Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): A potential index to screen drug-induced hepatic oxidative stress in rats and mice

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 8, 2013, Pages 2635-2642

  Cao, Lei ^a   Waldon, Daniel ^a   Teffera, Yohannes ^a   Roberts, John ^a   Wells, Mary ^a   Langley, Meghan ^a   Zhao, Zhiyang ^a  

^a AMGEN INC   (United States)

Author keywords

Biliary; GSH GSSG; Hepatotoxicity; LC MS; Oxidative stress; Quantitation

Indexed keywords

BILIARY; GSH/GSSG; HEPATOTOXICITY; LC-MS; QUANTITATION;

BIOMARKERS; BODY FLUIDS; PEPTIDES; RATS; TISSUE;

OXIDATIVE STRESS;

DIQUAT; DRUG; GLUTATHIONE; GLUTATHIONE DISULFIDE; PARACETAMOL; PARAQUAT; TERT BUTYL HYDROPEROXIDE;

ANIMAL; ARTICLE; BILE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; EVALUATION; LIVER; MALE; METABOLISM; METHODOLOGY; MOUSE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RAT; SPRAGUE DAWLEY RAT;

ACETAMINOPHEN; ANIMALS; BILE; DIQUAT; DRUG EVALUATION, PRECLINICAL; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIVER; MALE; MICE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PARAQUAT; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; TERT-BUTYLHYDROPEROXIDE;

MUS; RATTUS;

EID: 84878398748     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6661-8     Document Type: Article

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