Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 324-342

  Jadhav, Ravindra D ^a   Kadam, Kishorkumar S ^a   Kandre, Shivaji ^a   Guha, Tandra ^a   Reddy, M Mahesh Kumar ^a   Brahma, Manoja K ^a   Deshmukh, Nitin J ^a   Dixit, Amol ^a   Doshi, Lalit ^a   Potdar, Nisha ^a   Enose, Arno A ^a   Vishwakarma, Ram A ^a   Sivaramakrishnan, H ^a   Srinivasan, Shaila ^a   Nemmani, Kumar V S ^a   Gupte, Amol ^a   Gangopadhyay, Ashok K ^a   Sharma, Rajiv ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Diacylglycerol acyltransferase (DGAT1); Fat tolerance test (FTT); Obesity

Indexed keywords

2 [3 [4 [3 (2 CHLOROPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (2 FLUOROPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (2,4 DIFLUOROPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (3 CHLOROPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (3,4 DIMETHYLPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (4 CHLORO 2 FLUOROPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (4 CHLORO 2 PHENOXYPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (4 CHLOROPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (4 FLUOROPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO) 3 METHYLBUTANOIC ACID; 2 [3 [4 [3 (4 METHOXYPHENYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; 2 [[3 [4 (6 FLUOROBENZOTHIAZOL 2 YLAMINO)PHENYL]ISOXAZOLE 5 CARBONYL]AMINO] 3 METHYLBUTYRIC ACID; 2 [[3 [4 (6 FLUOROBENZOTHIAZOL 2 YLAMINO)PHENYL]ISOXAZOLE 5 CARBONYL]AMINO] 3 METHYLBUTYRIC ACID METHYL ESTER; 3 (4 AMINOPHENYL)ISOXAZOLE 5 CARBOXYLIC ACID ETHYL ESTER; 3 (4 NITROPHENYL)ISOXAZOL 5 CARBOXYLIC ACID ETHYL ESTER; 3 (4 NITROPHENYL)ISOXAZOLE 5 CARBOXYLIC ACID; 3 [4 (6 FLUOROBENZOTHIAZOL 2 YLAMINO)PHENYL]ISOXAZOLE 5 CARBOXYLIC ACID; 3 [4 (6 FLUOROBENZOTHIAZOL 2 YLAMINO)PHENYL]ISOXAZOLE 5 CARBOXYLIC ACID ETHYL ESTER; 3 METHYL 2 [3 [4 [3 (4 TOLYL)UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO]BUTANOIC ACID; 3 METHYL 2 [3 [4 [3 [3 (TRIFLUOROMETHYL)PHENYL]UREIDO]PHENYL]ISOXAZOLE 5 CARBOXAMIDO]BUTANOIC ACID; 4 NITROBENZALDEHYDE OXIME; ANTIOBESITY AGENT; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIACYLGLYCEROL ACYLTRANSFERASE 1 INHIBITOR; ENZYME INHIBITOR; HETEROCYCLIC COMPOUND; METHYL 2 [3 (4 AMINOPHENYL)ISOXAZOLE 5 CARBOXAMIDO] 3 METHYLBUTANOIC ACID; METHYL 3 METHYL 2 [3 (4 NITROPHENYL)ISOXAZOLE 5 CARBOXAMIDO] BUTANOIC ACID; N HYDROXY 4 NITROBENZIMIDOYL CHLORIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; FAT TOLERANCE TEST; IN VIVO STUDY; MOUSE; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; DIACYLGLYCEROL O-ACYLTRANSFERASE; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOXAZOLES; MICE; OXADIAZOLES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; WATER;

EID: 84864411094     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.016     Document Type: Article

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