Mycophenolate mofetil alleviates lupus nephritis through urokinase receptor signaling in a mice model

Lupus

Volumn 22, Issue 6, 2013, Pages 554-561

  Cheng, C C ^a   Lee, Y F ^a   Lan, J L ^a   Wu, M J ^a   Hsieh, T Y ^a   Lin, N N ^a   Wang, J M ^a   Chiu, Y T ^a,b  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

lupus nephritis; mycophenolate mofetil; uPAR

Indexed keywords

MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; UROKINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MOTILITY; DRUG EFFICACY; FEMALE; GLOMERULUS; IMMUNE COMPLEX DEPOSITION; INTRACELLULAR SIGNALING; KIDNEY FUNCTION; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEINURIA;

LUPUS NEPHRITIS; MYCOPHENOLATE MOFETIL; UPAR;

ANIMALS; BLOOD UREA NITROGEN; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUPUS NEPHRITIS; MICE; MICE, INBRED NZB; MYCOPHENOLIC ACID; PODOCYTES; PROTEINURIA; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84878330241     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203313480398     Document Type: Article

References (30)

1. Cameron JS, Turner DR, Ogg CS, et al. Systemic lupus with nephritis: A long-term study. Q J Med. 1979 ; 48: 1-24
2. Kraft SW, Schwartz MM, Korbet SM, Lewis EJ. Glomerular podocytopathy in patients with systemic lupus erythematosus. J Am Soc Nephrol. 2005 ; 16: 175-179
3. Kreidberg JA, Donovan MJ, Goldstein SL, et al. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development. 1996 ; 122: 3537-3547
4. Faul C, Asanuma K, Yanagida-Asanuma E, et al. Actin up: Regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol. 2007 ; 17: 428-437
5. Moeller MJ, Soofi A, Hartmann I, et al. Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis. J Am Soc Nephrol. 2004 ; 15: 61-67
6. Alfano M, Sidenius N, Panzeri B, et al. Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication. Proc Natl Acad Sci U S A. 2002 ; 99: 8862-8867
7. Madsen CD, Ferraris GM, Andolfo A, et al. uPAR induced cell adhesion and migration: vitronectin provides the key. J Cell Biol. 2007 ; 177: 927-939
8. Wei C, Möller CC, Altintas MM, et al. Modification of kidney barrier function by the urokinase receptor. Nat Med. 2008 ; 14: 55-63
9. Corna D, Morigi M, Facchinetti D, et al. Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease. Kidney Int. 1997 ; 51: 1583-1589
10. Zeher M, Doria A, Lan J, et al. Efficacy and safety of enteric-coated mycophenolate sodium in combination with two glucocorticoid regimens for the treatment of active lupus nephritis. Lupus. 2011 ; 20: 1484-1493
11. Guy M, Newall R, Borzomato J, et al. Diagnostic accuracy of the urinary albumin: creatinine ratio determined by the CLINITEK Microalbumin and DCA 2000+ for the rule-out of albuminuria in chronic kidney disease. Clin Chim Acta. 2009 ; 399: 54-58
12. Chiu YT, Chen YT, Lin NN, et al. Sympathetic activity and myocardial damage after stimulation of dorsal medulla and vagotomy in a novel animal model. Int J Cardiol. 2005 ; 100: 401-407
13. Ortega LM, Schultz DR, Lenz O, et al. Review: Lupus nephritis: Pathologic features, epidemiology and a guide to therapeutic decisions. Lupus. 2010 ; 19: 557-574
14. Ramos MA, Piñera C, Setién MA, et al. Modulation of autoantibody production by mycophenolate mofetil: Effects on the development of SLE in (NZB x NZW)F1 mice. Nephrol Dial Transplant. 2003 ; 18: 878-883
15. Wei C, Möller CC, Altintas MM, et al. Modification of kidney barrier function by the urokinase receptor. Nat Med. 2008 ; 14: 55-63
16. Korbet SM, Lewis EJ, Schwartz MM. Factors predictive of outcome in severe lupus nephritis. Lupus Nephritis Collaborative Study Group. Am J Kidney Dis. 2000 ; 35: 904-914
17. Aringer M, Smolen JS. Cytokine expression in lupus kidneys. Lupus. 2005 ; 14: 13-18
18. Sabry A, Sheashaa H, EI-Husseini A, et al. Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: Its correlation with disease activity. Cytokine. 2006 ; 35: 148-153
19. Reiser J, von Gersdorff G, Loos M, et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest. 2004 ; 113: 1390-1397
20. Daniel C, Ziswiler R, Frey B, et al. Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivative. Exp Nephrol. 2000 ; 8: 52-62
21. Reininger L, Winkler TH, Kalberer CP, et al. Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB x NZW) F1 mice. J Exp Med. 1996 ; 184: 853-861
22. Wei C, El Hindi S, Li J, et al. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med. 2011 ; 17: 952-960
23. Kuiper-Geertsma DG, Derksen RH. New drugs for the treatment of lupus nephritis. Drugs. 2003 ; 63: 167-180
24. Buratti S, Szer IS, Spencer CH. Mycophenolate mofetil treatment of severe renal disease in pediatric onset systemic lupus erythematosus. J Rheumatol. 2001 ; 28: 2103-2108
25. Chou CT. Alternative therapies: what role do they have in the management of lupus?. Lupus. 2010 ; 19: 1425-1429
26. Lanata CM, Mahmood T, Fine DM, Petri M. Combination therapy of mycophenolate mofetil and tacrolimus in lupus nephritis. Lupus. 2010 ; 19: 935-940
27. Lee YH, Woo JH, Choi SJ, et al. Induction and maintenance therapy for lupus nephritis: A systematic review and meta-analysis. Lupus. 2010 ; 19: 703-710
28. Lood C, Eriksson S, Gullstrand B, et al. Increased C1q, C4 and C3 deposition on platelets in patients with systemic lupus erythematosus - a possible link to venous thrombosis?. Lupus. 2012 ; 21: 1423-1432
29. de Groot PG, Urbanus RT, Derksen RH. Pathophysiology of thrombotic APS: where do we stand?. Lupus. 2012 ; 21(7): 704-707
30. Al-Homood IA. Thrombosis in systemic lupus erythematosus: a review article. ISRN Rheumatol. 2012 ; 2012: 428269-428269