The high angiogenic activity in very early breast cancer enables reliable imaging with VEGFR2-targeted microbubbles (BR55)

European Radiology

Volumn 23, Issue 2, 2013, Pages 468-475

  Bzyl, Jessica ^a   Palmowski, Moritz ^a   Rix, Anne ^a   Arns, Susanne ^a   Hyvelin, Jean Marc ^b   Pochon, Sibylle ^b   Ehling, Josef ^a   Schrading, Simone ^a   Kiessling, Fabian ^a   Lederle, Wiltrud ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Bracco Suisse SA   (Switzerland)

Author keywords

3D molecular ultrasound; Angiogenesis; Breast cancer; Small tumours; VEGFR2

Indexed keywords

VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLOOD VESSEL DIAMETER; BLOOD VOLUME; BREAST CANCER; CANCER SIZE; CELL STRAIN MCF 7; EARLY CANCER; FEMALE; GROWTH; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MICROBUBBLE; MOLECULAR IMAGING; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; THREE DIMENSIONAL IMAGING; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; ULTRASOUND;

EID: 84878560102     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-012-2594-z     Document Type: Article

References (42)

1. Palmowski M, Morgenstern B, Hauff P, et al. (2008) Pharmacodynamics of streptavidin-coated cyanoacrylate microbubbles designed for molecular ultrasound imaging. Invest Radiol 43:162-169
2. Palmowski M, Huppert J, Ladewig G, et al. (2008) Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects. Mol Cancer Ther 7:101-109
3. Lee DJ, Lyshchik A, Huamani J, et al. (2008) Relationship between retention of a vascular endothelial growth factor receptor 2 (VEGFR2)-targeted ultrasonographic contrast agent and the level of VEGFR2 expression in an in vivo breast cancer model. J Ultrasound Med 27:855-866
4. Willmann JK, Cheng Z, Davis C, et al. (2008) Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology 249:212-219
5. Ellegala DB, Leong-Poi H, Carpenter JE, et al. (2003) Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation 108:336-341
6. Leong-Poi H, Christiansen J, Klibanov AL, et al. (2003) Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation 107:455-460
7. Anderson CR, Rychak JJ, Backer M, et al. (2010) scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis. Invest Radiol 45:579-585
8. Pillai R, Marinelli ER, Fan H, et al. (2010) A phospholipid-PEG2000 conjugate of a vascular endothelial growth factor receptor 2 (VEGFR2)-targeting heterodimer peptide for contrast-enhanced ultrasound imaging of angiogenesis. Bioconjug Chem 21:556-562
9. Streeter JE, Gessner R, Miles I, et al. (2010) Improving sensitivity in ultrasound molecular imaging by tailoring contrast agent size distribution: in vivo studies. Mol Imaging 9:87-95
10. Anderson CR, Hu X, Zhang H, et al. (2011) Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol 46:215-224
11. Bzyl J, Lederle W, Rix A, et al. (2011) Molecular and functional ultrasound imaging in differently aggressive breast cancer xenografts using two novel ultrasound contrast agents (BR55 and BR38). Eur Radiol 21:1988-1995
12. Pochon S, Tardy I, Bussat P, et al. (2010) BR55: a lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis. Invest Radiol 45:89-95
13. Tardy I, Pochon S, Theraulaz M, et al. (2010) Ultrasound molecular imaging of VEGFR2 in a rat prostate tumor model using BR55. Invest Radiol 45:573-578
14. Pysz MA, Foygel K, Rosenberg J, et al. (2010) Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable contrast agent (BR55). Radiology 256:519-527
15. Bergers G, Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3:401-410
16. Thompson A, Brennan K, Cox A, et al. (2008) Evaluation of the current knowledge limitations in breast cancer research: a gap analysis. Breast Cancer Res 10:R26
17. Bombardieri E, Gianni L (2004) The choice of the correct imaging modality in breast cancer management. Eur J Nucl Med Mol Imaging 31(Suppl 1):S179-S186
18. Deshpande N, Ren Y, Foygel K, et al. (2011) Tumor angiogenic marker expression levels during tumor growth: longitudinal assessment with molecularly targeted microbubbles and US imaging. Radiology 258:804-811
19. Wenkel E, Heckmann M, Heinrich M, et al. (2008) Automated breast ultrasound: lesion detection and BI-RADS classification - a pilot study. Rofo 180:804-808
20. Kelly KM, Dean J, Comulada WS, et al. (2010) Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts. Eur Radiol 20:734-742
21. Reinhardt M, Hauff P, Briel A, et al. (2005) Sensitive particle acoustic quantification (SPAQ): a new ultrasound-based approach for the quantification of ultrasound contrast media in high concentrations. Invest Radiol 40:2-7
22. Schneider M, Anantharam B, Arditi M, et al. (2011) BR38, a new ultrasound blood pool agent. Invest Radiol 46:486-494
23. Palmowski M, Peschke P, Huppert J, et al. (2009) Molecular ultrasound imaging of early vascular response in prostate tumors irradiated with carbon ions. Neoplasia 11:856-863
24. Palmowski M, Lederle W, Gaetjens J, et al. (2010) Comparison of conventional time-intensity curves vs. maximum intensity over time for post-processing of dynamic contrast-enhanced ultrasound. Eur J Radiol 75:e149-e153
25. Hellstrom M, Kalen M, Lindahl P, et al. (1999) Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126:3047-3055
26. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
27. Vajkoczy P, Farhadi M, Gaumann A, et al. (2002) Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2. J Clin Invest 109:777-785
28. Kuhl C, Weigel S, Schrading S, et al. (2010) Prospective multicenter cohort study to refine management recommendations for women at elevated familial risk of breast cancer: the EVA trial. J Clin Oncol 28:1450-1457
29. Liberman L, Mason G, Morris EA, et al. (2006) Does size matter? Positive predictive value of MRI-detected breast lesions as a function of lesion size. AJR Am J Roentgenol 186:426-430
30. Kuhl C (2007) The current status of breast MR imaging. Part I. Choice of technique, image interpretation, diagnostic accuracy, and transfer to clinical practice. Radiology 244:356-378
31. Smith NR, Baker D, James NH, et al. (2010) Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. Clin Cancer Res 16:3548-3561
32. Jacobs TW, Schnitt SJ, Tan X, et al. (2002) Radial scars of the breast and breast carcinomas have similar alterations in expression of factors involved in vascular stroma formation. Hum Pathol 33:29-38
33. Hille H, Vetter M, Hackeloer BJ (2007) The suitability of high-resolution ultrasound for the detection of DCIS. Ultraschall Med 28:307-312
34. Schoonjans JM, Brem RF (2000) Sonographic appearance of ductal carcinoma in situ diagnosed with ultrasonographically guided large core needle biopsy: correlation with mammographic and pathologic findings. J Ultrasound Med 19:449-457
35. Moon WK, Myung JS, Lee YJ, et al. (2002) US of ductal carcinoma in situ. Radiographics 22:269-280
36. Guidi AJ, Fischer L, Harris JR, et al. (1994) Microvessel density and distribution in ductal carcinoma in situ of the breast. J Natl Cancer Inst 86:614-619
37. Guidi AJ, Schnitt SJ, Fischer L, et al. (1997) Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast. Cancer 80:1945-1953
38. Viacava P, Naccarato AG, Bocci G, et al. (2004) Angiogenesis and VEGF expression in pre-invasive lesions of the human breast. J Pathol 204:140-146
39. Raica M, Cimpean AM, Ribatti D (2009) Angiogenesis in pre-malignant conditions. Eur J Cancer 45:1924-1934
40. Lederle W, Stark HJ, Skobe M, et al. (2006) Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells. Am J Pathol 169:1767-1783
41. Lederle W, Linde N, Heusel J, et al. (2010) Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas. Am J Pathol 176:981-994
42. Jain RK (2001) Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7:987-989