Pharmacodynamic assay of thymidylate synthase activity in peripheral blood mononuclear cells

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 8, 2013, Pages 2495-2503

  Pluim, Dick ^a   Schilders, Kim A A ^a   Jacobs, Bart A W ^a   Vaartjes, Daniëlle ^a   Beijnen, Jos H ^b,c   Schellens, Jan H M ^a,c  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

3H release; PBMC; Pharmacodynamic; Thymidylate synthase activity

Indexed keywords

3H-RELEASE; LIQUID SCINTILLATION COUNTING; LOWER LIMIT OF QUANTIFICATIONS; PBMC; PERIPHERAL BLOOD MONONUCLEAR CELLS; PRECISE DETERMINATIONS; THYMIDYLATE SYNTHASE; VALIDATION PARAMETERS;

ACTIVATED CARBON; PHARMACODYNAMICS;

SUBSTRATES;

THYMIDYLATE SYNTHASE;

ARTICLE; CELL CULTURE; CELL LINE; CHEMISTRY; ENZYME ASSAY; ENZYMOLOGY; EVALUATION; HUMAN; KINETICS; METHODOLOGY; MONONUCLEAR CELL;

CELL LINE; CELLS, CULTURED; ENZYME ASSAYS; HUMANS; KINETICS; LEUKOCYTES, MONONUCLEAR; THYMIDYLATE SYNTHASE;

EID: 84878406673     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6676-1     Document Type: Article

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