Isoflurane affects the cytoskeleton but not survival, proliferation, or synaptogenic properties of rat astrocytes in vitro

British Journal of Anaesthesia

Volumn 110, Issue SUPPL.1, 2013, Pages

  Culley, D J ^a   Cotran, E K ^a   Karlsson, E ^a   Palanisamy, A ^a   Boyd, J D ^a   Xie, Z ^b   Crosby, G ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

astrocytes; isoflurane

Indexed keywords

INTERMEDIATE FILAMENT PROTEIN; ISOFLURANE; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSIN I;

ANESTHESIA; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY TEST; FEMALE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MICROTUBULE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTOGENESIS;

EID: 84878574208     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aet169     Document Type: Article

References (38)

1. Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al. Early exposure to commonanestheticagentscauseswidespreadneurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci, 2003; 23: 876-82
2. Head BP, Patel HH, Niesman IR, Drummond JC, Roth DM, Patel PM. Inhibition of p75 neurotrophin receptor attenuates isofluranemediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology 2009; 110: 813-25
3. Lunardi N, Ori C, Erisir A, Jevtovic-Todorovic V. General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats. Neurotox Res 2010; 17: 179-88
4. De Roo M, Klauser P, Briner A, et al. Anesthetics rapidly promote synaptogenesis during a critical period of brain development. PLoS ONE 2009; 4: e7043.
5. Briner A, De Roo M, Dayer A, Muller D, Habre W, Vutskits L. Volatile anesthetics rapidly increase dendritic spine density in the rat medial prefrontal cortex during synaptogenesis. Anesthesiology 2010; 112: 546-56
6. Stratmann G, Sall JW, May LD, et al. Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology 2009; 110: 834-48
7. Zhu C, Gao J, Karlsson N, et al. Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents. J Cereb Blood Flow Metab 2010; 30: 1017-30
8. Brambrink AM, Evers AS, Avidan MS, et al. isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 2010; 112: 8
9. Xie Z, Dong Y, Maeda U, et al. The inhalation anesthetic isoflurane induces avicious cycle of apoptosis andamyloid beta-protein accumulation. J Neurosci 2007; 27: 1247-54
10. Culley DJ, Baxter MG, Yukhananov R, Crosby G. Long-term impairment of acquisition of a spatial memory task following isofluranenitrous oxide anesthesia in rats. Anesthesiology 2004; 100: 309-14
11. Zhang Y, Xu Z,Wang H, et al. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol 2012; 71: 687-98
12. Barres BA. The mystery and magic of glia: a perspective on their roles in health and disease. Neuron, 2008; 60: 430-40
13. Eroglu C, Barres BA. Regulation of synaptic connectivity by glia. Nature 2010; 468: 223-31
14. Allen NJ, Barres BA. Neuroscience: glia-more than just brain glue. Nature 2009; 457: 675-7
15. Wang DD, Bordey A. The astrocyte odyssey. ProgNeurobiol 2008;86: 342-67
16. Halassa MM, Haydon PG. Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol 2010; 72: 335-55
17. MolofskyAV, Krenick R, Ullian E, et al. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev 2012; 26: 891-907
18. HemmingsHJr, Akabas M, Goldstein P, Trudell J, Orser B, Harrison N. Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci 2005; 26: 503-10
19. Lee M, Schwab C, McGeer PL. Astrocytes are GABAergic cells that modulate microglial activity. Glia 2011; 59: 152-65
20. Schummers J, Yu H, Sur M. Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science 2008; 320: 1638-43
21. Culley DJ, Boyd JD, Palanisamy A, et al. Isoflurane decreases selfrenewal capacity of rat cultured neural stem cells. Anesthesiology 2011; 115: 754-63
22. Chehrehasa F, Meedeniya AC, Dwyer P, Abrahamsen G, Mackay-Sim A. EdU, a new thymidine analogue for labelling proliferating cells in the nervous system. J Neurosci Methods 2009; 177: 122-30
23. Xie Z, Culley DJ, Dong Y, et al. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid betaprotein level in vivo. Ann Neurol 2008; 64: 618-27
24. Brozzi F, Arcuri C, Giambanco I, Donato R. S100B protein regulates astrocyte shape and migration via Interaction with Src Kinase: implications for astrocyte development, activation, and tumor growth. J Biol Chem 2009; 284: 8797-811
25. Ullian EM, Sapperstein SK, Christopherson KS, Barres BA. Control of synapse number by glia. Science 2001; 291: 657-61
26. Sall JW, Stratmann G, Leong J, et al. Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture. Anesthesiology 2009; 110: 826-33
27. Lunardi N, Hucklenbruch C, Latham JR, Scarpa J, Jevtovic-Todorovic V. Isoflurane impairs immature astroglia development in vitro: the role of actin cytoskeleton. J Neuropathol Exp Neurol 2011; 70: 281-91
28. Samain E, Bouillier H, Rucker-Martin C, et al. Isoflurane alters angiotensin II-induced Ca2+ mobilization in aortic smooth muscle cells fromhypertensive rats: implication of cytoskeleton. Anesthesiology 2002; 97: 642-51
29. Kaech S, Brinkhaus H, Matus A. Volatile anesthetics block actinbased motility in dendritic spines. Proc Natl Acad Sci USA 1999; 96: 10433-7
30. Lemkuil BP, Head BP, Pearn ML, Patel HH, Drummond JC, Patel PM. Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology 2011; 114: 49-57
31. Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420: 629-35
32. Tas PWL, Gambaryan S, Roewer N. Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation. J Cell Biochem 2007; 102: 368-76
33. Sullivan SM, Lee A, Bjorkman ST, et al. Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAP. J Biol Chem 2007; 282: 29414-23
34. Geraldo S, Gordon-Weeks PR. Cytoskeletal dynamics in growthcone steering. J Cell Sci 2009; 122: 3595-604
35. Vergara GA, Livingston A. Halothane modifies colchicine binding to tubulin. Pharmacology 1981; 23: 264-70
36. Hinkley RE. Microtubule-macrotubule transformations induced by volatile anesthetics. Mechanism of macrotubule assembly. J Ultrastruct Res 1976; 57: 237-50
37. Tang JX, Mardini F, Caltagarone BM, et al. Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimers Dement 2011; 7: 521-31.e1
38. Ventura R, Harris KM. Three-dimensional relationships between hippocampal synapses and astrocytes. J Neurosci 1999; 19: 6897-906