-
1
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
Konopleva M., Contractor R., Tsao T., Samudio I., Ruvolo P.P., Kitada S., et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 2006, 10:375-388.
-
(2006)
Cancer Cell
, vol.10
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
Samudio, I.4
Ruvolo, P.P.5
Kitada, S.6
-
2
-
-
84856270102
-
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
-
Glaser S.P., Lee E.F., Trounson E., Bouillet P., Wei A., Fairlie W.D., et al. Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes and Development 2012, 26:120-125.
-
(2012)
Genes and Development
, vol.26
, pp. 120-125
-
-
Glaser, S.P.1
Lee, E.F.2
Trounson, E.3
Bouillet, P.4
Wei, A.5
Fairlie, W.D.6
-
3
-
-
33846674886
-
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
-
Chen S., Dai Y., Harada H., Dent P., Grant S. Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Research 2007, 67:782-791.
-
(2007)
Cancer Research
, vol.67
, pp. 782-791
-
-
Chen, S.1
Dai, Y.2
Harada, H.3
Dent, P.4
Grant, S.5
-
4
-
-
27444436166
-
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
-
Rahmani M., Davis E.M., Bauer C., Dent P., Grant S. Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. Journal of Biological Chemistry 2005, 280:35217-35227.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 35217-35227
-
-
Rahmani, M.1
Davis, E.M.2
Bauer, C.3
Dent, P.4
Grant, S.5
-
5
-
-
42349087045
-
Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway
-
Zhang W., Konopleva M., Ruvolo V.R., McQueen T., Evans R.L., Bornmann W.G., et al. Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. Leukemia 2008, 22:808-818.
-
(2008)
Leukemia
, vol.22
, pp. 808-818
-
-
Zhang, W.1
Konopleva, M.2
Ruvolo, V.R.3
McQueen, T.4
Evans, R.L.5
Bornmann, W.G.6
-
6
-
-
84859627981
-
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex
-
Konopleva M., Milella M., Ruvolo P., Watts J.C., Ricciardi M.R., Korchin B., et al. MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex. Leukemia 2012, 26:778-787.
-
(2012)
Leukemia
, vol.26
, pp. 778-787
-
-
Konopleva, M.1
Milella, M.2
Ruvolo, P.3
Watts, J.C.4
Ricciardi, M.R.5
Korchin, B.6
-
7
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M., Marcellus R.C., Roulston A., Watson M., Serfass L., Murthy Madiraju S.R., et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:19512-19517.
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
Watson, M.4
Serfass, L.5
Murthy Madiraju, S.R.6
-
8
-
-
44849133234
-
Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax)
-
Konopleva M., Watt J., Contractor R., Tsao T., Harris D., Estrov Z., et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax). Cancer Research 2008, 68:3413-3420.
-
(2008)
Cancer Research
, vol.68
, pp. 3413-3420
-
-
Konopleva, M.1
Watt, J.2
Contractor, R.3
Tsao, T.4
Harris, D.5
Estrov, Z.6
-
9
-
-
84862737555
-
Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process
-
Rahmani M., Aust M.M., Attkisson E., Williams D.C., Ferreira-Gonzalez A., Grant S. Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process. Blood 2012, 119:6089-6098.
-
(2012)
Blood
, vol.119
, pp. 6089-6098
-
-
Rahmani, M.1
Aust, M.M.2
Attkisson, E.3
Williams, D.C.4
Ferreira-Gonzalez, A.5
Grant, S.6
-
10
-
-
84864065947
-
Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies
-
Kasper S., Breitenbuecher F., Heidel F., Hoffarth S., Markova B., Schuler M., et al. Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies. Blood Cancer Journal 2012, 2:e60.
-
(2012)
Blood Cancer Journal
, vol.2
-
-
Kasper, S.1
Breitenbuecher, F.2
Heidel, F.3
Hoffarth, S.4
Markova, B.5
Schuler, M.6
-
11
-
-
12244294475
-
Timed Sequential Therapy of Acute Leukemia with Flavopiridol
-
Karp J.E., Ross D.D., Yang W., Tidwell M.L., Wei Y., Greer J., et al. Timed Sequential Therapy of Acute Leukemia with Flavopiridol. Clinical Cancer Research 2003, 9:307-315.
-
(2003)
Clinical Cancer Research
, vol.9
, pp. 307-315
-
-
Karp, J.E.1
Ross, D.D.2
Yang, W.3
Tidwell, M.L.4
Wei, Y.5
Greer, J.6
-
12
-
-
77952902915
-
Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia
-
Karp J.E., Blackford A., Smith B.D., Alino K., Seung A.H., Bolanos-Meade J., et al. Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia. Leukemia Research 2010, 34:877-882.
-
(2010)
Leukemia Research
, vol.34
, pp. 877-882
-
-
Karp, J.E.1
Blackford, A.2
Smith, B.D.3
Alino, K.4
Seung, A.H.5
Bolanos-Meade, J.6
-
13
-
-
77951645227
-
Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
-
Ravandi F., Cortes J.E., Jones D., Faderl S., Garcia-Manero G., Konopleva M.Y., et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. Journal of Clinical Oncology 2010, 28:1856-1862.
-
(2010)
Journal of Clinical Oncology
, vol.28
, pp. 1856-1862
-
-
Ravandi, F.1
Cortes, J.E.2
Jones, D.3
Faderl, S.4
Garcia-Manero, G.5
Konopleva, M.Y.6
-
14
-
-
84878359602
-
Phase I/II study of sorafenib (Bay 43-9006) in combination with low dose cytarabine (LDAC) in elderly patients with AML or high-risk MDS from The NCIC Clinical Trials Group: Trial IND.186
-
[Epub ahead of print]
-
Macdonald D.A., Assouline S.E., Brandwein J., Kamel-Reid S., Eisenhauer E.A., Couban S., et al. Phase I/II study of sorafenib (Bay 43-9006) in combination with low dose cytarabine (LDAC) in elderly patients with AML or high-risk MDS from The NCIC Clinical Trials Group: Trial IND.186. Leukemia and Lymphoma 2012, Nov. 15, [Epub ahead of print].
-
(2012)
Leukemia and Lymphoma
-
-
Macdonald, D.A.1
Assouline, S.E.2
Brandwein, J.3
Kamel-Reid, S.4
Eisenhauer, E.A.5
Couban, S.6
-
15
-
-
80052017961
-
Phase I pharmacokinetic and pharmacodynamic study of the mssultikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia
-
Inaba H., Rubnitz J.E., Coustan-Smith E., Li L., Furmanski B.D., Mascara G.P., et al. Phase I pharmacokinetic and pharmacodynamic study of the mssultikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia. Journal of Clinical Oncology 2011, 29:3293-3300.
-
(2011)
Journal of Clinical Oncology
, vol.29
, pp. 3293-3300
-
-
Inaba, H.1
Rubnitz, J.E.2
Coustan-Smith, E.3
Li, L.4
Furmanski, B.D.5
Mascara, G.P.6
|