A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne

Journal of the European Academy of Dermatology and Venereology

Volumn 27, Issue SUPPL.2, 2013, Pages 6-11

  Angelova Fischer, I ^a   Rippke, F ^b   Fischer, T W ^a   Neufang, G ^b   Zillikens, D ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b BEIERSDORF AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DECANEDIOL; CARNITINE; COSMETIC; LICOCHALCONE A; UNCLASSIFIED DRUG;

ACNE; ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYDRATION; MALE; OUTCOME ASSESSMENT; PAPULAR RASH; PRIORITY JOURNAL; SEBUM SECRETION; SKIN CARE; STRATUM CORNEUM; TREATMENT DURATION;

ACNE VULGARIS; ADOLESCENT; ADULT; CARNITINE; CHALCONES; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FATTY ALCOHOLS; FEMALE; GLYCOLS; HUMANS; MALE; PHARMACEUTICAL VEHICLES; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84878525932     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/jdv.12168     Document Type: Article

References (29)

1. Bhate K, Williams HC,. Epidemiology of acne vulgaris. Br J Dermatol 2013; 168: 474-485.
2. Zaenglein A, Graber E, Thiboutot D,. Acne vulgaris and acneiform eruptions. In: Fitzpatrick's Dermatology in General Medicine (, Goldsmith L, Katz S, Gilchrest B, Paller A, Leffell D, Wolff K, eds.), McGraw Hill, New York, 2012: 897-917.
3. Kurokawa I, Danby FW, Qiang Ju, et al,. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009; 18: 821-832.
4. Thiboutot D, Gollnick H, Bettoli V, et al,. New insights into the management of acne: an update from a Global Alliance to Improve Outcomes in acne. J Am Acad Dermatol 2009; 60: S1-S50.
5. Jeremy A, Holland D, Roberts S, et al,. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003; 121: 20-27.
6. Makrantonaki E, Ganceviciene R, Zouboulis C,. An update on the role of the sebaceous gland in the pathogenesis of acne. Dermatoendocrinology 2011; 3: 41-49.
7. Bowe W, Patel N, Logan A,. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol 2012; 11: 742-746.
8. Nast A, Dreno B, Bettoli V, et al,. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol 2012; 26 (Suppl.1): 1-29.
9. Nast A, Bayerl C, Borelli C, et al,. S2-guideline for therapy of acne. J Dtsch Dermatol Ges 2010; 8: S1-S59.
10. Goodmann G,. Cleansing and moisturizing in acne patients. Am J Clin Dermatol 2009; 10 (Suppl. 1): 1-6.
11. Berardesca E, EEMCO Group. EEMCO guidance for the assessment of stratum corneum hydration: electrical methods. Skin Res Tech 1997; 3: 126-132.
12. Piérard G, Piérard-Franchimont C, Marks R, et al,. EEMCO guidance for the in vivo assessment of skin greasiness. Skin Pharmacol Appl Skin Physiol 2000; 13: 372-389.
13. Kligman A, Miller D, McGinley K,. Sebutape: a device for visualizing and measuring human sebaceous secretion. J Soc Cosmet Chem 1986; 37: 369-374.
14. Finlay AY, Khan GK,. Dermatology Life Quality Index (DLQI)-a simple practical measure for routine clinical use. Clin Exp Dermatol 1994; 19: 210-216.
15. Gollnick H, Cunliffe WJ, Berson D, et al,. Management of acne: a report from a global alliance to improve outcomes in acne. J Am Acad Dermatol 2003; 49: S1-S37.
16. Scherdin U, Presto S, Rippke F, et al,. In vivo assessment of the efficacy of an innovative face care system in subjects with mild acne vulgaris. Int J Cosmet Sci 2004; 26: 221-229.
17. Shibata S, Inoue H, Iwata S, et al,. Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice. Planta Med 1991; 57: 221-224.
18. Furusawa J, Funakoshi-Tago M, Mashino T, et al,. Glycyrrhiza inflata-derived chalcones, licochalcone A, licochalcone B and licochalcone D, inhibit phosphorylation of NF-kappa B p65 in LPS signalling pathway. Int Immunopharmacol 2009; 9: 499-507.
19. Kolbe L, Immeyer J, Eggers K, Neufang G,. Anti-oxidative properties of licochalcone A from Glycyrrhiza inflata on human skin in vitro and in vivo. J Am Acad Dermatol 2006; 54: AB1-AB270.
20. Kolbe L, Immeyer J, Batzer J, et al,. Anti-inflammatory efficacy of licochalcone A: correlation of clinical potency and in vitro effects. Arch Dermatol Res 2006; 298: 23-30.
21. Funakoshi-Tago M, Nakamura K, Tsuruya R, et al,. The fixed structure of licochalcone A by alpha, beta-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-kappa B activation. Int Immunopharmacol 2010; 10: 562-571.
22. Furuhashi I, Iwata S, Shibata S, et al,. Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1 beta-induced PGE2 production in human skin fibroblasts. J Pharm Pharmacol 2005; 57: 1661-1666.
23. Weber T, Ceilley R, Buerger A, et al,. Skin tolerance, efficacy and quality of life of patients with red facial skin using a skin care regimen containing licochalcone A. J Cosmet Dermatol 2006; 5: 227-232.
24. Udompataikul M, Srisatwaja W,. Comparative trial of moisturizer containing licochalcone A vs. hydrocortisone lotion in the treatment of childhood atopic dermatitis: a pilot study. J Eur Acad Dermatol Venereol 2011; 25: 660-665.
25. Zouboulis CC,. Acne and sebaceous gland function. Clin Dermatol 2004; 22: 360-366.
26. Peirano R, Hamann T, Düsing HJ, et al,. Topically applied l -carnitine effectively reduces sebum secretion in human skin. J Cosmet Dermatol 2012; 11: 30-36.
27. Zouboulis CC, Seltman H, Neitzel H, et al,. Establishment and characterisation of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 1999; 113: 1011-1020.
28. Motley RJ, Finlay AY,. Practical use of a disability index in the routine management of acne. Clin Exp Dermatol 1992; 17: 1-3.
29. Scherdin U, Treder-Conrad C, Berger B, et al,. Medical skin care significantly improves quality of life in subjects with mild acne vulgaris. J Eur Acad Dermatol Venereol 2004; 18 (Suppl.2): 202.