Serum insulin-like growth factor I in brain function

Keio Journal of Medicine

Volumn 55, Issue 2, 2006, Pages 59-63

  Carro, Eva ^a   Torres Aleman, Ignacio ^a  

^a INSTITUTO CAJAL   (Spain)

Author keywords

Blood brain barrier; Brain; Insulin like growth factors; Neurodegenerative illness

Indexed keywords

SOMATOMEDIN C;

BLOOD BRAIN BARRIER; BLOOD FLOW; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN GROWTH; CELL ENERGY; CELL GROWTH; CELL SURVIVAL; COGNITION; HUMAN; LIVER CELL; MUSCLE; NONHUMAN; ORGAN DISTRIBUTION; OVARY; PROTEIN SYNTHESIS; REVIEW;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHOROID PLEXUS; EPITHELIUM; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MOTOR ACTIVITY; SERUM;

EID: 33745888080     PISSN: 00229717     EISSN: 00229717     Source Type: Journal    
DOI: 10.2302/kjm.55.59     Document Type: Review

References (39)

1. McRory JE, Sherwood NM: Ancient divergence of insulin and insulin-like growth factor. DNA Cell Biol 1997; 16: 939-949
2. Kenyon C: A conserved regulatory system for aging. Cell 2001; 105: 165-168
3. Porte D Jr, Baskin DG, Schwartz MW: Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C elegans to humans. Diabetes 2005; 54: 1264-1276
4. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y: IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003; 421: 182-187
5. Baker J, Liu JP, Robertson EJ, Efstratiadis A: Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993; 75: 73-82
6. Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D: Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 1999; 96: 7324-7329
7. Trejo JL, Carro E, Garcia-Galloway E, Torres-Aleman I: Role of insulin-like growth factor I signaling in neurodegenerative diseases. J Mol Med 2004; 82: 156-162
8. Kastin AJ, Pan W, Maness LM, Banks WA: Peptides crossing the blood-brain barrier: some unusual observations. Brain Res 1999; 848: 96-100
9. Pardridge WM: Transport of insulin-related peptides and glucose across the blood-brain barrier. Ann N Y Acad Sci 1993; 692: 126-137
10. Zlokovic BV: Neurovascular mechanisms of Alzheimer's neuro-degeneration. Trends Neurosci 2005; 28: 202-208
11. Lee WH, Michels KM, Bondy CA: Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: correlation with insulin-like growth factors I and II. Neuroscience 1993; 53: 251-265
12. Carro E, Nunez A, Busiguina S, Torres-Aleman I: Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci 2000; 20: 2926-2933
13. Carro E, Trejo JL, Spuch C, Bohl D, Heard JM, Torres-Aleman I: Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: New cues into the human disease? Neurobiology of Aging. In press. Advanced on-line publication
14. Garcia-Segura LM, Rodriguez JR, Torres-Aleman I: Localization of the insulin-like growth factor I receptor in the cerebellum and hypothalamus of adult rats: an electron microscopic study. J Neurocytol 1997; 26: 479-490
15. Lopez-Lopez C, LeRoith D, Torres-Aleman I: Insulin-like growth factor I is required for vessel remodeling in the adult brain. Proc Natl Acad Sci USA 2004; 101: 9833-9838
16. Sonntag WE, Lynch CD, Bennett SA, Khan AS, Thornton PL, Cooney PT, Ingram RL, McShane T, Brunso-Bechtold JK: Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. Neuroscience 1999; 88: 269-279
17. Fernandez-Galaz MC, Torres-Aleman I, Garcia-Segura LM: Endocrine-dependent accumulation of IGF-I by hypothalamic glia. Neuroreport 1996; 8: 373-377
18. Guan J, Miller OT, Waugh KM, McCarthy DC, Gluckman PD: Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia-ischemia in rats. Neuroscience 2001; 105: 299-306
19. Ocrant I, Fay CT, Parmelee JT: Characterization of insulin-like growth factor binding proteins produced in the rat central nervous system. Endocrinology 1990; 127: 1260-1267
20. Jones JI, Clemmons DR: Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995; 16: 3-34
21. Banks WA, Jaspan JB, Kastin AJ: Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays. Peptides 1997; 18: 1257-1262
22. Bondy CA, Lee WH: Patterns of insulin-like growth factor and IGF receptor gene expression in the brain. Functional implications. Ann N Y Acad Sci 1993; 692: 33-43
23. Torres-Aleman I: Serum growth factors and neuroprotective surveillance. Mol Neurobiol 2000; 21: 153-160
24. Bach MA, Shen-Orr Z, Lowe WL, Jr., Roberts CT, Jr., LeRoith D: Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain. Mol Brain Res 1991; 10: 43-48
25. Nunez A, Carro E, Torres-Aleman I: Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons. J Neurophysiol 2003; 89: 3008-3017
26. Trejo JL, Carro E, Torres-Aleman I: Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J Neurosci 2001; 21: 1628-1634
27. Carro E, Trejo JL, Busiguina S, Torres-Aleman I: Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci 2001; 21: 5678-5684
28. Carro E, Trejo JL, Gomez-Isla T, LeRoith D, Torres-Aleman I: Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med 2002; 8: 1390-1397
29. Carro E, Trejo JL, Nunez A, Torres-Aleman I: Brain repair and neuroprotection by serum insulin-like growth factor I. Mol Neurobiol 2003; 27: 153-162
30. Eliakim A, Moromisato M, Moromisato D, Brasel JA, Roberts C, Cooper DM: Increase in muscle IGF-I protein but not IGF-I mRNA after 5 days of endurance training in young rats. Am J Physiol 1997; 273: R1557-R1561
31. Musaro A, McCullagh KJ, Naya FJ, Olson EN, Rosenthal N: IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature 1999; 400: 581-585
32. Trejo JL, Carro E, Nunez A, Torres-Aleman I: Sedentary life impairs self-reparative processes in the brain: the role of serum insulin-like growth factor-I. Rev Neurosci 2002; 13: 365-374
33. Marx J: NEUROSCIENCE: Preventing Alzheimer's: A Lifelong Commitment? Science 2005; 309: 864-866
34. Booth FW, Chakravarthy MV, Spangenburg EE: Exercise and gene expression: physiological regulation of the human genome through physical activity. J Physiol 2002; 543: 399-411
35. Cotman CW, Berchtold NC: Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci 2002; 25: 295-301
36. Kempermann G: Why new neurons? Possible functions for adult hippocampal neurogenesis. J Neurosci 2002; 22: 635-638
37. Aleman A, Verhaar HJ, de Haan EH, de Vries WR, Samson MM, Drent ML, van der Veen EA, Koppeschaar HP: Insulin-like growth factor-I and cognitive function in healthy older men. J Clin Endocrinol Metab 1999; 84: 471-475
38. Barnes CA: Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 1979; 93: 74-104
39. Bondolfi L, Ermini F, Long JM, Ingram DK, Jucker M: Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiol Aging 2004; 25: 333-340