Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 45, Issue , 2013, Pages 21-27

  Lee, Jiunn Tay ^a   Peng, Giia Sheun ^a   Chen, Shao Yuan ^b,c   Hsu, Chang Hung ^a   Lin, Chun Chieh ^a   Cheng, Chun An ^a   Hsu, Yaw Don ^a   Lin, Jiann Chyun ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b CARDINAL TIEN HOSPITAL   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Cell death; Ceramide; Cerebral endothelial cells; Homocysteine; Stroke

Indexed keywords

CERAMIDE; HOMOCYSTEINE; LACTATE DEHYDROGENASE; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; CEREBRAL ENDOTHELIAL CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; MOUSE; NONHUMAN;

Ρ; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYL-TETRAZOLIUM BROMIDE; AC-LDL; ACETYLATED LOW DENSITY LIPOPROTEIN; ACID SPHINGOMYELINASE; ANALYSIS OF VARIANCE; ANOVA; ASM; CECS; CELL DEATH; CERAMIDE; CEREBRAL ENDOTHELIAL CELLS; DMEM; DULBECCO'S MODIFIED EAGLE MEDIUM; FCS; FETAL CALF SERUM; HANK'S BALANCED SALT SOLUTION; HBSS; HCY; HOMOCYSTEINE; LACTATE DEHYDROGENASE; LDH; METHYLENE TETRAHYDROFOLATE REDUCTASE; MTHFR; MTT; NEUTRAL SPHINGOMYELINASE; NSM; REACTIVE OXYGEN SPECIES; ROS; SPEARMAN'S CORRELATION COEFFICIENT; STROKE; THIN LAYER CHROMATOGRAPHY; TLC;

AMITRIPTYLINE; ANIMALS; CELL DEATH; CELL SURVIVAL; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HOMOCYSTEINE; MICE; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; TIME FACTORS;

EID: 84878347271     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.05.003     Document Type: Article

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