Aneuploidy and elevated CEA indicate an increased risk for metachronous metastasis in colorectal cancer

International Journal of Colorectal Disease

Volumn 28, Issue 6, 2013, Pages 767-775

  Laubert, Tilman ^a   Bente, Verena ^a   Freitag Wolf, Sandra ^b   Voulgaris, Helena ^a   Oberländer, Martina ^a   Schillo, Katharina ^a   Kleemann, Markus ^a   Bürk, Conny ^a   Bruch, Hans Peter ^a   Roblick, Uwe J ^a   Habermann, Jens K ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Aneuploidy; Carcinoembryonic antigen; Colorectal cancer; Metastasis; Prognosis

Indexed keywords

CARCINOEMBRYONIC ANTIGEN;

ADULT; AGED; ANEUPLOIDY; ARTICLE; BLOOD LEVEL; CANCER PROGNOSIS; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE MARKER; DNA CONTENT; FEMALE; HUMAN; HUMAN CELL; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; PREDICTIVE VALUE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; ANEUPLOIDY; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; DEMOGRAPHY; FEMALE; FLOW CYTOMETRY; HUMANS; LOGISTIC MODELS; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; NEOPLASMS, SECOND PRIMARY; RISK FACTORS; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 84878525484     PISSN: 01791958     EISSN: 14321262     Source Type: Journal    
DOI: 10.1007/s00384-012-1625-1     Document Type: Article

References (29)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics, 2008. CA Cancer J Clin 58(2):71-96. doi: 10.3322/CA.2007.0010
2. Laubert T, Habermann JK, Hemmelmann C, Kleemann M, Oevermann E, Bouchard R, Hildebrand P, Jungbluth T, Burk C, Esnaashari H, Schloricke E, Hoffmann M, Ziegler A, Bruch HP, Roblick UJ (2012) Metachronous metastasis- and survival-analysis show prognostic importance of lymphadenectomy for colon carcinomas. BMC Gastroenterol 12:24. doi: 10.1186/1471-230X-12-24
3. Chuang SC, Su YC, Lu CY, Hsu HT, Sun LC, Shih YL, Ker CG, Hsieh JS, Lee KT, Wang JY (2011) Risk factors for the development of metachronous liver metastasis in colorectal cancer patients after curative resection. World J Surg 35(2):424-429. doi: 10.1007/s00268-010-0881-x
4. Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, Birchmeier W, Schlag PM (2009) MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med 15(1):59-67. doi: 10.1038/nm.1889
5. Schmiegel W, Reinacher-Schick A, Arnold D, Graeven U, Heinemann V, Porschen R, Riemann J, Rodel C, Sauer R, Wieser M, Schmitt W, Schmoll HJ, Seufferlein T, Kopp I, Pox C (2008) Update S3-guideline «colorectal cancer» 2008. Z Gastroenterol 46(8):799-840. doi: 10.1055/s-2008-1027726
6. Wiratkapun S, Kraemer M, Seow-Choen F, Ho YH, Eu KW (2001) High preoperative serum carcinoembryonic antigen predicts metastatic recurrence in potentially curative colonic cancer: results of a five-year study. Dis Colon Rectum 44(2):231-235
7. Park IJ, Choi GS, Lim KH, Kang BM, Jun SH (2009) Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level. Ann Surg Oncol 16(11):3087-3093. doi: 10.1245/s10434-009-0625-z
8. Araujo SE, Bernardo WM, Habr-Gama A, Kiss DR, Cecconello I (2007) DNA ploidy status and prognosis in colorectal cancer: a meta-analysis of published data. Dis Colon Rectum 50(11):1800-1810. doi: 10.1007/s10350-007-9013-6
9. Geigl JB, Obenauf AC, Schwarzbraun T, Speicher MR (2008) Defining 'chromosomal instability'. Trends Genet 24(2):64-69. doi: 10.1016/j.tig.2007.11. 006
10. Pino MS, Chung DC (2010) The chromosomal instability pathway in colon cancer. Gastroenterology 138(6):2059-2072. doi: 10.1053/j.gastro.2009.12.065
11. Witzig TE, Loprinzi CL, Gonchoroff NJ, Reiman HM, Cha SS, Wieand HS, Katzmann JA, Paulsen JK, Moertel CG (1991) DNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma. Cancer 68(4):879-888
12. Gerling M, Meyer KF, Fuchs K, Igl BW, Fritzsche B, Ziegler A, Bader F, Kujath P, Schimmelpenning H, Bruch HP, Roblick UJ, Habermann JK (2010) High frequency of aneuploidy defines ulcerative colitis-associated carcinomas: a comparative prognostic study to sporadic colorectal carcinomas. Ann Surg. doi: 10.1097/SLA.0b013e3181deb664
13. Lin JK, Chang SC, Yang SH, Jiang JK, Chen WC, Lin TC (2003) Prognostic value of DNA ploidy patterns of colorectal adenocarcinoma. Hepatogastroenterology 50(54):1927-1932
14. Deans GT, Williamson K, Hamilton P, Heatley M, Arthurs K, Patterson CC, Rowlands BJ, Parks TG, Spence RA (1993) DNA densitometry of colorectal cancer. Gut 34(11):1566-1571
15. Walther A, Houlston R, Tomlinson I (2008) Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis. Gut 57(7):941-950. doi: 10.1136/gut.2007.135004
16. Sun XF (2006) Clinicopathological and biological features of DNA tetraploid colorectal cancers. Cancer J 12(6):501-506
17. Bendardaf R, Lamlum H, Ristamaki R, Algars A, Collan Y, Pyrhonen S (2004) Response to chemotherapy (irinotecan plus 5-fluorouracil) in colorectal carcinoma can be predicted by tumour DNA content. Oncology 66(1):46-52. doi: 10.1159/000076334
18. Armitage NC, Ballantyne KC, Sheffield JP, Clarke P, Evans DF, Hardcastle JD (1991) A prospective evaluation of the effect of tumor cell DNA content on recurrence in colorectal cancer. Cancer 67(10):2599-2604
19. Tang R, Ho YS, Chen HH, See LC, Wang JY (1998) Different prognostic effect of postoperative chemoradiation therapy on diploid and nondiploid high-risk rectal cancers. Dis Colon Rectum 41(12):1494-1499
20. Fleming I, Cooper J, Henson DE et al (1997) AJCC Cancer Staging Manual, 5th edn. Lippincot-Raven, Philadelphia
21. Auer GU, Caspersson TO, Wallgren AS (1980) DNA content and survival in mammary carcinoma. Anal Quant Cytol 2(3):161-165
22. Risques RA, Moreno V, Ribas M, Marcuello E, Capella G, Peinado MA (2003) Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer. Cancer Res 63(21):7206-7214
23. Salazar R, Roepman P, Capella G, Moreno V, Simon I, Dreezen C, Lopez-Doriga A, Santos C, Marijnen C, Westerga J, Bruin S, Kerr D, Kuppen P, van de Velde C, Morreau H, Van Velthuysen L, Glas AM, Van't Veer LJ, Tollenaar R (2011) Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer. J Clin Oncol 29(1):17-24. doi: 10.1200/JCO.2010.30.1077
24. Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson JC, Schmidt C, Bailey CE, Eschrich S, Kis C, Levy S, Washington MK, Heslin MJ, Coffey RJ, Yeatman TJ, Shyr Y, Beauchamp RD (2010) Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology 138(3):958-968. doi: 10.1053/j.gastro.2009. 11.005
25. Heinzerling JH, Anthony T, Livingston EH, Huerta S (2007) Predictors of distant metastasis and mortality in patients with stage II colorectal cancer. Am Surg 73(3):230-238
26. Kerr D, Gray R, Quirke P, Watson D, Yothers G, Lavery IC, Lee M, O'Connell MJ, Shak S, Wolmark N (2009) A quantitative multigene RT-PCR assay for prediction of recurrence in stage II colon cancer: selection of the genes in four large studies and results of the independent, prospectively designed QUASAR validation study. J Clin Oncol 27(15s):suppl; abstr 4000
27. Soreide K, Slewa A, Stokkeland PJ, van Diermen B, Janssen EA, Soreide JA, Baak JP, Korner H (2009) Microsatellite instability and DNA ploidy in colorectal cancer: potential implications for patients undergoing systematic surveillance after resection. Cancer 115(2):271-282. doi: 10.1002/cncr.24024
28. Canna K, McArdle PA, McMillan DC, McNicol AM, Smith GW, McKee RF, McArdle CS (2005) The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Br J Cancer 92(4):651-654. doi: 10.1038/sj.bjc.6602419
29. Takagawa R, Fujii S, Ohta M, Nagano Y, Kunisaki C, Yamagishi S, Osada S, Ichikawa Y, Shimada H (2008) Preoperative serum carcinoembryonic antigen level as a predictive factor of recurrence after curative resection of colorectal cancer. Ann Surg Oncol 15(12):3433-3439. doi: 10.1245/s10434-008-0168-8