A modified model of gentamicin induced renal failure in rats: Toxicological effects of the iodinated X-ray contrast media ioversol and potential usefulness for toxicological evaluation of iodinated X-ray contrast media

Experimental and Toxicologic Pathology

Volumn 65, Issue 5, 2013, Pages 601-607

  Jensen, Hanne ^a,b   Doughty, Richard W ^a   Grant, Derek ^a   Myhre, Oddvar ^a  

^a GE HEALTHCARE   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Acute renal failure; Biomarkers; Gentamicin nephropathy; Iodinated X ray contrast media

Indexed keywords

CREATININE; GAMMA GLUTAMYLTRANSFERASE; GENTAMICIN; IOVERSOL; N ACETYL BETA GLUCOSAMINIDASE; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTRAST INDUCED NEPHROPATHY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; DIAGNOSTIC VALUE; DISEASE MARKER; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYMURIA; HISTOPATHOLOGY; KIDNEY EPITHELIUM; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MALE; NONHUMAN; PROTEIN URINE LEVEL; RAT; SINGLE DRUG DOSE; TOXICITY TESTING; URINE CYTOLOGY;

ACUTE KIDNEY INJURY; ANIMALS; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GENTAMICINS; KIDNEY FUNCTION TESTS; MALE; RATS; RATS, SPRAGUE-DAWLEY; TRIIODOBENZOIC ACIDS;

ANIMALIA; RATTUS;

EID: 84878376207     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2012.06.003     Document Type: Article

References (29)

1. Basnakian A.G., Kaushal G.P., Ueda N., Shah S.V. Oxidant mechanisms in toxic acute renal failure toxicology of the kidneys 2005, 499-523. CRC Press, Boca Raton. J.B. Tarloff, L.H. Lash (Eds.).
2. Bhargava A.S., Hofmeister R., Siegmund F., Schobel C., Gunzel P. Effect of three non-ionic contrast media on rats and rabbits with regard to renal changes. Interspecies comparison. Arzneimittel-Forschung 1990, 40:822-829.
3. Brayton C., Justice M., Montgomery C.A. Evaluating mutant mice: anatomic pathology. Veterinary Pathology 2001, 38:1-19.
4. Byrd L., Sherman R.L. Radiocontrast-induced acute renal failure: a clinical and pathophysiologic review. Medicine 1979, 58:270-279.
5. Duan S.B., Wu H.W., Luo J.A., Liu F.Y. Assessment of renal function in the early stages of nephrotoxicity induced by iodinated contrast media. Nephron 1999, 83:122-125.
6. Gilbert D.N., Houghton D.C., Bennett W.M., Plamp C.E., Reger K., Porter G.A. Reversibility of gentamicin nephrotoxicity in rats: recovery during continuous drug administration. Proceedings of the Society for Experimental Biology and Medicine 1979, 160:99-103.
7. Idee J.M., Bonnemain B. Reliability of experimental models of iodinated contrast media-induced acute renal failure. From methodological considerations to pathophysiology. Investigative Radiology 1996, 31:230-241.
8. Idee J.M., Santus R., Beaufils H., Balut C., Huntsman A.M., Bourbouze R., et al. Comparative effects of low- and high-osmolar contrast media on the renal function during early degenerative gentamicin-induced nephropathy in rats. American Journal of Nephrology 1995, 15:66-74.
9. Krause W. In vitro and animal experiments in contrast media testing. Investigative Radiology 1998, 33:182-191.
10. Lenz E.M., Bright J., Knight R., Westwood F.R., Davies D., Major H., et al. Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat. Biomarkers 2005, 10:173-187.
11. Marenzi G., Assanelli E., Campodonico J., Lauri G., Marana I., De Metrio M., et al. Contrast volume during primary percutaneous coronary intervention and subsequent contrast-induced nephropathy and mortality. Annals of Internal Medicine 2009, 150:170-177.
12. McCullough P.A., Adam A., Becker C.R., Davidson C., Lameire N., Stacul F., et al. Risk prediction of contrast-induced nephropathy. The American Journal of Cardiology 2006, 98:27K-36K.
13. Mehran R., Nikolsky E. Contrast-induced nephropathy: definition, epidemiology, and patients at risk. Kidney International: Supplement 2006, S11-S15.
14. Mingeot-Leclercq M.-P., Tulkens P.M. Aminoglycosides: nephrotoxicity. Antimicrobial Agents and Chemotherapy 1999, 43:1003-1012.
15. Moreau J.F., Droz D., Sabto J., Jungers P., Kleinknecht D., Hinglais N., et al. Osmotic nephrosis induced by water-soluble triiodinated contrast media in man. A retrospective study of 47 cases. Radiology 1975, 115:329-336.
16. Pettersson G., Towart R., Grant D., Thyberg K., Golman K. The rabbit renal toxicity test: a sensitive in vivo test for the nephrotoxicity of contrast agents. Academic Radiology 2002, 9(Suppl. 1):S62-S64.
17. Racusen L.C., Solez K. Nephrotoxic tubular and interstitial lesions: morphology and classification. Toxicologic Pathology 1986, 14:45-57.
18. Relyea M.J., Miller J., Boggess D., Sundberg J.P. Necropsy methods for laboratory mice: biological characterization of a new mutation. Systematic approach to evaluation of mouse mutations 2000, 57-89. CRC Press, Boca Raton. J.P. Sundberg, D. Boggess (Eds.).
19. Rihal C.S., Textor S.C., Grill D.E., Berger P.B., Ting H.H., Best P.J., et al. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation 2002, 105:2259-2264.
20. Schräder R. Contrast material-induced renal failure: an overview. Journal of Interventional Cardiology 2005, 18:417-423.
21. Solez K., Racusen L.C., Olsen S. The pathology of drug nephrotoxicity. Journal of Clinical Pharmacology 1983, 23:484-490.
22. Stanziale P., Fuiano G., Balletta M.M., Esposito A., Foscaldi A., Quaranta L., et al. Tubular lesions secondary to conventional urography: a study on renal biopsies by light microscopy. Advances in Experimental Medicine and Biology 1987, 212:151-154.
23. Thomsen H.S., Dorph S., Larsen S., Horn T., Hemmingsen L., Skaarup P., et al. Urine profiles and kidney histologic findings after intravenous injection of mannitol and iohexol in the degeneration phase of gentamicin nephropathy in rats. Investigative Radiology 1993, 28:133-141.
24. Thomsen H.S., Golman K., Larsen S., Hemmingsen L., Skaarup P. Urine profiles and kidney histology following intravenous diatrizoate and iohexol in the degeneration phase of gentamicin nephropathy in rats. Effects on urine and serum profiles. Investigative Radiology 1991, 26:951-959.
25. Thomsen H.S., Skaarup P., Larsen S., Golman K., Hemmingsen L. Gentamicin nephropathy and contrast media. A comparison between diatrizoate and iohexol in rats. Acta Radiologica 1990, 31:401-407.
26. Tulkens P.M. Nephrotoxicity of aminoglycoside antibiotics. Toxicology Letters 1989, 46:107-123.
27. Tumlin J., Stacul F., Adam A., Becker C.R., Davidson C., Lameire N., et al. Pathophysiology of contrast-induced nephropathy. The American Journal of Cardiology 2006, 98:14-20.
28. Uchimoto R., Miyazawa T., Fritz-Zieroth B. Effects of iotrolan, iopamidol, and iopromide in rats with and without experimental nephropathy. Investigative Radiology 1994, 29(Suppl. 2):S111-S112.
29. Waybill M.M., Waybill P.N. Contrast media-induced nephrotoxicity: identification of patients at risk and algorithms for prevention. Journal of Vascular and Interventional Radiology 2001, 12:3-9.