INOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation

Biochemical and Biophysical Research Communications

Volumn 435, Issue 2, 2013, Pages 244-249

  Park, Young Ho ^a,b,e   Shin, Hye Jun ^a   Kim, Sun Uk ^a,b,e   Kim, Jin Man ^c   Kim, Joo Hyun ^a   Bang, Dong Ho ^d   Chang, Kyu Tae ^b   Kim, Bo Yeon ^b   Yu, Dae Yeul ^a,e  

^a Research Center   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Chungnam National University   (South Korea)

^d Wonkwang University School of Medicine   (South Korea)

^e University of Science and Technology (UST)   (South Korea)

Author keywords

HBx; Hepatocellular carcinoma; INOS; JNK

Indexed keywords

CRE RECOMBINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; HEPATITIS B VIRUS X PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ACTIVATION; GENE DELETION; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN FUNCTION; TUMOR VOLUME; UPREGULATION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; ENZYME ACTIVATION; LIVER NEOPLASMS; MAP KINASE KINASE 4; MICE; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; UP-REGULATION;

HEPATITIS B VIRUS; MUS; MUS MUSCULUS;

EID: 84878432240     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.071     Document Type: Article

References (28)

1. Tiollais P., Pourcel C., Dejean A. The hepatitis B virus. Nature 1985, 317:489-495.
2. Bosch F.X., Ribes J., Diaz M., Cleries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004, 127:S5-S16.
3. Feitelson M.A., Duan L.X. Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma. Am. J. Pathol. 1997, 150:1141-1157.
4. Zhu H., Wang Y., Chen J., Cheng G., Xue J. Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis. Exp. Mol. Pathol. 2004, 76:44-50.
5. Yu D.Y., Moon H.B., Son J.K., Jeong S., Yu S.L., Yoon H., Han Y.M., Lee C.S., Park J.S., Lee C.H., Hyun B.H., Murakami S., Lee K.K. Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J. Hepatol. 1999, 31:123-132.
6. Gearhart T.L., Bouchard M.J. The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication. J. Virol. 2010, 84:2675-2686.
7. Kim J.Y., Song E.H., Lee H.J., Oh Y.K., Choi K.H., Yu D.Y., Park S.I., Seong J.K., Kim W.H. HBx-induced hepatic steatosis and apoptosis are regulated by TNFR1- and NF-kappaB-dependent pathways. J. Mol. Biol. 2010, 397:917-931.
8. Bui-Nguyen T.M., Pakala S.B., Sirigiri D.R., Martin E., Murad F., Kumar R. Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator. J. Biol. Chem. 2010, 285:6980-6986.
9. Geller D.A., Nussler A.K., Di Silvio M., Lowenstein C.J., Shapiro R.A., Wang S.C., Simmons R.L., Billiar T.R. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. USA 1993, 90:522-526.
10. Kleinert H., Schwarz P.M., Forstermann U. Regulation of the expression of inducible nitric oxide synthase. Biol. Chem. 2003, 384:1343-1364.
11. Lala P.K., Chakraborty C. Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol. 2001, 2:149-156.
12. Leifeld L., Fielenbach M., Dumoulin F.L., Speidel N., Sauerbruch T., Spengler U. Inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) expression in fulminant hepatic failure. J. Hepatol. 2002, 37:613-619.
13. Spruss A., Kanuri G., Uebel K., Bischoff S.C., Bergheim I. Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice. Antioxid. Redox Signalling 2011, 14:2121-2135.
14. Calvisi D.F., Pinna F., Ladu S., Pellegrino R., Muroni M.R., Simile M.M., Frau M., Tomasi M.L., De Miglio M.R., Seddaiu M.A., Daino L., Sanna V., Feo F., Pascale R.M. Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease. Carcinogenesis 2008, 29:1639-1647.
15. McNaughton L., Puttagunta L., Martinez-Cuesta M.A., Kneteman N., Mayers I., Moqbel R., Hamid Q., Radomski M.W. Distribution of nitric oxide synthase in normal and cirrhotic human liver. Proc. Natl. Acad. Sci. USA 2002, 99:17161-17166.
16. Garcia-Monzon C., Majano P.L., Zubia I., Sanz P., Apolinario A., Moreno-Otero R. Intrahepatic accumulation of nitrotyrosine in chronic viral hepatitis is associated with histological severity of liver disease. J. Hepatol. 2000, 32:331-338.
17. Shin H.J., Park Y.H., Kim S.U., Moon H.B., Park do S., Han Y.H., Lee C.H., Lee D.S., Song I.S., Lee D.H., Kim M., Kim N.S., Kim D.G., Kim J.M., Kim S.K., Kim Y.N., Kim S.S., Choi C.S., Kim Y.B., Yu D.Y. Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J. Biol. Chem. 2011, 286:29872-29881.
18. Aram G., Potter J.J., Liu X., Torbenson M.S., Mezey E. Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration. Hepatology 2008, 47:2051-2058.
19. Fan X., Roy E., Zhu L., Murphy T.C., Kozlowski M., Nanes M.S., Rubin J. Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion. J. Biol. Chem. 2003, 278:10232-10238.
20. Maguire H.F., Hoeffler J.P., Siddiqui A. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 1991, 252:842-844.
21. Riccio A., Alvania R.S., Lonze B.E., Ramanan N., Kim T., Huang Y., Dawson T.M., Snyder S.H., Ginty D.D. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell. 2006, 21:283-294.
22. Das M., Garlick D.S., Greiner D.L., Davis R.J. The role of JNK in the development of hepatocellular carcinoma. Genes Dev. 2011, 25:634-645.
23. Villalobo A. Nitric oxide and cell proliferation. FEBS J. 2006, 273:2329-2344.
24. Custro N., Carroccio A., Ganci A., Scafidi V., Campagna P., Di Prima L., Montalto G. Glycemic homeostasis in chronic viral hepatitis and liver cirrhosis. Diabetes Metab. 2001, 27:476-481.
25. Klein A., Guhl E., Tzeng Y.J., Fuhrhop J., Levrero M., Graessmann M., Graessmann A. HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53. Oncogene 2003, 22:2910-2919.
26. Matsuda Y., Ichida T. Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis. Med. Mol. Morphol. 2009, 42:138-142.
27. Schwabe R.F., Bradham C.A., Uehara T., Hatano E., Bennett B.L., Schoonhoven R., Brenner D.A. C-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003, 37:824-832.
28. Yano M., Ohkoshi S., Aoki Y.H., Takahashi H., Kurita S., Yamazaki K., Suzuki K., Yamagiwa S., Sanpei A., Fujimaki S., Wakai T., Kudo S.E., Matsuda Y., Aoyagi Y. Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up-regulation of cytoplasmic p21 expression. Liver Int. 2013, 10.1111/liv.12176.