Relationship betweencerebral microbleeds and cognitive function in lacunar infarct

Journal of International Medical Research

Volumn 41, Issue 2, 2013, Pages 347-355

  Zhang, Min ^a,b   Chen, Maogang ^c   Wang, Qizhang ^d   Yun, Wenwei ^a   Zhang, Zhizhong ^b   Yin, Qin ^b   Huang, Qinsong ^b   Zhu, Wusheng ^b  

^a THE AFFILIATED CHANGZHOU NO 2 PEOPLE S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c NANTONG UNIVERSITY   (China)

^d GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN REGION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EDUCATIONAL STATUS; FEMALE; HUMAN; LACUNAR STROKE; MAJOR CLINICAL STUDY; MALE; MONTREAL COGNITIVE ASSESSMENT; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PROSPECTIVE STUDY; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; COGNITION; COMPLICATION; DEMOGRAPHY; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICAL MODEL; ASIAN; BRAIN ISCHEMIA; LACUNAR INFARCT;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CEREBRAL HEMORRHAGE; CHINA; COGNITION; DEMOGRAPHY; FEMALE; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; STROKE, LACUNAR;

CEREBRAL MICROBLEED; COGNITION; ISCHAEMIC STROKE; LACUNAR INFARCT;

EID: 84878358251     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060513476448     Document Type: Article

References (26)

1. Greenberg SM, Vernooij MW, Cordonnier C, et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009; 8: 165-17.
2. Greenberg SM, Nandigam RN, Delgado P, et al. Microbleeds versus macrobleeds: evidence for distinct entities. Stroke 2009; 40: 2382-2386.
3. Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999; 20: 637-642.
4. Nighoghossian N, Hermier M, Adeleine P, et al. Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study. Stroke 2002; 33: 735-742.
5. Imaizumi T, Horita Y, Hashimoto Y, et al. Dotlike hemosiderin spots on T2*-weighted magnetic resonance imaging as a predictor of stroke recurrence: a prospective study. J Neurosurg 2004; 101: 915-920.
6. Werring DJ, Frazer DW, Coward LJ, et al. Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient- echo MRI. Brain 2004; 127: 2265-2275.
7. Seo SW, Hwa Lee B, Kim EJ, et al. Clinical significance of microbleeds in subcortical vascular dementia. Stroke 2007; 38: 1949-1951.
8. Yakushiji Y, Nishiyama M, Yakushiji S, et al. Brain microbleeds and global cognitive function in adults without neurological disorder. Stroke 2008; 39: 3323-3328.
9. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010; 9: 689-701.
10. Thompson CS and Hakim AM. Living beyond our physiological means: small vessel disease of the brain is an expression of a systemic failure in arteriolar function: a unifying hypothesis. Stroke 2009; 40: e322-e330.
11. Adams H, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41.
12. Lee SH, Bae HJ, Yoon BW, et al. Low concentration of serum total cholesterol is associated with multifocal signal loss lesions on gradient-echo magnetic resonance imaging: analysis of risk factors for multifocal signal loss lesions. Stroke 2002; 33: 2845-2849.
13. Kato H, Izumiyama M, Izumiyama K, et al. Silent cerebral microbleeds on T2*-weighted MRI: correlation with stroke subtype, stroke recurrence, and leukoaraiosis. Stroke 2002; 33: 1536-1540.
14. Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993; 43: 1683-1689.
15. Hassan A, Hunt BJ, O'Sullivan M, et al. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain 2003; 126: 424-432.
16. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005; 53: 695-699.
17. Vernooij MW, van der Lugt A, Ikram MA, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 2008; 70: 1208-1214.
18. Werring DJ, Gregoire SM and Cipolotti L. Cerebral microbleeds and vascular cognitive impairment. J Neurol Sci 2010; 299: 131-135.
19. Tang W, Chen Y, Lu J, et al. Cerebral microbleeds and symptom severity of poststroke depression: a magnetic resonance imaging study. J Affect Disord 2011; 129: 354-358.
20. Koh SH, Park CY, Kim MK, et al. Microbleeds and free active MMP-9 are independent risk factors for neurological deterioration in acute lacunar stroke. Eur J Neurol 2011; 18: 158-164.
21. Goos JD, Kester MI, Barkhof F, et al. Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition. Stroke 2009; 40: 3455-3460.
22. Tang WK, Chen YK, Lu JY, et al. Absence of cerebral microbleeds predicts reversion of vascular 'cognitive impairment no dementia' in stroke. Int J Stroke 2011; 6: 498-505.
23. Gregoire SM, Smith K, Jäger HR, et al. Cerebral microbleeds and long-term cognitive outcome: longitudinal cohort study of stroke clinic patients. Cerebrovasc Dis 2012; 33: 430-435.
24. Rosenberg GA, Navratil M, Barone F, et al. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat. J Cereb Blood Flow Metab 1996; 16: 360-366.
25. Bennett DA, Wilson R, Schneider J, et al. Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology 2003; 60: 1909-1915.
26. De Groot JC, De Leeuw FE, Oudkerk M, et al. Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann Neurol 2000; 47: 145-151.