메뉴 건너뛰기




Volumn 497, Issue 7451, 2013, Pages 619-623

Synthetic analog computation in living cells

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; GENE EXPRESSION; NUMERICAL MODEL; POWER LAW;

EID: 84878381909     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12148     Document Type: Article
Times cited : (353)

References (30)
  • 1
    • 84856790663 scopus 로고    scopus 로고
    • Synthetic biology: Advancing biological frontiers by building synthetic systems
    • Chen, Y. Y., Galloway, K. E. & Smolke, C. D. Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol. 13, 240 (2012).
    • (2012) Genome Biol , vol.13 , pp. 240
    • Chen, Y.Y.1    Galloway, K.E.2    Smolke, C.D.3
  • 2
    • 84863322344 scopus 로고    scopus 로고
    • Contextualizing context for synthetic biology: Identifying causes of failure of synthetic biological systems
    • Cardinale, S.&Arkin, A. P.Contextualizing context for synthetic biology: identifying causes of failure of synthetic biological systems. Biotechnol. J. 7, 856-866 (2012).
    • (2012) Biotechnol. J , vol.7 , pp. 856-866
    • Cardinale, S.1    Arkin, A.P.2
  • 3
    • 0032185581 scopus 로고    scopus 로고
    • Analog versus digital: Extrapolating from electronics to neurobiology
    • Sarpeshkar, R. Analog versus digital: extrapolating from electronics to neurobiology. Neural Comput. 10, 1601-1638 (1998).
    • (1998) Neural Comput , vol.10 , pp. 1601-1638
    • Sarpeshkar, R.1
  • 4
    • 71149086936 scopus 로고    scopus 로고
    • Signaling motifs and Weber's law
    • Ferrell, J. E. Signaling motifs and Weber's law. Mol. Cell 36, 724-727 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 724-727
    • Ferrell, J.E.1
  • 6
    • 77952092577 scopus 로고    scopus 로고
    • Cis-interactions between Notch and Delta generate mutually exclusive signalling states
    • Sprinzak, D. et al. Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature 465, 86-90 (2010).
    • (2010) Nature , vol.465 , pp. 86-90
    • Sprinzak, D.1
  • 7
    • 46949091517 scopus 로고    scopus 로고
    • Refinement and standardization of synthetic biological parts and devices
    • Canton, B., Labno, A. & Endy, D. Refinement and standardization of synthetic biological parts and devices. Nature Biotechnol. 26, 787-793 (2008).
    • (2008) Nature Biotechnol , vol.26 , pp. 787-793
    • Canton, B.1    Labno, A.2    Endy, D.3
  • 8
    • 75949115944 scopus 로고    scopus 로고
    • Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs
    • Giorgetti, L. et al. Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Mol. Cell 37, 418-428 (2010).
    • (2010) Mol. Cell , vol.37 , pp. 418-428
    • Giorgetti, L.1
  • 9
    • 33746480872 scopus 로고    scopus 로고
    • Neural coding: Hybrid analog and digital signalling in axons
    • Clark, B.&Hausser, M.Neural coding: hybrid analog and digital signalling in axons. Curr. Biol. 16, R585-R588 (2006).
    • (2006) Curr. Biol , vol.16
    • Clark, B.1    Hausser, M.2
  • 11
    • 13444252726 scopus 로고    scopus 로고
    • A sinh resistor and its application to tanh linearization
    • Tavakoli, M. & Sarpeshkar, R. A sinh resistor and its application to tanh linearization. IEEE J. Solid-State Circuits 40, 536-543 (2005).
    • (2005) IEEE J. Solid-State Circuits , vol.40 , pp. 536-543
    • Tavakoli, M.1    Sarpeshkar, R.2
  • 12
    • 0036739377 scopus 로고    scopus 로고
    • Conditionally amplifiable BACs: Switching from single-copy to high-copy vectors and genomic clones
    • Wild, J., Hradecna, Z. & Szybalski, W. Conditionally amplifiable BACs: switching from single-copy to high-copy vectors and genomic clones. Genome Res. 12, 1434-1444 (2002).
    • (2002) Genome Res , vol.12 , pp. 1434-1444
    • Wild, J.1    Hradecna, Z.2    Szybalski, W.3
  • 13
    • 79957946108 scopus 로고    scopus 로고
    • Scaling up digital circuit computation with DNA strand displacement cascades
    • Qian, L. & Winfree, E. Scaling up digital circuit computation with DNA strand displacement cascades. Science 332, 1196-1201 (2011).
    • (2011) Science , vol.332 , pp. 1196-1201
    • Qian, L.1    Winfree, E.2
  • 14
    • 57049159362 scopus 로고    scopus 로고
    • A fast, robust and tunable synthetic gene oscillator
    • Stricker, J. et al. A fast, robust and tunable synthetic gene oscillator. Nature 456, 516-519 (2008).
    • (2008) Nature , vol.456 , pp. 516-519
    • Stricker, J.1
  • 15
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz, M. B. & Leibler, S. A synthetic oscillatory network of transcriptional regulators. Nature 403, 335-338 (2000).
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 16
    • 0037154293 scopus 로고    scopus 로고
    • Synchronizing genetic relaxation oscillators by intercell signaling
    • McMillen, D., Kopell, N., Hasty, J. & Collins, J. J. Synchronizing genetic relaxation oscillators by intercell signaling. Proc. Natl Acad. Sci. USA 99, 679-684 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 679-684
    • McMillen, D.1    Kopell, N.2    Hasty, J.3    Collins, J.J.4
  • 17
    • 79960165588 scopus 로고    scopus 로고
    • Negative auto-regulation increases the input dynamic-range of the arabinose system of Escherichia coli
    • Madar, D., Dekel, E., Bren, A.&Alon, U.Negative auto-regulation increases the input dynamic-range of the arabinose system of Escherichia coli. BMC Syst. Biol. 5, 111 (2011).
    • (2011) BMC Syst. Biol , vol.5 , pp. 111
    • Madar, D.1    Dekel, E.2    Bren, A.3    Alon, U.4
  • 18
    • 62549083590 scopus 로고    scopus 로고
    • Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression
    • Nevozhay, D., Adams, R. M., Murphy, K. F., Josić, K. & Balázsi, G. Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression. Proc. Natl Acad. Sci. USA 106, 5123-5128 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 5123-5128
    • Nevozhay, D.1    Adams, R.M.2    Murphy, K.F.3    Josić, K.4    Balázsi, G.5
  • 19
    • 0036578795 scopus 로고    scopus 로고
    • Network motifs in the transcriptional regulation network of Escherichia coli
    • Shen-Orr, S. S., Milo, R., Mangan, S.& Alon, U. Network motifs in the transcriptional regulation network of Escherichia coli. Nature Genet. 31, 64-68 (2002).
    • (2002) Nature Genet , vol.31 , pp. 64-68
    • Shen-Orr, S.S.1    Milo, R.2    Mangan, S.3    Alon, U.4
  • 20
    • 1942467023 scopus 로고    scopus 로고
    • Programmed population control by cell-cell communication and regulated killing
    • You, L., Cox, R. S., Weiss, R.& Arnold, F. H. Programmed population control by cell-cell communication and regulated killing. Nature 428, 868-871 (2004).
    • (2004) Nature , vol.428 , pp. 868-871
    • You, L.1    Cox, R.S.2    Weiss, R.3    Arnold, F.H.4
  • 21
    • 67549145283 scopus 로고    scopus 로고
    • A synthetic genetic edge detection program
    • Tabor, J. J. et al. A synthetic genetic edge detection program. Cell 137, 1272-1281 (2009).
    • (2009) Cell , vol.137 , pp. 1272-1281
    • Tabor, J.J.1
  • 22
    • 78651397316 scopus 로고    scopus 로고
    • Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'
    • Tamsir, A., Tabor, J. J. & Voigt, C. A. Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'. Nature 469, 212-215 (2011).
    • (2011) Nature , vol.469 , pp. 212-215
    • Tamsir, A.1    Tabor, J.J.2    Voigt, C.A.3
  • 24
    • 3042741121 scopus 로고    scopus 로고
    • Engineered riboregulators enable post-transcriptional control of gene expression
    • Isaacs, F. J. et al. Engineered riboregulators enable post-transcriptional control of gene expression. Nature Biotechnol. 22, 841-847 (2004).
    • (2004) Nature Biotechnol , vol.22 , pp. 841-847
    • Isaacs, F.J.1
  • 25
    • 54249113318 scopus 로고    scopus 로고
    • Higher-order cellular information processing with synthetic RNA devices
    • Win, M. N. & Smolke, C. D. Higher-order cellular information processing with synthetic RNA devices. Science 322, 456-460 (2008).
    • (2008) Science , vol.322 , pp. 456-460
    • Win, M.N.1    Smolke, C.D.2
  • 26
    • 80052456127 scopus 로고    scopus 로고
    • Multi-input RNAibased logic circuit for identification of specific cancer cells
    • Xie, Z., Wroblewska, L., Prochazka, L., Weiss, R. & Benenson, Y. Multi-input RNAibased logic circuit for identification of specific cancer cells. Science 333, 1307-1311 (2011).
    • (2011) Science , vol.333 , pp. 1307-1311
    • Xie, Z.1    Wroblewska, L.2    Prochazka, L.3    Weiss, R.4    Benenson, Y.5
  • 27
    • 84864634066 scopus 로고    scopus 로고
    • A synthetic biology framework for programming eukaryotic transcription functions
    • Khalil, A. et al. A synthetic biology framework for programming eukaryotic transcription functions. Cell 150, 647-658 (2012).
    • (2012) Cell , vol.150 , pp. 647-658
    • Khalil, A.1
  • 28
    • 0141757323 scopus 로고    scopus 로고
    • Reprogramming control of an allosteric signaling switch through modular recombination
    • Dueber, J. E., Yeh, B. J., Chak, K.&Lim, W. A.Reprogramming control of an allosteric signaling switch through modular recombination. Science 301, 1904-1908 (2003).
    • (2003) Science , vol.301 , pp. 1904-1908
    • Dueber, J.E.1    Yeh, B.J.2    Chak, K.3    Lim, W.A.4
  • 29
    • 0034702306 scopus 로고    scopus 로고
    • Digital selection and analogue amplification coexist in a cortex-inspired silicon circuit
    • Hahnloser, R. H. R., Sarpeshkar, R., Mahowald, M. A., Douglas, R. J. & Seung, H. S. Digital selection and analogue amplification coexist in a cortex-inspired silicon circuit. Nature 405, 947-951 (2000).
    • (2000) Nature , vol.405 , pp. 947-951
    • Hahnloser, R.H.R.1    Sarpeshkar, R.2    Mahowald, M.A.3    Douglas, R.J.4    Seung, H.S.5
  • 30
    • 71849110893 scopus 로고    scopus 로고
    • Next-generation synthetic gene networks
    • Lu, T. K., Khalil, A. S.&Collins, J. J. Next-generation synthetic gene networks. Nature Biotechnol. 27, 1139-1150 (2009).
    • (2009) Nature Biotechnol , vol.27 , pp. 1139-1150
    • Lu, T.K.1    Khalil, A.S.2    Collins, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.