A prospective study of endothelial activation biomarkers, including plasma angiopoietin-1 and angiopoietin-2, in Kenyan women initiating antiretroviral therapy

BMC Infectious Diseases

Volumn 13, Issue 1, 2013, Pages

  Graham, Susan M ^a,b   Rajwans, Nimerta ^c   Tapia, Kenneth A ^a   Jaoko, Walter ^b   Estambale, Benson B A ^d   McClelland, R Scott ^a,b   Overbaugh, Julie ^e   Liles, W Conrad ^a,c,f  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c TORONTO GENERAL HOSPITAL   (Canada)

^d UNIVERSITY OF NAIROBI   (Kenya)

^e Fred Hutchinson Cancer Research Center   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angiopoietin 1; Angiopoietin 2; E selectin; Endothelium; HAART; HIV 1; ICAM 1; VCAM 1

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; LAMIVUDINE; NEVIRAPINE; STAVUDINE; VASCULAR CELL ADHESION MOLECULE 1; VIRUS RNA; ZIDOVUDINE;

ADULT; ARTICLE; BLOOD SAMPLING; CD4 LYMPHOCYTE COUNT; CELL ACTIVATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOWN REGULATION; ENDOTHELIUM CELL; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALNUTRITION; MORTALITY; ORAL CONTRACEPTIVE USE; PREDICTION; PREGNANCY; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; TREATMENT OUTCOME; TUBERCULOSIS; UPREGULATION;

ADULT; ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BIOLOGICAL MARKERS; CELL ADHESION MOLECULES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; KENYA; MALE; PREGNANCY; PROSPECTIVE STUDIES;

EID: 84878392871     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-13-263     Document Type: Article

References (40)

1. Phillips AN, Neaton J, Lundgren JD. The role of HIV in serious diseases other than AIDS. AIDS 2008, 22:2409-2418. 10.1097/QAD.0b013e3283174636, 2679976, 19005264.
2. Neuhaus J, Jacobs DR, Baker JV, Calmy A, Duprez D, La Rosa A, Kuller LH, Pett SL, Ristola M, Ross MJ, Shlipak MG, Tracy R, Neaton JD. Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. J Infect Dis 2010, 201:1788-1795. 10.1086/652749, 2872049, 20446848.
3. Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC, Ledergerber B, Lundgren J, Neuhaus J, Nixon D, Paton NI, Neaton JD, INSIGHT SMART Study Group Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008, 5:e203. 10.1371/journal.pmed.0050203, 2570418, 18942885, INSIGHT SMART Study Group.
4. Baker J, Quick H, Hullsiek KH, Tracy R, Duprez D, Henry K, Neaton JD. Interleukin-6 and D-dimer levels are associated with vascular dysfunction in patients with untreated HIV infection. HIV Med 2010, 11:608-609. 10.1111/j.1468-1293.2010.00835.x, 2942962, 20456504.
5. Baker J, Ayenew W, Quick H, Hullsiek KH, Tracy R, Henry K, Duprez D, Neaton JD. High-density lipoprotein particles and markers of inflammation and thrombotic activity in patients with untreated HIV infection. J Infect Dis 2010, 201:285-292. 10.1086/649560, 2798007, 19954384.
6. Ford ES, Greenwald JH, Richterman AG, Rupert A, Dutcher L, Badralmaa Y, Natarajan V, Rehm C, Hadigan C, Sereti I. Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection. AIDS 2010, 24:1509-1517. 10.1097/QAD.0b013e32833ad914, 2884071, 20505494.
7. Dube MP, Sattler FR. Inflammation and complications of HIV disease. J Infect Dis 2010, 201:1783-1785. 10.1086/652751, 20446849.
8. Calza L, Pocaterra D, Pavoni M, Colangeli V, Manfredi R, Verucchi G, Chiodo F, Cantu M, Pariali M. Plasma levels of VCAM-1, ICAM-1, E-Selectin, and P-Selectin in 99 HIV-positive patients versus 51 HIV-negative healthy controls. J Acquir Immune Defic Syndr 2009, 50:430-432. 10.1097/QAI.0b013e31819a292c, 19322038.
9. de Larranaga GF, Bocassi AR, Puga LM, Alonso BS, Benetucci JA. Endothelial markers and HIV infection in the era of highly active antiretroviral treatment. Thromb Res 2003, 110:93-98. 10.1016/S0049-3848(03)00291-3, 12893023.
10. Wolf K, Tsakiris DA, Weber R, Erb P, Battegay M, Swiss HIV Cohort Study Antiretroviral therapy reduces markers of endothelial and coagulation activation in patients infected with human immunodeficiency virus type 1. J Infect Dis 2002, 185:456-462. 10.1086/338572, 11865397, Swiss HIV Cohort Study.
11. Papasavvas E, Azzoni L, Pistilli M, Hancock A, Reynolds G, Gallo C, Ondercin J, Kostman JR, Mounzer K, Shull J, Montaner LJ. Increased soluble vascular cell adhesion molecule-1 plasma levels and soluble intercellular adhesion molecule-1 during antiretroviral therapy interruption and retention of elevated soluble vascular cellular adhesion molecule-1 levels following resumption of antiretroviral therapy. AIDS 2008, 22:1153-1161. 10.1097/QAD.0b013e328303be2a, 2726750, 18525261.
12. Sipsas NV, Sfikakis PP, Touloumi G, Pantazis N, Choremi H, Kordossis T. Elevated serum levels of soluble immune activation markers are associated with increased risk for death in HAART-naive HIV-1-infected patients. AIDS Patient Care STDS 2003, 17:147-153. 10.1089/108729103321619755, 12737638.
13. Fiedler U, Augustin HG. Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol 2006, 27:552-558. 10.1016/j.it.2006.10.004, 17045842.
14. Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med 2006, 3:e46. 10.1371/journal.pmed.0030046, 1334221, 16417407.
15. Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 2006, 12:235-239. 10.1038/nm1351, 16462802.
16. Mankhambo LA, Banda DL, Jeffers G, White SA, Balmer P, Nkhoma S, Phiri H, Molyneux EM, Hart CA, Molyneux ME, Heyderman RS, Carrol ED, IPD Study Group The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children. Crit Care 2010, 14:R91. 10.1186/cc9025, 2911728, 20492647, IPD Study Group.
17. Graham SM, Masese L, Gitau R, Jalalian-Lechak Z, Richardson BA, Peshu N, Mandaliya K, Kiarie JN, Jaoko W, Ndinya-Achola J, Overbaugh J, McClelland RS. Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment. J Infect Dis 2010, 202:1538-1542. 10.1086/656790, 2957525, 20923373.
18. Kenya Ministry of Health Guidelines to antiretroviral drug therapy in Kenya 2001, Nairobi: Kenya Ministry of Health, Kenya Ministry of Health.
19. Emery S, Bodrug S, Richardson BA, Giachetti C, Bott MA, Panteleeff D, Jagodzinski LL, Michael NL, Nduati R, Bwayo J, Kreiss JK, Overbaugh J. Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya. J Clin Microbiol 2000, 38:2688-2695. 87000, 10878065.
20. Ricciuto DR, dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, Lafferty EI, Cook DJ, Fox-Robichaud A, Kahnamoui K, Kain KC, Liaw PC, Liles WC. Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med 2011, 39:702-710. 10.1097/CCM.0b013e318206d285, 21242795.
21. Page AV, Kotb M, McGeer A, Low DE, Kain KC, Liles WC. Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. Clin Infect Dis 2011, 52:e157-e161. 10.1093/cid/cir125, 21460306.
22. Hartweg J, Gunter M, Perera R, Farmer A, Cull C, Schalkwijk C, Kok A, Twaalfhoven H, Holman R, Neil A. Stability of soluble adhesion molecules, selectins, and C-reactive protein at various temperatures: implications for epidemiological and large-scale clinical studies. Clin Chem 2007, 53:1858-1860. 10.1373/clinchem.2006.076380, 17675341.
23. Lukasz A, Hellpap J, Horn R, Kielstein JT, David S, Haller H, Kümpers P. Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays. Crit Care 2008, 12:R94. 10.1186/cc6966, 2575578, 18664247.
24. United Nations Administrative Committee on Coordination Sub-Committee on Nutrition (ACC/SCN) Nutrition throughout the life cycle: 4th report on the world nutrition situation 2000, Geneva: International Food Policy Research Institute, United Nations Administrative Committee on Coordination Sub-Committee on Nutrition (ACC/SCN).
25. Ren Z, Yao Q, Chen C. HIV-1 envelope glycoprotein 120 increases intercellular adhesion molecule-1 expression by human endothelial cells. Lab Invest 2002, 82:245-255. 10.1038/labinvest.3780418, 11896203.
26. Kranidioti H, Orfanos SE, Vaki I, Kotanidou A, Raftogiannis M, Dimopoulou I, Kotsaki A, Savva A, Papapetropoulos A, Armaganidis A, Giamarellos-Bourboulis EJ. Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes. Immunol Lett 2009, 125:65-71. 10.1016/j.imlet.2009.06.006, 19539650.
27. Nixon DE, Landay AL. Biomarkers of immune dysfunction in HIV. Curr Opin HIV AIDS 2010, 5:498-503. 10.1097/COH.0b013e32833ed6f4, 3032605, 20978393.
28. Sandler NG, Wand H, Roque A, Law M, Nason MC, Nixon DE, Pedersen C, Ruxrungtham K, Lewin SR, Emery S, Neaton JD, Brenchley JM, Deeks SG, Sereti I, Douek DC, INSIGHT SMART Study Group Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 2011, 203:780-790. 10.1093/infdis/jiq118, 3071127, 21252259, INSIGHT SMART Study Group.
29. Dunk C, Shams M, Nijjar S, Rhaman M, Qiu Y, Bussolati B, Ahmed A. Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development. Am J Pathol 2000, 156:2185-2199. 10.1016/S0002-9440(10)65089-4, 1850068, 10854239.
30. Ye F, Florian M, Magder SA, Hussain SN. Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Steroids 2002, 67:305-310. 10.1016/S0039-128X(01)00163-5, 11856554.
31. Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ. Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. Br J Cancer 2011, 104:51-59. 10.1038/sj.bjc.6606005, 3039823, 21081932.
32. Mehedint MG, Craciunescu CN, Zeisel SH. Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proc Natl Acad Sci USA 2010, 107:12834-12839. 10.1073/pnas.0914328107, 2919920, 20624989.
33. Baker JV, Neuhaus J, Duprez D, Kuller LH, Tracy R, Belloso WH, De Wit S, Drummond F, Lane HC, Ledergerber B, Lundgren J, Nixon DE, Paton NI, Neaton J, INSIGHT SMART Study Group Changes in inflammatory and coagulation biomarkers: a randomized comparison of immediate versus deferred antiretroviral therapy in patients with HIV infection. J Acquir Immune Defic Syndr 2011, 56:36-43. 10.1097/QAI.0b013e3181f7f61a, 3005856, 20930640, INSIGHT SMART Study Group.
34. Pettersen FO, Torheim EA, Dahm AE, Aaberge IS, Lind A, Holm M, Aandahl EM, Sandset PM, Taskén K, Kvale D. An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses. J Virol 2011, 85:6557-6566. 10.1128/JVI.00073-11, 3126508, 21490090.
35. Hileman CO, Carman TL, Storer N, Labbato DE, White CA, McComsey GA. Omega-3 fatty acids do not improve endothelial function in virologically-suppressed HIV-infected men: a randomized placebo-controlled trial. AIDS Res Hum Retroviruses 2012, 28:649-655. 10.1089/aid.2011.0088, 21870979.
36. Masia M, Bernal E, Padilla S, García N, Escribano JC, Martínez E, Gutiérrez F. A pilot randomized trial comparing an intensive versus a standard intervention in stable HIV-infected patients with moderate-high cardiovascular risk. J Antimicrob Chemother 2009, 64:589-598. 10.1093/jac/dkp250, 19625372.
37. Pett SL, Kelleher AD, Emery S. Role of interleukin-2 in patients with HIV infection. Drugs 2010, 70:1115-1130. 10.2165/10898620-000000000-00000, 20518579.
38. Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, Piera K, Price RN, Duffull SB, Celermajer DS, Anstey NM. Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proc Natl Acad Sci USA 2008, 105:17097-17102. 10.1073/pnas.0805782105, 2575222, 18957536.
39. Davis JS, Yeo TW, Piera KA, Woodberry T, Celermajer DS, Stephens DP, Anstey NM. Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care 2010, 14:R89. 10.1186/cc9020, 2911723, 20482750.
40. Cao Y, Liu Q. Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis. Adv Cancer Res 2007, 97:203-224.