^b   Wei, Jian Hua ^b   Wang, Meng ^b   Zhang, Guo Hai ^b   Liang, Hong ^a,b  

^a NANKAI UNIVERSITY   (China)

^b GUANGXI NORMAL UNIVERSITY   (China)

Author keywords

Crystal structure; Cytotoxicity; Mono aminophosphonate ester; Platinum(II) complexes; Synthesis

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; MONOAMINOPHOSPHONATE ESTER; ORGANIC SOLVENT; PLATINUM COMPLEX; UNCLASSIFIED DRUG; WATER;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL STRAIN HEPG2; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA REPLICATION; DRUG CYTOTOXICITY; DRUG SOLUBILITY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FLOW CYTOMETRY; GEOMETRY; HUMAN; HUMAN CELL; IC 50; LIVER CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINTS; HEP G2 CELLS; HUMANS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; ORGANOPHOSPHONATES; ORGANOPLATINUM COMPOUNDS; PLATINUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878582985     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.055     Document Type: Article

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