Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors

European Journal of Medicinal Chemistry

Volumn 65, Issue , 2013, Pages 337-347

  Kadam, Kishorkumar S ^a   Jadhav, Ravindra D ^a   Kandre, Shivaji ^a   Guha, Tandra ^a   Reddy, M Mahesh Kumar ^a   Brahma, Manoja K ^a   Deshmukh, Nitin J ^a   Dixit, Amol ^a   Doshi, Lalit ^a   Srinivasan, Shaila ^a   Devle, Jayendra ^a   Damre, Anagha ^a   Nemmani, Kumar V S ^a   Gupte, Amol ^a   Sharma, Rajiv ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

5 Phenylthiazole; Diacylglycerol acyltransferase (DGAT); Fat tolerance test; Obesity; Plasma triglycerides

Indexed keywords

2 PHENYLTHIAZOLE; 2 [5 [4 [3 (2 CHLOROPHENYL)UREIDO]PHENYL]THIAZOLE 2 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [5 [4 [4 (TERT BUTYL)BENZAMIDO]PHENYL]THIAZOLE 2 CARBO XAMIDO] 3 METHYLBUTANOIC ACID; 4 PHENYLTHIAZOLE; 5 PHENYLTHIAZOLE; ANTIOBESITY AGENT; DIACYLGLYCEROL ACYLTRANSFERASE 1; ENZYME INHIBITOR; THIAZOLE DERIVATIVE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG SCREENING; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME INHIBITION; FAT TOLERANCE TEST; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; TIME TO MAXIMUM PLASMA CONCENTRATION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84878388772     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.006     Document Type: Article

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