A Randomized, Double-Blind, Placebo-Controlled Trial of Fluticasone Propionate for Pediatric Eosinophilic Esophagitis

Gastroenterology

Volumn 131, Issue 5, 2006, Pages 1381-1391

  Konikoff, Michael R ^a   Noel, Richard J ^b   Blanchard, Carine ^a   Kirby, Cassie ^a   Jameson, Sean C ^a   Buckmeier, Bridget K ^a   Akers, Rachel ^a   Cohen, Mitchell B ^a   Collins, Margaret H ^a   Assa'ad, Amal H ^a   Aceves, Seema S ^c   Putnam, Philip E ^a   Rothenberg, Marc E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF WISCONSIN   (United States)

^c RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUTICASONE PROPIONATE; NYSTATIN; PLACEBO;

ADOLESCENT; ADULT; ALLERGY; ARTICLE; BODY HEIGHT; BODY WEIGHT; CD8+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; ENDOMETRIUM HYPERPLASIA; ENDOSCOPY; EOSINOPHIL COUNT; EOSINOPHILIC ESOPHAGITIS; EPITHELIUM HYPERPLASIA; ESOPHAGITIS; ESOPHAGUS CANDIDIASIS; FEMALE; GROUPS BY AGE; HISTOLOGY; HUMAN; HUMAN TISSUE; MALE; MAST CELL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; TREATMENT OUTCOME; VOMITING;

EID: 33750530713     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.08.033     Document Type: Article

References (33)

1. Rothenberg M.E. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 113 (2004) 11-28
2. Fox V.L., Nurko S., and Furuta G.T. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc 56 (2002) 260-270
3. Sant'Anna A.M., Rolland S., Fournet J.C., Yazbeck S., and Drouin E. Eosinophilic esophagitis in children: symptoms, histology and pH probe results. J Pediatr Gastroenterol Nutr 39 (2004) 373-377
4. Steiner S.J., Gupta S.K., Croffie J.M., and Fitzgerald J.F. Correlation between number of eosinophils and reflux index on same day esophageal biopsy and 24 hour esophageal pH monitoring. Am J Gastroenterol 99 (2004) 801-805
5. Ruchelli E., Wenner W., Voytek T., Brown K., and Liacouras C. Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr Dev Pathol 2 (1999) 15-18
6. Straumann A., Spichtin H.P., Bucher K.A., Heer P., and Simon H.U. Eosinophilic esophagitis: red on microscopy, white on endoscopy. Digestion 70 (2004) 109-116
7. Lim J.R., Gupta S.K., Croffie J.M., Pfefferkorn M.D., Molleston J.P., Corkins M.R., Davis M.M., Faught P.P., Steiner S.J., and Fitzgerald J.F. White specks in the esophageal mucosa: an endoscopic manifestation of non-reflux eosinophilic esophagitis in children. Gastrointest Endosc 59 (2004) 835-838
8. Remedios M., Campbell C., Jones D.M., and Kerlin P. Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate. Gastrointest Endosc 63 (2006) 3-12
9. Noel R.J., and Rothenberg M.E. Eosinophilic esophagitis. Curr Opin Pediatr 17 (2005) 690-694
10. Steiner S.J., Kernek K.M., and Fitzgerald J.F. Severity of basal cell hyperplasia differs in reflux versus eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 42 (2006) 506-509
11. Spergel J.M., Andrews T., Brown-Whitehorn T.F., Beausoleil J.L., and Liacouras C.A. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol 95 (2005) 336-343
12. Liacouras C.A., Spergel J.M., Ruchelli E., Verma R., Mascarenhas M., Semeao E., Flick J., Kelly J., Brown-Whitehorn T., Mamula P., and Markowitz J.E. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 3 (2005) 1198-1206
13. Markowitz J.E., Spergel J.M., Ruchelli E., and Liacouras C.A. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol 98 (2003) 777-782
14. Straumann A., Bauer M., Fischer B., Blaser K., and Simon H.U. Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. J Allergy Clin Immunol 108 (2001) 954-961
15. Mishra A., Hogan S.P., Brandt E.B., and Rothenberg M.E. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest 107 (2001) 83-90
16. Akei H.S., Mishra A., Blanchard C., and Rothenberg M.E. Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice. Gastroenterology 129 (2005) 985-994
17. Orenstein S.R., Shalaby T.M., Di Lorenzo C., Putnam P.E., Sigurdsson L., Mousa H., and Kocoshis S.A. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 95 (2000) 1422-1430
18. Liacouras C.A., and Ruchelli E. Eosinophilic esophagitis. Curr Opin Pediatr 16 (2004) 560-566
19. Kelly K.J., Lazenby A.J., Rowe P.C., Yardley J.H., Perman J.A., and Sampson H.A. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology 109 (1995) 1503-1512
20. Liacouras C.A., Wenner W.J., Brown K., and Ruchelli E. Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr 26 (1998) 380-385
21. Faubion Jr. W.A., Perrault J., Burgart L.J., Zein N.N., Clawson M., and Freese D.K. Treatment of eosinophilic esophagitis with inhaled corticosteroids. J Pediatr Gastroenterol Nutr 27 (1998) 90-93
22. Teitelbaum J.E., Fox V.L., Twarog F.J., Nurko S., Antonioli D., Gleich G., Badizadegan K., and Furuta G.T. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology 122 (2002) 1216-1225
23. Noel R.J., Putnam P.E., Collins M.H., Assa'ad A.H., Guajardo J.R., Jameson S.C., and Rothenberg M.E. Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis. Clin Gastroenterol Hepatol 2 (2004) 568-575
24. Falcoz C., Oliver R., McDowall J.E., Ventresca P., Bye A., and Daley-Yates P.T. Bioavailability of orally administered micronised fluticasone propionate. Clin Pharmacokinet 39 (2000) 9-15
25. Scholzen T., and Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 182 (2000) 311-322
26. Blanchard C., Wang N., Stringer K.F., Mishra A., Fulkerson P.C., Abonia J.P., Jameson S.C., Kirby C., Konikoff M.R., Collins M.H., Cohen M.B., Akers R., Hogan S.P., Assa'ad A.H., Putnam P.E., Aronow B.J., and Rothenberg M.E. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest 116 (2006) 536-547
27. Straumann A., Spichtin H.P., Grize L., Bucher K.A., Beglinger C., and Simon H.U. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology 125 (2003) 1660-1669
28. Spergel J.M., Beausoleil J.L., Mascarenhas M., and Liacouras C.A. The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol 109 (2002) 363-368
29. Fogg M.I., Ruchelli E., and Spergel J.M. Pollen and eosinophilic esophagitis. J Allergy Clin Immunol 112 (2003) 796-797
30. Onbasi K., Sin A.Z., Doganavsargil B., Onder G.F., Bor S., and Sebik F. Eosinophil infiltration of the oesophageal mucosa in patients with pollen allergy during the season. Clin Exp Allergy 35 (2005) 1423-1431
31. Putnam P.E., and Orenstein S.R. Determining esophageal length from crown-rump length. J Pediatr Gastroenterol Nutr 13 (1991) 354-359
32. Yang G.S., Bishop W.P., Smith B.J., Goudy S.L., Sato Y., and Bauman N.M. Radiographic and endoscopic measurements of esophageal length in pediatric patients. Ann Otol Rhinol Laryngol 114 (2005) 587-592
33. Gupta S.K., Fitzgerald J.F., Kondratyuk T., and Hogenesch H. Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 42 (2006) 22-26