Enzymatic properties of venoms from Brazilian scorpions of Tityus genus and the neutralisation potential of therapeutical antivenoms

Toxicon

Volumn 69, Issue , 2013, Pages 180-190

  Venancio, Emerson J ^a,b   Portaro, Fernanda C V ^b   Kuniyoshi, Alexandre K ^b   Carvalho, Daniela Cajado ^b   Pidde Queiroz, Giselle ^b   Tambourgi, Denise V ^b  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

Author keywords

Antivenoms; Dynorphin 1 13; Leu enkephalin; Metalloproteinases; Scorpion venom; Tityus spp.

Indexed keywords

1,10 PHENANTHROLINE; ANTI ARACHNIDIC ANTIVENOM; ANTI SCORPIONIC ANTIVENOM; ARGININE; BENZYLSULFONYL FLUORIDE; DYNORPHIN[1-13]; HYALURONIDASE; LEUCINE; LEUCINE ENKEPHALIN; METALLOPROTEINASE; PEPTIDASE; PHOSPHOLIPASE; SCORPION VENOM; SCORPION VENOM ANTISERUM; TOXIN; UNCLASSIFIED DRUG; VENOM ANTISERUM; ARGINYLARGININE; DIPEPTIDE; HYALURONOGLUCOSAMINIDASE; LEUCYLARGININE;

ARTICLE; BRADYCARDIA; BRAZIL; CHEMICAL BOND; CROSS REACTION; ENVENOMATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HYDROLYSIS; HYPOTENSION; INCIDENCE; NONHUMAN; POISONOUS SCORPION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PUBLIC HEALTH PROBLEM; TITYUS; TITYUS BAHIENSIS; TITYUS SERRULATUS; TITYUS STIGMURUS; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; ENZYMATIC DEGRADATION; SCORPION; SERODIAGNOSIS; ANIMAL; CLASSIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES; SCORPION STINGS; SPECIES DIFFERENCE; TOXICITY; METHODOLOGY; SCORPION STING;

ANIMALIA; SCORPIONES; SERPENTES; TITYUS; TITYUS BAHIENSIS; TITYUS SERRULATUS; TITYUS STIGMURUS;

ANIMALS; ANTIVENINS; BRAZIL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYALURONOGLUCOSAMINIDASE; INCIDENCE; METALLOPROTEASES; NEUTRALIZATION TESTS; PHOSPHOLIPASES; SCORPION STINGS; SCORPION VENOMS; SCORPIONS; SPECIES SPECIFICITY;

EID: 84878504067     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.02.012     Document Type: Article

References (46)

1. Abroug F., ElAtrous S., Nouira S., Haguiga H., Touzi N., Bouchoucha S. Serotherapy in scorpion envenomation: a randomized controlled trial. Lancet 1999, 354(9182):906-909.
2. Almeida D.D., Scortecci K.C., Kobashi L.S., Agnez-Lima L.F., Medeiros S.R.B., Silva-Junior A.A., Junqueira-de-Azevedo I.L.M., Fernandes-Pedrosa M.F. Profiling the resting venom gland of the scorpion Tityus stigmurus through a transcriptomic survey. BMC Genomics 2012, 13:362.
3. Almeida F.M., Pimenta A.M., De Figueiredo S.G., Santoro M.M., Martin-Eauclaire M.F., Diniz C.R., De Lima M.E. Enzymes with gelatinolytic activity can be found in Tityus bahiensis and Tityus serrulatus venoms. Toxicon 2002, 40(7):1041-1045.
4. Amaral C.F., Rezende N.A. Treatment of scorpion envenoming should include both a potent specific antivenom and support of vital functions. Toxicon 2000, 38(8):1005-1007.
5. Amitai Y. Clinical manifestations and management of scorpion envenomation. Public Health Rev. 1998, 26(3):257-263.
6. Araújo M.C., Melo R.L., Cesari M.H., Juliano M.A., Juliano L., Carmona A.K. Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme. Biochemistry 2000, 39(29):8519-8525.
7. Barbosa A.D., Magalhães D.F., Silva J.A., Silva M.X., Cardoso M.de F., Meneses J.N., Cunha M.da C. Caracterização dos acidentes escorpiÔnicos em Belo Horizonte, Minas Gerais, Brasil, 2005 a 2009. Cad. Saúde Publica 2012, 28(9):1785-1789.
8. Batista C.V., Román-González S.A., Salas-Castillo S.P., Zamudio F.Z., Gómez-Lagunas F., Possani L.D. Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species. Comp. Biochem. Physiol. Toxicol. Pharmacol. 2007, 146(1-2):147-157.
9. Beyer A., Schäfer M., Stein C. Antinociceptive effects of dynorphin peptides in a model of inflammatory pain. Pain 1997, 70(2-3):141-147.
10. Proteolytic Enzymes: a Practical Approach 2001, Oxford University Press, Oxford. second ed. R.J. Beynon, J.S. Bond (Eds.).
11. Boyer L.V., Theodorou A.A., Berg R.A., Joanne Mallie J., Chavez-Mendez A., Walter Garcia-Ubbelohde W., Hardiman S., Alagon A. Antivenom for critically Ill children with neurotoxicity from scorpion stings. N. Engl. J. Med. 2009, 360(20):2090-2098.
12. Bucaretchi F., Baracat E.C., Nogueira R.J., Chaves A., Zambrone F.A., Fonseca M.R., Tourinho F.S. A comparative study of severe scorpion envenomation in children caused by Tityus bahiensis and Tityus serrulatus. Rev. Inst. Med. Trop. São Paulo 1995, 37(4):331-336.
13. Chippaux J.P., Goyffon M. Epidemiology of scorpionism: a global appraisal. Acta Trop. 2008, 107(2):71-79.
14. De Sousa L., Borges A., Vásquez-Suárez A., Op den Camp H.J., Chadee-Burgos R.I., Romero-Bellorín M., Espinoza J., De Sousa-Insana L., Pino-García O. Differences in venom toxicity and antigenicity between females and males Tityus nororientalis (Buthidae) scorpions. J. Venom Res. 2010, 1:61-70.
15. Eickstedt V.R.D., Ribeiro L.A., Candido D.M., Albuquerque M.J., Jorge M.T. Evolution of scorpionism by Tityus bahiensis (PERTY) and Tityus serrulatus Lutz and Mello and geographical distribution of the two species in the state of São Paulo - Brazil. J. Venom. Anim. Toxin. 1996, 2(2):92-105.
16. Feldman P.D., Parveen N., Sezen S. Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat. Brain Res. 1996, 709:331-336.
17. Fletcher P.L., Fletcher M.D., Weninger K., Anderson T.E., Martin B.M. Vesicle-associated membrane protein (VAMP) cleavage by a new metalloprotease from the Brazilian scorpion Tityus serrulatus. J. Biol. Chem. 2010, 285(10):7405-7416.
18. Gazarian K.G., Gazarian T., Hernández R., Possani L.D. Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines. Vaccine 2005, 23(26):3357-3368.
19. Girish K.S., Kemparaju K. The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. Life Sci. 2007, 80(21):1921-1943.
20. Kanoo S., Deshpande S.B. Involvement of phospholipase A2 pathway for the Indian red scorpion venom-induced augmentation of cardiopulmonary reflexes elicited by phenyldiguanide. Neurosci. Lett. 2008, 440(3):242-245.
21. Kleiner D.E., Stetler-Stevenson W.G. Quantitative zymography: detection of picogram quantities of gelatinases. Anal. Biochem. 1994, 218(2):325-329.
22. Kuniyoshi A.K., Rocha M., Cajado Carvalho D., Juliano M.A., Juliano Neto L., Tambourgi D.V., Portaro F.C. Angiotensin-degrading serine peptidase: a new chymotrypsin-like activity in the venom of Bothrops jararaca partially blocked by the commercial antivenom. Toxicon 2012, 59(1):124-131.
23. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
24. Lira-da-Silva R.M., Amorim A.M., Brazil T.K. Poisonous sting by Tityus stigmurus (Scorpiones; Buthidae) in the state of Bahia, Brazil. Rev. Soc. Bras. Med. Trop. 2000, 33(3):239-245.
25. Lourenço W.R. Parthenogenesis in scorpions: some history - new data. J. Venom. Anim. Toxins incl. Trop. Dis. 2008, 14(1):19-44.
26. Ma Y., He Y., Zhao R., Wu Y., Li W., Cao Z. Extreme diversity of scorpion venom peptides and proteins revealed by transcriptomic analysis: implication for proteome evolution of scorpion venom arsenal. J. Proteomic 2012, 75:1563-1576.
27. Mika J., Obara I., Przewlocka B. The role of nociceptin and dynorphin in chronic pain: implications of neuro-glial interaction. Neuropeptides 2011, 45(4):247-261.
28. Ministério da Saúde Manual de diagnóstico e tratamento de acidentes por animais peçonhentos, Fundação Nacional de Saúde/Coordenação de Controle de Zoonoses e Animais Peçonhentos 2001, CENEPI, Brasília.
29. Morgenstern D., Rohde B.H., King G.F., Tal T., Sher D., Zlotkin E. The tale of a resting gland: transcriptome of a replete venom gland from the scorpion Hottentotta judaicus. Toxicon 2011, 57(5):695-703.
30. Pessini A.C., Takao T.T., Cavalheiro E.C., Vichnewski W., Sampaio S.V., Giglio J.R., Arantes E.C. A hyaluronidase from Tityus serrulatus scorpion venom: isolation, characterization and inhibition by flavonoids. Toxicon 2001, 39(10):1495-1504.
31. Porto T.J., Brazil T.K., Lira-da-Silva R.M. Scorpions, state of Bahia, northeastern Brazil. Check List 2010, 6(2):292-297.
32. + channels. Eur. J. Biochem. 1999, 264:287-300.
33. Possani L.D., Merino E., Corona M., Bolivar F., Becerril B. Peptides and genes coding for scorpion toxins that affect ion-channels. Biochimie 2000, 82(9-10):861-868.
34. 2 degradation of phosphatidylcholine at physiological pH. J. Biochem. Biophys. Methods 2007, 70(3):441-444.
35. Pukrittayakamee S., Warrell D.A., Desakorn V., McMichael A.J., White N.J., Bunnag D. The hyaluronidase activities of some Southeast Asian snake venoms. Toxicon 1988, 26(7):629-637.
36. Queiroz G.P., Pessoa L.A., Portaro F.C., Furtado M.F., Tambourgi D.V. Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus. Toxicon 2008, 52(8):842-851.
37. Ribeiro-Guimarães M.L., Marengo E.B., Tempone A.J., Amaral J.J., Klitzke C.F., Silveira E.K.X., Portaro F.C.V., Pessolani M.C.V. Cloning, expression and characterisation of an HtrA-like serine protease produced invivo by Mycobacterium leprae. Mem. Inst. Oswaldo Cruz, Rio de Janeiro 2009, 104(8):1132-1138.
38. Rodríguez de la Vega R.C., Schwartz E.F., Possani L.D. Mining on scorpion venom biodiversity. Toxicon 2010, 56:1155-1161.
39. Salzet M. Neuroimmunology of opioids from invertebrates to human. Neuro. Endocrinol. Lett. 2001, 22(6):467-474.
40. Seyedian R., Pipelzadeh M.H., Jalali A., Kim E., Lee H., Kang C., Cha M., Sohn E.T., Jung E.S., Rahmani A.H., Mirakabady A.Z. Enzymatic analysis of Hemiscorpius lepturus scorpion venom usingzymography and venom-specific antivenin. Toxicon 2010, 56(4):521-525.
41. Soares M.R., Azevedo C.S., De Maria M. Scorpionism in Belo Horizonte, MG: a retrospective study. Rev. Soc. Bras. Med. Trop. 2002, 35(4):359-363.
42. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. U. S. A. 1979, 76:4350-4354.
43. 2?. Biochimie 2000, 82(9-10):815-831.
44. Wu X.S., Jian X.C., Yin B., He Z.J. Development of the research on the application of chlorotoxin in imaging diagnostics and targeted therapies for tumors. Chin. J. Cancer 2010, 29(6):626-630.
45. Zeng X., Wang S., Nie Y., Zhanga L., Luo X. Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides. Peptides 2012, 33:44-51.
46. Zhao R., Dai H., Qiu S., Li T., He Y., Ma Y., Chen Z., Wu Y., Li W., Cao Zhijian SdPI, the first functionally characterized kunitz-type trypsin inhibitor from scorpion venom. PLoS ONE 2011, 6:e27548.