Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis

Molecular Biology Reports

Volumn 40, Issue 4, 2013, Pages 3015-3020

  S Belforte, F ^a   Coluccio Leskow, F ^b   Poskus, E ^a   Penas Steinhardt, A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b DEPARTAMENTO DE CIENCIAS BÁSICAS   (Argentina)

Author keywords

D299G; Diabetes; Meta analysis; Metabolic syndrome; Polymorphism; TLR4

Indexed keywords

TOLL LIKE RECEPTOR 4;

ARTICLE; CAUCASIAN; CELL INTERACTION; CROHN DISEASE; DIGESTIVE SYSTEM CANCER; DISEASE ASSOCIATION; ENTERITIS; ETHNICITY; GENE FREQUENCY; GEOGRAPHIC DISTRIBUTION; HUMAN; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN POLYMORPHISM; SYSTEMATIC REVIEW; ULCERATIVE COLITIS;

DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, INNATE; INFLAMMATORY BOWEL DISEASES; INSULIN RESISTANCE; LIPOPOLYSACCHARIDES; METABOLIC SYNDROME X; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TOLL-LIKE RECEPTOR 4;

EID: 84878408426     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-2374-5     Document Type: Article

References (26)

1. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (1998) A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 95(2):588-593
2. Barton GM, Medzhitov R (2003) Toll-like receptor signaling pathways. Science 300(5625):1524-1525
3. Pickup JC, Mattock MB, Chusney GD, Burt D. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia. 1997;40(11):1286-1292. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9389420. Accessed October 21, 2012
4. Pickup JC, Crook MA (1998) Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41(10):1241-1248
5. Takeda K, Kaisho T, Akira S. Toll-like receptors. Ann Rev Immunol. 2003;21:335-376. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12524386. Accessed October 13, 2010
6. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-867. Available at: http://www.ncbi.nlm.nih.gov/pubmed/ 17167474. Accessed October 4, 2012
7. Petruzzelli M, Moschetta A. Intestinal ecology in the metabolic syndrome. Cell Metab. 2010;11(5):345-346. Available at: http://dx.doi.org/10.1016/j.cmet. 2010.04.012
8. Tsukumo D, Carvalho-Filho M, Carvalheira J et al (2007) Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56:1986-1998
9. Maldonado-Bernal C, Trejo-de la O A, Sánchez-Contreras ME, et al. Low frequency of toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes. Int J Immunogenet. 2011;38(6):519-523. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21902816. Accessed October 10, 2012
10. Arbour NC, Lorenz E, Schutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000;25(2):187-191. Available at: http://www.ncbi.nlm.nih.gov/pubmed/10835634
11. Steinhardt AP, Aranguren F, Tellechea ML, et al. A functional nonsynonymous toll-like receptor 4 gene polymorphism is associated with metabolic syndrome, surrogates of insulin resistance, and syndromes of lipid accumulation. Metabolism. 2009. Available at: http://www.ncbi.nlm.nih.gov/ pubmed/19922963
12. Ferwerda B, McCall MBB, Verheijen K, et al. Functional consequences of toll-like receptor 4 polymorphisms. Mol Med. 2008;14(5-6):346. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215765/. Accessed March 5, 2012
13. Figueroa L, Xiong Y, Song C, et al. The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF. J Immunol. 2012;188(9):4506-4515. Available at: http://www.ncbi.nlm.nih.gov/pubmed/ 22474023. Accessed November 12, 2012
14. Shen X, Shi R, Zhang H, et al. The toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: a meta-analysis. Receptor. 2010:69-77
15. Jing JJ, Li M, Yuan Y. Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in cancer: a meta-analysis. Gene. 2012;499(2):237-242. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22441122. Accessed November 12, 2012
16. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-560. Available at: http://www. pubmedcentral.nih.gov/articlerender.fcgi?artid=192859&tool= pmcentrez&rendertype=abstract. Accessed October 6, 2012
17. Petitti DB (2000) Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis in medicine, 2nd edn. Oxford University Press, New York
18. Thomas I, Friedhelm B, Andreas S, Rolf H, Sylvia M, Wolfgang R, Wolfgang K, Christa M, Wichmann HE, Hubert K, for The KORA Study Group1 2 (2003) The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome. World Health 52:1-4
19. Kolek MJ, Carlquist JF, Muhlestein JB, et al. Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes. Am Heart J. 2004;148(6):1034-1040. Available at: http://www.ncbi.nlm.nih.gov/pubmed/ 15632890. Accessed June 22, 2011
20. Bagarolli R a, Saad MJ a, Saad STO. Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with type 2 diabetes. J Diabetes Complicat. 2009;4
21. Manolakis AC, Kapsoritakis AN, Tiaka EK, et al. TLR4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease. Eur J Endocrinol/Eur Fed Endocri Soc. 2011;165(2):261-267. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21628510. Accessed October 10, 2012
22. Amyot J, Semache M, Ferdaoussi M, Fontés G, Poitout V. Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via toll-like receptor-4 and NF-κB signalling. PLoS One. 2012;7(4):e36200. Available at: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=3338606&tool=pmcentrez&rendertype=abstract. Accessed October 22, 2012
23. Ferwerda B, Mccall MBB, Alonso S et al (2007) TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. PNAS USA 104(42):16645-16650
24. Johnson GB, Riggs BL, Platt JL, Biology T, Clinic M (2004) A genetic basis for the "Adonis" phenotype of low adiposity and strong bones. FASEB J 4:1-15
25. Penas-Steinhardt A, Barcos LS, Belforte FS, de Sereday M, Vilariño J et al (2012) Functional characterization of TLR4 +3725 G/C polymorphism and association with protection against overweight. PLoS ONE 7(12):e50992. doi: 10.1371/journal.pone.0050992
26. Sato K, Yoshimura A, Kaneko T, et al. A single nucleotide polymorphism in 3′-untranslated region contributes to the regulation of toll-like receptor 4 translation. J Biol Chem. 2012;287(30):25163-25172. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22661708. Accessed November 21, 2012