Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1

Gastroenterology

Volumn 144, Issue 7, 2013, Pages

  He, Wei Qi ^a   Qiao, Yan Ning ^a   Peng, Ya Jing ^a   Zha, Juan Min ^b   Zhang, Cheng Hai ^a   Chen, Chen ^a   Chen, Cai Ping ^a   Wang, Pei ^a   Yang, Xiao ^c   Li, Chao Jun ^a   Kamm, Kristine E ^d   Stull, James T ^d   Zhu, Min Sheng ^a,e  

^a NANJING UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

^e WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Calcium Signaling; Development; Mouse Model; Phosphorylation

Indexed keywords

ACETYLCHOLINE; CALCIUM; MYOSIN LIGHT CHAIN PHOSPHATASE; POTASSIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; EXON; FEMALE; INTESTINE MUSCLE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION;

EID: 84878289246     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.02.045     Document Type: Article

References (45)

1. K.E. Kamm, J.T. Stull Dedicated myosin light chain kinases with diverse cellular functions J Biol Chem 276 2001 4527 4530
2. A.P. Somlyo, A.V. Somlyo Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase Physiol Rev 83 2003 1325 1358
3. W.Q. He, Y.J. Peng, W.C. Zhang Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice Gastroenterology 135 2008 610 620
4. W.Q. He, Y.N. Qiao, C.H. Zhang Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension Am J Physiol Heart Circ Physiol 301 2011 H584 H591
5. F. Matsumura, D.J. Hartshorne Myosin phosphatase target subunit: many roles in cell function Biochem Biophys Res Commun 369 2008 149 156
6. W.C. Cole, D.G. Welsh Role of myosin light chain kinase and myosin light chain phosphatase in the resistance arterial myogenic response to intravascular pressure Arch Biochem Biophys 510 2011 160 173
7. M.E. Grassie, L.D. Moffat, M.P. Walsh The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ Arch Biochem Biophys 510 2011 147 159
8. M. Eto Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors J Biol Chem 284 2009 35273 35277
9. 2+ sensitization force of smooth muscle contraction J Biol Chem 284 2009 21569 21579
10. A.V. Somlyo, A.P. Somlyo Electromechanical and pharmacomechanical coupling in vascular smooth muscle J Pharmacol Exp Ther 159 1968 129 145
11. T.J. Eddinger, D.P. Meer Myosin II isoforms in smooth muscle: heterogeneity and function Am J Physiol Cell Physiol 293 2007 C493 C508
12. S.A. Fisher Vascular smooth muscle phenotypic diversity and function Physiol Genomics 42A 2010 169 187
13. G.W. Hennig, N.J. Spencer, S. Jokela-Willis ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine Neurogastroenterol Motil 22 2010 e138 e151
14. K.M. Sanders, S.D. Koh, S. Ro Regulation of gastrointestinal motility-insights from smooth muscle biology Nat Rev Gastroenterol Hepatol 11 2012 633 645
15. K. Horiuti, A.V. Somlyo, Y.E. Goldman Kinetics of contraction initiated by flash photolysis of caged adenosine triphosphate in tonic and phasic smooth muscles J Gen Physiol 94 1989 769 781
16. O. Ogut, F.V. Brozovich Determinants of the contractile properties in the embryonic chicken gizzard and aorta Am J Physiol Cell Physiol 279 2000 C1722 C1732
17. R. Okamoto, M. Ito, N. Suzuki The targeted disruption of the MYPT1 gene results in embryonic lethality Transgenic Res 14 2005 337 340
18. J.D. Matthew, A.S. Khromov, M.J. McDuffie Contractile properties and proteins of smooth muscles of a calponin knockout mouse J Physiol 529 2000 811 824
19. 2+, phosphorylation and caldesmon Pflugers Arch 437 1999 267 275
20. K.S. Murthy Signaling for contraction and relaxation in smooth muscle of the gut Annu Rev Physiol 68 2006 345 374
21. M. Ito, T. Nakano, F. Erdodi Myosin phosphatase: structure, regulation and function Mol Cell Biochem 259 2004 197 209
22. M.C. Gong, P. Cohen, T. Kitazawa Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle J Biol Chem 267 1992 14662 14668
23. M.C. Payne, H.Y. Zhang, T. Prosdocimo Myosin phosphatase isoform switching in vascular smooth muscle development J Mol Cell Cardiol 40 2006 274 282
24. 2+ sensitivity, and myosin light chain phosphorylation in urinary bladder smooth muscle of newborn mice J Gen Physiol 125 2005 187 196
25. C.A. Patel, S. Rattan Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle Am J Physiol Gastrointest Liver Physiol 291 2006 G830 G837
26. M.H. Tsai, K.E. Kamm, J.T. Stull Signalling to contractile proteins by muscarinic and purinergic pathways in neurally stimulated bladder smooth muscle J Physiol 590 2012 5107 5121
27. M. Nomura, J.T. Stull, K.E. Kamm Site-specific dephosphorylation of smooth muscle myosin light chain kinase by protein phosphatases 1 and 2A Biochemistry 31 1992 11915 11920
28. 2+ sensitization of contraction in arterial smooth muscle Circ Res 100 2007 121 129
29. 2+ sensitization in intestinal smooth muscle Neurogastroenterol Motil 23 2011 1111 1122
30. M. Eto, T. Kitazawa, D.L. Brautigan Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits Proc Natl Acad Sci U S A 101 2004 8888 8893
31. F. Hofmann, R. Feil, T. Kleppisch Function of cGMP-dependent protein kinases as revealed by gene deletion Physiol Rev 86 2006 1 23
32. A.Y. Rhee, O. Ogut, F.V. Brozovich Nonmuscle myosin, force maintenance, and the tonic contractile phenotype in smooth muscle Pflugers Arch 452 2006 766 774
33. K.J. Won, T. Suzuki, M. Hori Motility disorder in experimentally obstructed intestine: relationship between muscularis inflammation and disruption of the ICC network Neurogastroenterol Motil 18 2006 53 61
34. P. Liu, N.A. Jenkins, N.G. Copeland A highly efficient recombineering-based method for generating conditional knockout mutations Genome Res 13 2003 476 484
35. H. Machida, M. Ito, R. Okamoto Molecular cloning and analysis of the 5'-flanking region of the human MYPT1 gene Biochim Biophys Acta 1517 2001 424 429
36. M. Ito, T. Nakano, F. Erdodi Myosin phosphatase: structure, regulation and function Mol Cell Biochem 259 2004 197 209
37. Z. Wu, L. Yang, L. Cai Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse Respir Res 8 2007 1
38. E. Isotani, G. Zhi, K.S. Lau Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse Proc Natl Acad Sci U S A 101 2004 6279 6284
39. W.Q. He, Y.J. Peng, W.C. Zhang Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice Gastroenterology 135 2008 610 620
40. T. Nakagawa, H. Misawa, Y. Nakajima Absence of peristalsis in the ileum of W/W(V) mutant mice that are selectively deficient in myenteric interstitial cells of Cajal Journal of Smooth Muscle Research 41 2005 141 151
41. I.Y. Chang, N.J. Glasgow, I. Takayama Loss of interstitial cells of Cajal and development of electrical dysfunction in murine small bowel obstruction J Physiol 536 2001 555 568
42. G.J. Babu, E. Loukianov, T. Loukianova Loss of SM-B myosin affects muscle shortening velocity and maximal force development Nat Cell Biol 3 2001 1025 1029
43. D.P. Wilson, C. Sutherland, M.P. Walsh Ca2+ activation of smooth muscle contraction: evidence for the involvement of calmodulin that is bound to the triton insoluble fraction even in the absence of Ca2+ J Biol Chem 277 2002 2186 2192
44. A.S. Khromov, H. Wang, N. Choudhury Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation Proc Natl Acad Sci U S A 103 2006 2440 2445
45. R. Zhuge, R. Bao, K.E. Fogarty Ca2+ sparks act as potent regulators of excitation-contraction coupling in airway smooth muscle J Biol Chem 285 2010 2203 2210