Reversal of warfarin-induced excessive anticoagulation with recombinant human factor VIIa concentrate

Annals of Internal Medicine

Volumn 137, Issue 11, 2002, Pages 884-888

  Deveras, Ruby Anne E ^a   Kessler, Craig M ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT BLOOD CLOTTING FACTOR 7A; WARFARIN;

ADULT; AGED; ANTICOAGULATION; ARTICLE; BLEEDING; CLINICAL ARTICLE; DRUG ANTAGONISM; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEMOSTASIS; HUMAN; INTERNATIONAL STANDARD UNIT; MALE; PRIORITY JOURNAL; PROTHROMBIN TIME; TREATMENT OUTCOME;

EID: 0037016029     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-137-11-200212030-00009     Document Type: Article

References (20)

1. Fihn SD, Callahan CM, Martin DC, McDonell MB, Henikoff JG, White RH. The risk for and severity of bleeding complications in elderly patients treated with warfarin. The National Consortium of Anticoagulation Clinics. Ann Intern Med. 1996;124970-9. [PMID: 8624064]
2. Hirsh J, Dalen J, Anderson DR, Poller L, Bussey H, Ansell J, et al. Oral anticoagulants: Mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest. 2001;119:8S-21S. [PMID: 11157640]
3. Sedin MJ, Breckenridge AM. Drug interactions with warfarin. Drugs. 1983; 25;610-20. [PMID: 6347619]
4. Hylek EM, Chang YC, Skates SJ, Hughes RA, Singer DE. Prospective study of the outcomes of ambulatory patients with excessive warfarin anticoagulation. Arch Intern Med. 2000;160:1612-7. [PMID: 10847254]
5. Landefeld CS, Beyth RJ. Anticoagulant-related bleeding: Clinical epidemiology, prediction, and prevention. Am J Med. 1993;95:315-28. [PMID: 8368229]
6. Palareti G, Leali N, Coccheri S, Poggi M, Manotti C, D'Angelo A, et al. Bleeding complications of oral anticoagulant treatment: An inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy. Lancet. 1996;348:423-8. [PMID: 8709780]
7. Ansell J, Hirsh J, Dalen J, Bussey H, Anderson D, Poller L, et al. Managing oral anticoagulant therapy. Chest. 2001;119:22S-38S. [PMID: 11157641]
8. Crowther MA, Julian J, McCarty D, Douketis J, Kovacs M, Biagoni L, et al. Treatment of warfarin-associated coagulopathy with oral vitamin K: A randomised controlled trial. Lancet. 2000;356:1551-3. [PMID: 11075768]
9. Guideline for the use of fresh-frozen plasma. Medical Directors Advisory Committee, National Blood Transfusion Council. S Afr Med J. 1998;88:1344-7. [PMID: 9807194]
10. Pindur G, Mörsdorf S. The use of prothrombin complex concentrates in the treatment of hemorrhages induced by oral anticoagulation. Thromb Res. 1999; 95:S57-61. [PMID: 10499910]
11. Seitz R, Dodt J. Virus safety of prothrombin complex concentrates and factor IX concentrates. Thromb Res. 1999;95S19-23. [PMID: 10499905]
12. Lusher JM. Thrombogenicity associated with factor IX complex concentrates. Semin Hematol. 1991;28:3-5. [PMID: 1780767]
13. NovoSeven (Coagulation Factor VIIa Recombinant) [Package Insert]. Princeton, NJ: Novo Nordisk; 2002.
14. Kessler CM. New products for managing inhibitors to coagulation factors: A focus on recombinant factor VIIa concentrate. Curr Opin Hematol. 2000;7:408-13 [PMID: 11055516]
15. Diness V, Lund-Hansen T, Hedner U. Effect of recombinant human FVIIA on warfarin-induced bleeding in rats. Thromb Res. 1990;59:921-9. [PMID: 2264019]
16. Girard P, Nony P, Erhardtsen E, Delair S, Ffrench P, Dechavanne M, et al. Population pharmacokinetics of recombinant factor VIIa in volunteers anticoagulated with acenocoumarol. Thromb Haemost. 1998;80:109-13. [PMID: 9684795]
17. Abu-Hajir M, Hollowell J, Nagargoje G. Management of 2 patients with subdural hematoma and coagulopathy with recombinant human activated Factor VII (NovoSeven, rVIIa) [Abstract]. Blood. 2001;98:79b.
18. Shopnick R. Reversal of warfarin using recombinant factor VIIa prior to invasive procedures [Abstract]. Blood. 2001;98:99b.
19. Berntorp E, Stigendal L, Lethagen S, Olofsson L, Hedner U. NovoSeven in warfarin-treated patients. Blood Coagul Fibrinolysis. 2000;11 Suppl 1:S113-5. [PMID: 10850575]
20. Peerlinck K, Vermylen J. Acute myocardial infarction following administration of recombinant activated factor VII (Novo Seven) in a patient with haemophilia A and inhibitor [Letter]. Thromb Haemost. 1999;82:1775-6. [PMID: 10613674]