Retraction: Conversion of human umbilical cord mesenchymal stem cells in Wharton’s jelly to dopamine neurons mediated by the Lmx1a and Neurturin in Vitro: Potential therapeutic application for Parkinson’s disease in a rhesus monkey model (PLoS ONE (2013) 8: 5 (e64000) DOI: 10.1371/journal.pone.0064000);Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton's Jelly to Dopamine Neurons Mediated by the Lmx1a and Neurturin In Vitro: Potential Therapeutic Application for Parkinson's Disease in a Rhesus Monkey Model

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Yan, Min ^a   Sun, Maosheng ^a   Zhou, Yan ^a   Wang, Wanpu ^b   He, Zhanlong ^a   Tang, Donghong ^a   Lu, Shuaiyao ^a   Wang, Xiaonan ^a   Li, Song ^a   Wang, Wenju ^a   Li, Hongjun ^a  

^a INSTITUTE OF MEDICAL BIOLOGY   (China)

^b Geriatrics Hospital of Yunnan   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; BETA TUBULIN; BETA TUBULIN III; BETA1 INTEGRIN; HERMES ANTIGEN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; NEURTURIN; TH PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; FEMALE; GENE; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIM HOMEBOX TRANSCRIPTION FACTOR 1 ALPHA GENE; MESENCHYMAL STEM CELL; MESENCHYMAL STROMA CELL; NEURTURIN GENE; NONHUMAN; PARKINSON DISEASE; PITX3 GENE; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHESUS MONKEY; SUBSTANTIA NIGRA; TH GENE; WESTERN BLOTTING;

ADENOVIRIDAE; ANIMALIA; MACACA MULATTA; PARKINSONIA; RATTUS;

EID: 84878398778     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0242032     Document Type: Erratum

References (33)

1. Vernier P, Moret F, Callier S, Snapyan M, Wersinger C, et al. (2004) The degeneration of dopamine neurons in Parkinson's disease: insights from embryology and evolution of the mesostriatocortical system. Ann N Y Acad Sci 1035: 231-249.
2. Prakash N, Wurst W, (2006) Development of dopaminergic neurons in the mammalian brain. Cell Mol Life Sci 63: 187-206.
3. Prakash N, Wurst W, (2006) Genetic networks controlling the development of midbrain dopaminergic neurons. J Physiol 575: 403-410.
4. Morris JG, (1978) A review of some aspects of the pharmacology of levodopa. Clin Exp Neurol 15: 24-50.
5. Stromberg I, Bygdeman M, Goldstein M, Seiger A, Olson L, (1986) Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation. Neurosci Lett 71: 271-276.
6. Schulz TC, Noggle SA, Palmarini GM, Weiler DA, Lyons IG, et al. (2004) Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture. Stem Cells 22: 1218-1238.
7. Ostenfeld T, Caldwell MA, Prowse KR, Linskens MH, Jauniaux E, et al. (2000) Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation. Exp Neurol 164: 215-226.
8. Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, et al. (2012) Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's disease. Stem Cells 30: 935-945.
9. Hall VJ, (2008) Embryonic stem cells and Parkinson's disease: cell transplantation to cell therapy. Ann Acad Med Singapore 37: 163-162.
10. da Silva Meirelles L, Chagastelles PC, Nardi NB, (2006) Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119: 2204-2213.
11. Shih DT, Lee DC, Chen SC, Tsai RY, Huang CT, et al. (2005) Isolation and characterization of neurogenic mesenchymal stem cells in human scalp tissue. Stem Cells 23: 1012-1020.
12. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, et al. (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13: 4279-4295.
13. Sarugaser R, Lickorish D, Baksh D, Hosseini MM, Davies JE, (2005) Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells 23: 220-229.
14. Karahuseyinoglu S, Cinar O, Kilic E, Kara F, Akay GG, et al. (2007) Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells 25: 319-331.
15. Datta I, Mishra S, Mohanty L, Pulikkot S, Joshi PG, (2011) Neuronal plasticity of human Wharton's jelly mesenchymal stromal cells to the dopaminergic cell type compared with human bone marrow mesenchymal stromal cells. Cytotherapy 13: 918-932.
16. Fu YS, Cheng YC, Lin MY, Cheng H, Chu PM, et al. (2006) Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem Cells 24: 115-124.
17. Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Choi M, et al. (2006) Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells 24: 781-792.
18. Cai J, Donaldson A, Yang M, German MS, Enikolopov G, et al. (2009) The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model. Stem Cells 27: 220-229.
19. Friling S, Andersson E, Thompson LH, Jonsson ME, Hebsgaard JB, et al. (2009) Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc Natl Acad Sci U S A 106: 7613-7618.
20. Andersson E, Tryggvason U, Deng Q, Friling S, Alekseenko Z, et al. (2006) Identification of intrinsic determinants of midbrain dopamine neurons. Cell 124: 393-405.
21. Barzilay R, Ben-Zur T, Bulvik S, Melamed E, Offen D, (2009) Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cells. Stem Cells Dev 18: 591-601.
22. Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, et al. (1996) Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384: 467-470.
23. Kordower JH, Herzog CD, Dass B, Bakay RA, Stansell J 3rd, et al (2006) Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann Neurol 60: 706-715.
24. Gorska P, (2000) Principles in laboratory animal research for experimental purposes. Med Sci Monit 6: 171-180.
25. Wang W, Sun M, Li H, Yan M, (2012) The delivery of tyrosine hydroxylase accelerates the neurorestoration of Macaca Rhesus model of Parkinson's disease provided by Neurturin. Neurosci Lett 524: 10-15.
26. Kestendjieva S, Kyurkchiev D, Tsvetkova G, Mehandjiev T, Dimitrov A, et al. (2008) Characterization of mesenchymal stem cells isolated from the human umbilical cord. Cell Biol Int 32: 724-732.
27. Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, et al. (2004) Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells 22: 1330-1337.
28. Covas DT, Siufi JL, Silva AR, Orellana MD, (2003) Isolation and culture of umbilical vein mesenchymal stem cells. Braz J Med Biol Res 36: 1179-1183.
29. Rao MS, Mattson MP, (2001) Stem cells and aging: expanding the possibilities. Mech Ageing Dev 122: 713-734.
30. Kadivar M, Khatami S, Mortazavi Y, Shokrgozar MA, Taghikhani M, et al. (2006) In vitro cardiomyogenic potential of human umbilical vein-derived mesenchymal stem cells. Biochem Biophys Res Commun 340: 639-647.
31. Kitayama T, Onitsuka Y, Song L, Morioka N, Morita K, et al. (2007) Assessing an eating disorder induced by 6-OHDA and the possibility of nerve regeneration therapy by transplantation of neural progenitor cells in rats. Nihon Shinkei Seishin Yakurigaku Zasshi 27: 109-116.
32. Shan X, Chi L, Bishop M, Luo C, Lien L, et al. (2006) Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease-like mice. Stem Cells 24: 1280-1287.
33. Bjorklund A, Lindvall O, (2000) Cell replacement therapies for central nervous system disorders. Nat Neurosci 3: 537-544.