Obstructive Sleep Apnea Is a Predictor of Abnormal Glucose Metabolism in Chronically Sleep Deprived Obese Adults

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Cizza, Giovanni ^a   Piaggi, Paolo ^b   Lucassen, Eliane A ^a,c   de Jonge, Lilian ^a   Walter, Mary ^a   Mattingly, Megan S ^a   Kalish, Heather ^d   Csako, Gyorgy ^e   Rother, Kristina I ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY HOSPITAL OF PISA   (Italy)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d National Institute for Biomedical Imaging and Bioengineering   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CORTICOTROPIN; CYTOKINE; GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CHRONIC DISEASE; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DISORDERS OF CARBOHYDRATE METABOLISM; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PREDICTIVE VALUE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RESPIRATORY DISTURBANCE INDEX; SLEEP; SLEEP DEPRIVATION; SLEEP DISORDERED BREATHING; SLEEP QUALITY; SLEEP TIME;

ADRENOCORTICOTROPIC HORMONE; ADULT; BLOOD GLUCOSE; C-REACTIVE PROTEIN; CROSS-SECTIONAL STUDIES; CYTOKINES; FASTING; FEMALE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; PROSPECTIVE STUDIES; QUESTIONNAIRES; RISK FACTORS; SLEEP; SLEEP APNEA, OBSTRUCTIVE; SLEEP DEPRIVATION;

EID: 84878455471     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065400     Document Type: Article

References (31)

1. Cizza G, Skarulis M, Mignot E, (2005) A link between short sleep and obesity: building the evidence for causation. Sleep 10: 1217-20.
2. Punjabi NM, Sorking JD, Katzel LI, Goldberg AP, Schwarts AR, et al. (2002) Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 165: 677-82.
3. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, et al. (2000) Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance and hypercytokinemia. J Clin Endocrinol Metab 85: 1151-1158.
4. Young T, Palta M, Dempsey J, Skatrud J, Weber S, et al. (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328: 1230-1235.
5. Tassone F, Lanfranco F, Gianotti L, Pivetti S, Navone F, et al. (2003) Obstructive sleep apnoea syndrome impairs insulin sensitivity independently of anthropometric variables. Clin endocrinol (Oxf) 59: 374-379.
6. Pamidi S, Wroblewski K, Broussard J, Day A, Hanlon EC, et al. (2012) Obstructive sleep apnea in young lean men: impact on insulin sensitivity and secretion. Diabetes Care. 35: 2384-9.
7. Spiegel K, Leproult R, Van Cauter E, (1999) Impact of sleep debt on metabolic and endocrine function. Lancet 354: 1435-39.
8. Spiegel K, Leproult R, L'Hermite-Baleriaux M, Copinschi G, Penev PD, et al. (2004) Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab 89: 5762-5771.
9. Stamatakis KA, Punjabi NM, (2010) Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest 137: 95-101.
10. Cizza G, Marincola P, Mattingly M, Williams L, Mitler M, et al. (2010) Treatment of obesity with extension of sleep duration: a randomized, prospective, controlled trial. Clin Trials 7: 274-85.
11. Yao J, Sussman DL, Summers RM, (2011) Fully automated adipose tissue measurement on abdominal CT. Proceedings of SPIE 7965: 7965Z.
12. Knutson KL, Zhao X, Mattingly M, Galli G, Cizza G, (2012) Predictors of sleep-disordered breathing in obese adults who are chronic short sleepers. Sleep Med 13: 484-9.
13. Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28: 193-213.
14. Johns MW, (1991) A new method for measuring daytime sleepiness: The Epworth Sleepiness Scale. Sleep 14: 540-5.
15. Ayappa I, Norman RG, Seelall V, Rapoport DM, (2008) Validation of a self-applied unattended monitor for sleep disordered breathing. J Clin Sleep Med 4: 26-37.
16. Westbrook PR, Levendowski DJ, Cvetinovic M, Zavora T, Velimirovic V, et al. (2005) Description and validation of the apnea risk evaluation system: a novel method to diagnose sleep apnea-hypopnea in the home. Chest 128: 2166-2175.
17. Tasali E, Mokhlesi B, Van Cauter E, (2008) Obstructive sleep apnea and type 2 diabetes: interacting epidemics. Chest. 133: 496-506.
18. Louis M, Punjabi NM, (2009) Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J Appl Physiol. 106: 1538-44.
19. Peltier AC, Bagai K, Artibee K, Diedrich A, Garland E, et al. (2012) Effect of mild hyperglycemia on autonomic function in obstructive sleep apnea. Clin Auton Res. 22: 1-8.
20. Kelly KR, Williamson DL, Fealy CE, Kriz DA, Krishnan RK, et al. (2010) Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans. Metabolism. 59: 200-5.
21. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, et al. (1997) Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab. 82: 1313-6.
22. Cizza G, Eskandari F, Coyle M, Krishnamurthy P, Wright EC, et al. (2009) Plasma CRP levels in premenopausal women with major depression: a 12-month controlled study. Horm Metab Res. 41: 641-8.
23. O'Rourke RW, White AE, Metcalf MD, Olivas AS, Mitra P, et al. (2011) Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells. Diabetologia. 54: 1480-90.
24. Van Cauter E, Latta F, Nedeltcheva A, Spiegel K, Leproult R, et al. (2004) Reciprocal interactions between the GH axis and sleep. Growth Horm IGF Res. 4 Jun; 14 Suppl A: S10-7.
25. Fredheim JM, Rollheim J, Omland T, Hofsø D, Røislien J, et al. (2011) Type 2 diabetes and pre-diabetes are associated with obstructive sleep apnea in extremely obese subjects: a cross-sectional study. Cardiovasc Diabetol. 10: 84.
26. Lam JC, Tan KC, Lai AY, Lam DC, Ip MS, (2012) Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea. Sleep Med. 1: 15-20.
27. Van Cauter E, (2011) Sleep disturbances and insulin resistance. Diabet Med. 28: 1455-62.
28. Gruber A, Horwood F, Sithole J, Ali NJ, Idris I, (2006) Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state. Cardiovasc Diabetol 5: 22.
29. Papaioannou I, Patterson M, Twigg GL, Vazir A, Ghatei M, et al. (2011) Lack of association between impaired glucose tolerance and appetite regulating hormones in patients with obstructive sleep apnea. J Clin Sleep Med 7: 486-92B.
30. Li R, Zhang P, Barker LE, Chowdhury FM, Zhang X, (2010) Cost-effectiveness of interventions to prevent and control diabetes mellitus: a systematic review. Diabetes Care. 33: 1872-94.
31. Pietzsch JB, Garner A, Cipriano LE, Linehan JH, (2011) An integrated health-economic analysis of diagnostic and therapeutic strategies in the treatment of moderate-to-severe obstructive sleep apnea. Sleep. 34: 695-709.