Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans

Metabolism: Clinical and Experimental

Volumn 59, Issue 2, 2010, Pages 200-205

  Kelly, Karen R ^a,b   Williamson, David L ^c   Fealy, Ciarán E ^a   Kriz, David A ^d   Krishnan, Raj K ^d   Huang, Hazel ^a   Ahn, Janice ^b   Loomis, Joseph L ^d   Kirwan, John P ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C REACTIVE PROTEIN; GLUCOSE; INSULIN; LACTIC ACID; LEPTIN;

ADRENALIN BLOOD LEVEL; ADULT; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; HYPOXIA; INSULIN RELEASE; LACTATE BLOOD LEVEL; MALE; METABOLIC REGULATION; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; ALTITUDE; ANOXIA; BLOOD GLUCOSE; C-PEPTIDE; EPINEPHRINE; FEMALE; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; LACTIC ACID; LEPTIN; MALE; SOLUTIONS;

EID: 74049142850     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.07.014     Document Type: Article

References (39)

1. Jun J., and Polotsky V.Y. Metabolic consequences of sleep-disordered breathing. ILAR J 50 (2009) 289-306
2. Berger M., Hagg S.A., Goodman M.N., and Ruderman N.B. Glucose metabolism in perfused skeletal muscle. Biochem J 158 (1976) 191-202
3. Cartee G.D., Douen A.G., Ramlal T., Klip A., and Holloszy J.O. Stimulation of glucose transport in skeletal muscle by hypoxia. J Appl Physiol 70 (1991) 1593-1600
4. Holloszy J.O. Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol 99 (2005) 338-343
5. Holloszy J.O., and Narahara H.T. Enhanced permeability to sugar associated with muscle contraction. Studies of the role of Ca++. J Gen Physiol 50 (1967) 551-562
6. Constable S.H., Favier R.J., Cartee G.D., Young D.A., and Holloszy J.O. Muscle glucose transport: interactions of in vitro contractions, insulin, and exercise. J Appl Physiol 64 (1988) 2329-2332
7. Ploug T., Galbo H., Vinten J., Jorgensen M., and Richter E.A. Kinetics of glucose transport in rat muscle: effects of insulin and contractions. Endocrinol Metab 253 (1987) E12-E20
8. Youn J.H., Gulve E.A., Henriksen E.J., and Holloszy J.O. Interactions between effects of W-7, insulin, and hypoxia on glucose transport in skeletal muscle. Am J Physiol 267 (1994) R888-R894
9. Youn J.H., Gulve E.A., and Holloszy J.O. Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol 260 (1991) C555-561
10. Douen A.G., Ramlal T., Rastogi S., Bilan P.J., Cartee G.D., Vranic M., et al. Exercise induces recruitment of the "insulin-responsive glucose transporter." Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle. J Biol Chem 265 (1990) 13427-13430
11. Kirwan J.P., del Aguila L.F., Hernandez J.M., Williamson D.L., O'Gorman D.J., Lewis R., et al. Regular exercise enhances insulin activation of IRS-1 associated PI3-kinase in human skeletal muscle. J Appl Physiol 88 (2000) 797-803
12. White M.F., and Kahn C.R. The insulin signaling system. J Biol Chem 269 (1994) 1-4
13. Azevedo Jr. J.L., Carey J.O., Pories W.J., Morris P.G., and Dohm G.L. Hypoxia stimulates glucose transport in insulin-resistant human skeletal muscle. Diabetes 44 (1995) 695-698
14. Stickney J.C., Northup D.W., and Van Liere E.J. Blood sugar and dextrose tolerance during anoxia in the dog. Am J Physiol 154 (1948) 423-427
15. Wright D.C., Geiger P.C., Holloszy J.O., and Han D.H. Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle. Am J Physiol Endocrinol Metab 288 (2005) E1062-E1066
16. Rowell L.B., Johnson D.G., Chase P.B., Comess K.A., and Seals D.R. Hypoxemia raises muscle sympathetic activity but not norepinephrine in resting humans. J Appl Physiol 66 (1989) 1736-1743
17. Wolfel E.E., Groves B.M., Brooks G.A., Butterfield G.E., Mazzeo R.S., Moore L.G., Sutton J.R., Bender P.R., Dahms T.E., McCullough R.E., et al. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J Appl Physiol 70 (1991) 1129-1136
18. Campfield L.A., Smith F.J., Guisez Y., Devos R., and Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science (Wash DC) 269 (1995) 546-549
19. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., et al. Weight reducing effects of the plasma protein encoded by the obese gene. Science (Wash DC) 269 (1995) 543-546
20. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science (Wash DC) 269 (1995) 540-543
21. Muoio D.M., Dohm G.L., Fiedorek F.T., Tapscott E.B., and Coleman R.A. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46 (1997) 1360-1363
22. Shimabukuro M., Koyama K., Chen G., Wang M.-Y., Trieu F., Lee Y., et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci 94 (1997) 4637-4641
23. Solomon T.P., Sistrun S.N., Krishnan R.K., Del Aguila L.F., Marchetti C.M., O'Carroll S.M., et al. Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults. J Appl Physiol 104 (2008) 1313-1319
24. Sierra-Johnson J., Romero-Corral A., Somers V.K., and Johnson B.D. Effect of altitude on leptin levels, does it go up or down?. J Appl Physiol 105 (2008) 1684-1685
25. Shukla V., Singh S.N., Vats P., Singh V.K., Singh S.B., and Banerjee P.K. Ghrelin and leptin levels of sojourners and acclimatized lowlanders at high altitude. Nutr Neurosci 8 (2005) 161-165
26. Fritsche A., Wahl H.G., Metzinger E., Renn W., Kellerer M., Haring H., et al. Evidence for inhibition of leptin secretion by catecholamines in man. Exp Clin Endocrinol Diabetes 106 (1998) 415-418
27. Zaccaria M., Ermolao A., Bonvicini P., Travain G., and Varnier M. Decreased serum leptin levels during prolonged high altitude exposure. Eur J Appl Physiol 92 (2004) 249-253
28. Hjemdahl P., Daleskog M., and Kahan T. Determination of plasma catecholamines by high performance liquid chromatography with electrochemical detection: comparison with a radioenzymatic method. Life Sciences 25 (1979) 131-138
29. Kirwan J.P., O'Gorman D., and Evans W.J. A moderate glycemic meal before endurance exercise can enhance performance. J Appl Physiol 84 (1998) 53-59
30. Lowry O.H., and Passoneau J.V. A flexible system of enzymatic analysis (1972), Academic, New York
31. Oltmanns K.M., Gehring H., Rudolf S., Schultes B., Rook S., Schweiger U., et al. Hypoxia causes glucose intolerance in humans. Am J Respir Crit Care Med 169 (2004) 1231-1237
32. Larsen J.J., Hansen J.M., Olsen N.V., Galbo H., and Dela F. The effect of altitude hypoxia on glucose homeostasis in men. J Physiol 504 Pt 1 (1997) 241-249
33. Lager I., Attvall S., Eriksson B.M., von Schenk H., and Smith U. Studies on the insulin-antagonistic effect of catecholamines in normal man. Evidence for the importance of beta 2-receptors. Diabetologia 29 (1986) 409-416
34. Braun B., Butterfield G.E., Dominick S.B., Zamudio S., McCullough R.G., Rock P.B., et al. Women at altitude: changes in carbohydrate metabolism at 4,300-m elevation and across the menstrual cycle. J Appl Physiol 85 (1998) 1966-1973
35. Mazzeo R.S., Bender P.R., Brooks G.A., Butterfield G.E., Groves B.M., Sutton J.R., et al. Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am J Physiol 261 (1991) E419-E424
36. Mazzeo R.S., Child A., Butterfield G.E., Mawson J.T., Zamudio S., and Moore L.G. Catecholamine response during 12 days of high-altitude exposure (4, 300 m) in women. J Appl Physiol 84 (1998) 1151-1157
37. Laakso M., Edelman S.V., Brechtel G., and Baron A.D. Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow. Am J Physiol 263 (1992) E199-E204
38. Landt M., Lawson G.M., Helgeson J.M., Davila-Roman V.G., Ladenson J.H., Jaffe A.S., et al. Prolonged exercise decreases serum leptin concentrations. Metabolism 46 (1997) 1109-1112
39. Barkoukis H., Marchetti C.M., Nolan B., Sistrun S.N., Krishnan R.K., and Kirwan J.P. A high glycemic meal suppresses the postprandial leptin response in normal healthy adults. Ann Nutr Metab 51 (2007) 512-518