Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing?

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 6, 2013, Pages

  Beigelman, Avraham ^a   King, Tonya S ^b   Mauger, David ^b   Zeiger, Robert S ^c,d   Strunk, Robert C ^a   Kelly, H William ^e   Martinez, Fernando D ^f   Lemanske Jr , Robert F ^g   Rivera Spoljaric, Katherine ^a   Jackson, Daniel J ^g   Guilbert, Theresa ^h   Covar, Ronina ⁱ   Bacharier, Leonard B ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c KAISER PERMANENTE   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF ARIZONA   (United States)

^g UNIVERSITY OF WISCONSIN MADISON   (United States)

^h UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

ⁱ UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

episodic wheezing; Oral corticosteroids; preschool children

Indexed keywords

BUDESONIDE; CORTICOSTEROID; MONTELUKAST; PLACEBO; PREDNISOLONE; SALBUTAMOL;

ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; EVENING DOSAGE; FEMALE; GROUPS BY AGE; HUMAN; LOW DRUG DOSE; LOWER RESPIRATORY TRACT ILLNESS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SYMPTOMATOLOGY; TREATMENT OUTCOME; WHEEZING;

EID: 84878576579     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.01.034     Document Type: Article

References (35)

1. L.B. Bacharier, B.R. Phillips, G.R. Bloomberg, R.S. Zeiger, I.M. Paul, and M. Krawiec Severe intermittent wheezing in preschool children: a distinct phenotype J Allergy Clin Immunol 119 2007 604 610
2. L. Akinbami The state of childhood asthma, United States, 1980-2005 Adv Data 381 2006 1 24
3. National Asthma Education and Prevention Program Expert panel report III: guidelines for the diagnosis and management of asthma 2007 US Department of Health and Human Services Bethesda (MD)
4. T.W. Guilbert, W.J. Morgan, R.S. Zeiger, D.T. Mauger, S.J. Boehmer, and S.J. Szefler Long-term inhaled corticosteroids in preschool children at high risk for asthma N Engl J Med 354 2006 1985 1997
5. Global Initiative for Asthma (GINA). Available at: http://www.ginasthma. org. Accessed February 13, 2013.
6. B.H. Rowe, C. Spooner, F.M. Ducharme, J.A. Bretzlaff, and G.W. Bota Early emergency department treatment of acute asthma with systemic corticosteroids Cochrane Database Syst Rev 1 2001 CD002178
7. B.H. Rowe, M.L. Edmonds, C.H. Spooner, B. Diner, and C.A. Camargo Jr Corticosteroid therapy for acute asthma Respir Med 98 2004 275 284
8. G. Rachelefsky Treating exacerbations of asthma in children: the role of systemic corticosteroids Pediatrics 112 2003 382 397
9. B.H. Rowe, C.H. Spooner, F.M. Ducharme, J.A. Bretzlaff, and G.W. Bota Corticosteroids for preventing relapse following acute exacerbations of asthma Cochrane Database Syst Rev 3 2007 CD000195
10. A. Tal, N. Levy, and J.E. Bearman Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial Pediatrics 86 1990 350 356
11. A. Oommen, P.C. Lambert, and J. Grigg Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1-5 years: randomised controlled trial Lancet 362 2003 1433 1438
12. J. Panickar, M. Lakhanpaul, P.C. Lambert, P. Kenia, T. Stephenson, and A. Smyth Oral prednisolone for preschool children with acute virus-induced wheezing N Engl J Med 360 2009 329 338
13. A. Bush Practice imperfect - treatment for wheezing in preschoolers N Engl J Med 360 2009 409 410
14. J. Grigg Role of systemic steroids in acute preschool wheeze Arch Dis Child 95 2010 491 492
15. L.B. Bacharier, B.R. Phillips, R.S. Zeiger, S.J. Szefler, F.D. Martinez, and R.F. Lemanske Jr. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing J Allergy Clin Immunol 122 2008 1127 1135.e8
16. R.S. Zeiger, D. Mauger, L.B. Bacharier, T.W. Guilbert, F.D. Martinez, and R.F. Lemanske Jr. Daily or intermittent budesonide in preschool children with recurrent wheezing N Engl J Med 365 2011 1990 2001
17. T.W. Guilbert, W.J. Morgan, M. Krawiec, R.F. Lemanske Jr., C. Sorkness, and S.J. Szefler The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network Control Clin Trials 25 2004 286 310
18. The Childhood Asthma Management Program Research Group Long-term effects of budesonide or nedocromil in children with asthma N Engl J Med 343 2000 1054 1063
19. C.A. Sorkness, R.F. Lemanske Jr., D.T. Mauger, S.J. Boehmer, V.M. Chinchilli, and F.D. Martinez Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial J Allergy Clin Immunol 119 2007 64 72
20. R.F. Lemanske Jr., D.T. Mauger, C.A. Sorkness, D.J. Jackson, S.J. Boehmer, and F.D. Martinez Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids N Engl J Med 362 2010 975 985
21. F.D. Martinez, V.M. Chinchilli, W.J. Morgan, S.J. Boehmer, R.F. Lemanske Jr., and D.T. Mauger Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial Lancet 377 2011 650 657
22. N.C. Santanello, C. Demuro-Mercon, G. Davies, N. Ostrom, M. Noonan, and A. Rooklin Validation of a pediatric asthma caregiver diary J Allergy Clin Immunol 106 2000 861 866
23. P.C. Austin An introduction to propensity score methods for reducing the effects of confounding in observational studies Multivariate Behav Res 46 2011 399 424
24. S.B. Hulley, W.S. Browner, D.G. Grady, and T.B. Newman Propensity scores Designing clinical research 2007 Lippincott Williams & Wilkins Philadelphia 139 140
25. R.B. D'Agostino Jr. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group Stat Med 17 1998 2265 2281
26. P. Csonka, M. Kaila, P. Laippala, M. Iso-Mustajarvi, T. Vesikari, and P. Ashorn Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: a randomized, placebo-controlled trial J Pediatr 143 2003 725 730
27. C. Grant, A. Duggan, and C. DeAngelis Independent parental administration of prednisone in acute asthma: A double-blind, placebo-controlled, crossover study Pediatrics 96 1995 224 229
28. S.D. Message, and S.L. Johnston Viruses in asthma Br Med Bull 61 2002 29 43
29. J.E. Gern, M.S. Martin, K.A. Anklam, K. Shen, K.A. Roberg, and K.T. Carlson-Dakes Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy Pediatr Allergy Immunol 13 2002 386 393
30. Y. Kobayashi The role of chemokines in neutrophil biology Front Biosci 13 2008 2400 2407
31. M.Z. Norzila, K. Fakes, R.L. Henry, J. Simpson, and P.G. Gibson Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma Am J Respir Crit Care Med 161 2000 769 774
32. S. Saglani, D.N. Payne, J. Zhu, Z. Wang, A.G. Nicholson, and A. Bush Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers Am J Respir Crit Care Med 176 2007 858 864
33. J.A. Castro-Rodriguez, and G.J. Rodrigo Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis Pediatrics 123 2009 e519 e525
34. F.M. Ducharme, C. Lemire, F.J. Noya, G.M. Davis, N. Alos, and H. Leblond Preemptive use of high-dose fluticasone for virus-induced wheezing in young children N Engl J Med 360 2009 339 353
35. W.A. Ray, K.T. Murray, K. Hall, P.G. Arbogast, and C.M. Stein Azithromycin and the risk of cardiovascular death N Engl J Med 366 2012 1881 1890