Exercise training after spinal cord injury selectively alters synaptic properties in neurons in adult mouse spinal cord

Journal of Neurotrauma

Volumn 30, Issue 10, 2013, Pages 891-896

  Flynn, Jamie R ^a   Dunn, Lynda R ^a   Galea, Mary P ^b   Callister, Robin ^a   Callister, Robert J ^a   Rank, Michelle M ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b THE UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Action potential; Intrinsic properties; Patch clamp electrophysiology; Synaptic input

Indexed keywords

ACTION POTENTIAL; AFTERHYPERPOLARIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; EVOKED EXCITATORY SYNAPTIC CURRENT; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; EXERCISE; MALE; MEMBRANE STEADY POTENTIAL; MOUSE; NERVE CELL PLASTICITY; NERVE CELL STIMULATION; NONHUMAN; PATCH CLAMP; PYRAMIDAL TRACT; SPINAL CORD HEMISECTION; SPINAL CORD INJURY; SPINAL CORD NERVE CELL; SPONTANEOUS EXCITATORY SYNAPTIC CURRENT; SYNAPSE; SYNAPTIC TRANSMISSION; TREADMILL EXERCISE; WHOLE CELL;

ANIMALS; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; NEURONS; PHYSICAL CONDITIONING, ANIMAL; SPINAL CORD; SPINAL CORD INJURIES; SYNAPSES;

EID: 84878300269     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2714     Document Type: Article

References (27)

1. Bareyre, F.M., Kerschensteiner, M., Raineteau, O., Mettenleiter, T.C., Weinmann, O., and Schwab, M.E. (2004). The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat. Neurosci. 7, 269-277. (Pubitemid 38280451)
2. Fouad, K., Pedersen, V., Schwab, M.E., and Brosamle, C. (2001). Cervical sprouting of corticospinal fibers after thoracic spinal cord injury accompanies shifts in evoked motor responses. Curr. Biol. 11, 1766-1770. (Pubitemid 33092164)
3. Flynn, J.R., Graham, B.A., Galea, M.P., and Callister, R.J. (2011). The role of propriospinal interneurons in recovery from spinal cord injury. Neuropharmacology 60, 809-822.
4. Engesser-Cesar, C., Ichiyama, R.M., Nefas, A.L., Hill, M.A., Edgerton, V.R., Cotman, C.W., and Anderson, A.J. (2007). Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur. J. Neurosci. 25, 1931-1939. (Pubitemid 46581741)
5. Goldshmit, Y., Lythgo, N., Galea, M.P., and Turnley, A.M. (2008). Treadmill training after spinal cord hemisection in mice promotes axonal sprouting and synapse formation and improves motor recovery. J. Neurotrauma 25, 449-465. (Pubitemid 351685485)
6. Flynn, J.R., Brichta, A.M., Galea, M.P., Callister, R.J., and Graham, B.A. (2011). A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord. J. Neurosci. Methods 200, 113-120.
7. Hsu, J.Y., Stein, S.A., and Xu, X.M. (2006). Development of the corticospinal tract in the mouse spinal cord: a quantitative ultrastructural analysis. Brain Res. 1084, 16-27.
8. Steward, O., Zheng, B., Tessier-Lavigne, M., Hofstadter, M., Sharp, K., and Yee, K.M. (2008). Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. J. Neurosci. 28, 6836-6847.
9. Dodt, H.U., and Zieglgänsberger, W. (1990). Visualizing unstained neurones in living brain slices by infrared dic-videomicroscopy. Brain Res. 537, 333-336.
10. Barry, P.H., and Lynch, J.W. (1991). Liquid junction potentials and small cell effects in patch-clamp analysis. J. Membr. Biol. 121, 101-117.
11. Beaumont, E., Houle, J.D., Peterson, C.A., and Gardiner, P.F. (2004). Passive exercise and fetal spinal cord transplant both help to restore motoneuronal properties after spinal cord transection in rats. Muscle Nerve 29, 234-242. (Pubitemid 38166845)
12. Szucs, P., Odeh, F., Szokol, K., and Antal, M. (2003). Neurons with distinctive firing patterns, morphology and distribution in laminae v-vii of the neonatal rat lumbar spinal cord. Eur. J. Neurosci. 17, 537-544. (Pubitemid 36255890)
13. Willis, W.D., and Coggeshall, R.E. (2004). Sensory Mechanisms of the Spinal Cord. Vol. 1., 3rd ed. NewYork: Kluwer.
14. Watson, C., Paxinos, G., and Kayalioglu, G. (2009). The Spinal Cord. Academic Press: London.
15. Tracey, D.J. (2004). Ascending and descending pathways in the spinal cord, in: The Rat Nervous System. G. Paxinos (ed.). Academic Press: San Diego, pps. 149-164.
16. Harkema, S.J., Hurley, S.L., Patel, U.K., Requejo, P.S., Dobkin, B.H., and Edgerton, V.R. (1997). Human lumbosacral spinal cord interprets loading during stepping. J. Neurophysiol. 77, 797-811. (Pubitemid 27087781)
17. Fouad, K., Rank, M.M., Vavrek, R., Murray, K.C., Sanelli, L., and Bennett, D.J. (2010). Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors. J. Neurophysiol. 104, 2975-2984.
18. Ballermann, M., and Fouad, K. (2006). Spontaneous locomotor recovery in spinal cord injured rats is accompanied by anatomical plasticity of reticulospinal fibers. Eur. J. Neurosci. 23, 1988-1996.
19. Weidner, N., Ner, A., Salimi, N., and Tuszynski, M.H. (2001). Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc. Natl. Acad. Sci. U. S. A. 98, 3513-3518. (Pubitemid 32220876)
20. Courtine, G., Song, B., Roy, R.R., Zhong, H., Herrmann, J.E., Ao, Y., Qi, J., Edgerton, V.R., and Sofroniew, M.V. (2008). Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Nat. Med. 14, 69-74.
21. Hantman, A.W., and Jessell, T.M. (2010). Clarke's column neurons as the focus of a corticospinal corollary circuit. Nat. Neurosci. 13, 1233-1239.
22. Brown, L.T., Jr. (1971). Projections and termination of the corticospinal tract in rodents. Exp. Brain Res. 13, 432-450.
23. Brownstone, R.M., and Wilson, J.M. (2008). Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of hb9 interneurones in rhythmogenesis. Brain Res. Rev. 57, 64-76. (Pubitemid 350213100)
24. Goulding, M. (2009). Circuits controlling vertebrate locomotion: moving in a new direction. Nat. Rev. Neurosci. 10, 507-518.
25. Zheng, B., Lee, J.K., and Xie, F. (2006). Genetic mouse models for studying inhibitors of spinal axon regeneration. Trends Neurosci. 29, 640-646. (Pubitemid 44602263)
26. Turrigiano, G., Abbott, L.F., and Marder, E. (1994). Activity-dependent changes in the intrinsic properties of cultured neurons. Science 264, 974-977. (Pubitemid 24196170)
27. Battistuzzo, C.R., Callister, R.J., Callister, R., and Galea, M.P. (2012). A systematic review of exercise training to promote locomotor recovery in animal models of spinal cord injury. J. Neurotrauma 29, 1600-1613.