Effective melanoma inhibition by synthetic pentacyclic triterpenoid 2-(3-phenylprop-2-en-1-ylidene)-22β-hydroxy-3-oxoolean-12-en-28-oic acid: An in vitro and in vivo study

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 32, Issue 1, 2013, Pages 59-72

  Tailor, Navin Kumar ^a   Lee, Hong Boon ^b   Sharma, Manu ^a  

^a JAYPEE UNIVERSITY OF INFORMATION TECHNOLOGY   (India)

^b Drug Discovery Laboratory   (Malaysia)

Author keywords

Apoptosis; Bax; Bcl 2; c jun; C57BL 6 mice; Caspase 3; Lantadene A; NF B

Indexed keywords

2 (3 PHENYLPROP 2 EN 1 YLIDENE) 22BETA HYDROXY 3 OXOOLEAN 12 EN 28 OIC ACID; 22BETA [(2 METHYL 1 OXO 2 BUTENYL)OXY] 3 OXOOLEAN 12 EN 28 OIC ACID; ANTINEOPLASTIC AGENT; BETA ACTIN; CASPASE 3; CISPLATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INDUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; MALE; MELANOMA; MICE; MICE, INBRED C57BL; NF-KAPPA B; OLEANOLIC ACID; PENTACYCLIC TRITERPENES; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-JUN; SKIN NEOPLASMS; SURVIVAL RATE; TRANSPLANTATION, HOMOLOGOUS; VERO CELLS;

MUS;

EID: 84878430251     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.2013007125     Document Type: Article

References (24)

1. Abelson PH. Medicine from plants. Science. 1990; 247: 513.
2. Stepp JR, Moerman DE. The importance of weeds in ethnopharmacology. J Ethnopharmacol. 2001; 75: 25-31.
3. Ghisalberti EL. Lantana camara L. (Verbenaceae). Fitoterapia. 2000; 71: 467-86.
4. Inada A, Nakanishi T, Tokuda H, Nishino H, Iwashina A, Sharma OP. Inhibitory effects of Lantadenes and related triterpenoids on Epstein-Barr virus activation. Planta Medica. 1995; 61: 558-9.
5. Inada A, Nakanishi T, Tokuda H, Nishino H, Iwashina A, Sharma OP. Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors. Planta Medica. 1997; 63: 272-4.
6. Kaur J, Sharma M, Sharma PD, Bansal MP. Chemopreventive activity of lantadenes on two-stage carcinogenesis model in Swiss albino mice: AP-1 (c-jun), NF k{cyrillic}B (p65) and p55 expression by ELISA and immunohistochemical localization. Mole Cell Biol. 2008; 314: 1-8.
7. Kaur J, Sharma M, Sharma PD, Bansal MP. Antitumor activity of Lantadenes in DMBA/TPA induced skin tumors in mice: Expression of transcription factors. American J Biomed Sci. 2010; 2: 79-90.
8. Sharma M, Sharma PD, Bansal MP, Singh J. Lantadene A-induced apoptosis in human leukemia HL-60 cells. Ind J Pharmacol. 2007; 39: 140-4.
9. The 60-cell line test data of National Cancer Institute are accessible from the NSC numbers. http://dtp.nci.nih.gov/dtpstandard/dwindex/index.jsp
10. Sharma M, Sharma PD, Bansal MP. Lantadenes and their esters as potential antitumor agents. J Nat Prod. 2008; 71: 1222-7.
11. Sharma M, Sharma PD, Bansal MP, Singh J. Synthesis, cytotoxicity and antitumor activity of lantadene A congener. Chem Biodiversity. 2007; 4: 932-9.
12. Sharma M, Sharma PD, Bansal MP. Synthesis and antitumor activity of novel pentacyclic triterpenoid Lantadene D. Letts Drug Design Discov. 2007; 4: 201-6.
13. Sharma M, Rakhi A, Dalal N, Sharma N. Design, synthesis and evaluation of lantadene A congener with hydroxyl functionality in ring A as an antitumour agent. Nat Prod Res. 2011; 25: 387-396.
14. Sharma M, Sharma PD. Optimization of lantadene isolation and preparation of 22β-hydroxy oleanonic acid. Chem Nat Comp. 2006; 42: 442-4.
15. Shoemaker RH. The NCI 60 human tumour cell line anticancer drug screen. Nat Rev Cancer. 2006; 6: 813-23.
16. Smith J, Williams GT, Kingston R, Jenkison EJ, Owen JJ. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (Lond). 1989; 337: 181-4.
17. Ban HS, Lee SH, Kim YP, Yamaki K, Shin KH, Ohuchi K. Inhibition of prostaglandin E2 production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action. Biochem Pharmacol. 2002; 64: 1345-54.
18. Stark AA, Hochman J, Levy E Barr-Nea L, Goldschmied-Reouven A, Amizur M. Gamma-glutamyl transpeptidase in murine lymphomas. Eur J Cancer Clin Oncol. 1986; 22:77-87.
19. Fock RA, Vinolo MA, Crisma AR, Nakajima K, Rogero MM, Borelli P. Protein energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model. J Nutr Sci Vitaminol (Tokyo). 2008; 54:371-7.
20. Lopez-Beltran A, Maclennan GT, de la Haba R, Montironi R, Cheng L. Research advances in apoptosis-mediated cancer therapy: a review. Anal Quant Cytol Histol. 2007; 29: 71-8.
21. Crawford MJ, Krishnamoorthy RR, Rudick VL, Collier RJ, Kapin M, Aggarwal BB, Al-Ubaidi MR, Agarwal N. Bcl-2 over expression protects photooxidative stress-induced apoptosis of photoreceptor cells via NF-kappaB preservation. Biochem Biophys Res Commun. 2001; 281: 1304-12.
22. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002; 4:131-6.
23. Cormier SA, Taranova AG, Bedient C, Nguyen T Protheroe C, Pero R, Dimina D, Ochkur SI, O'Neill K, Colbert D, Lombari TR, Constant S, McGarry MP, Lee JJ, Lee NA. Pivotal advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. J Leukoc Biol. 2006; 79:1131-9.
24. Giovani MF, Michel FO, Karen AO, Milton SB, Primavera Borelli Francisco EB, Durvanei AM, Daniel F, Sergio PB. Simvastatin impairs murine melanoma growth. Lipids Health Disease. 2010; 9:142-150.