Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study

Lipids

Volumn 48, Issue 2, 2013, Pages 155-165

  Kraja, Aldi T ^a   Borecki, Ingrid B ^a   Tsai, Michael Y ^b   Ordovas, Jose M ^c,e,f   Hopkins, Paul N ^d   Lai, Chao Qiang ^c   Frazier Wood, Alexis C ^g   Straka, Robert J ^h   Hixson, James E ⁱ   Province, Michael A ^a   Arnett, Donna K ^g  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c TUFTS UNIVERSITY   (United States)

^d UNIVERSITY OF UTAH   (United States)

^e CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^f IMDEA FOOD INSTITUTE   (Spain)

^g UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^h UNIVERSITY OF MINNESOTA   (United States)

ⁱ UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Fenofibrate; Genome wide association; Lipoproteins; Nuclear magnetic resonance particles; Postprandial challenge

Indexed keywords

APOLIPOPROTEIN B; FENOFIBRATE; G PROTEIN COUPLED RECEPTOR; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PDZ PROTEIN; PROTEIN HOMER 1; VERY LOW DENSITY LIPOPROTEIN;

ADULT; APOLIPOPROTEIN B GENE; ARTICLE; BCL2 LIKE 11 GENE; CYSTEIN RICH PDZ BINDING PROTEIN GENE; DOK5 CBLN4 MC3R GENE; FAMILY WITH SEQUENCE SIMILARITY 84 MEMBER B GENE; G PROTEIN COUPLED RECEPTOR 133 GENE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC TRAIT; HOMER HOMOLOG 1 GENE; HUMAN; LIPID ANALYSIS; NELLI GENE; NR5A2 GENE; NUCLEAR MAGNETIC RESONANCE; NXPH1 GENE; PCDH10 GENE; QPRT GENE; RUNX3 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SLC24A4 GENE; STXBP6 GENE; SYNPR GENE; V KIT HARDY ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG GENE; VSNL1 GENE;

ADULT; FASTING; FEMALE; FENOFIBRATE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; HYPOLIPIDEMIC AGENTS; LIPOPROTEINS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTPRANDIAL PERIOD;

EID: 84878359274     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-012-3740-8     Document Type: Article

References (38)

1. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report (2002) Circulation 106(25):3143-3421
2. Carmena R, Duriez P, Fruchart JC: Atherogenic lipoprotein particles in atherosclerosis (2004) Circulation 109(23 Suppl 1):III2-III7
3. Otvos JD, Jeyarajah EJ, Bennett DW, Krauss RM (1992) Development of a proton nuclear magnetic resonance spectroscopic method for determining plasma lipoprotein concentrations and subspecies distributions from a single, rapid measurement. Clin Chem 38(9):1632-1638
4. Garvey WT, Kwon S, Zheng D, Shaughnessy S, Wallace P, Hutto A, Pugh K, Jenkins AJ, Klein RL, Liao Y (2003) Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. Diabetes 52(2):453-462
5. Blake GJ, Albert MA, Rifai N, Ridker PM (2003) Effect of pravastatin on LDL particle concentration as determined by NMR spectroscopy: a substudy of a randomized placebo controlled trial. Eur Heart J 24(20):1843-1847
6. Nofer JR (2011) Hyperlipidemia and cardiovascular disease: triglycerides - a revival of cardiovascular risk factor? Curr Opin Lipidol 22(4):319-321
7. Lada AT, Rudel LL (2004) Associations of low density lipoprotein particle composition with atherogenicity. Curr Opin Lipidol 15(1):19-24
8. Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikainen LP, Kangas AJ, Soininen P, Wurtz P, Silander K et al (2012) Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 44(3):269-276
9. Mora S, Otvos JD, Rosenson RS, Pradhan A, Buring JE, Ridker PM (2010) Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women. Diabetes 59(5):1153-1160
10. Chasman DI, Pare G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Malarstig A et al (2009) Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet 5(11):e1000730
11. Jenkins AJ, Lyons TJ, Zheng D, Otvos JD, Lackland DT, McGee D, Garvey WT, Klein RL (2003) Lipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathy. Kidney Int 64(3):817-828
12. Otvos JD, Collins D, Freedman DS, Shalaurova I, Schaefer EJ, McNamara JR, Bloomfield HE, Robins SJ (2006) Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation 113(12):1556-1563
13. Freedman DS, Otvos JD, Jeyarajah EJ, Shalaurova I, Cupples LA, Parise H, D'Agostino RB, Wilson PW, Schaefer EJ (2004) Sex and age differences in lipoprotein subclasses measured by nuclear magnetic resonance spectroscopy: the Framingham Study. Clin Chem 50(7):1189-1200
14. Kaess BM, Tomaszewski M, Braund PS, Stark K, Rafelt S, Fischer M, Hardwick R, Nelson CP, Debiec R, Huber F et al (2011) Large-scale candidate gene analysis of HDL particle features. PLoS ONE 6(1):e14529
15. Lai CQ, Arnett DK, Corella D, Straka RJ, Tsai MY, Peacock JM, Adiconis X, Parnell LD, Hixson JE, Province MA et al (2007) Fenofibrate effect on triglyceride and postprandial response of apolipoprotein A5 variants: the GOLDN study. Arterioscler Thromb Vasc Biol 27(6):1417-1425
16. Kraja AT, Province MA, Straka RJ, Ordovas JM, Borecki IB, Arnett DK (2010) Fenofibrate and metabolic syndrome. Endocr Metab Immune Disord Drug Targets 10(2):138-148
17. Patsch JR, Miesenbock G, Hopferwieser T, Muhlberger V, Knapp E, Dunn JK, Gotto AM Jr, Patsch W (1992) Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler Thromb 12(11):1336-1345
18. Tsai MY, Georgopoulos A, Otvos JD, Ordovas JM, Hanson NQ, Peacock JM, Arnett DK (2004) Comparison of ultracentrifugation and nuclear magnetic resonance spectroscopy in the quantification of triglyceride-rich lipoproteins after an oral fat load. Clin Chem 50(7):1201-1204
19. Otvos JD (2002) Measurement of lipoprotein subclass profiles by nuclear magnetic resonance spectroscopy. Clin Lab 48(3-4):171-180
20. Kenward MG, Roger JH (1997) Small sample inference for fixed effects from restricted maximum likelihood. Biometrics 53(3):983-997
21. Kraja AT, Rao DC, Weder AB, Mosley TH, Turner ST, Hsiung CA, Quertermous T, Cooper R, Curb JD, Province MA (2005) An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program. Nutr Metab (Lond) 2:17
22. Kim YJ, Go MJ, Hu C, Hong CB, Kim YK, Lee JY, Hwang JY, Oh JH, Kim DJ, Kim NH et al (2011) Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet 43(10):990-995
23. Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N et al (2010) Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 30(11):2264-2276
24. Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, Sovio U, Mathias RA, Sun YV, Franceschini N et al (2011) A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes 60(4):1329-1339
25. Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS et al (2008) Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40(2):189-197
26. Burkhardt R, Toh SA, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T et al (2010) Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest 120(12):4410-4414
27. Kathiresan S, Manning AK, Demissie S, D'Agostino RB, Surti A, Guiducci C, Gianniny L, Burtt NP, Melander O, Orho-Melander M et al (2007) A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet 8(Suppl 1):S17
28. Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G et al (2008) A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 4(5):e1000072
29. Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, Dupuis J (2007) Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet 8(Suppl 1):S16
30. Benjamin EJ, Dupuis J, Larson MG, Lunetta KL, Booth SL, Govindaraju DR, Kathiresan S, Keaney JF Jr, Keyes MJ, Lin JP et al (2007) Genome-wide association with select biomarker traits in the Framingham Heart Study. BMC Med Genet 8(Suppl 1):S11
31. Marroni F, Pfeufer A, Aulchenko YS, Franklin CS, Isaacs A, Pichler I, Wild SH, Oostra BA, Wright AF, Campbell H et al (2009) A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. Circ Cardiovasc Genet 2(4):322-328
32. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ et al (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466(7307):707-713
33. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T et al (2009) Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41(1):56-65
34. Murea M, Lu L, Ma L, Hicks PJ, Divers J, McDonough CW, Langefeld CD, Bowden DW, Freedman BI (2011) Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. Am J Nephrol 33(6):502-509
35. Tabassum R, Mahajan A, Chauhan G, Dwivedi OP, Ghosh S, Tandon N, Bharadwaj D (2010) Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population. BMC Med Genet 11:35
36. Santos JL, De la Cruz R, Holst C, Grau K, Naranjo C, Maiz A, Astrup A, Saris WH, MacDonald I, Oppert JM et al (2011) Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. PLoS ONE 6(6):e19934
37. Mencarelli M, Dubern B, Alili R, Maestrini S, Benajiba L, Tagliaferri M, Galan P, Rinaldi M, Simon C, Tounian P et al (2011) Rare melanocortin-3 receptor mutations with in vitro functional consequences are associated with human obesity. Hum Mol Genet 20(2):392-399
38. Soininen P, Kangas AJ, Wurtz P, Tukiainen T, Tynkkynen T, Laatikainen R, Jarvelin MR, Kahonen M, Lehtimaki T, Viikari J et al (2009) High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst 134(9):1781-1785