Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 6, 2013, Pages

  Otani, Iris M ^a,c   Anilkumar, Arjun A ^a,c   Newbury, Robert O ^b   Bhagat, Monica ^a,c   Beppu, Lisa Y ^a,b   Dohil, Ranjan ^a,b   Broide, David H ^a,c   Aceves, Seema S ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RADY CHILDREN'S HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Eosinophilic esophagitis; eosinophils; IL 5; IL 9; mast cells; pediatric

Indexed keywords

INTERLEUKIN 5; INTERLEUKIN 9; MEPOLIZUMAB; TRYPTASE;

ARTICLE; CELL GROWTH; CELL INFILTRATION; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; EOSINOPHIL; EOSINOPHIL COUNT; EOSINOPHILIC ESOPHAGITIS; ESOPHAGUS BIOPSY; HUMAN; HUMAN TISSUE; IMMUNOCHEMISTRY; MAST CELL; MAST CELL DEGRANULATION; PRIORITY JOURNAL; TREATMENT RESPONSE;

EID: 84878540875     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.02.042     Document Type: Article

References (27)

1. C.A. Liacouras, G.T. Furuta, I. Hirano, D. Atkins, S.E. Attwood, and P.A. Bonis Eosinophilic esophagitis: updated consensus recommendations for children and adults J Allergy Clin Immunol 128 2011 3 20
2. S.S. Aceves, R.O. Newbury, R. Dohil, J.F. Bastian, and D.H. Broide Esophageal remodeling in pediatric eosinophilic esophagitis J Allergy Clin Immunol 119 2007 206 212
3. A. Mishra, M. Wang, V.R. Pemmaraju, M.H. Collins, P.C. Fulkerson, and J.P. Abonia Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia Gastroenterology 134 2008 204 214
4. S.S. Aceves, D. Chen, R.O. Newbury, R. Dohil, J.F. Bastian, and D.H. Broide Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction J Allergy Clin Immunol 126 2010 1198 1204
5. A.F. Kagalwalla, N. Akhtar, S.A. Woodruff, B.A. Rea, J.C. Masterson, and V. Mukkada Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment J Allergy Clinical Immunol 129 2012 1387 1396.e7
6. A.F. Kagalwalla, T.A. Sentongo, S. Ritz, T. Hess, S.P. Nelson, and K.M. Emerick Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis Clin Gastroenterol Hepatol 4 2006 1097 1102
7. N. Gonsalves, G.Y. Yang, Doerfler, S. Ritz, A.M. Ditto, and I. Hirano Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors Gastroenterology 142 2012 1451 1459.e1 e14-15
8. C.A. Liacouras, J.M. Spergel, E. Ruchelli, R. Verma, M. Mascarenhas, and E. Semeao Eosinophilic esophagitis: a 10-year experience in 381 children Clin Gastroenterol Hepatol 3 2005 1198 1206
9. M.R. Konikoff, R.J. Noel, C. Blanchard, C. Kirby, S.C. Jameson, and B.K. Buckmeier A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis Gastroenterology 131 2006 1381 1391
10. R. Dohil, R. Newbury, L. Fox, J. Bastian, and S. Aceves Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial Gastroenterology 139 2010 418 429
11. A. Mishra, S.P. Hogan, E.B. Brandt, and M.E. Rothenberg IL-5 promotes eosinophil trafficking to the esophagus J Immunol 168 2002 2464 2469
12. M.M. Pizzichini, M. Kjarsgaard, M.D. Inman, A. Efthimiadis, E. Pizzichini, and F.E. Hargreave Mepolizumab for prednisone-dependent asthma with sputum eosinophilia N Engl J Med 360 2009 985 993
13. M.E. Rothenberg, A.D. Klion, F.E. Roufosse, J.E. Kahn, P.F. Weller, and H.U. Simon Treatment of patients with the hypereosinophilic syndrome with mepolizumab. Mepolizumab HES Study Group N Engl J Med 358 2008 1215 1228
14. S. Kim, G. Marigowda, E. Oren, E. Israel, and M.E. Wechsler Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome J Allergy Clin Immunol 125 2010 1336 1343
15. P. Gevaert, D. Lang-Loidolt, A. Lackner, H. Stammberger, H. Staudinger, and T. Van Zele Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps J Allergy Clin Immunol 118 2006 1133 1141
16. A. Straumann, S. Conus, P. Grzonka, H. Kita, G. Kephart, and C. Bussmann Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial Gut 59 2010 21 30
17. A.H. Assa'ad, S.K. Gupta, M.H. Collin, M. Thomson, A.T. Heath, and D.A. Smith Treatment of pediatric eosinophilic esophagitis with mepolizumab: a randomized, double blind, controlled clinical trial Gastroenterology 141 2011 1593 1604
18. J.M. Spergel, M.E. Rothenberg, M.H. Collins, G.T. Furuta, J.E. Markowitz, and G. Fuchs Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial J Allergy Clin Immunol 129 2012 456 463
19. J.P. Abonia, C. Blanchard, B.B. Butz, H.F. Rainey, M.H. Collins, and K. Stringer Involvement of mast cells in eosinophilic esophagitis J Allergy Clin Immunol 126 2010 140 149
20. K.S. Hsu Blatman, N. Gonsalves, I. Hirano, and P.J. Bryce Expression of mast cell-associated genes is upregulated in adult eosinophilic esophagitis and responds to steroid or dietary therapy J Allergy Clin Immunol 127 2011 1307 1308
21. C. Dahl, H.J. Hoffman, H. Saito, and P.O. Schiotz Human mast cells express receptors for IL-3, IL-5, and GM-CSF; a partial map of receptors on human mast cells cultured in vitro Allergy 59 2004 1087 1096
22. M. Elishmereni, H.T. Alenius, P. Bradding, S. Mizrahi, A. Shikotra, and Y. Minai-Fleminger Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro Allergy 66 2011 376 385
23. T.M. Wilson, I. Maric, J. Shukla, M. Brown, C. Santos, and O. Simakova IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis J Allergy Clin Immunol 128 2011 1086 1092
24. H. Ochi, N.H. DeJesus, F.H. Hsieh, K.F. Austen, and J.A. Boyce IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production Proc Natl Acad Sci U S A 97 2000 10509 10513
25. M.C. Siracusa, S.A. Saenz, D.A. Hill, B.S. Kim, M.B. Headley, and T.A. Doering TSLP promotes interleukin-3-independent basophil hematopoiesis and type 2 inflammation Nature 477 2011 229 233
26. T.G. Jones, J. Hallgren, A. Humbles, T. Burwell, F.D. Finkelman, and P. Alcaide Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells J Immunol 183 2009 5251 5260
27. A.S. Gounni, B. Gregory, E. Nutku, F. Aris, K. Latifa, and E. Minshall Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils Blood 96 2009 2163 2171