Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5812-5817

  Motiwala, Hashim ^a   Kandre, Shivaji ^a   Birar, Vishal ^a   Kadam, Kishorkumar S ^a   Rodge, Atish ^a   Jadhav, Ravindra D ^a   Mahesh Kumar Reddy, M ^a   Brahma, Manoja K ^a   Deshmukh, Nitin J ^a   Dixit, Amol ^a   Doshi, Lalit ^a   Gupte, Amol ^a   Gangopadhyay, Ashok K ^a   Vishwakarma, Ram A ^a   Srinivasan, Shaila ^a   Sharma, Mamta ^a   Nemmani, Kumar V S ^a   Sharma, Rajiv ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Diacylglycerol acyltransferase (DGAT); Fat tolerance test (FTT); Obesity; Triglycerides

Indexed keywords

ACYLTRANSFERASE INHIBITOR; CARBANILAMIDE DERIVATIVE; DIACYLGLYCEROL ACYLTRANSFERASE 1; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIDINE DERIVATIVE; TRIACYLGLYCEROL; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FAT TOLERANCE TEST; IC 50; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTI-OBESITY AGENTS; DIACYLGLYCEROL O-ACYLTRANSFERASE; DRUG DESIGN; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR TARGETED THERAPY; OBESITY; PYRIDINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES; UREA;

MUS;

EID: 84860410307     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.109     Document Type: Article

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