Cerebral microbleeds and vascular cognitive impairment

Journal of the Neurological Sciences

Volumn 299, Issue 1-2, 2010, Pages 131-135

  Werring, David J ^a   Gregoire, Simone M ^a   Cipolotti, Lisa ^b,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^c UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cerebral microbleeds; Dementia; MRI; Vascular cognitive impairment

Indexed keywords

ALZHEIMER DISEASE; BRAIN DAMAGE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBRAL MICROBLEED; CEREBROVASCULAR DISEASE; CLINICAL ASSESSMENT; COGNITION; COGNITIVE DEFECT; HUMAN; MULTIINFARCT DEMENTIA; NEURORADIOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; VASCULAR AMYLOIDOSIS; VASCULAR COGNITIVE IMPAIRMENT; WHITE MATTER;

EID: 78649512323     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2010.08.034     Document Type: Article

References (44)

1. V. Hachinski, C. Iadecola, R.C. Petersen, M.M. Breteler, D.L. Nyenhuis, and S.E. Black National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards Stroke 37 9 2006 Sep 2220 2241
2. E.J. van Dijk, N.D. Prins, H.A. Vrooman, A. Hofman, P.J. Koudstaal, and M.M. Breteler Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study Stroke 39 10 2008 Oct 2712 2719
3. S. Black, and C. Iadecola Vascular cognitive impairment: small vessels, big toll: introduction Stroke 40 3 Suppl 2009 Mar S38 S39
4. J.V. Bowler Modern concept of vascular cognitive impairment Br Med Bull 83 2007 291 305
5. S.M. Greenberg, M.W. Vernooij, C. Cordonnier, A. Viswanathan, S.R. Al-Shahi, and S. Warach Cerebral microbleeds: a guide to detection and interpretation Lancet Neurol 8 2 2009 Feb 165 174
6. H.C. Koennecke Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications Neurology 66 2 2006 Jan 24 165 171
7. F. Udaka, H. Sawada, and M. Kameyama White matter lesions and dementia: MRI-pathological correlation Ann NY Acad Sci 977 2002 Nov 411 415
8. M. O'Sullivan, D.J. Lythgoe, A.C. Pereira, P.E. Summers, J.M. Jarosz, and S.C. Williams Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis Neurology 59 3 2002 Aug 13 321 326
9. H.S. Markus, D.J. Lythgoe, L. Ostegaard, M. O'Sullivan, and S.C. Williams Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI J Neurol Neurosurg Psychiatry 69 1 2000 Jul 48 53
10. J.C. van Swieten, S. Staal, L.J. Kappelle, M.M. Derix, and G.J. Van Are white matter lesions directly associated with cognitive impairment in patients with lacunar infarcts? J Neurol 243 2 1996 Feb 196 200
11. O. Sabri, E.B. Ringelstein, D. Hellwig, R. Schneider, M. Schreckenberger, and H.J. Kaiser Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy Stroke 30 3 1999 Mar 556 566
12. R. Barber, P. Scheltens, A. Gholkar, C. Ballard, I. McKeith, and P. Ince White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging J Neurol Neurosurg Psychiatry 67 1 1999 Jul 66 72
13. M.G. Hennerici What are the mechanisms for post-stroke dementia? Lancet Neurol 8 11 2009 Nov 973 975
14. H.V. Vinters Cerebral amyloid angiopathy. A critical review Stroke 18 2 1987 Mar 311 324
15. C. Iadecola, L. Park, and C. Capone Threats to the mind: aging, amyloid, and hypertension Stroke 40 3 Suppl 2009 Mar S40 S44
16. F. Fazekas, R. Kleinert, G. Roob, G. Kleinert, P. Kapeller, and R. Schmidt Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds AJNR Am J Neuroradiol 20 4 1999 Apr 637 642
17. S.M. Gregoire, U.J. Chaudhary, M.M. Brown, T.A. Yousry, C. Kallis, and H.R. Jager The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds Neurology 73 21 2009 Nov 24 1759 1766
18. S. Tatsumi, M. Shinohara, and T. Yamamoto Direct comparison of histology of microbleeds with postmortem MR images: a case report Cerebrovasc Dis 26 2 2008 142 146
19. A. Tanaka, A. Ueno, Y. Takayama, and K. Takabayashi Small haemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas Stroke 30 1999 1637 1642
20. M. Schrag, G. McAuley, J. Pomakian, A. Jiffry, S. Tung, and C. Mueller Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study Acta Neuropathol 2009 Nov 25
21. C. Cordonnier, S.R. Al-Shahi, and J. Wardlaw Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting Brain 130 Pt 8 2007 Aug 1988 2003
22. D.J. Werring, L.J. Coward, N.A. Losseff, H.R. Jager, and M.M. Brown Cerebral microbleeds are common in ischemic stroke but rare in TIA Neurology 65 12 2005 Dec 27 1914 1918
23. J.A. Pettersen, G. Sathiyamoorthy, F.Q. Gao, G. Szilagyi, and N.K. Nadkarni St George-Hyslop P, et al. Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study Arch Neurol 65 6 2008 Jun 790 795
24. C. Cordonnier, W.M. van der Flier, J.D. Sluimer, D. Leys, F. Barkhof, and P. Scheltens Prevalence and severity of microbleeds in a memory clinic setting Neurology 66 9 2006 May 9 1356 1360
25. M.W. Vernooij, L.A. van der, M.A. Ikram, P.A. Wielopolski, W.J. Niessen, and A. Hofman Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study Neurology 70 14 2008 Apr 1 1208 1214 (Pubitemid 351482572)
26. D.J. Werring, D.W. Frazer, L.J. Coward, N.A. Losseff, H. Watt, and L. Cipolotti Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI Brain 127 Pt 10 2004 Oct 2265 2275
27. G. Roob, R. Schmidt, P. Kapeller, A. Lechner, H.P. Hartung, and F. Fazekas MRI evidence of past cerebral microbleeds in a healthy elderly population Neurology 52 5 1999 Mar 23 991 994
28. T. Jeerakathil, P.A. Wolf, A. Beiser, J.K. Hald, R. Au, and C.S. Kase Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study Stroke 35 8 2004 Aug 1831 1835
29. Y. Yakushiji, M. Nishiyama, S. Yakushiji, T. Hirotsu, A. Uchino, and J. Nakajima Brain microbleeds and global cognitive function in adults without neurological disorder Stroke 39 12 2008 Dec 3323 3328
30. D.J. Werring, D.W. Frazer, L.J. Coward, N.A. Losseff, H. Watt, and L. Cipolotti Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI Brain 127 Pt 10 2004 Oct 2265 2275
31. S.S. Won, L.B. Hwa, E.J. Kim, J. Chin, C.Y. Sun, and U. Yoon Clinical significance of microbleeds in subcortical vascular dementia Stroke 38 6 2007 Jun 1949 1951
32. A. Viswanathan, A. Gschwendtner, J.P. Guichard, F. Buffon, R. Cumurciuc, and M. O'Sullivan Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL Neurology 69 2 2007 Jul 10 172 179
33. S.T. Pendlebury, and P.M. Rothwell Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis Lancet Neurol 8 11 2009 Nov 1006 1018
34. S.M. Gregoire, K. Smith, N. Sokolowsky, L. Cipolotti, M. Brown, and H.R. Jager Brain microbleeds as a risk factor for cognitive decline in stroke clinic patients: 6-year follow-up study J Neurol Neurosurg Psychiatry 80 2009 10.1136/jnnp.2009.191726 e1
35. W.J. Henneman, J.D. Sluimer, C. Cordonnier, M.M. Baak, P. Scheltens, and F. Barkhof MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population Stroke 40 2 2009 Feb 492 498
36. J. Birns, R. Morris, J. Jarosz, H.S. Markus, and L. Kalra Hypertension-related cognitive decline: is the time right for intervention studies? Minerva Cardioangiol 61 6 2009 Dec 813 830
37. H. Hanyu, Y. Tanaka, S. Shimizu, M. Takasaki, and K. Abe Cerebral microbleeds in Alzheimer's disease J Neurol 250 12 2003 Dec 1496 1497
38. M. Schrag, G. McAuley, J. Pomakian, A. Jiffry, S. Tung, and C. Mueller Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study Acta Neuropathol 2009 Nov 25
39. J.D. Goos, M.I. Kester, F. Barkhof, M. Klein, M.A. Blankenstein, and P. Scheltens Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition Stroke 40 11 2009 Nov 3455 3460
40. S.M. Greenberg, M.E. Gurol, J. Rosand, and E.E. Smith Amyloid angiopathy-related vascular cognitive impairment Stroke 35 11 Suppl 1 2004 Nov 2616 2619
41. S.M. Greenberg, M.E. Gurol, J. Rosand, and E.E. Smith Amyloid angiopathy-related vascular cognitive impairment Stroke 35 11 Suppl 1 2004 Nov 2616 2619
42. K.A. Knudsen, J. Rosand, D. Karluk, and S.M. Greenberg Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria Neurology 56 4 2001 Feb 27 537 539 (Pubitemid 32172884)
43. A. Viswanathan, P. Patel, R. Rahman, R.N. Nandigam, C. Kinnecom, and L. Bracoud Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathy Stroke 39 7 2008 Jul 1988 1992
44. M. O'Sullivan, R.G. Morris, B. Huckstep, D.K. Jones, S.C. Williams, and H.S. Markus Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis J Neurol Neurosurg Psychiatry 75 3 2004 Mar 441 447