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Volumn 47, Issue 6, 2013, Pages 841-855

Current state of knowledge on oral anticoagulant reversal using procoagulant factors;Estado actual del conocimiento sobre el uso de factores procoagulantes para revertir el efecto de anticoagulantes orales

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; ANTICOAGULANT AGENT; APIXABAN; BLOOD CLOTTING FACTOR 9 COMPLEX; DABIGATRAN ETEXILATE; ENOXAPARIN; FATTY ACID BINDING PROTEIN; FRESH FROZEN PLASMA; PROCOAGULANT; PROTEIN C; PROTEIN S; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RIVAROXABAN; VITAMIN K GROUP; WARFARIN;

EID: 84878508201     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1R724     Document Type: Article
Times cited : (26)

References (106)
  • 1
    • 46749111159 scopus 로고    scopus 로고
    • Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: Focus on new anticoagulant agents
    • Crowther MA, Warkentin TE. Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents. Blood 2008;111:4871-4879.
    • (2008) Blood , vol.111 , pp. 4871-4879
    • Crowther, M.A.1    Warkentin, T.E.2
  • 2
    • 84878477196 scopus 로고    scopus 로고
    • Product information, Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc., April
    • Product information. Pradaxa (dabigatran etexilate mesylate). Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc., April 2013.
    • (2013) Pradaxa (dabigatran Etexilate Mesylate)
  • 3
    • 84878503138 scopus 로고    scopus 로고
    • Product information, Titusville, New Jersey: Janssen Pharmaceuticals, Inc., March
    • Product information. Xarelto (rivaroxaban). Titusville, New Jersey: Janssen Pharmaceuticals, Inc., March 2013.
    • (2013) Xarelto (rivaroxaban)
  • 4
    • 84876280387 scopus 로고    scopus 로고
    • Product information, Princeton, New Jersey: Bristol-Myers Squibb Company, December
    • Product information. Eliquis (apixaban). Princeton, New Jersey: Bristol-Myers Squibb Company, December 2012.
    • (2012) Eliquis (apixaban)
  • 5
    • 0035128503 scopus 로고    scopus 로고
    • Oral anticoagulants: Mechanism of action, clinical effectiveness, and optimal therapeutic range
    • Hirsh J, Dalen J, Anderson DR, et al. Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 2001; 119:8S-21S.
    • (2001) Chest , vol.119
    • Hirsh, J.1    Dalen, J.2    Anderson, D.R.3
  • 6
    • 84859178003 scopus 로고    scopus 로고
    • How I treat with anticoagulants in 2012: New and old anticoagulants, and when and how to switch
    • Schulman S, Crowther MA. How I treat with anticoagulants in 2012: new and old anticoagulants, and when and how to switch. Blood 2012; 119:3016-3023.
    • (2012) Blood , vol.119 , pp. 3016-3023
    • Schulman, S.1    Crowther, M.A.2
  • 7
    • 35449007749 scopus 로고    scopus 로고
    • Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: The RE-MODEL randomized trial
    • Eriksson BI, Dahl OE, Rosencher N, et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007;5:2178-2185.
    • (2007) J Thromb Haemost , vol.5 , pp. 2178-2185
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 8
    • 34548575058 scopus 로고    scopus 로고
    • Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomised, double-blind, non-inferiority trial
    • Eriksson BI, Dahl OE, Rosencher N, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet 2007;370:949-956.
    • (2007) Lancet , vol.370 , pp. 949-956
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 9
    • 79953836474 scopus 로고    scopus 로고
    • Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II*). A randomised, double-blind, non-inferiority trial
    • Eriksson BI, Dahl OE, Huo MH, et al. Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II*). A randomised, double-blind, non-inferiority trial. Thromb Haemost 2011;105:721-729.
    • (2011) Thromb Haemost , vol.105 , pp. 721-729
    • Eriksson, B.I.1    Dahl, O.E.2    Huo, M.H.3
  • 10
    • 57649123692 scopus 로고    scopus 로고
    • Oral thrombin inhibitor dabigatran etexilate vs North American enoxa-parin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
    • RE-MOBILIZE Writing Committee
    • RE-MOBILIZE Writing Committee; Ginsberg JS, Davidson BL, et al. Oral thrombin inhibitor dabigatran etexilate vs North American enoxa-parin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty 2009;24:1-9.
    • (2009) J Arthroplasty , vol.24 , pp. 1-9
    • Ginsberg, J.S.1    Davidson, B.L.2
  • 11
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 12
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • Schulman S, Kearon C, Kakkar AK, et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009; 361:2342-2352.
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 13
    • 45949099359 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxa-parin for thromboprophylaxis after hip arthroplasty
    • Eriksson BI, Borris LC, Friedman RJ, et al. Rivaroxaban versus enoxa-parin for thromboprophylaxis after hip arthroplasty. N Engl J Med 2008;358:2765-2775.
    • (2008) N Engl J Med , vol.358 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 14
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboem-bolism after total hip arthroplasty: A double-blind, randomised controlled trial
    • Kakkar AK, Brenner B, Dahl OE, et al. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboem-bolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet 2008;372:31-39.
    • (2008) Lancet , vol.372 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 15
    • 45949103416 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen MR, Ageno W, Borris LC, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008;358:2776-2786.
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 16
    • 65549169515 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxa-parin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomised trial
    • Turpie AG, Lassen MR, Davidson BL, et al. Rivaroxaban versus enoxa-parin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. Lancet 2009;373:1673-1680.
    • (2009) Lancet , vol.373 , pp. 1673-1680
    • Turpie, A.G.1    Lassen, M.R.2    Davidson, B.L.3
  • 17
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • EINSTEIN Investigators
    • EINSTEIN Investigators; Bauersachs R, Berkowitz SD, et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010;363:2499-2510.
    • (2010) N Engl J Med , vol.363 , pp. 2499-2510
    • Bauersachs, R.1    Berkowitz, S.D.2
  • 18
    • 79961199378 scopus 로고    scopus 로고
    • Oral rivaroxaban after symptomatic venous thromboembolism: The continued treatment study (EINSTEIN-extension study)
    • Romualdi E, Donadini MP, Ageno W. Oral rivaroxaban after symptomatic venous thromboembolism: the continued treatment study (EINSTEIN-extension study). Expert Rev Cardiovasc Ther 2011;9:841-844.
    • (2011) Expert Rev Cardiovasc Ther , vol.9 , pp. 841-844
    • Romualdi, E.1    Donadini, M.P.2    Ageno, W.3
  • 20
    • 78650587760 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after hip replacement
    • Lassen MR, Gallus A, Raskob GE, et al. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement. N Engl J Med 2010;363: 2487-2498.
    • (2010) N Engl J Med , vol.363 , pp. 2487-2498
    • Lassen, M.R.1    Gallus, A.2    Raskob, G.E.3
  • 21
    • 84857853180 scopus 로고    scopus 로고
    • Bleeding risk with dabigatran in the frail elderly
    • Harper P, Young L, Merriman E. Bleeding risk with dabigatran in the frail elderly. N Engl J Med 2012;366:864-866.
    • (2012) N Engl J Med , vol.366 , pp. 864-866
    • Harper, P.1    Young, L.2    Merriman, E.3
  • 22
    • 84865815830 scopus 로고    scopus 로고
    • Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: Implications for emergency surgery and resuscitation
    • Lillo-Le Louët A, Wolf M, Soufir L, et al. Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: implications for emergency surgery and resuscitation. Thromb Haemost 2012; 108:583-585.
    • (2012) Thromb Haemost , vol.108 , pp. 583-585
    • Lillo-Le Louët, A.1    Wolf, M.2    Soufir, L.3
  • 23
    • 84868251849 scopus 로고    scopus 로고
    • Regulation THS, Australia: TGA Health Safety Regulation, (accessed 2012 Oct 30)
    • Regulation THS. Dabigatran (Pradaxa): risk of bleeding relating to use. Australia: TGA Health Safety Regulation. http://www.tga.gov.au/safety/alerts-medicine-dabigatran-111005.htm (accessed 2012 Oct 30).
    • Dabigatran (Pradaxa): Risk of Bleeding Relating to Use
  • 24
    • 84857015053 scopus 로고    scopus 로고
    • Laboratory testing of anticoagulants: The present and the future
    • Favaloro EJ, Lippi G, Koutts J. Laboratory testing of anticoagulants: the present and the future. Pathology 2011;43:682-692.
    • (2011) Pathology , vol.43 , pp. 682-692
    • Favaloro, E.J.1    Lippi, G.2    Koutts, J.3
  • 25
    • 84859735736 scopus 로고    scopus 로고
    • Coagulation monitoring of the bleeding traumatized patient
    • Johansson PI. Coagulation monitoring of the bleeding traumatized patient. Curr Opin Anaesthesiol 2012;25:235-241.
    • (2012) Curr Opin Anaesthesiol , vol.25 , pp. 235-241
    • Johansson, P.I.1
  • 26
    • 84871055659 scopus 로고    scopus 로고
    • Effect of rivaroxaban on blood coagulation using the viscoelastic coagulation test ROTEM
    • Casutt M, Konrad C, Schuepfer G. Effect of rivaroxaban on blood coagulation using the viscoelastic coagulation test ROTEM. Anaesthesist 2012;61:948-953.
    • (2012) Anaesthesist , vol.61 , pp. 948-953
    • Casutt, M.1    Konrad, C.2    Schuepfer, G.3
  • 27
    • 77952738550 scopus 로고    scopus 로고
    • Dabiga-tran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitor
    • Ammollo CT, Semeraro F, Incampo F, Semeraro N, Colucci M. Dabiga-tran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost 2010;8:790-798.
    • (2010) J Thromb Haemost , vol.8 , pp. 790-798
    • Ammollo, C.T.1    Semeraro, F.2    Incampo, F.3    Semeraro, N.4    Colucci, M.5
  • 29
    • 28044470299 scopus 로고    scopus 로고
    • RCPA QAP in Haematology. How useful is the monitoring of (low molecular weight) heparin therapy by anti-Xa assay? The laboratory perspective
    • Favaloro EJ, Bonar R, Aboud M, et al.; RCPA QAP in Haematology. How useful is the monitoring of (low molecular weight) heparin therapy by anti-Xa assay? The laboratory perspective. Lab Hematol 2005;11: 157-162.
    • (2005) Lab Hematol , vol.11 , pp. 157-162
    • Favaloro, E.J.1    Bonar, R.2    Aboud, M.3
  • 30
    • 21744432055 scopus 로고    scopus 로고
    • An international survey of current practice in the laboratory assessment of anticoagulant therapy with heparin
    • on behalf of the RCPA QAP in Haematology
    • Favaloro EJ, Bonar R, Sioufi J, et al. on behalf of the RCPA QAP in Haematology. An international survey of current practice in the laboratory assessment of anticoagulant therapy with heparin. Pathology 2005;37: 234-238.
    • (2005) Pathology , vol.37 , pp. 234-238
    • Favaloro, E.J.1    Bonar, R.2    Sioufi, J.3
  • 31
    • 84872251979 scopus 로고    scopus 로고
    • Ex vivo effects of low-dose rivaroxaban on specific coagulation assays and coagulation factor activities in patients under real life conditions
    • Mani H, Hesse C, Stratmann G, Lindhoff-Last E. Ex vivo effects of low-dose rivaroxaban on specific coagulation assays and coagulation factor activities in patients under real life conditions. Thromb Haemost 2013; 109:127-136.
    • (2013) Thromb Haemost , vol.109 , pp. 127-136
    • Mani, H.1    Hesse, C.2    Stratmann, G.3    Lindhoff-Last, E.4
  • 32
    • 84865977200 scopus 로고    scopus 로고
    • Newer oral anticoagulants: A review of laboratory monitoring options and reversal agents in the hemorrhagic patient
    • Miyares MA, Davis K. Newer oral anticoagulants: a review of laboratory monitoring options and reversal agents in the hemorrhagic patient. Am J Health Syst Pharm 2012;69:e28-39.
    • (2012) Am J Health Syst Pharm , vol.69
    • Miyares, M.A.1    Davis, K.2
  • 33
    • 84861119185 scopus 로고    scopus 로고
    • Plasma components: Properties, differences, and uses
    • Benjamin RJ, McLaughlin LS. Plasma components: properties, differences, and uses. Transfusion.2012;52(suppl 1):9S-19S.
    • (2012) Transfusion , vol.52 , Issue.SUPPL. 1
    • Benjamin, R.J.1    McLaughlin, L.S.2
  • 34
    • 84865396554 scopus 로고    scopus 로고
    • Prothrombin complex concentrates in emergency bleeding disorders
    • Rodgers GM. Prothrombin complex concentrates in emergency bleeding disorders. Am J Hematol 2012;87:898-902.
    • (2012) Am J Hematol , vol.87 , pp. 898-902
    • Rodgers, G.M.1
  • 35
    • 77954403042 scopus 로고    scopus 로고
    • Prothrombin complex concentrates: An update
    • Franchini M, Lippi G. Prothrombin complex concentrates: an update. Blood Transfus 2010;8:149-154.
    • (2010) Blood Transfus , vol.8 , pp. 149-154
    • Franchini, M.1    Lippi, G.2
  • 36
    • 79953306391 scopus 로고    scopus 로고
    • Clinical review: -prothrombin complex concentrates-evaluation of safety and throm-bogenicity
    • Erratum: Crit Care 2011;15:409
    • Sørensen B, Spahn DR, Innerhofer P, Spannagl M, Rossaint R. Clinical review: -prothrombin complex concentrates-evaluation of safety and throm-bogenicity. Crit Care 2011;15:201-210. Erratum: Crit Care 2011;15:409.
    • (2011) Crit Care , vol.15 , pp. 201-210
    • Sørensen, B.1    Spahn, D.R.2    Innerhofer, P.3    Spannagl, M.4    Rossaint, R.5
  • 37
    • 51349086787 scopus 로고    scopus 로고
    • Prothrombin complex concentrates: A brief review
    • Samama CM. Prothrombin complex concentrates: a brief review. Eur J Anaesthesiol 2008;25:784-789.
    • (2008) Eur J Anaesthesiol , vol.25 , pp. 784-789
    • Samama, C.M.1
  • 38
    • 84878519253 scopus 로고    scopus 로고
    • Product information, Westlake Village, CA: Baxter Healthcare Corporation, April
    • Product information. Bebulin VH (factor IX Complex). Westlake Village, CA: Baxter Healthcare Corporation, April 2011.
    • (2011) Bebulin VH (factor IX Complex)
  • 39
    • 84878497468 scopus 로고    scopus 로고
    • Product information, Los Angeles, CA: Grifols Biologicals Inc., April
    • Product information. Profilnine SD (factor IX Complex). Los Angeles, CA: Grifols Biologicals Inc., April 2010.
    • (2010) Profilnine SD (factor IX Complex)
  • 40
    • 84878498401 scopus 로고    scopus 로고
    • Product information, Westlake Village, CA: Baxter Healthcare Corporation, February
    • Product information. FEIBA NF (anti-inhibitor coagulant complex). Westlake Village, CA: Baxter Healthcare Corporation, February 2011.
    • (2011) FEIBA NF (anti-inhibitor Coagulant Complex)
  • 41
    • 84878508378 scopus 로고    scopus 로고
    • Product information, Ottawa, Canada: CSL Behring Canada Inc., November
    • Product information. Beriplex P/N (human prothrombin complex). Ottawa, Canada: CSL Behring Canada Inc., November 2010.
    • (2010) Beriplex P/N (human Prothrombin Complex)
  • 42
    • 84878508378 scopus 로고    scopus 로고
    • Product information, Scarborough, Canada: Octapharma Canada, Inc., April 28
    • Product information. Octaplex (human prothrombin complex). Scarborough, Canada: Octapharma Canada, Inc., April 28, 2010.
    • (2010) Octaplex (human Prothrombin Complex)
  • 43
    • 84878485414 scopus 로고    scopus 로고
    • Product information, Amsterdam, Netherlands: Sanquin, December 25
    • Product information. Cofact (human prothrombin complex). Amsterdam, Netherlands: Sanquin, December 25, 2011.
    • (2011) Cofact (human Prothrombin Complex)
  • 44
    • 84878492581 scopus 로고    scopus 로고
    • Product information, Courtabœuf, Cedex, France: LFB-Biomedicaments, February 18
    • Product information. Kanokad (human prothrombin complex). Courtabœuf, Cedex, France: LFB-Biomedicaments, February 18, 2009.
    • (2009) Kanokad (human Prothrombin Complex)
  • 45
    • 51349129452 scopus 로고    scopus 로고
    • Biochemical comparison of seven commercially available prothrombin complex concentrates
    • Kalina U, Bickhard H, Schulte S. Biochemical comparison of seven commercially available prothrombin complex concentrates. Int J Clin Pract 2008;62:1614-1622.
    • (2008) Int J Clin Pract , vol.62 , pp. 1614-1622
    • Kalina, U.1    Bickhard, H.2    Schulte, S.3
  • 46
    • 77953861708 scopus 로고    scopus 로고
    • Controversies of anticoagulation reversal in life-threatening bleeds
    • Rolfe S, Papadopoulos S, Cabral KP. Controversies of anticoagulation reversal in life-threatening bleeds. J Pharm Pract 2010;23:217-225.
    • (2010) J Pharm Pract , vol.23 , pp. 217-225
    • Rolfe, S.1    Papadopoulos, S.2    Cabral, K.P.3
  • 47
    • 0036183415 scopus 로고    scopus 로고
    • Rapid reversal of oral anti-coagulation with warfarin by a prothrombin complex concentrate (Beriplex): Efficacy and safety in 42 patients
    • Preston FE, Laidlaw ST, Sampson B, Kitchen S. Rapid reversal of oral anti-coagulation with warfarin by a prothrombin complex concentrate (Beriplex): efficacy and safety in 42 patients. Br J Haematol 2002;116:619-624.
    • (2002) Br J Haematol , vol.116 , pp. 619-624
    • Preston, F.E.1    Laidlaw, S.T.2    Sampson, B.3    Kitchen, S.4
  • 48
    • 33746787177 scopus 로고    scopus 로고
    • Individualized dosing regimen for prothrombin complex concentrate more effective than standard treatment in the reversal of oral anticoagulant therapy: An open, prospective randomized controlled trial
    • van Aart L, Eijkhout HW, Kamphuis JS, et al. Individualized dosing regimen for prothrombin complex concentrate more effective than standard treatment in the reversal of oral anticoagulant therapy: an open, prospective randomized controlled trial. Thromb Res 2006;118:313-320.
    • (2006) Thromb Res , vol.118 , pp. 313-320
    • van Aart, L.1    Eijkhout, H.W.2    Kamphuis, J.S.3
  • 49
    • 77955094322 scopus 로고    scopus 로고
    • Prothrombin complex concentrates for oral anticoagulant therapy-related intracranial hemorrhage: A review of the literature
    • Bershad EM, Suarez JI. Prothrombin complex concentrates for oral anticoagulant therapy-related intracranial hemorrhage: a review of the literature. Neurocrit Care 2010;12:403-413.
    • (2010) Neurocrit Care , vol.12 , pp. 403-413
    • Bershad, E.M.1    Suarez, J.I.2
  • 50
    • 0026643411 scopus 로고
    • Emergency reversal of anti-coagulation after intracerebral hemorrhage
    • Fredriksson K, Norrving B, Stromblad LG. Emergency reversal of anti-coagulation after intracerebral hemorrhage. Stroke 1992;23:972-977.
    • (1992) Stroke , vol.23 , pp. 972-977
    • Fredriksson, K.1    Norrving, B.2    Stromblad, L.G.3
  • 51
    • 0030933639 scopus 로고    scopus 로고
    • Emergency oral anticoagulant reversal: The relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy
    • Makris M, Greaves M, Phillips WS, Kitchen S, Rosendaal FR, Preston FE. Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy. Thromb Haemost 1997;77:477-480.
    • (1997) Thromb Haemost , vol.77 , pp. 477-480
    • Makris, M.1    Greaves, M.2    Phillips, W.S.3    Kitchen, S.4    Rosendaal, F.R.5    Preston, F.E.6
  • 52
    • 0032703196 scopus 로고    scopus 로고
    • Use of factor IX complex in warfarin-related intracranial hemorrhage
    • Boulis NM, Bobek MP, Schmaier A, Hoff JT. Use of factor IX complex in warfarin-related intracranial hemorrhage. Neurosurgery 1999;45:1113-1118.
    • (1999) Neurosurgery , vol.45 , pp. 1113-1118
    • Boulis, N.M.1    Bobek, M.P.2    Schmaier, A.3    Hoff, J.T.4
  • 53
    • 0033765008 scopus 로고    scopus 로고
    • Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies
    • Cartmill M, Dolan G, Byrne JL, Byrne PO. Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies. Br J Neurosurg 2000;14:458-461.
    • (2000) Br J Neurosurg , vol.14 , pp. 458-461
    • Cartmill, M.1    Dolan, G.2    Byrne, J.L.3    Byrne, P.O.4
  • 54
    • 40749092074 scopus 로고    scopus 로고
    • Effectiveness of Factor IX complex concentrate in reversing warfarin associated coagulopathy for intracere-bral hemorrhage
    • Siddiq F, Jalil A, McDaniel C, et al. Effectiveness of Factor IX complex concentrate in reversing warfarin associated coagulopathy for intracere-bral hemorrhage. Neurocrit Care 2008;8:36-41.
    • (2008) Neurocrit Care , vol.8 , pp. 36-41
    • Siddiq, F.1    Jalil, A.2    McDaniel, C.3
  • 55
    • 77956621410 scopus 로고    scopus 로고
    • Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: A randomized study
    • Demeyere R, Gillardin S, Arnout J, Strengers PF. Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: a randomized study. Vox Sang 2010;99:251-260.
    • (2010) Vox Sang , vol.99 , pp. 251-260
    • Demeyere, R.1    Gillardin, S.2    Arnout, J.3    Strengers, P.F.4
  • 56
    • 80052212754 scopus 로고    scopus 로고
    • Pharmacologic anticoagulation reversal in the emergency department
    • Lemon SJ Jr, Crannage AJ. Pharmacologic anticoagulation reversal in the emergency department. Adv Emer Nurs J 2011;33:212-223.
    • (2011) Adv Emer Nurs J , vol.33 , pp. 212-223
    • Lemon Jr., S.J.1    Crannage, A.J.2
  • 57
    • 69849096957 scopus 로고    scopus 로고
    • Bench-to-bedside review: Optimising emergency reversal of vitamin K antagonists in severe haemorrhage-from theory to practice
    • Vigue B. Bench-to-bedside review: optimising emergency reversal of vitamin K antagonists in severe haemorrhage-from theory to practice. Crit Care 2009;13:209-219.
    • (2009) Crit Care , vol.13 , pp. 209-219
    • Vigue, B.1
  • 60
    • 84878520473 scopus 로고    scopus 로고
    • Medscape, (accessed 2012 Oct 30)
    • Medscape. Fresh frozen plasma (blood component). http://reference.medscape.com/drug/ffp-fresh-frozen-plasma-999499 (accessed 2012 Oct 30).
    • Fresh Frozen Plasma (blood Component)
  • 61
    • 84878479730 scopus 로고    scopus 로고
    • Product information, Bagsvaerd, Denmark: Novo Nordisk, December
    • Product information. NovoSeven RT (coagulation factor VIIa recombi-nant). Bagsvaerd, Denmark: Novo Nordisk, December 2012.
    • (2012) NovoSeven RT (coagulation Factor VIIa Recombi-nant)
  • 62
    • 73549085173 scopus 로고    scopus 로고
    • Activated prothrombin complex concentrate factor VIII inhibitor bypassing activity (FEIBA) for the reversal of warfarin-induced coagulopathy
    • Wójcik C, Schymik ML, Cure EG. Activated prothrombin complex concentrate factor VIII inhibitor bypassing activity (FEIBA) for the reversal of warfarin-induced coagulopathy. Int J Emerg Med 2009;2:217-225.
    • (2009) Int J Emerg Med , vol.2 , pp. 217-225
    • Wójcik, C.1    Schymik, M.L.2    Cure, E.G.3
  • 63
    • 84878517436 scopus 로고    scopus 로고
    • Puget Sound Blood Center, (accessed 2012 Oct 30)
    • Gernsheimer T. Puget Sound Blood Center. Blood component therapy 2010. http://www.psbc.org/therapy/ffp.htm (accessed 2012 Oct 30).
    • Blood Component Therapy 2010
    • Gernsheimer, T.1
  • 64
    • 79959476160 scopus 로고    scopus 로고
    • How I treat warfarin-associated coagulopa-thy in patients with intracerebral hemorrhage
    • Goodnough LT, Shander A. How I treat warfarin-associated coagulopa-thy in patients with intracerebral hemorrhage. Blood 2011;117:6091-6099.
    • (2011) Blood , vol.117 , pp. 6091-6099
    • Goodnough, L.T.1    Shander, A.2
  • 65
    • 44649185707 scopus 로고    scopus 로고
    • Warfarin-induced bleeding complications- clinical presentation and therapeutic options
    • Wiedermann CJ, Stockner I. Warfarin-induced bleeding complications- clinical presentation and therapeutic options. Thromb Res 2008;122(suppl 2):S13-S18.
    • (2008) Thromb Res , vol.122 , Issue.SUPPL. 2
    • Wiedermann, C.J.1    Stockner, I.2
  • 66
    • 84856784474 scopus 로고    scopus 로고
    • Oral anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • American College of Chest Physicians
    • Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G; American College of Chest Physicians. Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012;141:e44S-88S.
    • (2012) Chest , vol.141
    • Ageno, W.1    Gallus, A.S.2    Wittkowsky, A.3    Crowther, M.4    Hylek, E.M.5    Palareti, G.6
  • 67
    • 34249785974 scopus 로고    scopus 로고
    • Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: A guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group
    • Broderick J, Connolly S, Feldmann E, et al. Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke 2007;38:2001-2023.
    • (2007) Stroke , vol.38 , pp. 2001-2023
    • Broderick, J.1    Connolly, S.2    Feldmann, E.3
  • 68
    • 77951761476 scopus 로고    scopus 로고
    • The acute management of intracerebral hemorrhage: A clinical review
    • Elliott J, Smith M. The acute management of intracerebral hemorrhage: a clinical review. Anesth Analg 2010;110:1419-1427.
    • (2010) Anesth Analg , vol.110 , pp. 1419-1427
    • Elliott, J.1    Smith, M.2
  • 69
    • 8444221659 scopus 로고    scopus 로고
    • Warfarin reversal
    • Hanley JP. Warfarin reversal. J Clin Pathol 2004;57:1132-1139.
    • (2004) J Clin Pathol , vol.57 , pp. 1132-1139
    • Hanley, J.P.1
  • 70
    • 40949148098 scopus 로고    scopus 로고
    • Pro-thrombin complex concentrate (Beriplex P/N) for emergency anticoagu-lation reversal: A prospective multinational clinical trial
    • Pabinger I, Brenner B, Kalina U, Knaub S, Nagy A, Ostermann H. Pro-thrombin complex concentrate (Beriplex P/N) for emergency anticoagu-lation reversal: a prospective multinational clinical trial. J Thromb Haemost 2008;6:622-631.
    • (2008) J Thromb Haemost , vol.6 , pp. 622-631
    • Pabinger, I.1    Brenner, B.2    Kalina, U.3    Knaub, S.4    Nagy, A.5    Ostermann, H.6
  • 71
    • 84863301351 scopus 로고    scopus 로고
    • Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal
    • Dowlatshahi D, Butcher KS, Asdaghi N, et al. Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal. Stroke 2012;43:1812-1817.
    • (2012) Stroke , vol.43 , pp. 1812-1817
    • Dowlatshahi, D.1    Butcher, K.S.2    Asdaghi, N.3
  • 72
    • 66549108216 scopus 로고    scopus 로고
    • Sub-optimal effect of a three-factor prothrombin complex concentrate (profil-nin-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdosage
    • Holland L, Warkentin TE, Crowther MA, Johnston MA, Sarode R. Sub-optimal effect of a three-factor prothrombin complex concentrate (profil-nin-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdosage. Transfusion 2009;49:1171-1177.
    • (2009) Transfusion , vol.49 , pp. 1171-1177
    • Holland, L.1    Warkentin, T.E.2    Crowther, M.A.3    Johnston, M.A.4    Sarode, R.5
  • 73
    • 84862202450 scopus 로고    scopus 로고
    • A review of the clinical utility of INR to monitor and guide administration of prothrombin complex concentrate to orally anticoagulated patients
    • Solbeck S, Ostrowski SR, Johansson PI. A review of the clinical utility of INR to monitor and guide administration of prothrombin complex concentrate to orally anticoagulated patients. Thromb J 2012;10:5.
    • (2012) Thromb J , vol.10 , pp. 5
    • Solbeck, S.1    Ostrowski, S.R.2    Johansson, P.I.3
  • 74
    • 79955026271 scopus 로고    scopus 로고
    • Recombinant factor VIIa: An assessment of evidence regarding its efficacy and safety in the off-label setting
    • Logan AC, Goodnough LT. Recombinant factor VIIa: an assessment of evidence regarding its efficacy and safety in the off-label setting. Hema-tology 2010;2010:153-159.
    • (2010) Hema-tology , vol.2010 , pp. 153-159
    • Logan, A.C.1    Goodnough, L.T.2
  • 75
    • 30944461398 scopus 로고    scopus 로고
    • Thromboem-bolic adverse events after use of recombinant human coagulation factor VIIa
    • O'Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM. Thromboem-bolic adverse events after use of recombinant human coagulation factor VIIa. JAMA 2006;295:293-298.
    • (2006) JAMA , vol.295 , pp. 293-298
    • O'Connell, K.A.1    Wood, J.J.2    Wise, R.P.3    Lozier, J.N.4    Braun, M.M.5
  • 76
    • 78049498149 scopus 로고    scopus 로고
    • Safety of recombinant activated factor VII in randomized clinical trials
    • Levi M, Levy JH, Andersen HF, Truloff D. Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 2010; 363:1791-1800.
    • (2010) N Engl J Med , vol.363 , pp. 1791-1800
    • Levi, M.1    Levy, J.H.2    Andersen, H.F.3    Truloff, D.4
  • 77
    • 46249125890 scopus 로고    scopus 로고
    • Recombinant factor VIIa for warfarin-associated intracranial bleeding
    • Ilyas C, Beyer GM, Dutton RP, Scalea TM, Hess JR. Recombinant factor VIIa for warfarin-associated intracranial bleeding. J Clin Anesth 2008;20: 276-279.
    • (2008) J Clin Anesth , vol.20 , pp. 276-279
    • Ilyas, C.1    Beyer, G.M.2    Dutton, R.P.3    Scalea, T.M.4    Hess, J.R.5
  • 78
    • 33746712273 scopus 로고    scopus 로고
    • Reversal of elevated international normalized ratios and bleeding with low-dose recombinant activated factor VII in patients receiving warfarin
    • Dager WE, King JH, Regalia RC, et al. Reversal of elevated international normalized ratios and bleeding with low-dose recombinant activated factor VII in patients receiving warfarin. Pharmacotherapy 2006;26:1091-1098.
    • (2006) Pharmacotherapy , vol.26 , pp. 1091-1098
    • Dager, W.E.1    King, J.H.2    Regalia, R.C.3
  • 79
    • 27644434462 scopus 로고    scopus 로고
    • Human recombinant factor VII for emergency reversal of co-agulopathy in neurosurgical patients: A retrospective comparative study
    • Roitberg B, Emechebe-Kennedy O, Amin-Hanjani S, Mucksavage J, Tesoro E. Human recombinant factor VII for emergency reversal of co-agulopathy in neurosurgical patients: a retrospective comparative study. Neurosurgery 2005;57:832-836.
    • (2005) Neurosurgery , vol.57 , pp. 832-836
    • Roitberg, B.1    Emechebe-Kennedy, O.2    Amin-Hanjani, S.3    Mucksavage, J.4    Tesoro, E.5
  • 80
    • 23444448265 scopus 로고    scopus 로고
    • Use of recombi-nant factor VIIa in patients with warfarin-associated intracranial hemorrhage
    • Brody DL, Aiyagari V, Shackleford AM, Diringer MN. Use of recombi-nant factor VIIa in patients with warfarin-associated intracranial hemorrhage. Neurocrit Care 2005;2:263-267.
    • (2005) Neurocrit Care , vol.2 , pp. 263-267
    • Brody, D.L.1    Aiyagari, V.2    Shackleford, A.M.3    Diringer, M.N.4
  • 81
    • 9644254211 scopus 로고    scopus 로고
    • Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage
    • Freeman WD, Brott TG, Barrett KM, et al. Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage. Mayo Clin Proc 2004;79:1495-1500.
    • (2004) Mayo Clin Proc , vol.79 , pp. 1495-1500
    • Freeman, W.D.1    Brott, T.G.2    Barrett, K.M.3
  • 82
    • 0037382290 scopus 로고    scopus 로고
    • The use of recombinant activated factor VII to reverse warfarin-induced anticoagulation in patients with hemorrhages in the central nervous system: Preliminary findings
    • Lin J, Hanigan WC, Tarantino M, Wang J. The use of recombinant activated factor VII to reverse warfarin-induced anticoagulation in patients with hemorrhages in the central nervous system: preliminary findings. J Neurosurg 2003;98:737-740.
    • (2003) J Neurosurg , vol.98 , pp. 737-740
    • Lin, J.1    Hanigan, W.C.2    Tarantino, M.3    Wang, J.4
  • 83
    • 0042125355 scopus 로고    scopus 로고
    • Reversal of the international normalized ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophy-laxis: Clinical and biochemical aspects
    • Sorensen B, Johansen P, Nielsen GL, Sorensen JC, Ingerslev J. Reversal of the international normalized ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophy-laxis: clinical and biochemical aspects. Blood Coagul Fibrinolysis 2003; 14:469-477.
    • (2003) Blood Coagul Fibrinolysis , vol.14 , pp. 469-477
    • Sorensen, B.1    Johansen, P.2    Nielsen, G.L.3    Sorensen, J.C.4    Ingerslev, J.5
  • 84
    • 0036962116 scopus 로고    scopus 로고
    • Recombinant coagulation factor VIIa for rapid preoperative correction of warfarin-related coagulopathy in patients with acute subdural hematoma
    • Veshchev I, Elran H, Salame K. Recombinant coagulation factor VIIa for rapid preoperative correction of warfarin-related coagulopathy in patients with acute subdural hematoma. Med Sci Monit 2002;8:CS98-100.
    • (2002) Med Sci Monit , vol.8
    • Veshchev, I.1    Elran, H.2    Salame, K.3
  • 85
    • 0037016029 scopus 로고    scopus 로고
    • Reversal of warfarin-induced excessive anti-coagulation with recombinant human factor VIIa concentrate
    • Deveras RA, Kessler CM. Reversal of warfarin-induced excessive anti-coagulation with recombinant human factor VIIa concentrate. Ann Intern Med 2002;137:884-888.
    • (2002) Ann Intern Med , vol.137 , pp. 884-888
    • Deveras, R.A.1    Kessler, C.M.2
  • 86
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etex-ilate: An open-label, parallel-group, single-centre study
    • Stangier J, Rathgen K, Stahle H, Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etex-ilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 2010;49:259-268.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Mazur, D.4
  • 87
    • 84859703006 scopus 로고    scopus 로고
    • Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment
    • doi: 10.1345/aph.1Q747
    • Wychowski MK, Kouides PA. Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment. Ann Pharmacother. 2012;46:e10. doi: 10.1345/aph.1Q747.
    • (2012) Ann Pharmacother , vol.e10 , pp. 46
    • Wychowski, M.K.1    Kouides, P.A.2
  • 88
    • 84859971855 scopus 로고    scopus 로고
    • Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
    • Kaatz S, Kouides PA, Garcia DA, et al. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Am J Hematol 2012; 87:S141-145.
    • (2012) Am J Hematol , vol.87
    • Kaatz, S.1    Kouides, P.A.2    Garcia, D.A.3
  • 89
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
    • van Ryn J, Stangier J, Haertter S, et al. Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010;103: 1116-1127.
    • (2010) Thromb Haemost , vol.103 , pp. 1116-1127
    • van Ryn, J.1    Stangier, J.2    Haertter, S.3
  • 90
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011;124:1573-1579.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 91
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: A randomised crossover ex-vivo study in healthy volunteers
    • Marlu R, Hodaj E, Paris A, et al. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex-vivo study in healthy volunteers. Thromb Haemost 2012; 108:217-224.
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3
  • 92
    • 84876398583 scopus 로고    scopus 로고
    • Treatment of dabigatran-associat-ed bleeding: Case report and review of the literature
    • Nov 16. [Epub ahead of print]
    • Harinstein LM, Morgan JW, Russo N. Treatment of dabigatran-associat-ed bleeding: case report and review of the literature. J Pharm Pract 2012 Nov 16. [Epub ahead of print]
    • (2012) J Pharm Pract
    • Harinstein, L.M.1    Morgan, J.W.2    Russo, N.3
  • 93
    • 84871951795 scopus 로고    scopus 로고
    • Risky anticoagulants: Meds have the potential to turn minor trauma into a major disaster
    • Harvey P. Risky anticoagulants: meds have the potential to turn minor trauma into a major disaster. JEMS 2012;37(8):30-31.
    • (2012) JEMS , vol.37 , Issue.8 , pp. 30-31
    • Harvey, P.1
  • 94
    • 84867699158 scopus 로고    scopus 로고
    • Hemorrhagic complications associated with dabigatran use
    • Chen BC, Viny AD, Garlich FM, et al. Hemorrhagic complications associated with dabigatran use. Clin Toxicol (Phila) 2012;50:854-857.
    • (2012) Clin Toxicol (Phila) , vol.50 , pp. 854-857
    • Chen, B.C.1    Viny, A.D.2    Garlich, F.M.3
  • 95
    • 84864762326 scopus 로고    scopus 로고
    • Hemopericardium and cardiac tamponade associated with dabigatran use
    • doi: 10.1345/aph.1R112
    • Dy EA, Shiltz DL. Hemopericardium and cardiac tamponade associated with dabigatran use. Ann Pharmacother 2012;46:e18. doi: 10.1345/aph.1R112.
    • (2012) Ann Pharmacother , vol.46
    • Dy, E.A.1    Shiltz, D.L.2
  • 96
  • 97
    • 84865045736 scopus 로고    scopus 로고
    • Fatal gastrointestinal hemorrhage after a single dose of dabigatran
    • Kernan L, Ito S, Shirazi F, Boesen K. Fatal gastrointestinal hemorrhage after a single dose of dabigatran. Clin Toxicol (Phila) 2012;50:571-573.
    • (2012) Clin Toxicol (Phila) , vol.50 , pp. 571-573
    • Kernan, L.1    Ito, S.2    Shirazi, F.3    Boesen, K.4
  • 98
    • 84869189977 scopus 로고    scopus 로고
    • Periprocedural management and approach to bleeding in patients taking dabigatran
    • Weitz JI, Quinlan DJ, Eikelboom JW. Periprocedural management and approach to bleeding in patients taking dabigatran. Circulation 2012; 126:2428-2432.
    • (2012) Circulation , vol.126 , pp. 2428-2432
    • Weitz, J.I.1    Quinlan, D.J.2    Eikelboom, J.W.3
  • 101
    • 84878517309 scopus 로고    scopus 로고
    • Updated: 18 December 2012. Australian Government. Department of Health and Ageing, (accessed 2012 Oct 30)
    • Review of anticoagulation therapies in atrial fibrillation. Updated: 18 December 2012. Australian Government. Department of Health and Ageing. http://www.pbs.gov.au/info/publication/factsheets/shared/anticoagulation-review (accessed 2012 Oct 30).
    • Review of Anticoagulation Therapies In Atrial Fibrillation
  • 102
    • 84878510566 scopus 로고    scopus 로고
    • Portland, ME: Maine Medical Center, Department of Emergency Medicine, February 9, (accessed 2012 Dec 15)
    • Guideline for the management of bleeding on dabigatran (Pradaxa). Portland, ME: Maine Medical Center, Department of Emergency Medicine, February 9, 2012: 3. http://www.guideline.gov/content.aspx?id=36840&search=bleeding (accessed 2012 Dec 15).
    • (2012) Guideline For the Management of Bleeding On Dabigatran (Pradaxa) , pp. 3
  • 103
    • 84873377457 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence (NICE), Clinical guideline no. 141. London, England: National Institute for Health and Clinical Excellence, June 23
    • National Institute for Health and Clinical Excellence (NICE). Acute upper gastrointestinal bleeding: management. Clinical guideline no. 141. London, England: National Institute for Health and Clinical Excellence, June 23, 2012.
    • (2012) Acute Upper Gastrointestinal Bleeding: Management
  • 105
    • 84255201932 scopus 로고    scopus 로고
    • Polyphosphate is a cofactor for the activation of factor XI by thrombin
    • Choi SH, Smith SA, Morrissey JH. Polyphosphate is a cofactor for the activation of factor XI by thrombin. Blood 2011;118:6963-6970.
    • (2011) Blood , vol.118 , pp. 6963-6970
    • Choi, S.H.1    Smith, S.A.2    Morrissey, J.H.3
  • 106
    • 84871528525 scopus 로고    scopus 로고
    • Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation
    • Smith SA, Choi SH, Collins JN, Travers RJ, Cooley BC, Morrissey JH. Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood 2012;120:5103-5110.
    • (2012) Blood , vol.120 , pp. 5103-5110
    • Smith, S.A.1    Choi, S.H.2    Collins, J.N.3    Travers, R.J.4    Cooley, B.C.5    Morrissey, J.H.6


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