A hyaluronidase from Tityus serrulatus scorpion venom: Isolation, characterization and inhibition by flavonoids

Toxicon

Volumn 39, Issue 10, 2001, Pages 1495-1504

  Pessini, Andréa C ^a   Takao, Tânia T ^a   Cavalheiro, Elisângela C ^a   Vichnewski, Walter ^a   Sampaio, Suely V ^a   Giglio, José R ^a   Arantes, Eliane C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Flavonoid; Hyaluronidase; Scorpion venom; Serum enzymes; T. serrulatus

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; FLAVANOID; HYALURONIDASE; LACTATE DEHYDROGENASE; SCORPION VENOM; TITYUS TOXIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME PURIFICATION; ION EXCHANGE CHROMATOGRAPHY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TEMPERATURE SENSITIVITY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHROMATOGRAPHY, ION EXCHANGE; CREATINE KINASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLAVONOIDS; HEAT; HYALURONIC ACID; HYALURONOGLUCOSAMINIDASE; HYDROGEN-ION CONCENTRATION; INSECT PROTEINS; KINETICS; L-LACTATE DEHYDROGENASE; MALE; MOLECULAR WEIGHT; NEUROTOXINS; RATS; RATS, WISTAR; SCORPION VENOMS; SCORPIONS; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

SCORPIONES; TITYUS SERRULATUS;

EID: 0034900149     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00122-2     Document Type: Article

References (42)

1. A simplified procedure for the fractionation of Tityus serrulatus venom: Isolation and partial characterization of TsTX-IV, a new neurotoxin
2. Toxins and genes isolated from scorpions of the genus Tityus
3. Signs, symptoms and treatment of severe scorpion sting in children
4. Óbitos por escorpionismo no Brasil (1990-1993)
5. Molecular mass determination and assay of venom hyaluronidases by sodium dodecyl sulfate-poliacrylamide gel electrophoresis
6. Effects of adjuvant hyaluronidase in tumors refractory to chemotherapy. Review of the literature and pharmacokinetics of cisplatin after regional administration in animals and humans
7. Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin Tityustoxin-I
8. Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers
9. Severe scorpion envenomation in Brazil. Clinical, laboratory and anatomopathological aspects
10. Studies on a certain spreading factor existing in bacteria and its significance for bacterial invasiveness
11. Structure/activity studies of flavonoids as inhibitors of cAMP PDE and relationship to quantum chemical indices
12. Hyalulonidase polymorphism detected by polyacrylamide gel electrophoresis. Application to hyaluronidases from bacteria, slime molds, bee and snake venoms, bovine testes, rat liver lysosomes, and human serum
13. Approaches to the treatment of Scorpion envenoming
14. What is the treatment for the cardiovascular manifestations of scorpion envenomation?
15. Nature, distribution and function of plant flavonoids
16. Flavonoids, a class of natural products of high pharmacological potency
17. Reversible cardiomyopathy in patients with severe scorpion envenoming by Tityus serrulatus: Evolution of enzymatic, electrocardiographic and echocardiographic alterations
18. Experimental treatment protocols for scorpion envenomation: A review of common therapies and an effect of kallikrein-kinin inhibitors
19. Enzymes in snake venom
20. Toxin γ of the scorpion Tityus serrulatus modifies both activation and inactivation of sodium permeability of nerve membrane
21. Inhibitory effects of hydrangenol derivatives on the activation of hyaluronidase and their antiallergic activities
22. A note on the spectrophotometric assay of glutamic oxalacetic transaminase in human blood serum
23. Recommended methods for determination of four enzymes in blood
24. The purification and characterization of hyaluronidase from the venom of the honey bee, Apis mellifera
25. Hyaluronidases - A group of neglected enzymes
26. Inhibitory effects of flavonoids on several venom hyaluronidases
27. Structure-activity studies of flavonoids as inhibitors of hyaluronidase
28. Cleavage of structural protein during the assembly of the head of bacteriophage "T4"
29. Hyaluronidase and its substrate: Biochemistry, biological activities and therapeutic uses
30. A spectrophotometric method for the determination of creatine phosphokinase and myokinase
31. 50 stimation
32. Purification and partial characterization of hyaluronidase from stonefish (Synanceja horrida) venom
33. Purification and properties of mammalian toxins from the Brazilian scorpion Tityus serrulatus Lutz and Mello
34. The hyaluronidase activities of some Southeast Asian snake venoms
35. Body distribution of Tityus serrulatus scorpion venom in mice and effects of scorpion antivenom
36. 2IV from Tityus serrulatus scorpion venom
37. Pharmacokinetics of Tityus serrulatus scorpion venom determined by enzyme-linked immunosorbent assay in the rat
38. Characterization of lizard venom hyaluronidase and evidence for its action as a spreading factor
39. The effect of Tityus serrulatus scorpion toxin on Na channels in neuroblastoma cells
40. Eupatorium cannabinum L. A review emphasizing the sesquiterpene lactones and their biological activity
41. Purification and partial characterization of hyaluronidase from five pace snake (Agkistrodon acutus) venom