1H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos

Journal of Assisted Reproduction and Genetics

Volumn 29, Issue 12, 2012, Pages 1435-1442

  Rinaudo, Paolo ^a   Shen, Shehua ^a,c   Hua, Jia ^b,d   Qian, Su ^b   Prabhu, Uday ^b,e   Garcia, Erwin ^b,f   Cedars, Marcelle ^a   Sukumaran, Dinesh ^b   Szyperski, Thomas ^b   Andrews, Chris ^b,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c Auxogyn Inc   (United States)

^d Fresenius Kabi   (United States)

^e Bruker India   (India)

^f LIPOSCIENCE INC   (United States)

^g UNIVERSITY OF MICHIGAN   (United States)

Author keywords

1H NMR; ART; Implantation success; IVF; Metabonomics

Indexed keywords

ADULT; ARTICLE; CULTURE MEDIUM; EMBRYO; EMBRYO CULTURE; EMBRYO GROWTH; EMBRYO TRANSFER; FEMALE; HEART RATE; HUMAN; HUMAN EMBRYO; INFERTILITY THERAPY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; NIDATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREGNANCY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RETROSPECTIVE STUDY; VALIDATION STUDY;

ADULT; CULTURE MEDIA, CONDITIONED; EMBRYO IMPLANTATION; EMBRYO TRANSFER; EMBRYONIC DEVELOPMENT; FEMALE; FERTILIZATION IN VITRO; FETUS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PREGNANCY; PREGNANCY RATE; PROGNOSIS; PROTONS; REPRODUCTIVE TECHNIQUES, ASSISTED; RETROSPECTIVE STUDIES; SINGLE EMBRYO TRANSFER;

EID: 84878368821     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-012-9877-9     Document Type: Article

References (34)

1. 2009 Guidelines on number of embryos transferred. Fertil Steril. 92 1518-9.
2. Adler W, Brenning A, Patapov S, Schmid M, Lausen B. Ensemble classification of paired data. Comput Stat Data Anal. 2011;55:1933-41.
3. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B (Methodological). 1995;57:289-300.
4. Blake DA, Farquhar CM, Johnson N, Proctor M. Cleavage stage versus blastocyst stage embryo transfer in assisted conception. Cochrane Database Syst Rev. 2007;CD002118.
5. Conaghan J, Hardy K, Handyside AH, Winston RM, Leese HJ. Selection criteria for human embryo transfer: a comparison of pyruvate uptake and morphology. J Assist Reprod Genet. 1993;10:21-30.
6. Frattarelli JL, Leondires MP, McKeeby JL, Miller BT, Segars JH. Blastocyst transfer decreases multiple pregnancy rates in in vitro fertilization cycles: a randomized controlled trial. Fertil Steril. 2003;79:228-30.
7. Garcia E, Andrews C, Hua J, Kim HL, Sukumaran DK, Szyperski T, Odunsi K. Diagnosis of early stage ovarian cancer by 1H NMR metabonomics of serum explored by use of a microflow NMR probe. J Proteome Res. 2011;10:1765-71.
8. Gardner DK, Lane M, Stevens J, Schoolcraft WB. Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential. Fertil Steril. 2001;76:1175-80.
9. Gardner DK, Wale PL, Collins R, Lane M. Glucose consumption of single post-compaction human embryos is predictive of embryo sex and live birth outcome. Hum Reprod. 2011;26:1981-6.
10. Grady R, Alavi N, Vale R, Khandwala M, McDonald SD. Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis. Fertil Steril. 2012;97:324-31.
11. Hardarson T, Ahlstrom A, Rogberg L, Botros L, Hillensjo T, Westlander G, Sakkas D, Wikland M. Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: a prospective randomized trial. Hum Reprod. 2012;27:89-96.
12. Janvier A, Spelke B, Barrington KJ. The epidemic of multiple gestations and neonatal intensive care unit use: the cost of irresponsibility. J Pediatr. 2011;159:409-13.
13. Kallen B, Finnstrom O, Lindam A, Nilsson E, Nygren KG, Olausson PO. Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome? Fertil Steril. 2010;94:1680-3.
14. Kawachiya S, Bodri D, Shimada N, Kato K, Takehara Y, Kato O. Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer. Fertil Steril. 2011;95:2140-2.
15. Lindon JC, Nicholson JK, Holmes E. The Handbook of metabonomics and metabolomics. Amsterdam: Elsevier; 2007.
16. Mastenbroek S, van der Veen F, Aflatoonian A, Shapiro B, Bossuyt P, Repping S. Embryo selection in IVF. Hum Reprod. 2011;26:964-6.
17. Nel-Themaat L, Nagy ZP. A review of the promises and pitfalls of oocyte and embryo metabolomics. Placenta. 2011;32 Suppl 3:S257-63.
18. Pudakalakatti SM, Uppangala S, D'Souza F, Kalthur G, Kumar P, Adiga SK, Atreya HS. NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential. NMR Biomed. 2012
19. Racowsky C, Vernon M, Mayer J, Ball GD, Behr B, Pomeroy KO, Wininger D, Gibbons W, Conaghan J, Stern JE. Standardization of grading embryo morphology. Fertil Steril. 2010;94:1152-3.
20. Reh A, Fino E, Krey L, Berkeley A, Noyes N, Grifo J. Optimizing embryo selection with day 5 transfer. Fertil Steril. 2010;93:609-15.
21. Revelli A, Delle Piane L, Casano S, Molinari E, Massobrio M, Rinaudo P. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod Biol Endocrinol. 2009;7:40.
22. Rijnders PM, Jansen CA. The predictive value of day 3 embryo morphology regarding blastocyst formation, pregnancy and implantation rate after day 5 transfer following in-vitro fertilization or intracytoplasmic sperm injection. Hum Reprod. 1998;13:2869-73.
23. Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo PF, Lamb JD, Cedars MI. The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reprod Biol Endocrinol. 2009;7:35.
24. Schervish M. A review of multivariate analysis. Stat Sci. 1987;2:396-413.
25. Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH. Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Fertil Steril. 2008;90:77-83.
26. Seli E, Botros L, Sakkas D, Burns DH. Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril. 2008;90:2183-9.
27. Seli E, Bruce C, Botros L, Henson M, Roos P, Judge K, Hardarson T, Ahlstrom A, Harrison P, Henman M, Go K, Acevedo N, Siques J, Tucker M, Sakkas D. Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome. J Assist Reprod Genet. 2011;28:137-44.
28. Seli E, Sakkas D, Scott R, Kwok SC, Rosendahl SM, Burns DH. Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril. 2007;88:1350-7.
29. Sukumaran DK, Garcia E, Hua J, Tabaczynski W, Odunsi K, Andrews C, Szyperski T. Standard operating procedure for metabonomics studies of blood serum and plasma samples using a 1H-NMR micro-flow probe. Magn Reson Chem. 2009;47 Suppl 1:S81-5.
30. Varmuza K, Filzmoser P. Introduction to multivariate statistical analysis in chemometrics. Boca Raton: CRC Press; 2009.
31. Vergouw CG, Botros LL, Judge K, Henson M, Roos P, Hanna Kostelijk E, Schats R, Twisk JW, Hompes PG, Sakkas D, Lambalk CB. Non-invasive viability assessment of day-4 frozen-thawed human embryos using near infrared spectroscopy. Reprod Biomed Online. 2011;23:769-76.
32. Vergouw CG, Botros LL, Roos P, Lens JW, Schats R, Hompes PG, Burns DH, Lambalk CB. Metabolomic profiling by near-infrared spectroscopy as a tool to assess embryo viability: a novel, non-invasive method for embryo selection. Hum Reprod. 2008;23:1499-504.
33. Vergouw CG, Kieslinger DC, Kostelijk EH, Hompes PG, Schats R & Lambalk CB. Metabolomic profiling of culture media by near infrared spectroscopy as an adjunct to morphology for selection of a single day 3 embryo to transfer in Ivf: a double blind randomised trial. In American Society of Reproductive Medicine O:7, 2011.
34. Wright VC, Chang J, Jeng G, Macaluso M. Assisted reproductive technology surveillance-United States, 2005. MMWR Surveill Summ. 2008;57:1-23.